Reactome: A Curated Pathway Database

Caspase-mediated cleavage of cytoskeletal proteins (R-HSA-264870)

Species Homo sapiens

Summation

Caspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and plectin) may directly contribute to apoptotic changes in cell shape.

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000243, BIOMD0000000407, BIOMD0000000220
Literature References
pubMedId Title Journal Year
12655297 Many cuts to ruin: a comprehensive update of caspase substrates Cell Death Differ 2003
17599937 CASVM: web server for SVM-based prediction of caspase substrates cleavage sites Bioinformatics 2007
17254298 SVM-based prediction of caspase substrate cleavage sites BMC Bioinformatics 2006