Insulin-containing secretory vesicles are translocated along microtubules (polymerized tubulin) from the trans-golgi to the cellular cortex. Motor activity is provided by Dynamin-1 but the complex that connects the secretory granule to the Kinesin-1 is not yet fully known. The process is stimulated by intracellular calcium ions (Ca2+).
|KIF5B-like proteins||microtubule motor activity (0003777)|
|16714477||Insulin vesicle release: walk, kiss, pause ... then run||Physiology (Bethesda)||2006|