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About
What is Reactome ?
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H2O [cytosol]
Stable Identifier
R-ALL-29356
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
water
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
Selective autophagy (Bos taurus)
Pexophagy (Bos taurus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
H2O [cytosol]
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Nuclear Envelope (NE) Reassembly (Bos taurus)
Initiation of Nuclear Envelope (NE) Reformation (Bos taurus)
ANKLE2 is deacetylated by SIRT2 (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Bos taurus)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Bos taurus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Bos taurus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)
H2O [cytosol]
Mitotic Prometaphase (Bos taurus)
Condensation of Prometaphase Chromosomes (Bos taurus)
Dephosphorylation of CK2-modified condensin I (Bos taurus)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Bos taurus)
PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Bos taurus)
H2O [cytosol]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)
H2O [cytosol]
Regulation of mitotic cell cycle (Bos taurus)
APC/C-mediated degradation of cell cycle proteins (Bos taurus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Bos taurus)
Dephosphorylation of phospho-Cdh1 (Bos taurus)
H2O [cytosol]
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to chemical stress (Bos taurus)
Cytoprotection by HMOX1 (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Bos taurus)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Bos taurus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Bos taurus)
Nuclear events mediated by NFE2L2 (Bos taurus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Bos taurus)
PRDX1 overoxidizes (Bos taurus)
H2O [cytosol]
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
H2O [cytosol]
Chromatin organization (Bos taurus)
Chromatin modifying enzymes (Bos taurus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)
H2O [cytosol]
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)
H2O [cytosol]
L1CAM interactions (Bos taurus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)
H2O [cytosol]
Semaphorin interactions (Bos taurus)
Sema4D in semaphorin signaling (Bos taurus)
Sema4D mediated inhibition of cell attachment and migration (Bos taurus)
Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
H2O [cytosol]
Signaling by ROBO receptors (Bos taurus)
Regulation of expression of SLITs and ROBOs (Bos taurus)
USP33 deubiquitinates ROBO1 (Bos taurus)
H2O [cytosol]
SLIT2:ROBO1 increases RHOA activity (Bos taurus)
MYO9B inactivates RHOA (Bos taurus)
H2O [cytosol]
Drug ADME (Bos taurus)
Abacavir ADME (Bos taurus)
Abacavir metabolism (Bos taurus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)
H2O [cytosol]
Aspirin ADME (Bos taurus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
H2O [cytosol]
Atorvastatin ADME (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
H2O [cytosol]
Azathioprine ADME (Bos taurus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Bos taurus)
H2O [cytosol]
Ciprofloxacin ADME (Bos taurus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)
H2O [cytosol]
Paracetamol ADME (Bos taurus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Bos taurus)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Bos taurus)
H2O [cytosol]
Prednisone ADME (Bos taurus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Bos taurus)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Bos taurus)
H2O [cytosol]
Ribavirin ADME (Bos taurus)
ADA deamidates RBV (Bos taurus)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)
H2O [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
PRDX1 overoxidizes (Bos taurus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
H2O [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Arachidonate production from DAG (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Bos taurus)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
H2O [cytosol]
Platelet homeostasis (Bos taurus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)
H2O [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Bos taurus)
Disassembly of COPII coated vesicle (Bos taurus)
H2O [cytosol]
Transport of Antigen peptide in to ER (Bos taurus)
H2O [cytosol]
MHC class II antigen presentation (Bos taurus)
Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)
H2O [cytosol]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
H2O [cytosol]
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Bos taurus)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Bos taurus)
H2O [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Negative regulation of FLT3 (Bos taurus)
PTPRJ dephosphorylates active FLT3 (Bos taurus)
H2O [cytosol]
Growth hormone receptor signaling (Bos taurus)
PTP1B dephosphorylates GHR (Bos taurus)
H2O [cytosol]
Interferon Signaling (Bos taurus)
Antiviral mechanism by IFN-stimulated genes (Bos taurus)
OAS antiviral response (Bos taurus)
PDE12 cleaves 2'-5' oligoadenylates (Bos taurus)
H2O [cytosol]
Interferon alpha/beta signaling (Bos taurus)
Regulation of IFNA/IFNB signaling (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Bos taurus)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Bos taurus)
H2O [cytosol]
Signaling by Interleukins (Bos taurus)
Interleukin-1 family signaling (Bos taurus)
Interleukin-1 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
CLEC7A (Dectin-1) induces NFAT activation (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Bos taurus)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Role of phospholipids in phagocytosis (Bos taurus)
Conversion of PA into DAG by PAP-1 (Bos taurus)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Bos taurus)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Bos taurus)
H2O [cytosol]
Toll-like Receptor Cascades (Bos taurus)
Toll Like Receptor 10 (TLR10) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Bos taurus)
Toll Like Receptor TLR1:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Bos taurus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Bos taurus)
MyD88-independent TLR4 cascade (Bos taurus)
TRIF (TICAM1)-mediated TLR4 signaling (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Bos taurus)
MyD88 cascade initiated on plasma membrane (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Bos taurus)
MyD88 dependent cascade initiated on endosome (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TAK1-dependent IKK and NF-kappa-B activation (Bos taurus)
Regulation of NF-kappa B signaling (Bos taurus)
USP14 deubiquitinates NLRC5 (Bos taurus)
H2O [cytosol]
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Pyruvate metabolism (Bos taurus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
H2O [cytosol]
Regulation of pyruvate metabolism (Bos taurus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Bos taurus)
H2O [cytosol]
Biological oxidations (Bos taurus)
Aflatoxin activation and detoxification (Bos taurus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
H2O [cytosol]
Phase I - Functionalization of compounds (Bos taurus)
AADAC deacetylates PHEN (Bos taurus)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)
H2O [cytosol]
Amine Oxidase reactions (Bos taurus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Bos taurus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Bos taurus)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Bos taurus)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Bos taurus)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Bos taurus)
Eicosanoids (Bos taurus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
H2O [cytosol]
Endogenous sterols (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Bos taurus)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Bos taurus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
H2O [cytosol]
Vitamins (Bos taurus)
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)
H2O [cytosol]
Ethanol oxidation (Bos taurus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)
H2O [cytosol]
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
ABHD14B hydrolyses PNPB (Bos taurus)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)
H2O [cytosol]
Glucuronidation (Bos taurus)
Formation of the active cofactor, UDP-glucuronate (Bos taurus)
UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)
H2O [cytosol]
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
H2O [cytosol]
Methylation (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
H2O [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Bos taurus)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Bos taurus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)
H2O [cytosol]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Acetylcholine regulates insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Bos taurus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
H2O [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Aspartate and asparagine metabolism (Bos taurus)
ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Bos taurus)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
H2O [cytosol]
Carnitine synthesis (Bos taurus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)
H2O [cytosol]
Histidine catabolism (Bos taurus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)
H2O [cytosol]
Metabolism of polyamines (Bos taurus)
Agmatine biosynthesis (Bos taurus)
Agmatine + H2O <=> putrescine + urea (Bos taurus)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)
H2O [cytosol]
Tyrosine catabolism (Bos taurus)
FAH cleaves 4FAA (Bos taurus)
H2O [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested MeSeO2H into MeSeH (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
H2O [cytosol]
Serine biosynthesis (Bos taurus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)
H2O [cytosol]
Sulfur amino acid metabolism (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
H2O [cytosol]
Cysteine formation from homocysteine (Bos taurus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)
H2O [cytosol]
Degradation of cysteine and homocysteine (Bos taurus)
Cysteine is degraded to serine and H2S (Bos taurus)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Bos taurus)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
H2O [cytosol]
Methionine salvage pathway (Bos taurus)
Acireductone is created (Bos taurus)
H2O [cytosol]
Threonine catabolism (Bos taurus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)
H2O [cytosol]
Tryptophan catabolism (Bos taurus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
H2O [cytosol]
Urea cycle (Bos taurus)
arginine + H2O => ornithine + urea [ARG1] (Bos taurus)
H2O [cytosol]
Metabolism of carbohydrates (Bos taurus)
Fructose metabolism (Bos taurus)
Fructose catabolism (Bos taurus)
ALDH1A1 oxidises GA to DGA (Bos taurus)
H2O [cytosol]
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Bos taurus)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)
H2O [cytosol]
Glycolysis (Bos taurus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Bos taurus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)
H2O [cytosol]
Glycogen metabolism (Bos taurus)
Glycogen synthesis (Bos taurus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Bos taurus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)
H2O [cytosol]
Pentose phosphate pathway (Bos taurus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)
H2O [cytosol]
Metabolism of lipids (Bos taurus)
Biosynthesis of specialized proresolving mediators (SPMs) (Bos taurus)
Biosynthesis of DHA-derived SPMs (Bos taurus)
Biosynthesis of D-series resolvins (Bos taurus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Bos taurus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)
H2O [cytosol]
Biosynthesis of maresins (Bos taurus)
Biosynthesis of maresin-like SPMs (Bos taurus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
H2O [cytosol]
Biosynthesis of protectins (Bos taurus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Bos taurus)
Biosynthesis of E-series 18(R)-resolvins (Bos taurus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Bos taurus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Bos taurus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Bos taurus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)
H2O [cytosol]
Fatty acid metabolism (Bos taurus)
Arachidonic acid metabolism (Bos taurus)
FAAH hydrolyses AEA to AA and ETA (Bos taurus)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Bos taurus)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Bos taurus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Bos taurus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Bos taurus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Bos taurus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Bos taurus)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
SCD desaturates ST-CoA to OLE-CoA (Bos taurus)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Bos taurus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Bos taurus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)
H2O [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Bos taurus)
H2O [cytosol]
Cholesterol biosynthesis (Bos taurus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Bos taurus)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Bos taurus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Bos taurus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
H2O [cytosol]
Squalene is oxidized to its epoxide (Bos taurus)
H2O [cytosol]
Metabolism of steroid hormones (Bos taurus)
Androgen biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Bos taurus)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
H2O [cytosol]
Estrogen biosynthesis (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
H2O [cytosol]
Glucocorticoid biosynthesis (Bos taurus)
CYP17A1 17-hydroxylates PREG (Bos taurus)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Bos taurus)
H2O [cytosol]
Mineralocorticoid biosynthesis (Bos taurus)
CYP21A2 21-hydroxylates PROG (Bos taurus)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
H2O [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Acyl chain remodeling of DAG and TAG (Bos taurus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PC (Bos taurus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PE (Bos taurus)
ABHD4 hydrolyses NAPE (Bos taurus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Bos taurus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PG (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PI (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)
H2O [cytosol]
Acyl chain remodelling of PS (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)
H2O [cytosol]
Hydrolysis of LPC (Bos taurus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
H2O [cytosol]
Synthesis of PA (Bos taurus)
DDHD1,2 hydrolyse PA (Bos taurus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)
H2O [cytosol]
Synthesis of PC (Bos taurus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Bos taurus)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)
H2O [cytosol]
Synthesis of PE (Bos taurus)
PA is dephosphorylated to DAG by LPIN (Bos taurus)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)
H2O [cytosol]
PI Metabolism (Bos taurus)
Glycerophospholipid catabolism (Bos taurus)
GDE1 hydrolyzes GroPIns (Bos taurus)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
H2O [cytosol]
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
Glycosphingolipid catabolism (Bos taurus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Bos taurus)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Bos taurus)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Bos taurus)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Bos taurus)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Bos taurus)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Bos taurus)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Bos taurus)
H2O [cytosol]
Sphingolipid catabolism (Bos taurus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Bos taurus)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Bos taurus)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Bos taurus)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Bos taurus)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Bos taurus)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Bos taurus)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Bos taurus)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Bos taurus)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Bos taurus)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Bos taurus)
H2O [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Bos taurus)
H2O [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)
H2O [cytosol]
Triglyceride catabolism (Bos taurus)
PNPLA4 hydrolyzes TAG (Bos taurus)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
eNOS activation (Bos taurus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)
H2O [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Bos taurus)
H2O [cytosol]
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
H2O [cytosol]
FAICAR => IMP + H2O (Bos taurus)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
H2O [cytosol]
Pyrimidine biosynthesis (Bos taurus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Bos taurus)
H2O [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Bos taurus)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Bos taurus)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Bos taurus)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Bos taurus)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Bos taurus)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Bos taurus)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Bos taurus)
H2O [cytosol]
Pyrimidine catabolism (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
H2O [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)
H2O [cytosol]
Pyrimidine salvage (Bos taurus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)
H2O [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
4 PBGs bind to form HMB (Bos taurus)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Bos taurus)
H2O [cytosol]
UROS transforms HMB to URO3 (Bos taurus)
H2O [cytosol]
Heme degradation (Bos taurus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
H2O [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Transport of RCbl within the body (Bos taurus)
ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Bos taurus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)
H2O [cytosol]
Metabolism of folate and pterines (Bos taurus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Bos taurus)
Cyclisation of GTP to precursor Z (Bos taurus)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Bos taurus)
H2O [cytosol]
Nicotinate metabolism (Bos taurus)
NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Bos taurus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Bos taurus)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Bos taurus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Bos taurus)
H2O [cytosol]
Pyrophosphate hydrolysis (Bos taurus)
LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
H2O [cytosol]
Reversible hydration of carbon dioxide (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)
H2O [cytosol]
Metabolism of RNA (Bos taurus)
Deadenylation-dependent mRNA decay (Bos taurus)
Deadenylation of mRNA (Bos taurus)
CCR4-NOT complex deadenylates mRNA (Bos taurus)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)
H2O [cytosol]
PARN deadenylates mRNA (Bos taurus)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Bos taurus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Bos taurus)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Bos taurus)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Bos taurus)
DCP1-DCP2 complex decaps mRNA (Bos taurus)
H2O [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
GDP-fucose biosynthesis (Bos taurus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)
H2O [cytosol]
Sialic acid metabolism (Bos taurus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Bos taurus)
DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Bos taurus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Bos taurus)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Bos taurus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPII-mediated vesicle transport (Bos taurus)
PP6 dephosphorylates SEC24 (Bos taurus)
H2O [cytosol]
Deubiquitination (Bos taurus)
Josephin domain DUBs (Bos taurus)
ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)
H2O [cytosol]
ATXN3 family cleave Ub chains (Bos taurus)
H2O [cytosol]
Metalloprotease DUBs (Bos taurus)
BRISC complex deubiquitinates NLRP3 (Bos taurus)
H2O [cytosol]
Ovarian tumor domain proteases (Bos taurus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
H2O [cytosol]
UCH proteinases (Bos taurus)
UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Bos taurus)
H2O [cytosol]
Ub-specific processing proteases (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Bos taurus)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Bos taurus)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Bos taurus)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Bos taurus)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Bos taurus)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Bos taurus)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Bos taurus)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Bos taurus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)
H2O [cytosol]
USP5 cleaves polyubiquitin (Bos taurus)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Bos taurus)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Bos taurus)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
Hypusine synthesis from eIF5A-lysine (Bos taurus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
H2O [cytosol]
Neddylation (Bos taurus)
UCHL3, SENP8 cleave NEDD8 (Bos taurus)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Bos taurus)
Synthesis of glycosylphosphatidylinositol (GPI) (Bos taurus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)
H2O [cytosol]
Surfactant metabolism (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
H2O [cytosol]
Translation (Bos taurus)
Eukaryotic Translation Termination (Bos taurus)
APEH hydrolyses NAc-Ser-protein (Bos taurus)
H2O [cytosol]
tRNA Aminoacylation (Bos taurus)
Cytosolic tRNA aminoacylation (Bos taurus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
H2O [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
H2O [cytosol]
Physiological factors (Bos taurus)
CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)
H2O [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter clearance (Bos taurus)
Dopamine clearance from the synaptic cleft (Bos taurus)
Enzymatic degradation of Dopamine by monoamine oxidase (Bos taurus)
MAOA:FAD deaminates DA to DOPAC (Bos taurus)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Bos taurus)
MAOA:FAD deaminates 3MT to HVA (Bos taurus)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Bos taurus)
Metabolism of serotonin (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
H2O [cytosol]
Neurotransmitter release cycle (Bos taurus)
Norepinephrine Neurotransmitter Release Cycle (Bos taurus)
Catabolism of Noradrenaline (Bos taurus)
H2O [cytosol]
Organelle biogenesis and maintenance (Bos taurus)
Cilium Assembly (Bos taurus)
Cargo trafficking to the periciliary membrane (Bos taurus)
VxPx cargo-targeting to cilium (Bos taurus)
ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)
H2O [cytosol]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BAD and translocation to mitochondria (Bos taurus)
Activation of BAD by calcineurin (Bos taurus)
H2O [cytosol]
Protein localization (Bos taurus)
Peroxisomal protein import (Bos taurus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)
H2O [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Bos taurus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)
H2O [cytosol]
The phototransduction cascade (Bos taurus)
Activation of the phototransduction cascade (Bos taurus)
PDE6 hydrolyses cGMP to GMP (Bos taurus)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Bos taurus)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Bos taurus)
OPN1LW binds 11cRAL (Bos taurus)
H2O [cytosol]
OPN1MW binds 11cRAL (Bos taurus)
H2O [cytosol]
OPN1SW binds 11cRAL (Bos taurus)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)
H2O [cytosol]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
H2O [cytosol]
Intracellular signaling by second messengers (Bos taurus)
DAG and IP3 signaling (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
Cam-PDE 1 activation (Bos taurus)
cAMP hydrolysis by Cam-PDE 1 (Bos taurus)
H2O [cytosol]
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
H2O [cytosol]
PTEN Regulation (Bos taurus)
Regulation of PTEN stability and activity (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
H2O [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Bos taurus)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Bos taurus)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Bos taurus)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
H2O [cytosol]
RAF activation (Bos taurus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Bos taurus)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Bos taurus)
H2O [cytosol]
RAS processing (Bos taurus)
RAS proteins are depalmitoylated (Bos taurus)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Bos taurus)
H2O [cytosol]
MTOR signalling (Bos taurus)
Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
AMPK is dephosphorylated (Bos taurus)
H2O [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Bos taurus)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Bos taurus)
H2O [cytosol]
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
Ca-dependent events (Bos taurus)
CaM pathway (Bos taurus)
Calmodulin induced events (Bos taurus)
Cam-PDE 1 activation (Bos taurus)
cAMP hydrolysis by Cam-PDE 1 (Bos taurus)
H2O [cytosol]
phospho-PLA2 pathway (Bos taurus)
Hydrolysis of phosphatidylcholine (Bos taurus)
H2O [cytosol]
Inactivation of PLC beta (Bos taurus)
H2O [cytosol]
PIP2 hydrolysis (Bos taurus)
H2O [cytosol]
G alpha (q) signalling events (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Arachidonate production from DAG (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Bos taurus)
