Reactome: A Curated Pathway Database

FCERI mediated MAPK activation (R-HSA-2871796) [Homo sapiens]


Formation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as the sequence that leads to degranulation. However, the pathways that lead to cytokine production require the guanine-nucleotide-exchange factors SOS and VAV that regulate GDP-GTP exchange of RAS. After its activation, RAS positively regulates the RAF-dependent pathway that leads to phosphorylation and, in part, activation of the mitogen-activated protein kinases (MAPKs) extracellular-signal-regulated kinase 1 (ERK1) and ERK2 (Gilfillan & Tkaczyk 2006).

Additional Information
Compartment cytosol , nucleoplasm , plasma membrane
Cross References
Database Identifier
BioModels Database BIOMD0000000175, BIOMD0000000477, BIOMD0000000019, BIOMD0000000424, BIOMD0000000255, BIOMD0000000399, BIOMD0000000427
Literature References
pubMedId Title Journal Year
19909365 Adapters in the organization of mast cell signaling Immunol. Rev. 2009
19290926 The tyrosine kinase network regulating mast cell activation Immunol. Rev. 2009
17122878 Intracellular signaling pathways in IgE-dependent mast cell activation Arch. Immunol. Ther. Exp. (Warsz.) 2006