Reactome: A Curated Pathway Database

Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (R-HSA-265153) [Homo sapiens]

Black Box Event

Immature, clathrin-coated vesicles containing proinsulin-zinc-calcium complexes bud from the trans-golgi network.

Additional Information
Compartment Golgi-associated vesicle
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Literature References
pubMedId Title Journal Year
3896518 Direct identification of prohormone conversion site in insulin-secreting cells Cell 1985
9631292 The role of assembly in insulin's biosynthesis Curr Opin Struct Biol 1998