H2O [cytosol]
G alpha (s) signalling events (Bos taurus)
PDE3A hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Bos taurus)
H2O [cytosol]
Signaling by Hedgehog (Bos taurus)
Hedgehog ligand biogenesis (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)
H2O [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Down-Regulation (Bos taurus)
PTPN1 dephosphorylates PTK6 (Bos taurus)
H2O [cytosol]
Signaling by Nuclear Receptors (Bos taurus)
Signaling by Retinoic Acid (Bos taurus)
RA biosynthesis pathway (Bos taurus)
ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Bos taurus)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
MDK and PTN in ALK signaling (Bos taurus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Bos taurus)
H2O [cytosol]
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
PTPN3 dephosphorylates EPS15 (Bos taurus)
H2O [cytosol]
GAB1 signalosome (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Bos taurus)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Bos taurus)
H2O [cytosol]
Signaling by ERBB2 (Bos taurus)
Downregulation of ERBB2 signaling (Bos taurus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)
H2O [cytosol]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor recycling (Bos taurus)
Insulin receptor de-phosphorylation (Bos taurus)
H2O [cytosol]
Insulin receptor signalling cascade (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PKB-mediated events (Bos taurus)
PDE3B signalling (Bos taurus)
p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
Signaling by MET (Bos taurus)
Negative regulation of MET activity (Bos taurus)
PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)
H2O [cytosol]
PTPRJ dephosphorylates MET (Bos taurus)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Bos taurus)
H2O [cytosol]
Signaling by PDGF (Bos taurus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Bos taurus)
IGF1R signaling cascade (Bos taurus)
IRS-related events triggered by IGF1R (Bos taurus)
IRS-mediated signalling (Bos taurus)
PI3K Cascade (Bos taurus)
PKB-mediated events (Bos taurus)
PDE3B signalling (Bos taurus)
p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Miro GTPase Cycle (Bos taurus)
RHOT1 GTPase cycle (Bos taurus)
RHOT1 hydrolyzes GTP (Bos taurus)
H2O [cytosol]
RHOT2 GTPase cycle (Bos taurus)
RHOT2 hydrolyzes GTP (Bos taurus)
H2O [cytosol]
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 hydrolyzes ATP (Bos taurus)
H2O [cytosol]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate Formins (Bos taurus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)
H2O [cytosol]
RHO GTPase cycle (Bos taurus)
CDC42 GTPase cycle (Bos taurus)
CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)
H2O [cytosol]
RAC1 GTPase cycle (Bos taurus)
RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)
H2O [cytosol]
RAC2 GTPase cycle (Bos taurus)
RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)
H2O [cytosol]
RAC3 GTPase cycle (Bos taurus)
RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)
H2O [cytosol]
RHOA GTPase cycle (Bos taurus)
RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)
H2O [cytosol]
RHOC GTPase cycle (Bos taurus)
RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)
H2O [cytosol]
RHOD GTPase cycle (Bos taurus)
RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)
H2O [cytosol]
RHOF GTPase cycle (Bos taurus)
RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)
H2O [cytosol]
RHOG GTPase cycle (Bos taurus)
RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)
H2O [cytosol]
RHOJ GTPase cycle (Bos taurus)
RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)
H2O [cytosol]
RHOQ GTPase cycle (Bos taurus)
RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)
H2O [cytosol]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
MTMR4 dephosphorylates SMAD2/3 (Bos taurus)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
H2O [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Bos taurus)
H2O [cytosol]
TCF dependent signaling in response to WNT (Bos taurus)
Regulation of FZD by ubiquitination (Bos taurus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
H2O [cytosol]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
ABC transporters in lipid homeostasis (Bos taurus)
ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Bos taurus)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Bos taurus)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
HCO3- transport through ion channel (Bos taurus)
H2O [cytosol]
Mitochondrial ABC transporters (Bos taurus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
H2O [cytosol]
The ABCC family mediates organic anion transport (Bos taurus)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
H2O [cytosol]
Aquaporin-mediated transport (Bos taurus)
Passive transport by Aquaporins (Bos taurus)
Aquaporins passively transport water into cells (Bos taurus)
H2O [cytosol]
Aquaporins passively transport water out of cells (Bos taurus)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Bos taurus)
Aquaporin-1 passively transports water into cell (Bos taurus)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Bos taurus)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Bos taurus)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Bos taurus)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Bos taurus)
H2O [cytosol]
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
H2O [cytosol]
Iron uptake and transport (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
H2O [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Bos taurus)
Erythrocytes take up carbon dioxide and release oxygen (Bos taurus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Bos taurus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein assembly (Bos taurus)
HDL assembly (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
H2O [cytosol]
Plasma lipoprotein clearance (Bos taurus)
LDL clearance (Bos taurus)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Bos taurus)
H2O [cytosol]
Plasma lipoprotein remodeling (Bos taurus)
HDL remodeling (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
H2O [cytosol]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
H2O [cytosol]
ER to Golgi Anterograde Transport (Bos taurus)
COPII-mediated vesicle transport (Bos taurus)
PP6 dephosphorylates SEC24 (Bos taurus)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
Golgi-to-ER retrograde transport (Bos taurus)
COPI-independent Golgi-to-ER retrograde traffic (Bos taurus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Bos taurus)
H2O [cytosol]
Rab regulation of trafficking (Bos taurus)
TBC/RABGAPs (Bos taurus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)
H2O [cytosol]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
Mitotic Anaphase (Caenorhabditis elegans)
Nuclear Envelope (NE) Reassembly (Caenorhabditis elegans)
Initiation of Nuclear Envelope (NE) Reformation (Caenorhabditis elegans)
PP2A dephosphorylates BANF1 (Caenorhabditis elegans)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Caenorhabditis elegans)
RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)
H2O [cytosol]
Mitotic Prometaphase (Caenorhabditis elegans)
Resolution of Sister Chromatid Cohesion (Caenorhabditis elegans)
PPP1CC dephosphorylates PLK1 (Caenorhabditis elegans)
H2O [cytosol]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)
H2O [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
Detoxification of Reactive Oxygen Species (Caenorhabditis elegans)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Caenorhabditis elegans)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
Nuclear events mediated by NFE2L2 (Caenorhabditis elegans)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Caenorhabditis elegans)
PRDX1 overoxidizes (Caenorhabditis elegans)
H2O [cytosol]
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)
H2O [cytosol]
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by ROBO receptors (Caenorhabditis elegans)
SLIT2:ROBO1 increases RHOA activity (Caenorhabditis elegans)
MYO9B inactivates RHOA (Caenorhabditis elegans)
H2O [cytosol]
Drug ADME (Caenorhabditis elegans)
Abacavir ADME (Caenorhabditis elegans)
Abacavir metabolism (Caenorhabditis elegans)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)
H2O [cytosol]
Aspirin ADME (Caenorhabditis elegans)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
H2O [cytosol]
Atorvastatin ADME (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
H2O [cytosol]
Azathioprine ADME (Caenorhabditis elegans)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
H2O [cytosol]
Ciprofloxacin ADME (Caenorhabditis elegans)
ABCG2 transports Cipro from hepatic cell to extracellular space (Caenorhabditis elegans)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Caenorhabditis elegans)
H2O [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Caenorhabditis elegans)
H2O [cytosol]
Ribavirin ADME (Caenorhabditis elegans)
ADA deamidates RBV (Caenorhabditis elegans)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)
H2O [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
PRDX1 overoxidizes (Caenorhabditis elegans)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Caenorhabditis elegans)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)
H2O [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Arachidonate production from DAG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
H2O [cytosol]
Platelet homeostasis (Caenorhabditis elegans)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)
H2O [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
H2O [cytosol]
Costimulation by the CD28 family (Caenorhabditis elegans)
CTLA4 inhibitory signaling (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
H2O [cytosol]
TCR signaling (Caenorhabditis elegans)
Downstream TCR signaling (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
H2O [cytosol]
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Interferon Signaling (Caenorhabditis elegans)
Antiviral mechanism by IFN-stimulated genes (Caenorhabditis elegans)
OAS antiviral response (Caenorhabditis elegans)
PDE12 cleaves 2'-5' oligoadenylates (Caenorhabditis elegans)
H2O [cytosol]
Innate Immune System (Caenorhabditis elegans)
Fcgamma receptor (FCGR) dependent phagocytosis (Caenorhabditis elegans)
Role of phospholipids in phagocytosis (Caenorhabditis elegans)
Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)
H2O [cytosol]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Pyruvate metabolism (Caenorhabditis elegans)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
H2O [cytosol]
Regulation of pyruvate metabolism (Caenorhabditis elegans)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Caenorhabditis elegans)
H2O [cytosol]
Biological oxidations (Caenorhabditis elegans)
Aflatoxin activation and detoxification (Caenorhabditis elegans)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)
H2O [cytosol]
Phase I - Functionalization of compounds (Caenorhabditis elegans)
AADAC deacetylates PHEN (Caenorhabditis elegans)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Caenorhabditis elegans)
Endogenous sterols (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
H2O [cytosol]
Vitamins (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)
H2O [cytosol]
Ethanol oxidation (Caenorhabditis elegans)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)
H2O [cytosol]
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
ABHD14B hydrolyses PNPB (Caenorhabditis elegans)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Glucuronidation (Caenorhabditis elegans)
Formation of the active cofactor, UDP-glucuronate (Caenorhabditis elegans)
UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)
H2O [cytosol]
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
H2O [cytosol]
Methylation (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)
H2O [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Caenorhabditis elegans)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Aspartate and asparagine metabolism (Caenorhabditis elegans)
ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
H2O [cytosol]
Carnitine synthesis (Caenorhabditis elegans)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)
H2O [cytosol]
Histidine catabolism (Caenorhabditis elegans)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)
H2O [cytosol]
Tyrosine catabolism (Caenorhabditis elegans)
FAH cleaves 4FAA (Caenorhabditis elegans)
H2O [cytosol]
Selenoamino acid metabolism (Caenorhabditis elegans)
Metabolism of ingested MeSeO2H into MeSeH (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
H2O [cytosol]
Selenocysteine synthesis (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
H2O [cytosol]
Serine biosynthesis (Caenorhabditis elegans)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)
H2O [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
H2O [cytosol]
Cysteine formation from homocysteine (Caenorhabditis elegans)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)
H2O [cytosol]
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
Cysteine is degraded to serine and H2S (Caenorhabditis elegans)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)
H2O [cytosol]
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is created (Caenorhabditis elegans)
H2O [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
H2O [cytosol]
Urea cycle (Caenorhabditis elegans)
arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Fructose metabolism (Caenorhabditis elegans)
Fructose catabolism (Caenorhabditis elegans)
ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)
H2O [cytosol]
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Caenorhabditis elegans)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)
H2O [cytosol]
Glycolysis (Caenorhabditis elegans)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Caenorhabditis elegans)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Glycogen metabolism (Caenorhabditis elegans)
Glycogen synthesis (Caenorhabditis elegans)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)
H2O [cytosol]
Pentose phosphate pathway (Caenorhabditis elegans)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Biosynthesis of specialized proresolving mediators (SPMs) (Caenorhabditis elegans)
Biosynthesis of DHA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of D-series resolvins (Caenorhabditis elegans)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Caenorhabditis elegans)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of maresins (Caenorhabditis elegans)
Biosynthesis of maresin-like SPMs (Caenorhabditis elegans)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Caenorhabditis elegans)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of protectins (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Caenorhabditis elegans)
Biosynthesis of E-series 18(R)-resolvins (Caenorhabditis elegans)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Caenorhabditis elegans)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)
H2O [cytosol]
Fatty acid metabolism (Caenorhabditis elegans)
Arachidonic acid metabolism (Caenorhabditis elegans)
FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Caenorhabditis elegans)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Caenorhabditis elegans)
LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Caenorhabditis elegans)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Caenorhabditis elegans)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Bile acid and bile salt metabolism (Caenorhabditis elegans)
Recycling of bile acids and salts (Caenorhabditis elegans)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of bile acids and bile salts (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
H2O [cytosol]
Cholesterol biosynthesis (Caenorhabditis elegans)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of steroid hormones (Caenorhabditis elegans)
Estrogen biosynthesis (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
H2O [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Acyl chain remodeling of DAG and TAG (Caenorhabditis elegans)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PC (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PE (Caenorhabditis elegans)
ABHD4 hydrolyses NAPE (Caenorhabditis elegans)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PG (Caenorhabditis elegans)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Caenorhabditis elegans)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PI (Caenorhabditis elegans)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Caenorhabditis elegans)
H2O [cytosol]
Acyl chain remodelling of PS (Caenorhabditis elegans)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PA (Caenorhabditis elegans)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Caenorhabditis elegans)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Caenorhabditis elegans)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Caenorhabditis elegans)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PC (Caenorhabditis elegans)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PE (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
H2O [cytosol]
PI Metabolism (Caenorhabditis elegans)
Glycerophospholipid catabolism (Caenorhabditis elegans)
GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
H2O [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid catabolism (Caenorhabditis elegans)
ENPP7 hydrolyzes sphingomyelin (Caenorhabditis elegans)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Caenorhabditis elegans)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Caenorhabditis elegans)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Caenorhabditis elegans)
H2O [cytosol]
Sphingolipid catabolism (Caenorhabditis elegans)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Caenorhabditis elegans)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Caenorhabditis elegans)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Caenorhabditis elegans)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Caenorhabditis elegans)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Caenorhabditis elegans)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Caenorhabditis elegans)
H2O [cytosol]
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)
H2O [cytosol]
Triglyceride catabolism (Caenorhabditis elegans)
PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
H2O [cytosol]
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
H2O [cytosol]
FAICAR => IMP + H2O (Caenorhabditis elegans)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
H2O [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
H2O [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Caenorhabditis elegans)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Caenorhabditis elegans)
H2O [cytosol]
Pyrimidine catabolism (Caenorhabditis elegans)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
H2O [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)
H2O [cytosol]
Pyrimidine salvage (Caenorhabditis elegans)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Heme degradation (Caenorhabditis elegans)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Transport of RCbl within the body (Caenorhabditis elegans)
ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Caenorhabditis elegans)
Cyclisation of GTP to precursor Z (Caenorhabditis elegans)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)
H2O [cytosol]
Nicotinate metabolism (Caenorhabditis elegans)
NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
PANK4 hydrolyzes PPANT to pantetheine (Caenorhabditis elegans)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Caenorhabditis elegans)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
H2O [cytosol]
Pyrophosphate hydrolysis (Caenorhabditis elegans)
LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Reversible hydration of carbon dioxide (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of RNA (Caenorhabditis elegans)
Deadenylation-dependent mRNA decay (Caenorhabditis elegans)
mRNA decay by 3' to 5' exoribonuclease (Caenorhabditis elegans)
DCPS scavenges the 7-methylguanosine cap of mRNA (Caenorhabditis elegans)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Caenorhabditis elegans)
DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)
H2O [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
GDP-fucose biosynthesis (Caenorhabditis elegans)
GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Caenorhabditis elegans)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Caenorhabditis elegans)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)
H2O [cytosol]
Deubiquitination (Caenorhabditis elegans)
Josephin domain DUBs (Caenorhabditis elegans)
ATXN3 family cleave Ub chains (Caenorhabditis elegans)
H2O [cytosol]
UCH proteinases (Caenorhabditis elegans)
UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)
H2O [cytosol]
Ub-specific processing proteases (Caenorhabditis elegans)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Caenorhabditis elegans)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Caenorhabditis elegans)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Caenorhabditis elegans)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
Hypusine synthesis from eIF5A-lysine (Caenorhabditis elegans)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
H2O [cytosol]
Neddylation (Caenorhabditis elegans)
UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Caenorhabditis elegans)
Synthesis of glycosylphosphatidylinositol (GPI) (Caenorhabditis elegans)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)
H2O [cytosol]
Surfactant metabolism (Caenorhabditis elegans)
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
H2O [cytosol]
Translation (Caenorhabditis elegans)
Eukaryotic Translation Termination (Caenorhabditis elegans)
APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)
H2O [cytosol]
tRNA Aminoacylation (Caenorhabditis elegans)
Cytosolic tRNA aminoacylation (Caenorhabditis elegans)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
H2O [cytosol]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Physiological factors (Caenorhabditis elegans)
CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)
H2O [cytosol]
Protein localization (Caenorhabditis elegans)
Peroxisomal protein import (Caenorhabditis elegans)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Caenorhabditis elegans)
H2O [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The canonical retinoid cycle in rods (twilight vision) (Caenorhabditis elegans)
11cRAL binds to opsin to form 11c-retinyl:RHO (Caenorhabditis elegans)
H2O [cytosol]
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)
H2O [cytosol]
The phototransduction cascade (Caenorhabditis elegans)
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
PP2A dephosphorylates p-RHO to RHO (Caenorhabditis elegans)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Caenorhabditis elegans)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Caenorhabditis elegans)
OPN1LW binds 11cRAL (Caenorhabditis elegans)
H2O [cytosol]
OPN1MW binds 11cRAL (Caenorhabditis elegans)
H2O [cytosol]
OPN1SW binds 11cRAL (Caenorhabditis elegans)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Caenorhabditis elegans)
H2O [cytosol]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
DAG and IP3 signaling (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
Cam-PDE 1 activation (Caenorhabditis elegans)
cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)
H2O [cytosol]
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
H2O [cytosol]
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN stability and activity (Caenorhabditis elegans)
USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)
H2O [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF-independent MAPK1/3 activation (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
H2O [cytosol]
RAF/MAP kinase cascade (Caenorhabditis elegans)
Negative regulation of MAPK pathway (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Caenorhabditis elegans)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)
H2O [cytosol]
RAF activation (Caenorhabditis elegans)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Caenorhabditis elegans)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)
H2O [cytosol]
RAS processing (Caenorhabditis elegans)
RAS proteins are depalmitoylated (Caenorhabditis elegans)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)
H2O [cytosol]
MTOR signalling (Caenorhabditis elegans)
Energy dependent regulation of mTOR by LKB1-AMPK (Caenorhabditis elegans)
AMPK is dephosphorylated (Caenorhabditis elegans)
H2O [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
DARPP-32 events (Caenorhabditis elegans)
PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)
H2O [cytosol]
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
Ca-dependent events (Caenorhabditis elegans)
CaM pathway (Caenorhabditis elegans)
Calmodulin induced events (Caenorhabditis elegans)
Cam-PDE 1 activation (Caenorhabditis elegans)
cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)
H2O [cytosol]
Inactivation of PLC beta (Caenorhabditis elegans)
H2O [cytosol]
PIP2 hydrolysis (Caenorhabditis elegans)
H2O [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Arachidonate production from DAG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
H2O [cytosol]
G alpha (s) signalling events (Caenorhabditis elegans)
PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Nuclear Receptors (Caenorhabditis elegans)
Signaling by Retinoic Acid (Caenorhabditis elegans)
RA biosynthesis pathway (Caenorhabditis elegans)
ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
H2O [cytosol]
Signaling by ERBB2 (Caenorhabditis elegans)
Downregulation of ERBB2 signaling (Caenorhabditis elegans)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Insulin receptor (Caenorhabditis elegans)
Insulin receptor signalling cascade (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PKB-mediated events (Caenorhabditis elegans)
PDE3B signalling (Caenorhabditis elegans)
p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by MET (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
PTPRJ dephosphorylates MET (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Caenorhabditis elegans)
IGF1R signaling cascade (Caenorhabditis elegans)
IRS-related events triggered by IGF1R (Caenorhabditis elegans)
IRS-mediated signalling (Caenorhabditis elegans)
PI3K Cascade (Caenorhabditis elegans)
PKB-mediated events (Caenorhabditis elegans)
PDE3B signalling (Caenorhabditis elegans)
p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Miro GTPase Cycle (Caenorhabditis elegans)
