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Insulin secretory granules translocate across the cortical actin network to dock at plasma membrane

Stable Identifier
R-HSA-265178
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Myosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane. A beta cell contains about 10 000 secretory granules. Of these, about 1000 are docked at the inner surface of the plasma membrane and a subset of about 100 docked granules form the "readily releasable" pool (granules which are released within about 5 minutes of glucose stimulation). Docking occurs by interaction between EXOC3/Sec6 located on the membrane of the secretory granule and EXOC4/Sec8 located at the plasma membrane. Additional components (EXOC1, EXOC2, EXOC5, EXOC6, EXOC7, EXOC8) form the Exocyst Complex.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
microfilament motor activity of MYO5A:MYRIP:RAB27A [cytosol]
Physical Entity
Activity
Title
SNARE binding activity of Core SNARE Complex [plasma membrane]
Physical Entity
Activity
Title
protein binding activity of MYO5A:MYRIP:RAB27A [cytosol]
Physical Entity
Activity
This entity is regulated by
Inferred From