Reactome: A Curated Pathway Database

Signaling by NOTCH1 HD Domain Mutants in Cancer (R-HSA-2691230)

Species Homo sapiens

Summation

NOTCH1 heterodimerization domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL) (Weng et al. 2004) and result in constitutive activity of NOTCH1 mutants (Malecki et al. 2006).

Locations in the PathwayBrowser
Diseases
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]