RHOT1 GTPase cycle (Caenorhabditis elegans)
RHOT1 hydrolyzes GTP (Caenorhabditis elegans)
H2O [cytosol]
RHOT2 GTPase cycle (Caenorhabditis elegans)
RHOT2 hydrolyzes GTP (Caenorhabditis elegans)
H2O [cytosol]
RHOBTB3 ATPase cycle (Caenorhabditis elegans)
RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)
H2O [cytosol]
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
CDC42 GTPase cycle (Caenorhabditis elegans)
CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RAC1 GTPase cycle (Caenorhabditis elegans)
RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RAC2 GTPase cycle (Caenorhabditis elegans)
RAC2 GAPs stimulate RAC2 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RAC3 GTPase cycle (Caenorhabditis elegans)
RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOA GTPase cycle (Caenorhabditis elegans)
RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOB GTPase cycle (Caenorhabditis elegans)
RHOB GAPs stimulate RHOB GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOD GTPase cycle (Caenorhabditis elegans)
RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOF GTPase cycle (Caenorhabditis elegans)
RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOG GTPase cycle (Caenorhabditis elegans)
RHOG GAPs stimulate RHOG GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOJ GTPase cycle (Caenorhabditis elegans)
RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
RHOQ GTPase cycle (Caenorhabditis elegans)
RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)
H2O [cytosol]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Caenorhabditis elegans)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Caenorhabditis elegans)
USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)
H2O [cytosol]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
ABC transporters in lipid homeostasis (Caenorhabditis elegans)
ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Caenorhabditis elegans)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
HCO3- transport through ion channel (Caenorhabditis elegans)
H2O [cytosol]
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)
H2O [cytosol]
The ABCC family mediates organic anion transport (Caenorhabditis elegans)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
H2O [cytosol]
Aquaporin-mediated transport (Caenorhabditis elegans)
Passive transport by Aquaporins (Caenorhabditis elegans)
Aquaporins passively transport water into cells (Caenorhabditis elegans)
H2O [cytosol]
Aquaporins passively transport water out of cells (Caenorhabditis elegans)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Caenorhabditis elegans)
Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)
H2O [cytosol]
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)
H2O [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
H2O [cytosol]
Transferrin endocytosis and recycling (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Caenorhabditis elegans)
Erythrocytes take up carbon dioxide and release oxygen (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Caenorhabditis elegans)
Plasma lipoprotein clearance (Caenorhabditis elegans)
LDL clearance (Caenorhabditis elegans)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)
H2O [cytosol]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Caenorhabditis elegans)
Golgi-to-ER retrograde transport (Caenorhabditis elegans)
COPI-independent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)
H2O [cytosol]
Rab regulation of trafficking (Caenorhabditis elegans)
TBC/RABGAPs (Caenorhabditis elegans)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Caenorhabditis elegans)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
H2O [cytosol]
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Pexophagy (Canis familiaris)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)
H2O [cytosol]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Nuclear Envelope (NE) Reassembly (Canis familiaris)
Initiation of Nuclear Envelope (NE) Reformation (Canis familiaris)
ANKLE2 is deacetylated by SIRT2 (Canis familiaris)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Canis familiaris)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Canis familiaris)
RAN stimulates fusion of nuclear envelope (NE) membranes (Canis familiaris)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Canis familiaris)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Canis familiaris)
H2O [cytosol]
Mitotic Prometaphase (Canis familiaris)
Condensation of Prometaphase Chromosomes (Canis familiaris)
Dephosphorylation of CK2-modified condensin I (Canis familiaris)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Canis familiaris)
PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Canis familiaris)
H2O [cytosol]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)
H2O [cytosol]
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Canis familiaris)
Dephosphorylation of phospho-Cdh1 (Canis familiaris)
H2O [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Cytoprotection by HMOX1 (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Canis familiaris)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)
H2O [cytosol]
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Canis familiaris)
Nuclear events mediated by NFE2L2 (Canis familiaris)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Canis familiaris)
PRDX1 overoxidizes (Canis familiaris)
H2O [cytosol]
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)
H2O [cytosol]
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)
H2O [cytosol]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
H2O [cytosol]
L1CAM interactions (Canis familiaris)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Canis familiaris)
H2O [cytosol]
Semaphorin interactions (Canis familiaris)
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D mediated inhibition of cell attachment and migration (Canis familiaris)
Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
H2O [cytosol]
Signaling by ROBO receptors (Canis familiaris)
SLIT2:ROBO1 increases RHOA activity (Canis familiaris)
MYO9B inactivates RHOA (Canis familiaris)
H2O [cytosol]
Drug ADME (Canis familiaris)
Abacavir ADME (Canis familiaris)
Abacavir metabolism (Canis familiaris)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)
H2O [cytosol]
Aspirin ADME (Canis familiaris)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
H2O [cytosol]
Atorvastatin ADME (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
H2O [cytosol]
Azathioprine ADME (Canis familiaris)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Canis familiaris)
H2O [cytosol]
Ciprofloxacin ADME (Canis familiaris)
ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)
H2O [cytosol]
Paracetamol ADME (Canis familiaris)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Canis familiaris)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Canis familiaris)
H2O [cytosol]
Prednisone ADME (Canis familiaris)
ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Canis familiaris)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)
H2O [cytosol]
Ribavirin ADME (Canis familiaris)
ADA deamidates RBV (Canis familiaris)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)
H2O [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
H2O [cytosol]
PRDX1 overoxidizes (Canis familiaris)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)
H2O [cytosol]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Arachidonate production from DAG (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Canis familiaris)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
ABCC4 accumulation of dense granule contents (Canis familiaris)
H2O [cytosol]
Platelet homeostasis (Canis familiaris)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Canis familiaris)
H2O [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Canis familiaris)
Disassembly of COPII coated vesicle (Canis familiaris)
H2O [cytosol]
MHC class II antigen presentation (Canis familiaris)
Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
H2O [cytosol]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Canis familiaris)
H2O [cytosol]
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Canis familiaris)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
H2O [cytosol]
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Negative regulation of FLT3 (Canis familiaris)
PTPRJ dephosphorylates active FLT3 (Canis familiaris)
H2O [cytosol]
Growth hormone receptor signaling (Canis familiaris)
PTP1B dephosphorylates GHR (Canis familiaris)
H2O [cytosol]
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
OAS antiviral response (Canis familiaris)
PDE12 cleaves 2'-5' oligoadenylates (Canis familiaris)
H2O [cytosol]
Interferon alpha/beta signaling (Canis familiaris)
Regulation of IFNA/IFNB signaling (Canis familiaris)
Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
H2O [cytosol]
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)
H2O [cytosol]
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Canis familiaris)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
Conversion of PA into DAG by PAP-1 (Canis familiaris)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Canis familiaris)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Canis familiaris)
H2O [cytosol]
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP14 deubiquitinates NLRC5 (Canis familiaris)
H2O [cytosol]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Pyruvate metabolism (Canis familiaris)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
H2O [cytosol]
Regulation of pyruvate metabolism (Canis familiaris)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Canis familiaris)
H2O [cytosol]
Biological oxidations (Canis familiaris)
Aflatoxin activation and detoxification (Canis familiaris)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
H2O [cytosol]
Phase I - Functionalization of compounds (Canis familiaris)
AADAC deacetylates PHEN (Canis familiaris)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)
H2O [cytosol]
Amine Oxidase reactions (Canis familiaris)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Canis familiaris)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Canis familiaris)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Canis familiaris)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Canis familiaris)
Eicosanoids (Canis familiaris)
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
H2O [cytosol]
Endogenous sterols (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Canis familiaris)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
H2O [cytosol]
Vitamins (Canis familiaris)
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)
H2O [cytosol]
Ethanol oxidation (Canis familiaris)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)
H2O [cytosol]
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
ABHD14B hydrolyses PNPB (Canis familiaris)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)
H2O [cytosol]
Glucuronidation (Canis familiaris)
Formation of the active cofactor, UDP-glucuronate (Canis familiaris)
UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)
H2O [cytosol]
Glutathione conjugation (Canis familiaris)
Glutathione synthesis and recycling (Canis familiaris)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
H2O [cytosol]
Methylation (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
H2O [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Canis familiaris)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Canis familiaris)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)
H2O [cytosol]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Acetylcholine regulates insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Canis familiaris)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
H2O [cytosol]
Metabolism of amino acids and derivatives (Canis familiaris)
Aspartate and asparagine metabolism (Canis familiaris)
ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
H2O [cytosol]
Carnitine synthesis (Canis familiaris)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)
H2O [cytosol]
Histidine catabolism (Canis familiaris)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Canis familiaris)
H2O [cytosol]
Metabolism of polyamines (Canis familiaris)
Agmatine biosynthesis (Canis familiaris)
Agmatine + H2O <=> putrescine + urea (Canis familiaris)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)
H2O [cytosol]
Tyrosine catabolism (Canis familiaris)
FAH cleaves 4FAA (Canis familiaris)
H2O [cytosol]
Selenoamino acid metabolism (Canis familiaris)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
H2O [cytosol]
Selenocysteine synthesis (Canis familiaris)
SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)
H2O [cytosol]
Serine biosynthesis (Canis familiaris)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Canis familiaris)
H2O [cytosol]
Sulfur amino acid metabolism (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
H2O [cytosol]
Cysteine formation from homocysteine (Canis familiaris)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)
H2O [cytosol]
Degradation of cysteine and homocysteine (Canis familiaris)
Cysteine is degraded to serine and H2S (Canis familiaris)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
H2O [cytosol]
Methionine salvage pathway (Canis familiaris)
Acireductone is created (Canis familiaris)
H2O [cytosol]
Threonine catabolism (Canis familiaris)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)
H2O [cytosol]
Tryptophan catabolism (Canis familiaris)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
H2O [cytosol]
Urea cycle (Canis familiaris)
arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)
H2O [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Fructose metabolism (Canis familiaris)
Fructose catabolism (Canis familiaris)
ALDH1A1 oxidises GA to DGA (Canis familiaris)
H2O [cytosol]
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Canis familiaris)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Canis familiaris)
H2O [cytosol]
Glycolysis (Canis familiaris)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Canis familiaris)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)
H2O [cytosol]
Glycogen metabolism (Canis familiaris)
Glycogen synthesis (Canis familiaris)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Canis familiaris)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)
H2O [cytosol]
Pentose phosphate pathway (Canis familiaris)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)
H2O [cytosol]
Metabolism of lipids (Canis familiaris)
Biosynthesis of specialized proresolving mediators (SPMs) (Canis familiaris)
Biosynthesis of DHA-derived SPMs (Canis familiaris)
Biosynthesis of D-series resolvins (Canis familiaris)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Canis familiaris)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)
H2O [cytosol]
Biosynthesis of maresins (Canis familiaris)
Biosynthesis of maresin-like SPMs (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
H2O [cytosol]
Biosynthesis of protectins (Canis familiaris)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Canis familiaris)
Biosynthesis of E-series 18(R)-resolvins (Canis familiaris)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Canis familiaris)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Canis familiaris)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Canis familiaris)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)
H2O [cytosol]
Fatty acid metabolism (Canis familiaris)
Arachidonic acid metabolism (Canis familiaris)
FAAH hydrolyses AEA to AA and ETA (Canis familiaris)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Canis familiaris)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Canis familiaris)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Canis familiaris)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Canis familiaris)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Canis familiaris)
H2O [cytosol]
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Canis familiaris)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Canis familiaris)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Canis familiaris)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Canis familiaris)
SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Canis familiaris)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Canis familiaris)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)
H2O [cytosol]
Metabolism of steroids (Canis familiaris)
Bile acid and bile salt metabolism (Canis familiaris)
Recycling of bile acids and salts (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Canis familiaris)
27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
H2O [cytosol]
Cholesterol biosynthesis (Canis familiaris)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Canis familiaris)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Canis familiaris)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Canis familiaris)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)
H2O [cytosol]
Squalene is oxidized to its epoxide (Canis familiaris)
H2O [cytosol]
Metabolism of steroid hormones (Canis familiaris)
Androgen biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Canis familiaris)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
H2O [cytosol]
Estrogen biosynthesis (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)
H2O [cytosol]
Glucocorticoid biosynthesis (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Canis familiaris)
H2O [cytosol]
Mineralocorticoid biosynthesis (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
H2O [cytosol]
Phospholipid metabolism (Canis familiaris)
Glycerophospholipid biosynthesis (Canis familiaris)
Acyl chain remodeling of DAG and TAG (Canis familiaris)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PC (Canis familiaris)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PE (Canis familiaris)
ABHD4 hydrolyses NAPE (Canis familiaris)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PG (Canis familiaris)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PI (Canis familiaris)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)
H2O [cytosol]
Acyl chain remodelling of PS (Canis familiaris)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)
H2O [cytosol]
Hydrolysis of LPC (Canis familiaris)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
H2O [cytosol]
Synthesis of PA (Canis familiaris)
DDHD1,2 hydrolyse PA (Canis familiaris)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)
H2O [cytosol]
Synthesis of PC (Canis familiaris)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Canis familiaris)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)
H2O [cytosol]
Synthesis of PE (Canis familiaris)
PA is dephosphorylated to DAG by LPIN (Canis familiaris)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)
H2O [cytosol]
PI Metabolism (Canis familiaris)
Glycerophospholipid catabolism (Canis familiaris)
GDE1 hydrolyzes GroPIns (Canis familiaris)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Canis familiaris)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Canis familiaris)
H2O [cytosol]
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
Glycosphingolipid catabolism (Canis familiaris)
ASAH2 hydrolyzes ceramide (plasma membrane) (Canis familiaris)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Canis familiaris)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Canis familiaris)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Canis familiaris)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Canis familiaris)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Canis familiaris)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)
H2O [cytosol]
Sphingolipid catabolism (Canis familiaris)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Canis familiaris)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Canis familiaris)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Canis familiaris)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Canis familiaris)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Canis familiaris)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Canis familiaris)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Canis familiaris)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Canis familiaris)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Canis familiaris)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Canis familiaris)
H2O [cytosol]
Triglyceride metabolism (Canis familiaris)
Triglyceride biosynthesis (Canis familiaris)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)
H2O [cytosol]
Triglyceride catabolism (Canis familiaris)
PNPLA4 hydrolyzes TAG (Canis familiaris)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Canis familiaris)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
eNOS activation (Canis familiaris)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)
H2O [cytosol]
Metabolism of nucleotides (Canis familiaris)
Interconversion of nucleotide di- and triphosphates (Canis familiaris)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Canis familiaris)
H2O [cytosol]
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
H2O [cytosol]
FAICAR => IMP + H2O (Canis familiaris)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
H2O [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
H2O [cytosol]
Nucleotide catabolism (Canis familiaris)
Purine catabolism (Canis familiaris)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Canis familiaris)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Canis familiaris)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Canis familiaris)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Canis familiaris)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Canis familiaris)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Canis familiaris)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Canis familiaris)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Canis familiaris)
H2O [cytosol]
Pyrimidine catabolism (Canis familiaris)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Canis familiaris)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
H2O [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)
H2O [cytosol]
Pyrimidine salvage (Canis familiaris)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)
H2O [cytosol]
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
4 PBGs bind to form HMB (Canis familiaris)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Canis familiaris)
H2O [cytosol]
UROS transforms HMB to URO3 (Canis familiaris)
H2O [cytosol]
Heme degradation (Canis familiaris)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
H2O [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Transport of RCbl within the body (Canis familiaris)
ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Canis familiaris)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)
H2O [cytosol]
Metabolism of folate and pterines (Canis familiaris)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Canis familiaris)
Cyclisation of GTP to precursor Z (Canis familiaris)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Canis familiaris)
H2O [cytosol]
Nicotinate metabolism (Canis familiaris)
NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Canis familiaris)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Canis familiaris)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Canis familiaris)
PANK4 hydrolyzes PPANT to pantetheine (Canis familiaris)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Canis familiaris)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)
H2O [cytosol]
Pyrophosphate hydrolysis (Canis familiaris)
LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
H2O [cytosol]
Reversible hydration of carbon dioxide (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)
H2O [cytosol]
Metabolism of RNA (Canis familiaris)
Deadenylation-dependent mRNA decay (Canis familiaris)
Deadenylation of mRNA (Canis familiaris)
CCR4-NOT complex deadenylates mRNA (Canis familiaris)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)
H2O [cytosol]
PARN deadenylates mRNA (Canis familiaris)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Canis familiaris)
DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Canis familiaris)
DCP1-DCP2 complex decaps mRNA (Canis familiaris)
H2O [cytosol]
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Canis familiaris)
Synthesis of substrates in N-glycan biosythesis (Canis familiaris)
GDP-fucose biosynthesis (Canis familiaris)
GMDS dehydrates GDP-Man to GDP-DHDMan (Canis familiaris)
H2O [cytosol]
Sialic acid metabolism (Canis familiaris)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Canis familiaris)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Canis familiaris)
DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Canis familiaris)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Canis familiaris)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Canis familiaris)
ER to Golgi Anterograde Transport (Canis familiaris)
COPII-mediated vesicle transport (Canis familiaris)
PP6 dephosphorylates SEC24 (Canis familiaris)
H2O [cytosol]
Deubiquitination (Canis familiaris)
Josephin domain DUBs (Canis familiaris)
ATXN3 deubiquitinates polyUb-PARK2 (Canis familiaris)
H2O [cytosol]
ATXN3 family cleave Ub chains (Canis familiaris)
H2O [cytosol]
Metalloprotease DUBs (Canis familiaris)
BRISC complex deubiquitinates NLRP3 (Canis familiaris)
H2O [cytosol]
Ovarian tumor domain proteases (Canis familiaris)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)
H2O [cytosol]
UCH proteinases (Canis familiaris)
UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Canis familiaris)
H2O [cytosol]
Ub-specific processing proteases (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Canis familiaris)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Canis familiaris)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Canis familiaris)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Canis familiaris)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Canis familiaris)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)
H2O [cytosol]
USP5 cleaves polyubiquitin (Canis familiaris)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Canis familiaris)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Canis familiaris)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Hypusine synthesis from eIF5A-lysine (Canis familiaris)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
H2O [cytosol]
Neddylation (Canis familiaris)
