Reactome: A Curated Pathway Database

Insulin secretory granule translocates to cell cortex (R-HSA-265160)

Species Homo sapiens


Insulin-containing secretory vesicles are translocated along microtubules (polymerized tubulin) from the trans-golgi to the cellular cortex. Motor activity is provided by Dynamin-1 but the complex that connects the secretory granule to the Kinesin-1 is not yet fully known. The process is stimulated by intracellular calcium ions (Ca2+).

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Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
KIF5B-like proteins microtubule motor activity (0003777)
Literature References
pubMedId Title Journal Year
16714477 Insulin vesicle release: walk, kiss, pause ... then run Physiology (Bethesda) 2006