FCERI mediated NF-kB activation (R-HSA-2871837) [Homo sapiens]


The increase in intracellular Ca+2 in conjunction with DAG also activates PKC and RasGRP, which inturn contributes to cytokine production by mast cells (Kambayashi et al. 2007). Activation of the FCERI engages CARMA1, BCL10 and MALT1 complex to activate NF-kB through PKC-theta (Klemm et al. 2006, Chen et al. 2007). FCERI stimulation leads to phosphorylation, and degradation of IkB which allows the release and nuclear translocation of the NF-kB proteins. Activation of the NF-kB transcription factors then results in the synthesis of several cytokines. NF-kB activation by FCERI is critical for proinflammatory cytokine production during mast cell activation and is crucial for allergic inflammatory diseases (Klemm et al. 2006).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , nucleoplasm , plasma membrane
Cross References
Database Identifier
BioModels Database BIOMD0000000477
Literature References
pubMedId Title Journal Year
17336609 Proximal signaling events in Fc epsilon RI-mediated mast cell activation J. Allergy Clin. Immunol. 2007
16432253 The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation J. Exp. Med. 2006
Inferred Entries
Orthologous events