UCHL3, SENP8 cleave NEDD8 (Canis familiaris)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Canis familiaris)
Synthesis of glycosylphosphatidylinositol (GPI) (Canis familiaris)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)
H2O [cytosol]
Surfactant metabolism (Canis familiaris)
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
H2O [cytosol]
Translation (Canis familiaris)
Eukaryotic Translation Termination (Canis familiaris)
APEH hydrolyses NAc-Ser-protein (Canis familiaris)
H2O [cytosol]
tRNA Aminoacylation (Canis familiaris)
Cytosolic tRNA aminoacylation (Canis familiaris)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
H2O [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
H2O [cytosol]
Physiological factors (Canis familiaris)
CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)
H2O [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter clearance (Canis familiaris)
Dopamine clearance from the synaptic cleft (Canis familiaris)
Enzymatic degradation of Dopamine by monoamine oxidase (Canis familiaris)
MAOA:FAD deaminates DA to DOPAC (Canis familiaris)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Canis familiaris)
MAOA:FAD deaminates 3MT to HVA (Canis familiaris)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Canis familiaris)
Metabolism of serotonin (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
H2O [cytosol]
Neurotransmitter release cycle (Canis familiaris)
Norepinephrine Neurotransmitter Release Cycle (Canis familiaris)
Catabolism of Noradrenaline (Canis familiaris)
H2O [cytosol]
Organelle biogenesis and maintenance (Canis familiaris)
Cilium Assembly (Canis familiaris)
Cargo trafficking to the periciliary membrane (Canis familiaris)
VxPx cargo-targeting to cilium (Canis familiaris)
ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)
H2O [cytosol]
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Activation of BH3-only proteins (Canis familiaris)
Activation of BAD and translocation to mitochondria (Canis familiaris)
Activation of BAD by calcineurin (Canis familiaris)
H2O [cytosol]
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
The canonical retinoid cycle in rods (twilight vision) (Canis familiaris)
11cRAL binds to opsin to form 11c-retinyl:RHO (Canis familiaris)
H2O [cytosol]
ABCA4 mediates atRAL transport (Canis familiaris)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)
H2O [cytosol]
The phototransduction cascade (Canis familiaris)
Activation of the phototransduction cascade (Canis familiaris)
PDE6 hydrolyses cGMP to GMP (Canis familiaris)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Canis familiaris)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Canis familiaris)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Canis familiaris)
OPN1LW binds 11cRAL (Canis familiaris)
H2O [cytosol]
OPN1MW binds 11cRAL (Canis familiaris)
H2O [cytosol]
OPN1SW binds 11cRAL (Canis familiaris)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Canis familiaris)
H2O [cytosol]
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
H2O [cytosol]
Intracellular signaling by second messengers (Canis familiaris)
DAG and IP3 signaling (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)
H2O [cytosol]
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
H2O [cytosol]
PTEN Regulation (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
H2O [cytosol]
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
RAF/MAP kinase cascade (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Canis familiaris)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Canis familiaris)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Canis familiaris)
H2O [cytosol]
RAS processing (Canis familiaris)
RAS proteins are depalmitoylated (Canis familiaris)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Canis familiaris)
H2O [cytosol]
MTOR signalling (Canis familiaris)
Energy dependent regulation of mTOR by LKB1-AMPK (Canis familiaris)
AMPK is dephosphorylated (Canis familiaris)
H2O [cytosol]
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
DARPP-32 events (Canis familiaris)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Canis familiaris)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Canis familiaris)
H2O [cytosol]
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
Ca-dependent events (Canis familiaris)
CaM pathway (Canis familiaris)
Calmodulin induced events (Canis familiaris)
Cam-PDE 1 activation (Canis familiaris)
cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)
H2O [cytosol]
phospho-PLA2 pathway (Canis familiaris)
Hydrolysis of phosphatidylcholine (Canis familiaris)
H2O [cytosol]
Inactivation of PLC beta (Canis familiaris)
H2O [cytosol]
PIP2 hydrolysis (Canis familiaris)
H2O [cytosol]
G alpha (q) signalling events (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Arachidonate production from DAG (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Canis familiaris)
H2O [cytosol]
G alpha (s) signalling events (Canis familiaris)
PDE3A hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Canis familiaris)
H2O [cytosol]
Signaling by Hedgehog (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
H2O [cytosol]
Signaling by Nuclear Receptors (Canis familiaris)
Signaling by Retinoic Acid (Canis familiaris)
RA biosynthesis pathway (Canis familiaris)
ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Canis familiaris)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Canis familiaris)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
MDK and PTN in ALK signaling (Canis familiaris)
PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Canis familiaris)
H2O [cytosol]
Signaling by EGFR (Canis familiaris)
EGFR downregulation (Canis familiaris)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)
H2O [cytosol]
PTPN3 dephosphorylates EPS15 (Canis familiaris)
H2O [cytosol]
GAB1 signalosome (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Canis familiaris)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
H2O [cytosol]
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)
H2O [cytosol]
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor recycling (Canis familiaris)
Insulin receptor de-phosphorylation (Canis familiaris)
H2O [cytosol]
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PKB-mediated events (Canis familiaris)
PDE3B signalling (Canis familiaris)
p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
Signaling by MET (Canis familiaris)
Negative regulation of MET activity (Canis familiaris)
PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
H2O [cytosol]
PTPRJ dephosphorylates MET (Canis familiaris)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Canis familiaris)
H2O [cytosol]
Signaling by PDGF (Canis familiaris)
PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PKB-mediated events (Canis familiaris)
PDE3B signalling (Canis familiaris)
p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Miro GTPase Cycle (Canis familiaris)
RHOT1 GTPase cycle (Canis familiaris)
RHOT1 hydrolyzes GTP (Canis familiaris)
H2O [cytosol]
RHOBTB3 ATPase cycle (Canis familiaris)
RHOBTB3 hydrolyzes ATP (Canis familiaris)
H2O [cytosol]
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate Formins (Canis familiaris)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)
H2O [cytosol]
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)
H2O [cytosol]
RAC1 GTPase cycle (Canis familiaris)
RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)
H2O [cytosol]
RAC2 GTPase cycle (Canis familiaris)
RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)
H2O [cytosol]
RAC3 GTPase cycle (Canis familiaris)
RAC3 GAPs stimulate RAC3 GTPase activity (Canis familiaris)
H2O [cytosol]
RHOA GTPase cycle (Canis familiaris)
RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)
H2O [cytosol]
RHOB GTPase cycle (Canis familiaris)
RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)
H2O [cytosol]
RHOC GTPase cycle (Canis familiaris)
RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)
H2O [cytosol]
RHOD GTPase cycle (Canis familiaris)
RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)
H2O [cytosol]
RHOF GTPase cycle (Canis familiaris)
RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)
H2O [cytosol]
RHOG GTPase cycle (Canis familiaris)
RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)
H2O [cytosol]
RHOJ GTPase cycle (Canis familiaris)
RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)
H2O [cytosol]
RHOQ GTPase cycle (Canis familiaris)
RHOQ GAPs stimulate RHOQ GTPase activity (Canis familiaris)
H2O [cytosol]
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
H2O [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Canis familiaris)
H2O [cytosol]
TCF dependent signaling in response to WNT (Canis familiaris)
USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
H2O [cytosol]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
ABC transporters in lipid homeostasis (Canis familiaris)
ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
H2O [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Canis familiaris)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Canis familiaris)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCA4 mediates atRAL transport (Canis familiaris)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
HCO3- transport through ion channel (Canis familiaris)
H2O [cytosol]
Mitochondrial ABC transporters (Canis familiaris)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)
H2O [cytosol]
The ABCC family mediates organic anion transport (Canis familiaris)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
H2O [cytosol]
Aquaporin-mediated transport (Canis familiaris)
Passive transport by Aquaporins (Canis familiaris)
Aquaporins passively transport water into cells (Canis familiaris)
H2O [cytosol]
Aquaporins passively transport water out of cells (Canis familiaris)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Canis familiaris)
Aquaporin-1 passively transports water into cell (Canis familiaris)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Canis familiaris)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Canis familiaris)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Canis familiaris)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Canis familiaris)
H2O [cytosol]
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)
H2O [cytosol]
Iron uptake and transport (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
H2O [cytosol]
Transferrin endocytosis and recycling (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Canis familiaris)
Erythrocytes take up carbon dioxide and release oxygen (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein assembly (Canis familiaris)
HDL assembly (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)
H2O [cytosol]
Plasma lipoprotein clearance (Canis familiaris)
LDL clearance (Canis familiaris)
NCEH1 hydrolyzes cholesterol esters (Canis familiaris)
H2O [cytosol]
Plasma lipoprotein remodeling (Canis familiaris)
HDL remodeling (Canis familiaris)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
H2O [cytosol]
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
H2O [cytosol]
ER to Golgi Anterograde Transport (Canis familiaris)
COPII-mediated vesicle transport (Canis familiaris)
PP6 dephosphorylates SEC24 (Canis familiaris)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Canis familiaris)
Golgi-to-ER retrograde transport (Canis familiaris)
COPI-independent Golgi-to-ER retrograde traffic (Canis familiaris)
PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)
H2O [cytosol]
Rab regulation of trafficking (Canis familiaris)
TBC/RABGAPs (Canis familiaris)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)
H2O [cytosol]
Cell Cycle (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
M Phase (Danio rerio)
Mitotic Metaphase and Anaphase (Danio rerio)
Mitotic Anaphase (Danio rerio)
Nuclear Envelope (NE) Reassembly (Danio rerio)
Initiation of Nuclear Envelope (NE) Reformation (Danio rerio)
ANKLE2 is deacetylated by SIRT2 (Danio rerio)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Danio rerio)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Danio rerio)
RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)
H2O [cytosol]
Regulation of mitotic cell cycle (Danio rerio)
APC/C-mediated degradation of cell cycle proteins (Danio rerio)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Danio rerio)
Dephosphorylation of phospho-Cdh1 (Danio rerio)
H2O [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
Cytoprotection by HMOX1 (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Danio rerio)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Danio rerio)
Nuclear events mediated by NFE2L2 (Danio rerio)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Danio rerio)
PRDX1 overoxidizes (Danio rerio)
H2O [cytosol]
Cellular response to heat stress (Danio rerio)
Regulation of HSF1-mediated heat shock response (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)
H2O [cytosol]
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPHB-mediated forward signaling (Danio rerio)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)
H2O [cytosol]
L1CAM interactions (Danio rerio)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Danio rerio)
H2O [cytosol]
Semaphorin interactions (Danio rerio)
Sema4D in semaphorin signaling (Danio rerio)
Sema4D mediated inhibition of cell attachment and migration (Danio rerio)
Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)
H2O [cytosol]
Drug ADME (Danio rerio)
Abacavir ADME (Danio rerio)
Abacavir metabolism (Danio rerio)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)
H2O [cytosol]
Aspirin ADME (Danio rerio)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)
H2O [cytosol]
Atorvastatin ADME (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
H2O [cytosol]
Azathioprine ADME (Danio rerio)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)
H2O [cytosol]
Paracetamol ADME (Danio rerio)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Danio rerio)
H2O [cytosol]
Prednisone ADME (Danio rerio)
CYP3A4 oxidizes PREDN,PREDL (Danio rerio)
H2O [cytosol]
Ribavirin ADME (Danio rerio)
ADA deamidates RBV (Danio rerio)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)
H2O [cytosol]
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
TP53 Regulates Metabolic Genes (Danio rerio)
PRDX1 overoxidizes (Danio rerio)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)
H2O [cytosol]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Arachidonate production from DAG (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Danio rerio)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
ABCC4 accumulation of dense granule contents (Danio rerio)
H2O [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
TCR signaling (Danio rerio)
Downstream TCR signaling (Danio rerio)
PTEN dephosphorylates PIP3 (Danio rerio)
H2O [cytosol]
Generation of second messenger molecules (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
H2O [cytosol]
Cytokine Signaling in Immune system (Danio rerio)
Growth hormone receptor signaling (Danio rerio)
PTP1B dephosphorylates GHR (Danio rerio)
H2O [cytosol]
Innate Immune System (Danio rerio)
Antimicrobial peptides (Danio rerio)
Ion influx/efflux at host-pathogen interface (Danio rerio)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)
H2O [cytosol]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
H2O [cytosol]
Regulation of pyruvate metabolism (Danio rerio)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Danio rerio)
H2O [cytosol]
Biological oxidations (Danio rerio)
Aflatoxin activation and detoxification (Danio rerio)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
H2O [cytosol]
Phase I - Functionalization of compounds (Danio rerio)
ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)
H2O [cytosol]
Amine Oxidase reactions (Danio rerio)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Danio rerio)
MAOB:FAD oxidatively deaminates TYR (Danio rerio)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Danio rerio)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Danio rerio)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Danio rerio)
Eicosanoids (Danio rerio)
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
H2O [cytosol]
Endogenous sterols (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Danio rerio)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
H2O [cytosol]
Vitamins (Danio rerio)
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)
H2O [cytosol]
Phase II - Conjugation of compounds (Danio rerio)
Cytosolic sulfonation of small molecules (Danio rerio)
ABHD14B hydrolyses PNPB (Danio rerio)
H2O [cytosol]
Glucuronidation (Danio rerio)
Formation of the active cofactor, UDP-glucuronate (Danio rerio)
UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)
H2O [cytosol]
Glutathione conjugation (Danio rerio)
Glutathione synthesis and recycling (Danio rerio)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
H2O [cytosol]
Methylation (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)
H2O [cytosol]
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Danio rerio)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Danio rerio)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)
H2O [cytosol]
Metabolism of amino acids and derivatives (Danio rerio)
Aspartate and asparagine metabolism (Danio rerio)
ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)
H2O [cytosol]
Carnitine synthesis (Danio rerio)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)
H2O [cytosol]
Histidine catabolism (Danio rerio)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Danio rerio)
H2O [cytosol]
Metabolism of polyamines (Danio rerio)
Agmatine biosynthesis (Danio rerio)
Agmatine + H2O <=> putrescine + urea (Danio rerio)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)
H2O [cytosol]
Selenoamino acid metabolism (Danio rerio)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Danio rerio)
SeMet is converted to AdoSeMet by MAT (Danio rerio)
H2O [cytosol]
Selenocysteine synthesis (Danio rerio)
SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)
H2O [cytosol]
Serine biosynthesis (Danio rerio)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)
H2O [cytosol]
Sulfur amino acid metabolism (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
H2O [cytosol]
Cysteine formation from homocysteine (Danio rerio)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)
H2O [cytosol]
Degradation of cysteine and homocysteine (Danio rerio)
Cysteine is degraded to serine and H2S (Danio rerio)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Danio rerio)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
H2O [cytosol]
Methionine salvage pathway (Danio rerio)
Acireductone is created (Danio rerio)
H2O [cytosol]
Tryptophan catabolism (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
H2O [cytosol]
Metabolism of carbohydrates (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Danio rerio)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Danio rerio)
H2O [cytosol]
Glycolysis (Danio rerio)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Danio rerio)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)
H2O [cytosol]
Glycogen metabolism (Danio rerio)
Glycogen synthesis (Danio rerio)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)
H2O [cytosol]
Metabolism of lipids (Danio rerio)
Biosynthesis of specialized proresolving mediators (SPMs) (Danio rerio)
Biosynthesis of DHA-derived SPMs (Danio rerio)
Biosynthesis of D-series resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)
H2O [cytosol]
Biosynthesis of maresins (Danio rerio)
Biosynthesis of maresin-like SPMs (Danio rerio)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
H2O [cytosol]
Biosynthesis of protectins (Danio rerio)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Danio rerio)
Biosynthesis of E-series 18(R)-resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)
H2O [cytosol]
Fatty acid metabolism (Danio rerio)
Arachidonic acid metabolism (Danio rerio)
Hydrolysis of phosphatidylcholine (Danio rerio)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Danio rerio)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Danio rerio)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Danio rerio)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Danio rerio)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Danio rerio)
SCD desaturates ST-CoA to OLE-CoA (Danio rerio)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Danio rerio)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)
H2O [cytosol]
Metabolism of steroids (Danio rerio)
Bile acid and bile salt metabolism (Danio rerio)
Recycling of bile acids and salts (Danio rerio)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Danio rerio)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Danio rerio)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
H2O [cytosol]
Cholesterol biosynthesis (Danio rerio)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Danio rerio)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Danio rerio)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Danio rerio)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)
H2O [cytosol]
Squalene is oxidized to its epoxide (Danio rerio)
H2O [cytosol]
Metabolism of steroid hormones (Danio rerio)
Androgen biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Danio rerio)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
H2O [cytosol]
Estrogen biosynthesis (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
H2O [cytosol]
Glucocorticoid biosynthesis (Danio rerio)
CYP17A1 17-hydroxylates PREG (Danio rerio)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
H2O [cytosol]
Phospholipid metabolism (Danio rerio)
Glycerophospholipid biosynthesis (Danio rerio)
Acyl chain remodeling of DAG and TAG (Danio rerio)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PC (Danio rerio)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Danio rerio)
H2O [cytosol]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PE (Danio rerio)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PG (Danio rerio)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PI (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)
H2O [cytosol]
Acyl chain remodelling of PS (Danio rerio)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)
H2O [cytosol]
Hydrolysis of LPC (Danio rerio)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
H2O [cytosol]
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
H2O [cytosol]
Hydrolysis of LPE (Danio rerio)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
H2O [cytosol]
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
H2O [cytosol]
Synthesis of PA (Danio rerio)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)
H2O [cytosol]
Synthesis of PC (Danio rerio)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Danio rerio)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)
H2O [cytosol]
Synthesis of PE (Danio rerio)
PA is dephosphorylated to DAG by LPIN (Danio rerio)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)
H2O [cytosol]
PI Metabolism (Danio rerio)
Glycerophospholipid catabolism (Danio rerio)
GDE1 hydrolyzes GroPIns (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Danio rerio)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Danio rerio)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Danio rerio)
H2O [cytosol]
Sphingolipid metabolism (Danio rerio)
Glycosphingolipid metabolism (Danio rerio)
Glycosphingolipid catabolism (Danio rerio)
ASAH2 hydrolyzes ceramide (plasma membrane) (Danio rerio)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Danio rerio)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Danio rerio)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Danio rerio)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Danio rerio)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Danio rerio)
H2O [cytosol]
Sphingolipid catabolism (Danio rerio)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Danio rerio)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Danio rerio)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Danio rerio)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Danio rerio)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Danio rerio)
DEGS1 dehydrogenates dihydroceramide (Danio rerio)
H2O [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Danio rerio)
H2O [cytosol]
Triglyceride metabolism (Danio rerio)
Triglyceride biosynthesis (Danio rerio)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)
H2O [cytosol]
Triglyceride catabolism (Danio rerio)
PNPLA5 hydrolyzes TAG (Danio rerio)
H2O [cytosol]
Metabolism of nucleotides (Danio rerio)
Interconversion of nucleotide di- and triphosphates (Danio rerio)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Danio rerio)
H2O [cytosol]
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
H2O [cytosol]
FAICAR => IMP + H2O (Danio rerio)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)
H2O [cytosol]
Nucleotide catabolism (Danio rerio)
Purine catabolism (Danio rerio)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Danio rerio)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Danio rerio)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Danio rerio)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Danio rerio)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Danio rerio)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Danio rerio)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
H2O [cytosol]
Pyrimidine catabolism (Danio rerio)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)
H2O [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)
H2O [cytosol]
Pyrimidine salvage (Danio rerio)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)
H2O [cytosol]
Metabolism of porphyrins (Danio rerio)
Heme biosynthesis (Danio rerio)
ALAD condenses 2 dALAs to form PBG (Danio rerio)
H2O [cytosol]
UROS transforms HMB to URO3 (Danio rerio)
H2O [cytosol]
Heme degradation (Danio rerio)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
H2O [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Metabolism of folate and pterines (Danio rerio)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
H2O [cytosol]
Nicotinate metabolism (Danio rerio)
NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Danio rerio)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Danio rerio)
AOX1 oxidises PXL to PDXate (Danio rerio)
H2O [cytosol]
Pyrophosphate hydrolysis (Danio rerio)
LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
H2O [cytosol]
Reversible hydration of carbon dioxide (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)
H2O [cytosol]
