Reactome: A Curated Pathway Database

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 (R-HSA-2660822) [Homo sapiens]

Black Box Event

NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant, which results from fusion of NOTCH1 intron 24 with the promoter of T-cell receptor TCRB, lacks extracellular EGF repeats involved in ligand binding and is not able to bind JAG1 (Ellisen et al. 1991).

Additional Information
Compartment plasma membrane
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]