Reactome: A Curated Pathway Database

Insulin secretory granule translocates to cell cortex

Stable Identifier
R-HSA-265160
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Insulin-containing secretory vesicles are translocated along microtubules (polymerized tubulin) from the trans-golgi to the cellular cortex. Motor activity is provided by Dynamin-1 but the complex that connects the secretory granule to the Kinesin-1 is not yet fully known. The process is stimulated by intracellular calcium ions (Ca2+).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
microtubule motor activity of KIF5B-like proteins [cytosol] KIF5B-like proteins [cytosol] microtubule motor activity (0003777)
Inferred From