Metabolism of RNA (Danio rerio)
Deadenylation-dependent mRNA decay (Danio rerio)
mRNA decay by 5' to 3' exoribonuclease (Danio rerio)
DCP1-DCP2 complex decaps mRNA (Danio rerio)
H2O [cytosol]
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Danio rerio)
Synthesis of substrates in N-glycan biosythesis (Danio rerio)
Sialic acid metabolism (Danio rerio)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Danio rerio)
DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Danio rerio)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Danio rerio)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Danio rerio)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Danio rerio)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)
H2O [cytosol]
Deubiquitination (Danio rerio)
Josephin domain DUBs (Danio rerio)
ATXN3 family cleave Ub chains (Danio rerio)
H2O [cytosol]
Ovarian tumor domain proteases (Danio rerio)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)
H2O [cytosol]
UCH proteinases (Danio rerio)
UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Danio rerio)
H2O [cytosol]
Ub-specific processing proteases (Danio rerio)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Danio rerio)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Danio rerio)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Danio rerio)
H2O [cytosol]
USP5 cleaves polyubiquitin (Danio rerio)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Danio rerio)
Hypusine synthesis from eIF5A-lysine (Danio rerio)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
H2O [cytosol]
Neddylation (Danio rerio)
UCHL3, SENP8 cleave NEDD8 (Danio rerio)
H2O [cytosol]
Translation (Danio rerio)
tRNA Aminoacylation (Danio rerio)
Cytosolic tRNA aminoacylation (Danio rerio)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
H2O [cytosol]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
H2O [cytosol]
Physiological factors (Danio rerio)
CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)
H2O [cytosol]
Organelle biogenesis and maintenance (Danio rerio)
Cilium Assembly (Danio rerio)
Cargo trafficking to the periciliary membrane (Danio rerio)
VxPx cargo-targeting to cilium (Danio rerio)
ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)
H2O [cytosol]
Sensory Perception (Danio rerio)
Visual phototransduction (Danio rerio)
The canonical retinoid cycle in rods (twilight vision) (Danio rerio)
11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)
H2O [cytosol]
The phototransduction cascade (Danio rerio)
Inactivation, recovery and regulation of the phototransduction cascade (Danio rerio)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Danio rerio)
OPN1LW binds 11cRAL (Danio rerio)
H2O [cytosol]
OPN1MW binds 11cRAL (Danio rerio)
H2O [cytosol]
OPN1SW binds 11cRAL (Danio rerio)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)
H2O [cytosol]
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Danio rerio)
H2O [cytosol]
PTEN Regulation (Danio rerio)
Regulation of PTEN stability and activity (Danio rerio)
USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)
H2O [cytosol]
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF-independent MAPK1/3 activation (Danio rerio)
Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
RAF/MAP kinase cascade (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
H2O [cytosol]
RAF activation (Danio rerio)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)
H2O [cytosol]
RAS processing (Danio rerio)
RAS proteins are depalmitoylated (Danio rerio)
H2O [cytosol]
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Opioid Signalling (Danio rerio)
G-protein mediated events (Danio rerio)
PLC beta mediated events (Danio rerio)
Ca-dependent events (Danio rerio)
phospho-PLA2 pathway (Danio rerio)
Hydrolysis of phosphatidylcholine (Danio rerio)
H2O [cytosol]
G alpha (q) signalling events (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Arachidonate production from DAG (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Danio rerio)
H2O [cytosol]
G alpha (s) signalling events (Danio rerio)
cAMP degradation by Phosphodiesterases (Danio rerio)
H2O [cytosol]
Signaling by Hedgehog (Danio rerio)
Hedgehog ligand biogenesis (Danio rerio)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)
H2O [cytosol]
Signaling by Nuclear Receptors (Danio rerio)
Signaling by Retinoic Acid (Danio rerio)
RA biosynthesis pathway (Danio rerio)
ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Danio rerio)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Downregulation of ERBB2 signaling (Danio rerio)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Danio rerio)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)
H2O [cytosol]
Signaling by PDGF (Danio rerio)
PTPN12 dephosphorylates PDGFRB at Y1021 (Danio rerio)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Miro GTPase Cycle (Danio rerio)
RHOT1 GTPase cycle (Danio rerio)
RHOT1 hydrolyzes GTP (Danio rerio)
H2O [cytosol]
RHOT2 GTPase cycle (Danio rerio)
RHOT2 hydrolyzes GTP (Danio rerio)
H2O [cytosol]
Signaling by Rho GTPases (Danio rerio)
RHO GTPase Effectors (Danio rerio)
RHO GTPases Activate Formins (Danio rerio)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)
H2O [cytosol]
RHO GTPase cycle (Danio rerio)
CDC42 GTPase cycle (Danio rerio)
CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)
H2O [cytosol]
RAC1 GTPase cycle (Danio rerio)
RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)
H2O [cytosol]
RAC2 GTPase cycle (Danio rerio)
RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)
H2O [cytosol]
RAC3 GTPase cycle (Danio rerio)
RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)
H2O [cytosol]
RHOA GTPase cycle (Danio rerio)
RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)
H2O [cytosol]
RHOD GTPase cycle (Danio rerio)
RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)
H2O [cytosol]
RHOF GTPase cycle (Danio rerio)
RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)
H2O [cytosol]
RHOG GTPase cycle (Danio rerio)
RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)
H2O [cytosol]
RHOQ GTPase cycle (Danio rerio)
RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)
H2O [cytosol]
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
ABC transporters in lipid homeostasis (Danio rerio)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Danio rerio)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Danio rerio)
H2O [cytosol]
HCO3- transport through ion channel (Danio rerio)
H2O [cytosol]
The ABCC family mediates organic anion transport (Danio rerio)
H2O [cytosol]
Aquaporin-mediated transport (Danio rerio)
Passive transport by Aquaporins (Danio rerio)
Aquaporins passively transport water into cells (Danio rerio)
H2O [cytosol]
Aquaporins passively transport water out of cells (Danio rerio)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Danio rerio)
Aquaporin-1 passively transports water into cell (Danio rerio)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Danio rerio)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Danio rerio)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)
H2O [cytosol]
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)
H2O [cytosol]
Iron uptake and transport (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
H2O [cytosol]
Transferrin endocytosis and recycling (Danio rerio)
Acidification of Tf:TfR1 containing endosome (Danio rerio)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Danio rerio)
Erythrocytes take up carbon dioxide and release oxygen (Danio rerio)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Danio rerio)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Danio rerio)
Plasma lipoprotein assembly (Danio rerio)
HDL assembly (Danio rerio)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)
H2O [cytosol]
Plasma lipoprotein clearance (Danio rerio)
LDL clearance (Danio rerio)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Danio rerio)
H2O [cytosol]
Plasma lipoprotein remodeling (Danio rerio)
HDL remodeling (Danio rerio)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
H2O [cytosol]
Vesicle-mediated transport (Danio rerio)
Membrane Trafficking (Danio rerio)
Intra-Golgi and retrograde Golgi-to-ER traffic (Danio rerio)
Golgi-to-ER retrograde transport (Danio rerio)
COPI-independent Golgi-to-ER retrograde traffic (Danio rerio)
PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)
H2O [cytosol]
Rab regulation of trafficking (Danio rerio)
TBC/RABGAPs (Danio rerio)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)
H2O [cytosol]
Cell Cycle (Dictyostelium discoideum)
Cell Cycle, Mitotic (Dictyostelium discoideum)
M Phase (Dictyostelium discoideum)
Mitotic Metaphase and Anaphase (Dictyostelium discoideum)
Mitotic Anaphase (Dictyostelium discoideum)
Nuclear Envelope (NE) Reassembly (Dictyostelium discoideum)
Sealing of the nuclear envelope (NE) by ESCRT-III (Dictyostelium discoideum)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)
H2O [cytosol]
Mitotic Prometaphase (Dictyostelium discoideum)
Condensation of Prometaphase Chromosomes (Dictyostelium discoideum)
Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Dictyostelium discoideum)
PPP1CC dephosphorylates PLK1 (Dictyostelium discoideum)
H2O [cytosol]
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to chemical stress (Dictyostelium discoideum)
Detoxification of Reactive Oxygen Species (Dictyostelium discoideum)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Dictyostelium discoideum)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Dictyostelium discoideum)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Dictyostelium discoideum)
Nuclear events mediated by NFE2L2 (Dictyostelium discoideum)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Dictyostelium discoideum)
PRDX1 overoxidizes (Dictyostelium discoideum)
H2O [cytosol]
Cellular response to heat stress (Dictyostelium discoideum)
Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
Drug ADME (Dictyostelium discoideum)
Aspirin ADME (Dictyostelium discoideum)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)
H2O [cytosol]
Azathioprine ADME (Dictyostelium discoideum)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
H2O [cytosol]
Ciprofloxacin ADME (Dictyostelium discoideum)
ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)
H2O [cytosol]
Paracetamol ADME (Dictyostelium discoideum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)
H2O [cytosol]
Prednisone ADME (Dictyostelium discoideum)
ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)
H2O [cytosol]
Ribavirin ADME (Dictyostelium discoideum)
ADA deamidates RBV (Dictyostelium discoideum)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Dictyostelium discoideum)
H2O [cytosol]
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Metabolic Genes (Dictyostelium discoideum)
PRDX1 overoxidizes (Dictyostelium discoideum)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)
H2O [cytosol]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Arachidonate production from DAG (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Dictyostelium discoideum)
Platelet degranulation (Dictyostelium discoideum)
ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)
H2O [cytosol]
Immune System (Dictyostelium discoideum)
Adaptive Immune System (Dictyostelium discoideum)
Costimulation by the CD28 family (Dictyostelium discoideum)
CTLA4 inhibitory signaling (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
H2O [cytosol]
TCR signaling (Dictyostelium discoideum)
Downstream TCR signaling (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
H2O [cytosol]
Generation of second messenger molecules (Dictyostelium discoideum)
PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)
H2O [cytosol]
Cytokine Signaling in Immune system (Dictyostelium discoideum)
Signaling by Interleukins (Dictyostelium discoideum)
Interleukin-1 family signaling (Dictyostelium discoideum)
Interleukin-1 signaling (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Innate Immune System (Dictyostelium discoideum)
C-type lectin receptors (CLRs) (Dictyostelium discoideum)
CLEC7A (Dectin-1) signaling (Dictyostelium discoideum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
Role of phospholipids in phagocytosis (Dictyostelium discoideum)
Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)
H2O [cytosol]
Toll-like Receptor Cascades (Dictyostelium discoideum)
Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
MyD88-independent TLR4 cascade (Dictyostelium discoideum)
TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
TAK1-dependent IKK and NF-kappa-B activation (Dictyostelium discoideum)
Regulation of NF-kappa B signaling (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
H2O [cytosol]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Pyruvate metabolism (Dictyostelium discoideum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)
H2O [cytosol]
Biological oxidations (Dictyostelium discoideum)
Aflatoxin activation and detoxification (Dictyostelium discoideum)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
H2O [cytosol]
Phase I - Functionalization of compounds (Dictyostelium discoideum)
AADAC deacetylates PHEN (Dictyostelium discoideum)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)
H2O [cytosol]
Amine Oxidase reactions (Dictyostelium discoideum)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Dictyostelium discoideum)
Endogenous sterols (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
H2O [cytosol]
Vitamins (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
H2O [cytosol]
Ethanol oxidation (Dictyostelium discoideum)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)
H2O [cytosol]
Phase II - Conjugation of compounds (Dictyostelium discoideum)
Cytosolic sulfonation of small molecules (Dictyostelium discoideum)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Glutathione conjugation (Dictyostelium discoideum)
Glutathione synthesis and recycling (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
H2O [cytosol]
Methylation (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)
H2O [cytosol]
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Dictyostelium discoideum)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)
H2O [cytosol]
Integration of energy metabolism (Dictyostelium discoideum)
Regulation of insulin secretion (Dictyostelium discoideum)
Acetylcholine regulates insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Dictyostelium discoideum)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Aspartate and asparagine metabolism (Dictyostelium discoideum)
ASPG hydrolyses L-Asn to L-Asp (Dictyostelium discoideum)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
H2O [cytosol]
Histidine catabolism (Dictyostelium discoideum)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)
H2O [cytosol]
Tyrosine catabolism (Dictyostelium discoideum)
FAH cleaves 4FAA (Dictyostelium discoideum)
H2O [cytosol]
Selenoamino acid metabolism (Dictyostelium discoideum)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Dictyostelium discoideum)
SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
H2O [cytosol]
Selenocysteine synthesis (Dictyostelium discoideum)
SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)
H2O [cytosol]
Serine biosynthesis (Dictyostelium discoideum)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)
H2O [cytosol]
Sulfur amino acid metabolism (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
H2O [cytosol]
Cysteine formation from homocysteine (Dictyostelium discoideum)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)
H2O [cytosol]
Degradation of cysteine and homocysteine (Dictyostelium discoideum)
Cysteine is degraded to serine and H2S (Dictyostelium discoideum)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
H2O [cytosol]
Methionine salvage pathway (Dictyostelium discoideum)
Acireductone is created (Dictyostelium discoideum)
H2O [cytosol]
Threonine catabolism (Dictyostelium discoideum)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)
H2O [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
H2O [cytosol]
Urea cycle (Dictyostelium discoideum)
arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Fructose metabolism (Dictyostelium discoideum)
Fructose catabolism (Dictyostelium discoideum)
ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)
H2O [cytosol]
Glucose metabolism (Dictyostelium discoideum)
Gluconeogenesis (Dictyostelium discoideum)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Dictyostelium discoideum)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)
H2O [cytosol]
Glycolysis (Dictyostelium discoideum)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Dictyostelium discoideum)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Dictyostelium discoideum)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)
H2O [cytosol]
Pentose phosphate pathway (Dictyostelium discoideum)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Biosynthesis of specialized proresolving mediators (SPMs) (Dictyostelium discoideum)
Biosynthesis of DHA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of D-series resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of maresins (Dictyostelium discoideum)
Biosynthesis of maresin-like SPMs (Dictyostelium discoideum)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of protectins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Dictyostelium discoideum)
Biosynthesis of E-series 18(R)-resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Dictyostelium discoideum)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)
H2O [cytosol]
Fatty acid metabolism (Dictyostelium discoideum)
Arachidonic acid metabolism (Dictyostelium discoideum)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Dictyostelium discoideum)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Dictyostelium discoideum)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Dictyostelium discoideum)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Dictyostelium discoideum)
SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Dictyostelium discoideum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Dictyostelium discoideum)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of steroids (Dictyostelium discoideum)
Bile acid and bile salt metabolism (Dictyostelium discoideum)
Recycling of bile acids and salts (Dictyostelium discoideum)
ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of bile acids and bile salts (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Dictyostelium discoideum)
ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Cholesterol biosynthesis (Dictyostelium discoideum)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Dictyostelium discoideum)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)
H2O [cytosol]
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of steroid hormones (Dictyostelium discoideum)
Glucocorticoid biosynthesis (Dictyostelium discoideum)
CYP21A2 oxidises 17HPROG (Dictyostelium discoideum)
H2O [cytosol]
Mineralocorticoid biosynthesis (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
H2O [cytosol]
Phospholipid metabolism (Dictyostelium discoideum)
Glycerophospholipid biosynthesis (Dictyostelium discoideum)
Acyl chain remodeling of DAG and TAG (Dictyostelium discoideum)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)
H2O [cytosol]
Acyl chain remodelling of PC (Dictyostelium discoideum)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)
H2O [cytosol]
Acyl chain remodelling of PE (Dictyostelium discoideum)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)
H2O [cytosol]
Acyl chain remodelling of PI (Dictyostelium discoideum)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)
H2O [cytosol]
Hydrolysis of LPC (Dictyostelium discoideum)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PA (Dictyostelium discoideum)
DDHD1,2 hydrolyse PA (Dictyostelium discoideum)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PC (Dictyostelium discoideum)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PE (Dictyostelium discoideum)
PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
H2O [cytosol]
PI Metabolism (Dictyostelium discoideum)
Synthesis of PIPs at the ER membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
H2O [cytosol]
Sphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid catabolism (Dictyostelium discoideum)
ASAH2 hydrolyzes ceramide (plasma membrane) (Dictyostelium discoideum)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Dictyostelium discoideum)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Dictyostelium discoideum)
H2O [cytosol]
Sphingolipid catabolism (Dictyostelium discoideum)
ACER3 hydrolyzes phytoceramide (Dictyostelium discoideum)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Dictyostelium discoideum)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Dictyostelium discoideum)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Dictyostelium discoideum)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Dictyostelium discoideum)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Dictyostelium discoideum)
H2O [cytosol]
Triglyceride metabolism (Dictyostelium discoideum)
Triglyceride biosynthesis (Dictyostelium discoideum)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Interconversion of nucleotide di- and triphosphates (Dictyostelium discoideum)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
H2O [cytosol]
Nucleotide biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
FAICAR => IMP + H2O (Dictyostelium discoideum)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
H2O [cytosol]
Pyrimidine biosynthesis (Dictyostelium discoideum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
H2O [cytosol]
Nucleotide catabolism (Dictyostelium discoideum)
Purine catabolism (Dictyostelium discoideum)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Dictyostelium discoideum)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Dictyostelium discoideum)
H2O [cytosol]
Pyrimidine catabolism (Dictyostelium discoideum)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)
H2O [cytosol]
Nucleotide salvage (Dictyostelium discoideum)
Purine salvage (Dictyostelium discoideum)
ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)
H2O [cytosol]
Pyrimidine salvage (Dictyostelium discoideum)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)
H2O [cytosol]
UROS transforms HMB to URO3 (Dictyostelium discoideum)
H2O [cytosol]
Heme degradation (Dictyostelium discoideum)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Transport of RCbl within the body (Dictyostelium discoideum)
ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Dictyostelium discoideum)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of folate and pterines (Dictyostelium discoideum)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Dictyostelium discoideum)
Cyclisation of GTP to precursor Z (Dictyostelium discoideum)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)
H2O [cytosol]
Nicotinate metabolism (Dictyostelium discoideum)
NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Dictyostelium discoideum)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Dictyostelium discoideum)
PANK4 hydrolyzes PPANT to pantetheine (Dictyostelium discoideum)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Dictyostelium discoideum)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
H2O [cytosol]
Pyrophosphate hydrolysis (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of RNA (Dictyostelium discoideum)
Deadenylation-dependent mRNA decay (Dictyostelium discoideum)
mRNA decay by 3' to 5' exoribonuclease (Dictyostelium discoideum)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Dictyostelium discoideum)
DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)
H2O [cytosol]
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Asparagine N-linked glycosylation (Dictyostelium discoideum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Dictyostelium discoideum)
Synthesis of substrates in N-glycan biosythesis (Dictyostelium discoideum)
GDP-fucose biosynthesis (Dictyostelium discoideum)
GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Dictyostelium discoideum)
DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Dictyostelium discoideum)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPII-mediated vesicle transport (Dictyostelium discoideum)
PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
H2O [cytosol]
Deubiquitination (Dictyostelium discoideum)
Josephin domain DUBs (Dictyostelium discoideum)
ATXN3 family cleave Ub chains (Dictyostelium discoideum)
H2O [cytosol]
UCH proteinases (Dictyostelium discoideum)
UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)
H2O [cytosol]
Ub-specific processing proteases (Dictyostelium discoideum)
USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Dictyostelium discoideum)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Dictyostelium discoideum)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Dictyostelium discoideum)
H2O [cytosol]
USP5 cleaves polyubiquitin (Dictyostelium discoideum)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
Hypusine synthesis from eIF5A-lysine (Dictyostelium discoideum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
H2O [cytosol]
Neddylation (Dictyostelium discoideum)
UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Dictyostelium discoideum)
Synthesis of glycosylphosphatidylinositol (GPI) (Dictyostelium discoideum)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)
H2O [cytosol]
Surfactant metabolism (Dictyostelium discoideum)
ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
H2O [cytosol]
Translation (Dictyostelium discoideum)
Eukaryotic Translation Termination (Dictyostelium discoideum)
APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)
H2O [cytosol]
tRNA Aminoacylation (Dictyostelium discoideum)
Cytosolic tRNA aminoacylation (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
H2O [cytosol]
Muscle contraction (Dictyostelium discoideum)
Cardiac conduction (Dictyostelium discoideum)
Physiological factors (Dictyostelium discoideum)
CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)
H2O [cytosol]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter clearance (Dictyostelium discoideum)
Dopamine clearance from the synaptic cleft (Dictyostelium discoideum)
Enzymatic degradation of Dopamine by monoamine oxidase (Dictyostelium discoideum)
MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Dictyostelium discoideum)
MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Dictyostelium discoideum)
Metabolism of serotonin (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
H2O [cytosol]
