Reactome: A Curated Pathway Database

FCERI mediated MAPK activation

Stable Identifier
R-HSA-2871796
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Formation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as the sequence that leads to degranulation. However, the pathways that lead to cytokine production require the guanine-nucleotide-exchange factors SOS and VAV that regulate GDP-GTP exchange of RAS. After its activation, RAS positively regulates the RAF-dependent pathway that leads to phosphorylation and, in part, activation of the mitogen-activated protein kinases (MAPKs) extracellular-signal-regulated kinase 1 (ERK1) and ERK2 (Gilfillan & Tkaczyk 2006).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events
Cross References