Reactome: A Curated Pathway Database

Signaling by NOTCH1 HD Domain Mutants in Cancer

Stable Identifier
R-HSA-2691230
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

NOTCH1 heterodimerization domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL) (Weng et al. 2004) and result in constitutive activity of NOTCH1 mutants (Malecki et al. 2006).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]