Neurotransmitter release cycle (Dictyostelium discoideum)
Norepinephrine Neurotransmitter Release Cycle (Dictyostelium discoideum)
Catabolism of Noradrenaline (Dictyostelium discoideum)
H2O [cytosol]
Protein localization (Dictyostelium discoideum)
Peroxisomal protein import (Dictyostelium discoideum)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)
H2O [cytosol]
Sensory Perception (Dictyostelium discoideum)
Visual phototransduction (Dictyostelium discoideum)
The canonical retinoid cycle in rods (twilight vision) (Dictyostelium discoideum)
ABCA4 mediates atRAL transport (Dictyostelium discoideum)
H2O [cytosol]
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
DAG and IP3 signaling (Dictyostelium discoideum)
CaM pathway (Dictyostelium discoideum)
Calmodulin induced events (Dictyostelium discoideum)
Cam-PDE 1 activation (Dictyostelium discoideum)
cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)
H2O [cytosol]
PIP3 activates AKT signaling (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Dictyostelium discoideum)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
H2O [cytosol]
PTEN Regulation (Dictyostelium discoideum)
Regulation of PTEN stability and activity (Dictyostelium discoideum)
USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)
H2O [cytosol]
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF-independent MAPK1/3 activation (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
RAF/MAP kinase cascade (Dictyostelium discoideum)
Negative regulation of MAPK pathway (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)
H2O [cytosol]
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Opioid Signalling (Dictyostelium discoideum)
DARPP-32 events (Dictyostelium discoideum)
PDE4A,C,D hydrolyse cAMP (Dictyostelium discoideum)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Dictyostelium discoideum)
H2O [cytosol]
G-protein mediated events (Dictyostelium discoideum)
PLC beta mediated events (Dictyostelium discoideum)
Ca-dependent events (Dictyostelium discoideum)
CaM pathway (Dictyostelium discoideum)
Calmodulin induced events (Dictyostelium discoideum)
Cam-PDE 1 activation (Dictyostelium discoideum)
cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)
H2O [cytosol]
Inactivation of PLC beta (Dictyostelium discoideum)
H2O [cytosol]
PIP2 hydrolysis (Dictyostelium discoideum)
H2O [cytosol]
G alpha (q) signalling events (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Arachidonate production from DAG (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
H2O [cytosol]
G alpha (s) signalling events (Dictyostelium discoideum)
PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Nuclear Receptors (Dictyostelium discoideum)
Signaling by Retinoic Acid (Dictyostelium discoideum)
RA biosynthesis pathway (Dictyostelium discoideum)
ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by Insulin receptor (Dictyostelium discoideum)
Insulin receptor signalling cascade (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
PKB-mediated events (Dictyostelium discoideum)
PDE3B signalling (Dictyostelium discoideum)
p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Dictyostelium discoideum)
IGF1R signaling cascade (Dictyostelium discoideum)
IRS-related events triggered by IGF1R (Dictyostelium discoideum)
IRS-mediated signalling (Dictyostelium discoideum)
PI3K Cascade (Dictyostelium discoideum)
PKB-mediated events (Dictyostelium discoideum)
PDE3B signalling (Dictyostelium discoideum)
p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
Miro GTPase Cycle (Dictyostelium discoideum)
RHOT1 GTPase cycle (Dictyostelium discoideum)
RHOT1 hydrolyzes GTP (Dictyostelium discoideum)
H2O [cytosol]
RHOT2 GTPase cycle (Dictyostelium discoideum)
RHOT2 hydrolyzes GTP (Dictyostelium discoideum)
H2O [cytosol]
RHOBTB3 ATPase cycle (Dictyostelium discoideum)
RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)
H2O [cytosol]
Signaling by Rho GTPases (Dictyostelium discoideum)
RHO GTPase cycle (Dictyostelium discoideum)
CDC42 GTPase cycle (Dictyostelium discoideum)
CDC42 GAPs stimulate CDC42 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RAC1 GTPase cycle (Dictyostelium discoideum)
RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RAC2 GTPase cycle (Dictyostelium discoideum)
RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RAC3 GTPase cycle (Dictyostelium discoideum)
RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RHOJ GTPase cycle (Dictyostelium discoideum)
RHOJ GAPs stimulate RHOJ GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
RHOQ GTPase cycle (Dictyostelium discoideum)
RHOQ GAPs stimulate RHOQ GTPase activity (Dictyostelium discoideum)
H2O [cytosol]
Transport of small molecules (Dictyostelium discoideum)
ABC-family proteins mediated transport (Dictyostelium discoideum)
ABC transporters in lipid homeostasis (Dictyostelium discoideum)
ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)
H2O [cytosol]
ABCAs mediate lipid efflux (Dictyostelium discoideum)
H2O [cytosol]
ABCAs mediate lipid influx (Dictyostelium discoideum)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCA4 mediates atRAL transport (Dictyostelium discoideum)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
HCO3- transport through ion channel (Dictyostelium discoideum)
H2O [cytosol]
The ABCC family mediates organic anion transport (Dictyostelium discoideum)
H2O [cytosol]
Aquaporin-mediated transport (Dictyostelium discoideum)
Passive transport by Aquaporins (Dictyostelium discoideum)
Aquaporins passively transport water into cells (Dictyostelium discoideum)
H2O [cytosol]
Aquaporins passively transport water out of cells (Dictyostelium discoideum)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Dictyostelium discoideum)
Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)
H2O [cytosol]
Ion channel transport (Dictyostelium discoideum)
Ion transport by P-type ATPases (Dictyostelium discoideum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)
H2O [cytosol]
Iron uptake and transport (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
H2O [cytosol]
Transferrin endocytosis and recycling (Dictyostelium discoideum)
Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Dictyostelium discoideum)
Plasma lipoprotein clearance (Dictyostelium discoideum)
LDL clearance (Dictyostelium discoideum)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)
H2O [cytosol]
Plasma lipoprotein remodeling (Dictyostelium discoideum)
HDL remodeling (Dictyostelium discoideum)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
H2O [cytosol]
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
ER to Golgi Anterograde Transport (Dictyostelium discoideum)
COPII-mediated vesicle transport (Dictyostelium discoideum)
PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
H2O [cytosol]
Rab regulation of trafficking (Dictyostelium discoideum)
TBC/RABGAPs (Dictyostelium discoideum)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
H2O [cytosol]
Autophagy (Drosophila melanogaster)
Macroautophagy (Drosophila melanogaster)
Selective autophagy (Drosophila melanogaster)
Pexophagy (Drosophila melanogaster)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
H2O [cytosol]
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Nuclear Envelope (NE) Reassembly (Drosophila melanogaster)
Initiation of Nuclear Envelope (NE) Reformation (Drosophila melanogaster)
ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Drosophila melanogaster)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Drosophila melanogaster)
RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)
H2O [cytosol]
Mitotic Prometaphase (Drosophila melanogaster)
Condensation of Prometaphase Chromosomes (Drosophila melanogaster)
Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Drosophila melanogaster)
PPP1CC dephosphorylates PLK1 (Drosophila melanogaster)
H2O [cytosol]
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)
H2O [cytosol]
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Drosophila melanogaster)
Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)
H2O [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
Cytoprotection by HMOX1 (Drosophila melanogaster)
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Drosophila melanogaster)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
Nuclear events mediated by NFE2L2 (Drosophila melanogaster)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Drosophila melanogaster)
PRDX1 overoxidizes (Drosophila melanogaster)
H2O [cytosol]
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPHB-mediated forward signaling (Drosophila melanogaster)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)
H2O [cytosol]
Signaling by ROBO receptors (Drosophila melanogaster)
Regulation of expression of SLITs and ROBOs (Drosophila melanogaster)
USP33 deubiquitinates ROBO1 (Drosophila melanogaster)
H2O [cytosol]
Drug ADME (Drosophila melanogaster)
Abacavir ADME (Drosophila melanogaster)
Abacavir metabolism (Drosophila melanogaster)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)
H2O [cytosol]
Aspirin ADME (Drosophila melanogaster)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)
H2O [cytosol]
Azathioprine ADME (Drosophila melanogaster)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
H2O [cytosol]
Ciprofloxacin ADME (Drosophila melanogaster)
ABCG2 transports Cipro from hepatic cell to extracellular space (Drosophila melanogaster)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)
H2O [cytosol]
Paracetamol ADME (Drosophila melanogaster)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Drosophila melanogaster)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Drosophila melanogaster)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)
H2O [cytosol]
Ribavirin ADME (Drosophila melanogaster)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)
H2O [cytosol]
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Metabolic Genes (Drosophila melanogaster)
PRDX1 overoxidizes (Drosophila melanogaster)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
H2O [cytosol]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Arachidonate production from DAG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Drosophila melanogaster)
Platelet degranulation (Drosophila melanogaster)
ABCC4 accumulation of dense granule contents (Drosophila melanogaster)
H2O [cytosol]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Costimulation by the CD28 family (Drosophila melanogaster)
CTLA4 inhibitory signaling (Drosophila melanogaster)
Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
H2O [cytosol]
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
H2O [cytosol]
Generation of second messenger molecules (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
H2O [cytosol]
Cytokine Signaling in Immune system (Drosophila melanogaster)
Interferon Signaling (Drosophila melanogaster)
Antiviral mechanism by IFN-stimulated genes (Drosophila melanogaster)
OAS antiviral response (Drosophila melanogaster)
PDE12 cleaves 2'-5' oligoadenylates (Drosophila melanogaster)
H2O [cytosol]
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
CLEC7A (Dectin-1) induces NFAT activation (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Role of phospholipids in phagocytosis (Drosophila melanogaster)
Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Drosophila melanogaster)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)
H2O [cytosol]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism (Drosophila melanogaster)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)
H2O [cytosol]
Regulation of pyruvate metabolism (Drosophila melanogaster)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Drosophila melanogaster)
H2O [cytosol]
Biological oxidations (Drosophila melanogaster)
Aflatoxin activation and detoxification (Drosophila melanogaster)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Drosophila melanogaster)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Drosophila melanogaster)
H2O [cytosol]
Phase I - Functionalization of compounds (Drosophila melanogaster)
ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Drosophila melanogaster)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Drosophila melanogaster)
Endogenous sterols (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
H2O [cytosol]
Vitamins (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)
H2O [cytosol]
Ethanol oxidation (Drosophila melanogaster)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)
H2O [cytosol]
Phase II - Conjugation of compounds (Drosophila melanogaster)
Cytosolic sulfonation of small molecules (Drosophila melanogaster)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Glucuronidation (Drosophila melanogaster)
Formation of the active cofactor, UDP-glucuronate (Drosophila melanogaster)
UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)
H2O [cytosol]
Glutathione conjugation (Drosophila melanogaster)
Glutathione synthesis and recycling (Drosophila melanogaster)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
H2O [cytosol]
Methylation (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)
H2O [cytosol]
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Drosophila melanogaster)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)
H2O [cytosol]
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Acetylcholine regulates insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Aspartate and asparagine metabolism (Drosophila melanogaster)
ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)
H2O [cytosol]
Tyrosine catabolism (Drosophila melanogaster)
FAH cleaves 4FAA (Drosophila melanogaster)
H2O [cytosol]
Selenoamino acid metabolism (Drosophila melanogaster)
Selenocysteine synthesis (Drosophila melanogaster)
SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)
H2O [cytosol]
Serine biosynthesis (Drosophila melanogaster)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)
H2O [cytosol]
Sulfur amino acid metabolism (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
H2O [cytosol]
Cysteine formation from homocysteine (Drosophila melanogaster)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)
H2O [cytosol]
Degradation of cysteine and homocysteine (Drosophila melanogaster)
Cysteine is degraded to serine and H2S (Drosophila melanogaster)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)
H2O [cytosol]
Methionine salvage pathway (Drosophila melanogaster)
Acireductone is created (Drosophila melanogaster)
H2O [cytosol]
Tryptophan catabolism (Drosophila melanogaster)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
H2O [cytosol]
Urea cycle (Drosophila melanogaster)
arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)
H2O [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Fructose metabolism (Drosophila melanogaster)
Fructose catabolism (Drosophila melanogaster)
ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)
H2O [cytosol]
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Drosophila melanogaster)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)
H2O [cytosol]
Glycolysis (Drosophila melanogaster)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Drosophila melanogaster)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Glycogen metabolism (Drosophila melanogaster)
Glycogen synthesis (Drosophila melanogaster)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)
H2O [cytosol]
Pentose phosphate pathway (Drosophila melanogaster)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Biosynthesis of specialized proresolving mediators (SPMs) (Drosophila melanogaster)
Biosynthesis of DHA-derived SPMs (Drosophila melanogaster)
Biosynthesis of D-series resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of maresins (Drosophila melanogaster)
Biosynthesis of maresin-like SPMs (Drosophila melanogaster)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Drosophila melanogaster)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Drosophila melanogaster)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of protectins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Drosophila melanogaster)
Biosynthesis of E-series 18(R)-resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)
H2O [cytosol]
Fatty acid metabolism (Drosophila melanogaster)
Arachidonic acid metabolism (Drosophila melanogaster)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Drosophila melanogaster)
LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Drosophila melanogaster)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Drosophila melanogaster)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Drosophila melanogaster)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Drosophila melanogaster)
SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Drosophila melanogaster)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Drosophila melanogaster)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)
H2O [cytosol]
Metabolism of steroids (Drosophila melanogaster)
Bile acid and bile salt metabolism (Drosophila melanogaster)
Recycling of bile acids and salts (Drosophila melanogaster)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
H2O [cytosol]
Synthesis of bile acids and bile salts (Drosophila melanogaster)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Drosophila melanogaster)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
H2O [cytosol]
Cholesterol biosynthesis (Drosophila melanogaster)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of steroid hormones (Drosophila melanogaster)
Estrogen biosynthesis (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
H2O [cytosol]
Phospholipid metabolism (Drosophila melanogaster)
Glycerophospholipid biosynthesis (Drosophila melanogaster)
Acyl chain remodeling of DAG and TAG (Drosophila melanogaster)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PC (Drosophila melanogaster)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Drosophila melanogaster)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PE (Drosophila melanogaster)
ABHD4 hydrolyses NAPE (Drosophila melanogaster)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PG (Drosophila melanogaster)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Drosophila melanogaster)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PI (Drosophila melanogaster)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Drosophila melanogaster)
H2O [cytosol]
Acyl chain remodelling of PS (Drosophila melanogaster)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PA (Drosophila melanogaster)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Drosophila melanogaster)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Drosophila melanogaster)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Drosophila melanogaster)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PC (Drosophila melanogaster)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PE (Drosophila melanogaster)
PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)
H2O [cytosol]
PI Metabolism (Drosophila melanogaster)
Glycerophospholipid catabolism (Drosophila melanogaster)
GDE1 hydrolyzes GroPIns (Drosophila melanogaster)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
H2O [cytosol]
Sphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid catabolism (Drosophila melanogaster)
ASAH2 hydrolyzes ceramide (plasma membrane) (Drosophila melanogaster)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Drosophila melanogaster)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Drosophila melanogaster)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)
H2O [cytosol]
Sphingolipid catabolism (Drosophila melanogaster)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Drosophila melanogaster)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Drosophila melanogaster)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Drosophila melanogaster)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Drosophila melanogaster)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Drosophila melanogaster)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Drosophila melanogaster)
H2O [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Drosophila melanogaster)
H2O [cytosol]
Triglyceride metabolism (Drosophila melanogaster)
Triglyceride biosynthesis (Drosophila melanogaster)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Triglyceride catabolism (Drosophila melanogaster)
PNPLA5 hydrolyzes TAG (Drosophila melanogaster)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
eNOS activation (Drosophila melanogaster)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)
H2O [cytosol]
Metabolism of nucleotides (Drosophila melanogaster)
Interconversion of nucleotide di- and triphosphates (Drosophila melanogaster)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
H2O [cytosol]
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
H2O [cytosol]
FAICAR => IMP + H2O (Drosophila melanogaster)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
H2O [cytosol]
Pyrimidine biosynthesis (Drosophila melanogaster)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
H2O [cytosol]
Nucleotide catabolism (Drosophila melanogaster)
Purine catabolism (Drosophila melanogaster)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Drosophila melanogaster)
H2O [cytosol]
Pyrimidine catabolism (Drosophila melanogaster)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)
H2O [cytosol]
Nucleotide salvage (Drosophila melanogaster)
Purine salvage (Drosophila melanogaster)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)
H2O [cytosol]
Pyrimidine salvage (Drosophila melanogaster)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)
H2O [cytosol]
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
4 PBGs bind to form HMB (Drosophila melanogaster)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)
H2O [cytosol]
UROS transforms HMB to URO3 (Drosophila melanogaster)
H2O [cytosol]
Heme degradation (Drosophila melanogaster)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
H2O [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Drosophila melanogaster)
Transport of RCbl within the body (Drosophila melanogaster)
ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)
H2O [cytosol]
Metabolism of folate and pterines (Drosophila melanogaster)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Drosophila melanogaster)
Cyclisation of GTP to precursor Z (Drosophila melanogaster)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)
H2O [cytosol]
Nicotinate metabolism (Drosophila melanogaster)
NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Drosophila melanogaster)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Drosophila melanogaster)
H2O [cytosol]
Pyrophosphate hydrolysis (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Reversible hydration of carbon dioxide (Drosophila melanogaster)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)
H2O [cytosol]
Metabolism of RNA (Drosophila melanogaster)
Deadenylation-dependent mRNA decay (Drosophila melanogaster)
mRNA decay by 3' to 5' exoribonuclease (Drosophila melanogaster)
DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Drosophila melanogaster)
DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)
H2O [cytosol]
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Drosophila melanogaster)
Synthesis of substrates in N-glycan biosythesis (Drosophila melanogaster)
GDP-fucose biosynthesis (Drosophila melanogaster)
GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)
H2O [cytosol]
Sialic acid metabolism (Drosophila melanogaster)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Drosophila melanogaster)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Drosophila melanogaster)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)
H2O [cytosol]
Deubiquitination (Drosophila melanogaster)
Josephin domain DUBs (Drosophila melanogaster)
ATXN3 family cleave Ub chains (Drosophila melanogaster)
H2O [cytosol]
Ovarian tumor domain proteases (Drosophila melanogaster)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)
H2O [cytosol]
UCH proteinases (Drosophila melanogaster)
UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)
H2O [cytosol]
Ub-specific processing proteases (Drosophila melanogaster)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Drosophila melanogaster)
H2O [cytosol]
USP5 cleaves polyubiquitin (Drosophila melanogaster)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Drosophila melanogaster)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
Hypusine synthesis from eIF5A-lysine (Drosophila melanogaster)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
H2O [cytosol]
Neddylation (Drosophila melanogaster)
UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Drosophila melanogaster)
Synthesis of glycosylphosphatidylinositol (GPI) (Drosophila melanogaster)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)
H2O [cytosol]
Surfactant metabolism (Drosophila melanogaster)
ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
H2O [cytosol]
Translation (Drosophila melanogaster)
tRNA Aminoacylation (Drosophila melanogaster)
Cytosolic tRNA aminoacylation (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
H2O [cytosol]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Physiological factors (Drosophila melanogaster)
CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)
H2O [cytosol]
Organelle biogenesis and maintenance (Drosophila melanogaster)
Cilium Assembly (Drosophila melanogaster)
Cargo trafficking to the periciliary membrane (Drosophila melanogaster)
VxPx cargo-targeting to cilium (Drosophila melanogaster)
ASAP1 stimulates GTPase activity of ARF4 (Drosophila melanogaster)
H2O [cytosol]
Protein localization (Drosophila melanogaster)
Peroxisomal protein import (Drosophila melanogaster)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)
H2O [cytosol]
Sensory Perception (Drosophila melanogaster)
Visual phototransduction (Drosophila melanogaster)
The canonical retinoid cycle in rods (twilight vision) (Drosophila melanogaster)
ABCA4 mediates atRAL transport (Drosophila melanogaster)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)
H2O [cytosol]
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
H2O [cytosol]
Intracellular signaling by second messengers (Drosophila melanogaster)
DAG and IP3 signaling (Drosophila melanogaster)
CaM pathway (Drosophila melanogaster)
Calmodulin induced events (Drosophila melanogaster)
Cam-PDE 1 activation (Drosophila melanogaster)
cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)
H2O [cytosol]
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)
H2O [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
H2O [cytosol]
