FCERI mediated MAPK activation

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Formation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as the sequence that leads to degranulation. However, the pathways that lead to cytokine production require the guanine-nucleotide-exchange factors SOS and VAV that regulate GDP-GTP exchange of RAS. After its activation, RAS positively regulates the RAF-dependent pathway that leads to phosphorylation and, in part, activation of the mitogen-activated protein kinases (MAPKs) extracellular-signal-regulated kinase 1 (ERK1) and ERK2 (Gilfillan & Tkaczyk 2006).

Literature References
PubMed ID Title Journal Year
19909365 Adapters in the organization of mast cell signaling Immunol. Rev. 2009
17122878 Intracellular signaling pathways in IgE-dependent mast cell activation Arch. Immunol. Ther. Exp. (Warsz.) 2006
19290926 The tyrosine kinase network regulating mast cell activation Immunol. Rev. 2009
Participant Of
Orthologous Events