Reactome: A Curated Pathway Database

Insulin secretory granule translocates to cell cortex (R-HSA-265160) [Homo sapiens]

Black Box Event

Insulin-containing secretory vesicles are translocated along microtubules (polymerized tubulin) from the trans-golgi to the cellular cortex. Motor activity is provided by Dynamin-1 but the complex that connects the secretory granule to the Kinesin-1 is not yet fully known. The process is stimulated by intracellular calcium ions (Ca2+).

Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
KIF5B-like proteins microtubule motor activity (0003777)  
Literature References
pubMedId Title Journal Year
16714477 Insulin vesicle release: walk, kiss, pause ... then run Physiology (Bethesda) 2006