Reactome: A Curated Pathway Database

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1

Stable Identifier
R-HSA-2660819
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant, which results from fusion of NOTCH1 intron 24 with the promoter of T-cell receptor TCRB, lacks extracellular EGF repeats involved in ligand binding and is not able to bind DLL1 (Ellisen et al. 1991).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]