Reactome: A Curated Pathway Database

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (R-HSA-2660815) [Homo sapiens]

Black Box Event
Summation

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant, which results from fusion of NOTCH1 intron 24 with the promoter of T-cell receptor TCRB, lacks extracellular EGF repeats involved in ligand binding and is not able to bind to DLL4 (Ellisen et al. 1991).

Additional Information
Compartment plasma membrane
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]