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN stability and activity (Drosophila melanogaster)
USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)
H2O [cytosol]
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
H2O [cytosol]
RAF/MAP kinase cascade (Drosophila melanogaster)
Negative regulation of MAPK pathway (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Drosophila melanogaster)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)
H2O [cytosol]
RAF activation (Drosophila melanogaster)
PP2A dephosphorylates KSR1 (Drosophila melanogaster)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)
H2O [cytosol]
RAS processing (Drosophila melanogaster)
RAS proteins are depalmitoylated (Drosophila melanogaster)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)
H2O [cytosol]
MTOR signalling (Drosophila melanogaster)
Energy dependent regulation of mTOR by LKB1-AMPK (Drosophila melanogaster)
AMPK is dephosphorylated (Drosophila melanogaster)
H2O [cytosol]
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Opioid Signalling (Drosophila melanogaster)
DARPP-32 events (Drosophila melanogaster)
PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)
H2O [cytosol]
G-protein mediated events (Drosophila melanogaster)
PLC beta mediated events (Drosophila melanogaster)
Ca-dependent events (Drosophila melanogaster)
CaM pathway (Drosophila melanogaster)
Calmodulin induced events (Drosophila melanogaster)
Cam-PDE 1 activation (Drosophila melanogaster)
cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)
H2O [cytosol]
Inactivation of PLC beta (Drosophila melanogaster)
H2O [cytosol]
PIP2 hydrolysis (Drosophila melanogaster)
H2O [cytosol]
G alpha (q) signalling events (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Arachidonate production from DAG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
H2O [cytosol]
G alpha (s) signalling events (Drosophila melanogaster)
PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Drosophila melanogaster)
H2O [cytosol]
Signaling by Hedgehog (Drosophila melanogaster)
Hedgehog ligand biogenesis (Drosophila melanogaster)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)
H2O [cytosol]
Signaling by Nuclear Receptors (Drosophila melanogaster)
Signaling by Retinoic Acid (Drosophila melanogaster)
RA biosynthesis pathway (Drosophila melanogaster)
ALDHs oxidise atRAL to atRA (Drosophila melanogaster)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
H2O [cytosol]
GAB1 signalosome (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
H2O [cytosol]
Signaling by ERBB2 (Drosophila melanogaster)
Downregulation of ERBB2 signaling (Drosophila melanogaster)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Drosophila melanogaster)
H2O [cytosol]
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor recycling (Drosophila melanogaster)
Insulin receptor de-phosphorylation (Drosophila melanogaster)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Miro GTPase Cycle (Drosophila melanogaster)
RHOT1 GTPase cycle (Drosophila melanogaster)
RHOT1 hydrolyzes GTP (Drosophila melanogaster)
H2O [cytosol]
RHOT2 GTPase cycle (Drosophila melanogaster)
RHOT2 hydrolyzes GTP (Drosophila melanogaster)
H2O [cytosol]
RHOBTB3 ATPase cycle (Drosophila melanogaster)
RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)
H2O [cytosol]
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
CDC42 GTPase cycle (Drosophila melanogaster)
CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RAC1 GTPase cycle (Drosophila melanogaster)
RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RAC2 GTPase cycle (Drosophila melanogaster)
RAC2 GAPs stimulate RAC2 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RAC3 GTPase cycle (Drosophila melanogaster)
RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOA GTPase cycle (Drosophila melanogaster)
RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOB GTPase cycle (Drosophila melanogaster)
RHOB GAPs stimulate RHOB GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOD GTPase cycle (Drosophila melanogaster)
RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOF GTPase cycle (Drosophila melanogaster)
RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOG GTPase cycle (Drosophila melanogaster)
RHOG GAPs stimulate RHOG GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOJ GTPase cycle (Drosophila melanogaster)
RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)
H2O [cytosol]
RHOQ GTPase cycle (Drosophila melanogaster)
RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)
H2O [cytosol]
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Downregulation of TGF-beta receptor signaling (Drosophila melanogaster)
MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
H2O [cytosol]
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
Ca2+ pathway (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)
H2O [cytosol]
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
ABC transporters in lipid homeostasis (Drosophila melanogaster)
ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
ABCA4 mediates atRAL transport (Drosophila melanogaster)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
HCO3- transport through ion channel (Drosophila melanogaster)
H2O [cytosol]
Mitochondrial ABC transporters (Drosophila melanogaster)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)
H2O [cytosol]
The ABCC family mediates organic anion transport (Drosophila melanogaster)
H2O [cytosol]
Aquaporin-mediated transport (Drosophila melanogaster)
Passive transport by Aquaporins (Drosophila melanogaster)
Aquaporins passively transport water into cells (Drosophila melanogaster)
H2O [cytosol]
Aquaporins passively transport water out of cells (Drosophila melanogaster)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Drosophila melanogaster)
Aquaporin-1 passively transports water into cell (Drosophila melanogaster)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)
H2O [cytosol]
Ion channel transport (Drosophila melanogaster)
Ion transport by P-type ATPases (Drosophila melanogaster)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)
H2O [cytosol]
Iron uptake and transport (Drosophila melanogaster)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
H2O [cytosol]
Transferrin endocytosis and recycling (Drosophila melanogaster)
Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Drosophila melanogaster)
Erythrocytes take up carbon dioxide and release oxygen (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Drosophila melanogaster)
Plasma lipoprotein clearance (Drosophila melanogaster)
LDL clearance (Drosophila melanogaster)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)
H2O [cytosol]
Plasma lipoprotein remodeling (Drosophila melanogaster)
HDL remodeling (Drosophila melanogaster)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
H2O [cytosol]
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Drosophila melanogaster)
Golgi-to-ER retrograde transport (Drosophila melanogaster)
COPI-independent Golgi-to-ER retrograde traffic (Drosophila melanogaster)
PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)
H2O [cytosol]
Rab regulation of trafficking (Drosophila melanogaster)
TBC/RABGAPs (Drosophila melanogaster)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
H2O [cytosol]
Autophagy (Gallus gallus)
Macroautophagy (Gallus gallus)
Selective autophagy (Gallus gallus)
Pexophagy (Gallus gallus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)
H2O [cytosol]
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
M Phase (Gallus gallus)
Mitotic Metaphase and Anaphase (Gallus gallus)
Mitotic Anaphase (Gallus gallus)
Nuclear Envelope (NE) Reassembly (Gallus gallus)
Initiation of Nuclear Envelope (NE) Reformation (Gallus gallus)
ANKLE2 is deacetylated by SIRT2 (Gallus gallus)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Gallus gallus)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Gallus gallus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)
H2O [cytosol]
Mitotic Prometaphase (Gallus gallus)
Condensation of Prometaphase Chromosomes (Gallus gallus)
Dephosphorylation of CK2-modified condensin I (Gallus gallus)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Gallus gallus)
PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Gallus gallus)
H2O [cytosol]
Mitotic G2-G2/M phases (Gallus gallus)
G2/M Transition (Gallus gallus)
Cyclin A/B1/B2 associated events during G2/M transition (Gallus gallus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)
H2O [cytosol]
Regulation of mitotic cell cycle (Gallus gallus)
APC/C-mediated degradation of cell cycle proteins (Gallus gallus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Gallus gallus)
Dephosphorylation of phospho-Cdh1 (Gallus gallus)
H2O [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
Cytoprotection by HMOX1 (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Gallus gallus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Gallus gallus)
Nuclear events mediated by NFE2L2 (Gallus gallus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Gallus gallus)
PRDX1 overoxidizes (Gallus gallus)
H2O [cytosol]
Chromatin organization (Gallus gallus)
Chromatin modifying enzymes (Gallus gallus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)
H2O [cytosol]
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
EPH-Ephrin signaling (Gallus gallus)
EPHB-mediated forward signaling (Gallus gallus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)
H2O [cytosol]
L1CAM interactions (Gallus gallus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)
H2O [cytosol]
Semaphorin interactions (Gallus gallus)
Sema4D in semaphorin signaling (Gallus gallus)
Sema4D mediated inhibition of cell attachment and migration (Gallus gallus)
Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)
H2O [cytosol]
Signaling by ROBO receptors (Gallus gallus)
SLIT2:ROBO1 increases RHOA activity (Gallus gallus)
MYO9B inactivates RHOA (Gallus gallus)
H2O [cytosol]
Drug ADME (Gallus gallus)
Abacavir ADME (Gallus gallus)
Abacavir metabolism (Gallus gallus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)
H2O [cytosol]
Aspirin ADME (Gallus gallus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)
H2O [cytosol]
Atorvastatin ADME (Gallus gallus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
H2O [cytosol]
Azathioprine ADME (Gallus gallus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Gallus gallus)
H2O [cytosol]
Paracetamol ADME (Gallus gallus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Gallus gallus)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Gallus gallus)
H2O [cytosol]
Prednisone ADME (Gallus gallus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Gallus gallus)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)
H2O [cytosol]
Ribavirin ADME (Gallus gallus)
ADA deamidates RBV (Gallus gallus)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)
H2O [cytosol]
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
H2O [cytosol]
PRDX1 overoxidizes (Gallus gallus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)
H2O [cytosol]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Effects of PIP2 hydrolysis (Gallus gallus)
Arachidonate production from DAG (Gallus gallus)
2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Gallus gallus)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Gallus gallus)
Platelet degranulation (Gallus gallus)
ABCC4 accumulation of dense granule contents (Gallus gallus)
H2O [cytosol]
Platelet homeostasis (Gallus gallus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)
H2O [cytosol]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Gallus gallus)
Disassembly of COPII coated vesicle (Gallus gallus)
H2O [cytosol]
MHC class II antigen presentation (Gallus gallus)
Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)
H2O [cytosol]
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
H2O [cytosol]
Generation of second messenger molecules (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Gallus gallus)
Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Gallus gallus)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Gallus gallus)
PTPN22 dephosphorylates ZAP70 (Gallus gallus)
H2O [cytosol]
Cytokine Signaling in Immune system (Gallus gallus)
Growth hormone receptor signaling (Gallus gallus)
PTP1B dephosphorylates GHR (Gallus gallus)
H2O [cytosol]
Interferon Signaling (Gallus gallus)
Antiviral mechanism by IFN-stimulated genes (Gallus gallus)
OAS antiviral response (Gallus gallus)
PDE12 cleaves 2'-5' oligoadenylates (Gallus gallus)
H2O [cytosol]
Interferon alpha/beta signaling (Gallus gallus)
Regulation of IFNA/IFNB signaling (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Gallus gallus)
H2O [cytosol]
Signaling by Interleukins (Gallus gallus)
Interleukin-1 family signaling (Gallus gallus)
Interleukin-1 signaling (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Innate Immune System (Gallus gallus)
Antimicrobial peptides (Gallus gallus)
Ion influx/efflux at host-pathogen interface (Gallus gallus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)
H2O [cytosol]
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
CLEC7A (Dectin-1) induces NFAT activation (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT (Gallus gallus)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT (Gallus gallus)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Gallus gallus)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Role of phospholipids in phagocytosis (Gallus gallus)
Conversion of PA into DAG by PAP-1 (Gallus gallus)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Gallus gallus)
H2O [cytosol]
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
Regulation of NF-kappa B signaling (Gallus gallus)
USP14 deubiquitinates NLRC5 (Gallus gallus)
H2O [cytosol]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Pyruvate metabolism (Gallus gallus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Gallus gallus)
H2O [cytosol]
Regulation of pyruvate metabolism (Gallus gallus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Gallus gallus)
H2O [cytosol]
Biological oxidations (Gallus gallus)
Aflatoxin activation and detoxification (Gallus gallus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Gallus gallus)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Gallus gallus)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Gallus gallus)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Gallus gallus)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Gallus gallus)
H2O [cytosol]
Phase I - Functionalization of compounds (Gallus gallus)
AADAC deacetylates PHEN (Gallus gallus)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Gallus gallus)
H2O [cytosol]
Amine Oxidase reactions (Gallus gallus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Gallus gallus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Gallus gallus)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Gallus gallus)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Gallus gallus)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Gallus gallus)
Endogenous sterols (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Gallus gallus)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Gallus gallus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Gallus gallus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
H2O [cytosol]
Vitamins (Gallus gallus)
CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Gallus gallus)
H2O [cytosol]
Ethanol oxidation (Gallus gallus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Gallus gallus)
H2O [cytosol]
Phase II - Conjugation of compounds (Gallus gallus)
Cytosolic sulfonation of small molecules (Gallus gallus)
ABHD14B hydrolyses PNPB (Gallus gallus)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Gallus gallus)
H2O [cytosol]
Glucuronidation (Gallus gallus)
Formation of the active cofactor, UDP-glucuronate (Gallus gallus)
UDP-glucose is oxidised to UDP-glucuronate (Gallus gallus)
H2O [cytosol]
Glutathione conjugation (Gallus gallus)
Glutathione synthesis and recycling (Gallus gallus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Gallus gallus)
H2O [cytosol]
Methylation (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Gallus gallus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Gallus gallus)
H2O [cytosol]
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP2, IP, and Ins in the cytosol (Gallus gallus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Gallus gallus)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Gallus gallus)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Gallus gallus)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Gallus gallus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Gallus gallus)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Gallus gallus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Gallus gallus)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Gallus gallus)
H2O [cytosol]
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Acetylcholine regulates insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Gallus gallus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
H2O [cytosol]
Metabolism of amino acids and derivatives (Gallus gallus)
Aspartate and asparagine metabolism (Gallus gallus)
ASPA deacetylates NAA to acetate and L-aspartate (Gallus gallus)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Gallus gallus)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Gallus gallus)
H2O [cytosol]
Carnitine synthesis (Gallus gallus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Gallus gallus)
H2O [cytosol]
Histidine catabolism (Gallus gallus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Gallus gallus)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Gallus gallus)
H2O [cytosol]
Metabolism of polyamines (Gallus gallus)
Agmatine biosynthesis (Gallus gallus)
Agmatine + H2O <=> putrescine + urea (Gallus gallus)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Gallus gallus)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Gallus gallus)
H2O [cytosol]
Tyrosine catabolism (Gallus gallus)
FAH cleaves 4FAA (Gallus gallus)
H2O [cytosol]
Selenoamino acid metabolism (Gallus gallus)
Metabolism of ingested MeSeO2H into MeSeH (Gallus gallus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Gallus gallus)
SeMet is converted to AdoSeMet by MAT (Gallus gallus)
H2O [cytosol]
Serine biosynthesis (Gallus gallus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Gallus gallus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Gallus gallus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Gallus gallus)
H2O [cytosol]
Sulfur amino acid metabolism (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
H2O [cytosol]
Cysteine formation from homocysteine (Gallus gallus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Gallus gallus)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Gallus gallus)
H2O [cytosol]
Degradation of cysteine and homocysteine (Gallus gallus)
Cysteine is degraded to serine and H2S (Gallus gallus)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Gallus gallus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
H2O [cytosol]
Methionine salvage pathway (Gallus gallus)
Acireductone is created (Gallus gallus)
H2O [cytosol]
Threonine catabolism (Gallus gallus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Gallus gallus)
H2O [cytosol]
Tryptophan catabolism (Gallus gallus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Gallus gallus)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)
H2O [cytosol]
Metabolism of carbohydrates (Gallus gallus)
Fructose metabolism (Gallus gallus)
Fructose catabolism (Gallus gallus)
ALDH1A1 oxidises GA to DGA (Gallus gallus)
H2O [cytosol]
Glucose metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Gallus gallus)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Gallus gallus)
H2O [cytosol]
Glycolysis (Gallus gallus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Gallus gallus)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Gallus gallus)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Gallus gallus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Gallus gallus)
H2O [cytosol]
Glycogen metabolism (Gallus gallus)
Glycogen synthesis (Gallus gallus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Gallus gallus)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Gallus gallus)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Gallus gallus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Gallus gallus)
H2O [cytosol]
Pentose phosphate pathway (Gallus gallus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Gallus gallus)
H2O [cytosol]
Metabolism of lipids (Gallus gallus)
Biosynthesis of specialized proresolving mediators (SPMs) (Gallus gallus)
Biosynthesis of DHA-derived SPMs (Gallus gallus)
Biosynthesis of D-series resolvins (Gallus gallus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Gallus gallus)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Gallus gallus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Gallus gallus)
H2O [cytosol]
Biosynthesis of maresins (Gallus gallus)
Biosynthesis of maresin-like SPMs (Gallus gallus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Gallus gallus)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Gallus gallus)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Gallus gallus)
H2O [cytosol]
Biosynthesis of protectins (Gallus gallus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Gallus gallus)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Gallus gallus)
Biosynthesis of E-series 18(R)-resolvins (Gallus gallus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Gallus gallus)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Gallus gallus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Gallus gallus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Gallus gallus)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Gallus gallus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Gallus gallus)
H2O [cytosol]
Fatty acid metabolism (Gallus gallus)
Arachidonic acid metabolism (Gallus gallus)
FAAH hydrolyses AEA to AA and ETA (Gallus gallus)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Gallus gallus)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Gallus gallus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Gallus gallus)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Gallus gallus)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Gallus gallus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Gallus gallus)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Gallus gallus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Gallus gallus)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Gallus gallus)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Gallus gallus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Gallus gallus)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Gallus gallus)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Gallus gallus)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Gallus gallus)
SCD desaturates ST-CoA to OLE-CoA (Gallus gallus)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Gallus gallus)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Gallus gallus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Gallus gallus)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Gallus gallus)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Gallus gallus)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Gallus gallus)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Gallus gallus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Gallus gallus)
H2O [cytosol]
Metabolism of steroids (Gallus gallus)
Bile acid and bile salt metabolism (Gallus gallus)
Recycling of bile acids and salts (Gallus gallus)
ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts (Gallus gallus)
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
H2O [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Gallus gallus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Gallus gallus)
27-hydroxycholesterol is 7alpha-hydroxylated (Gallus gallus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Gallus gallus)
ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
H2O [cytosol]
Cholesterol biosynthesis (Gallus gallus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Gallus gallus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Gallus gallus)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Gallus gallus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Gallus gallus)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Gallus gallus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Gallus gallus)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Gallus gallus)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Gallus gallus)
H2O [cytosol]
Squalene is oxidized to its epoxide (Gallus gallus)
H2O [cytosol]
Metabolism of steroid hormones (Gallus gallus)
Androgen biosynthesis (Gallus gallus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Gallus gallus)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Gallus gallus)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Gallus gallus)
H2O [cytosol]
Estrogen biosynthesis (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Gallus gallus)
H2O [cytosol]
Glucocorticoid biosynthesis (Gallus gallus)
CYP17A1 17-hydroxylates PREG (Gallus gallus)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Gallus gallus)
H2O [cytosol]
Mineralocorticoid biosynthesis (Gallus gallus)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Gallus gallus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
H2O [cytosol]
Phospholipid metabolism (Gallus gallus)
Glycerophospholipid biosynthesis (Gallus gallus)
Acyl chain remodeling of DAG and TAG (Gallus gallus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Gallus gallus)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Gallus gallus)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PC (Gallus gallus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Gallus gallus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Gallus gallus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PE (Gallus gallus)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Gallus gallus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Gallus gallus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PG (Gallus gallus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Gallus gallus)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Gallus gallus)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PI (Gallus gallus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Gallus gallus)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Gallus gallus)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Gallus gallus)
