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Insulin secretory granule translocates to cell cortex

Stable Identifier
R-HSA-265160
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Insulin-containing secretory vesicles are translocated along microtubules (polymerized tubulin) from the trans-golgi to the cellular cortex. Motor activity is provided by Dynamin-1 but the complex that connects the secretory granule to the Kinesin-1 is not yet fully known. The process is stimulated by intracellular calcium ions (Ca2+).

Literature References
PubMed ID Title Journal Year
16714477 Insulin vesicle release: walk, kiss, pause ... then run Physiology (Bethesda) 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
microtubule motor activity of KIF5B-like proteins [cytosol]
Physical Entity
Activity
Inferred From