H2O [cytosol]
Acyl chain remodelling of PS (Gallus gallus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Gallus gallus)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Gallus gallus)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Gallus gallus)
H2O [cytosol]
Hydrolysis of LPC (Gallus gallus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)
H2O [cytosol]
Synthesis of PA (Gallus gallus)
DDHD1,2 hydrolyse PA (Gallus gallus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Gallus gallus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Gallus gallus)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Gallus gallus)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Gallus gallus)
H2O [cytosol]
Synthesis of PC (Gallus gallus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Gallus gallus)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Gallus gallus)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Gallus gallus)
H2O [cytosol]
Synthesis of PE (Gallus gallus)
PA is dephosphorylated to DAG by LPIN (Gallus gallus)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Gallus gallus)
H2O [cytosol]
PI Metabolism (Gallus gallus)
Glycerophospholipid catabolism (Gallus gallus)
GDE1 hydrolyzes GroPIns (Gallus gallus)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Gallus gallus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Gallus gallus)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Gallus gallus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Gallus gallus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
H2O [cytosol]
Sphingolipid metabolism (Gallus gallus)
Glycosphingolipid metabolism (Gallus gallus)
Glycosphingolipid catabolism (Gallus gallus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Gallus gallus)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Gallus gallus)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Gallus gallus)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Gallus gallus)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Gallus gallus)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Gallus gallus)
H2O [cytosol]
Sphingolipid catabolism (Gallus gallus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Gallus gallus)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Gallus gallus)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Gallus gallus)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Gallus gallus)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Gallus gallus)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Gallus gallus)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Gallus gallus)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Gallus gallus)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Gallus gallus)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Gallus gallus)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Gallus gallus)
H2O [cytosol]
Triglyceride metabolism (Gallus gallus)
Triglyceride biosynthesis (Gallus gallus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Gallus gallus)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Gallus gallus)
H2O [cytosol]
Triglyceride catabolism (Gallus gallus)
PNPLA4 hydrolyzes TAG (Gallus gallus)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Gallus gallus)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Gallus gallus)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Gallus gallus)
H2O [cytosol]
Metabolism of nucleotides (Gallus gallus)
Interconversion of nucleotide di- and triphosphates (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Gallus gallus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Gallus gallus)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Gallus gallus)
H2O [cytosol]
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
H2O [cytosol]
FAICAR => IMP + H2O (Gallus gallus)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Gallus gallus)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
H2O [cytosol]
Nucleotide catabolism (Gallus gallus)
Purine catabolism (Gallus gallus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Gallus gallus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Gallus gallus)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Gallus gallus)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Gallus gallus)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Gallus gallus)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Gallus gallus)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Gallus gallus)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Gallus gallus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Gallus gallus)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Gallus gallus)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Gallus gallus)
H2O [cytosol]
Pyrimidine catabolism (Gallus gallus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Gallus gallus)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Gallus gallus)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Gallus gallus)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Gallus gallus)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Gallus gallus)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Gallus gallus)
H2O [cytosol]
Nucleotide salvage (Gallus gallus)
Purine salvage (Gallus gallus)
ADA catalyzes the deamination of (deoxy)adenosine (Gallus gallus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Gallus gallus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Gallus gallus)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Gallus gallus)
H2O [cytosol]
Pyrimidine salvage (Gallus gallus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Gallus gallus)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Gallus gallus)
H2O [cytosol]
Metabolism of porphyrins (Gallus gallus)
Heme biosynthesis (Gallus gallus)
4 PBGs bind to form HMB (Gallus gallus)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Gallus gallus)
H2O [cytosol]
UROS transforms HMB to URO3 (Gallus gallus)
H2O [cytosol]
Heme degradation (Gallus gallus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
H2O [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Gallus gallus)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Transport of RCbl within the body (Gallus gallus)
ABCC1 transports cytosolic RCbl to extracellular region (Gallus gallus)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Gallus gallus)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Gallus gallus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Gallus gallus)
H2O [cytosol]
Metabolism of folate and pterines (Gallus gallus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Gallus gallus)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Gallus gallus)
Cyclisation of GTP to precursor Z (Gallus gallus)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Gallus gallus)
H2O [cytosol]
Nicotinate metabolism (Gallus gallus)
NADSYN1 hexamer amidates NAAD to NAD+ (Gallus gallus)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Gallus gallus)
2xTRAP hydrolyzes FMN to RIB (Gallus gallus)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Gallus gallus)
PANK4 hydrolyzes PPANT to pantetheine (Gallus gallus)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Gallus gallus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Gallus gallus)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Gallus gallus)
H2O [cytosol]
Pyrophosphate hydrolysis (Gallus gallus)
LHPP:Mg2+ dimer hydrolyses PPi (Gallus gallus)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
H2O [cytosol]
Reversible hydration of carbon dioxide (Gallus gallus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Gallus gallus)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Gallus gallus)
H2O [cytosol]
Metabolism of RNA (Gallus gallus)
Deadenylation-dependent mRNA decay (Gallus gallus)
Deadenylation of mRNA (Gallus gallus)
CCR4-NOT complex deadenylates mRNA (Gallus gallus)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)
H2O [cytosol]
PARN deadenylates mRNA (Gallus gallus)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Gallus gallus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Gallus gallus)
DCP1-DCP2 complex decaps mRNA (Gallus gallus)
H2O [cytosol]
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Asparagine N-linked glycosylation (Gallus gallus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Gallus gallus)
Synthesis of substrates in N-glycan biosythesis (Gallus gallus)
GDP-fucose biosynthesis (Gallus gallus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)
H2O [cytosol]
Sialic acid metabolism (Gallus gallus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Gallus gallus)
DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Gallus gallus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Gallus gallus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Gallus gallus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Gallus gallus)
ER to Golgi Anterograde Transport (Gallus gallus)
COPII-mediated vesicle transport (Gallus gallus)
PP6 dephosphorylates SEC24 (Gallus gallus)
H2O [cytosol]
Deubiquitination (Gallus gallus)
Josephin domain DUBs (Gallus gallus)
ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)
H2O [cytosol]
ATXN3 family cleave Ub chains (Gallus gallus)
H2O [cytosol]
Metalloprotease DUBs (Gallus gallus)
BRISC complex deubiquitinates NLRP3 (Gallus gallus)
H2O [cytosol]
Ovarian tumor domain proteases (Gallus gallus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)
H2O [cytosol]
UCH proteinases (Gallus gallus)
UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Gallus gallus)
H2O [cytosol]
Ub-specific processing proteases (Gallus gallus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Gallus gallus)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Gallus gallus)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Gallus gallus)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Gallus gallus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)
H2O [cytosol]
USP5 cleaves polyubiquitin (Gallus gallus)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Gallus gallus)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Gallus gallus)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
Hypusine synthesis from eIF5A-lysine (Gallus gallus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
H2O [cytosol]
Neddylation (Gallus gallus)
UCHL3, SENP8 cleave NEDD8 (Gallus gallus)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Gallus gallus)
Synthesis of glycosylphosphatidylinositol (GPI) (Gallus gallus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Gallus gallus)
H2O [cytosol]
Surfactant metabolism (Gallus gallus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)
H2O [cytosol]
Translation (Gallus gallus)
Eukaryotic Translation Termination (Gallus gallus)
APEH hydrolyses NAc-Ser-protein (Gallus gallus)
H2O [cytosol]
tRNA Aminoacylation (Gallus gallus)
Cytosolic tRNA aminoacylation (Gallus gallus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
H2O [cytosol]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Ion homeostasis (Gallus gallus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)
H2O [cytosol]
Physiological factors (Gallus gallus)
CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)
H2O [cytosol]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter clearance (Gallus gallus)
Dopamine clearance from the synaptic cleft (Gallus gallus)
Enzymatic degradation of Dopamine by monoamine oxidase (Gallus gallus)
MAOA:FAD deaminates DA to DOPAC (Gallus gallus)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Gallus gallus)
MAOA:FAD deaminates 3MT to HVA (Gallus gallus)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Gallus gallus)
Metabolism of serotonin (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
H2O [cytosol]
Neurotransmitter release cycle (Gallus gallus)
Norepinephrine Neurotransmitter Release Cycle (Gallus gallus)
Catabolism of Noradrenaline (Gallus gallus)
H2O [cytosol]
Organelle biogenesis and maintenance (Gallus gallus)
Cilium Assembly (Gallus gallus)
Cargo trafficking to the periciliary membrane (Gallus gallus)
VxPx cargo-targeting to cilium (Gallus gallus)
ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)
H2O [cytosol]
Protein localization (Gallus gallus)
Peroxisomal protein import (Gallus gallus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)
H2O [cytosol]
Sensory Perception (Gallus gallus)
Visual phototransduction (Gallus gallus)
The canonical retinoid cycle in rods (twilight vision) (Gallus gallus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Gallus gallus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)
H2O [cytosol]
The phototransduction cascade (Gallus gallus)
Inactivation, recovery and regulation of the phototransduction cascade (Gallus gallus)
PP2A dephosphorylates p-RHO to RHO (Gallus gallus)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Gallus gallus)
OPN1LW binds 11cRAL (Gallus gallus)
H2O [cytosol]
OPN1MW binds 11cRAL (Gallus gallus)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)
H2O [cytosol]
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
H2O [cytosol]
Intracellular signaling by second messengers (Gallus gallus)
DAG and IP3 signaling (Gallus gallus)
CaM pathway (Gallus gallus)
Calmodulin induced events (Gallus gallus)
Cam-PDE 1 activation (Gallus gallus)
cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)
H2O [cytosol]
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Gallus gallus)
H2O [cytosol]
PTEN Regulation (Gallus gallus)
Regulation of PTEN stability and activity (Gallus gallus)
USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)
H2O [cytosol]
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF-independent MAPK1/3 activation (Gallus gallus)
Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)
H2O [cytosol]
RAF/MAP kinase cascade (Gallus gallus)
Negative regulation of MAPK pathway (Gallus gallus)
Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Gallus gallus)
H2O [cytosol]
RAF activation (Gallus gallus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)
H2O [cytosol]
RAS processing (Gallus gallus)
RAS proteins are depalmitoylated (Gallus gallus)
H2O [cytosol]
MTOR signalling (Gallus gallus)
Energy dependent regulation of mTOR by LKB1-AMPK (Gallus gallus)
AMPK is dephosphorylated (Gallus gallus)
H2O [cytosol]
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Opioid Signalling (Gallus gallus)
DARPP-32 events (Gallus gallus)
PDE4A,C,D hydrolyse cAMP (Gallus gallus)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Gallus gallus)
H2O [cytosol]
G-protein mediated events (Gallus gallus)
PLC beta mediated events (Gallus gallus)
Ca-dependent events (Gallus gallus)
CaM pathway (Gallus gallus)
Calmodulin induced events (Gallus gallus)
Cam-PDE 1 activation (Gallus gallus)
cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)
H2O [cytosol]
phospho-PLA2 pathway (Gallus gallus)
Hydrolysis of phosphatidylcholine (Gallus gallus)
H2O [cytosol]
Inactivation of PLC beta (Gallus gallus)
H2O [cytosol]
PIP2 hydrolysis (Gallus gallus)
H2O [cytosol]
G alpha (q) signalling events (Gallus gallus)
Effects of PIP2 hydrolysis (Gallus gallus)
Arachidonate production from DAG (Gallus gallus)
2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Gallus gallus)
H2O [cytosol]
G alpha (s) signalling events (Gallus gallus)
PDE3A hydrolyses cAMP to AMP (Gallus gallus)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Gallus gallus)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Gallus gallus)
H2O [cytosol]
Signaling by Hedgehog (Gallus gallus)
Hedgehog ligand biogenesis (Gallus gallus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)
H2O [cytosol]
Signaling by Nuclear Receptors (Gallus gallus)
Signaling by Retinoic Acid (Gallus gallus)
RA biosynthesis pathway (Gallus gallus)
ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Gallus gallus)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
MDK and PTN in ALK signaling (Gallus gallus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)
H2O [cytosol]
Signaling by EGFR (Gallus gallus)
EGFR downregulation (Gallus gallus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)
H2O [cytosol]
PTPN3 dephosphorylates EPS15 (Gallus gallus)
H2O [cytosol]
GAB1 signalosome (Gallus gallus)
Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Gallus gallus)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
H2O [cytosol]
Signaling by ERBB2 (Gallus gallus)
Downregulation of ERBB2 signaling (Gallus gallus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Gallus gallus)
H2O [cytosol]
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor recycling (Gallus gallus)
Insulin receptor de-phosphorylation (Gallus gallus)
H2O [cytosol]
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PKB-mediated events (Gallus gallus)
PDE3B signalling (Gallus gallus)
p-S295-PDE3B hydrolyses cAMP to AMP (Gallus gallus)
H2O [cytosol]
Signaling by MET (Gallus gallus)
Negative regulation of MET activity (Gallus gallus)
PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)
H2O [cytosol]
PTPRJ dephosphorylates MET (Gallus gallus)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Gallus gallus)
H2O [cytosol]
Signaling by PDGF (Gallus gallus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Gallus gallus)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PKB-mediated events (Gallus gallus)
PDE3B signalling (Gallus gallus)
p-S295-PDE3B hydrolyses cAMP to AMP (Gallus gallus)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Miro GTPase Cycle (Gallus gallus)
RHOT1 GTPase cycle (Gallus gallus)
RHOT1 hydrolyzes GTP (Gallus gallus)
H2O [cytosol]
RHOT2 GTPase cycle (Gallus gallus)
RHOT2 hydrolyzes GTP (Gallus gallus)
H2O [cytosol]
RHOBTB3 ATPase cycle (Gallus gallus)
RHOBTB3 hydrolyzes ATP (Gallus gallus)
H2O [cytosol]
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase cycle (Gallus gallus)
CDC42 GTPase cycle (Gallus gallus)
CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)
H2O [cytosol]
RAC1 GTPase cycle (Gallus gallus)
RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)
H2O [cytosol]
RAC2 GTPase cycle (Gallus gallus)
RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)
H2O [cytosol]
RAC3 GTPase cycle (Gallus gallus)
RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)
H2O [cytosol]
RHOA GTPase cycle (Gallus gallus)
RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)
H2O [cytosol]
RHOB GTPase cycle (Gallus gallus)
RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)
H2O [cytosol]
RHOC GTPase cycle (Gallus gallus)
RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)
H2O [cytosol]
RHOD GTPase cycle (Gallus gallus)
RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)
H2O [cytosol]
RHOF GTPase cycle (Gallus gallus)
RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)
H2O [cytosol]
RHOG GTPase cycle (Gallus gallus)
RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)
H2O [cytosol]
RHOJ GTPase cycle (Gallus gallus)
RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)
H2O [cytosol]
RHOQ GTPase cycle (Gallus gallus)
RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)
H2O [cytosol]
Signaling by TGFB family members (Gallus gallus)
Signaling by TGF-beta Receptor Complex (Gallus gallus)
TGF-beta receptor signaling activates SMADs (Gallus gallus)
Downregulation of TGF-beta receptor signaling (Gallus gallus)
MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)
H2O [cytosol]
Signaling by WNT (Gallus gallus)
Beta-catenin independent WNT signaling (Gallus gallus)
Ca2+ pathway (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Gallus gallus)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Gallus gallus)
H2O [cytosol]
TCF dependent signaling in response to WNT (Gallus gallus)
Regulation of FZD by ubiquitination (Gallus gallus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Gallus gallus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)
H2O [cytosol]
Transport of small molecules (Gallus gallus)
ABC-family proteins mediated transport (Gallus gallus)
ABC transporters in lipid homeostasis (Gallus gallus)
ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)
H2O [cytosol]
ABCAs mediate lipid efflux (Gallus gallus)
H2O [cytosol]
ABCAs mediate lipid influx (Gallus gallus)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Gallus gallus)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Gallus gallus)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Gallus gallus)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Gallus gallus)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)
H2O [cytosol]
HCO3- transport through ion channel (Gallus gallus)
H2O [cytosol]
Mitochondrial ABC transporters (Gallus gallus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)
H2O [cytosol]
The ABCC family mediates organic anion transport (Gallus gallus)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)
H2O [cytosol]
Aquaporin-mediated transport (Gallus gallus)
Passive transport by Aquaporins (Gallus gallus)
Aquaporins passively transport water into cells (Gallus gallus)
H2O [cytosol]
Aquaporins passively transport water out of cells (Gallus gallus)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Gallus gallus)
Aquaporin-1 passively transports water into cell (Gallus gallus)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Gallus gallus)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Gallus gallus)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Gallus gallus)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Gallus gallus)
H2O [cytosol]
Ion channel transport (Gallus gallus)
Ion transport by P-type ATPases (Gallus gallus)
ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)
H2O [cytosol]
Iron uptake and transport (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
H2O [cytosol]
Transferrin endocytosis and recycling (Gallus gallus)
Acidification of Tf:TfR1 containing endosome (Gallus gallus)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Gallus gallus)
Erythrocytes take up carbon dioxide and release oxygen (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Gallus gallus)
Plasma lipoprotein assembly (Gallus gallus)
HDL assembly (Gallus gallus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)
H2O [cytosol]
Plasma lipoprotein clearance (Gallus gallus)
LDL clearance (Gallus gallus)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Gallus gallus)
H2O [cytosol]
Plasma lipoprotein remodeling (Gallus gallus)
HDL remodeling (Gallus gallus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)
H2O [cytosol]
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Clathrin-mediated endocytosis (Gallus gallus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
H2O [cytosol]
ER to Golgi Anterograde Transport (Gallus gallus)
COPII-mediated vesicle transport (Gallus gallus)
PP6 dephosphorylates SEC24 (Gallus gallus)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Gallus gallus)
Golgi-to-ER retrograde transport (Gallus gallus)
COPI-independent Golgi-to-ER retrograde traffic (Gallus gallus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)
H2O [cytosol]
Rab regulation of trafficking (Gallus gallus)
TBC/RABGAPs (Gallus gallus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)
H2O [cytosol]
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Pexophagy (Homo sapiens)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)
H2O [cytosol]
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
ANKLE2 is deacetylated by SIRT2 (Homo sapiens)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Homo sapiens)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
H2O [cytosol]
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
H2O [cytosol]
Mitotic Prometaphase (Homo sapiens)
Condensation of Prometaphase Chromosomes (Homo sapiens)
Dephosphorylation of CK2-modified condensin I (Homo sapiens)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Homo sapiens)
H2O [cytosol]
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)
H2O [cytosol]
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
Dephosphorylation of phospho-Cdh1 (Homo sapiens)
H2O [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Homo sapiens)
ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)
H2O [cytosol]
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)
H2O [cytosol]
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
PRDX1 overoxidizes (Homo sapiens)
H2O [cytosol]
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
H2O [cytosol]
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Homo sapiens)
H2O [cytosol]
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote (Homo sapiens)
H2O [cytosol]
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)
H2O [cytosol]
CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA (Homo sapiens)
H2O [cytosol]
Z-decay: degradation of maternal mRNAs by zygotically expressed factors (Homo sapiens)
DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)
H2O [cytosol]
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)
H2O [cytosol]
L1CAM interactions (Homo sapiens)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)
H2O [cytosol]
Netrin-1 signaling (Homo sapiens)
Role of second messengers in netrin-1 signaling (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
H2O [cytosol]
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
H2O [cytosol]
Signaling by ROBO receptors (Homo sapiens)
Inactivation of CDC42 and RAC1 (Homo sapiens)
Inactivation of CDC42 (Homo sapiens)
H2O [cytosol]
Inactivation of RAC1 (Homo sapiens)
H2O [cytosol]
Regulation of expression of SLITs and ROBOs (Homo sapiens)
USP33 deubiquitinates ROBO1 (Homo sapiens)
H2O [cytosol]
SLIT2:ROBO1 increases RHOA activity (Homo sapiens)
MYO9B inactivates RHOA (Homo sapiens)
H2O [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in cobalamin (B12) metabolism (Homo sapiens)
Defective ABCD4 causes MAHCJ (Homo sapiens)
Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)
H2O [cytosol]
Diseases associated with surfactant metabolism (Homo sapiens)
Defective ABCA3 causes SMDP3 (Homo sapiens)
Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)
H2O [cytosol]
Diseases of carbohydrate metabolism (Homo sapiens)
Glycogen storage diseases (Homo sapiens)
Myoclonic epilepsy of Lafora (Homo sapiens)
Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)
H2O [cytosol]
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosylation precursor biosynthesis (Homo sapiens)
Defective GNE causes sialuria, NK and IBM2 (Homo sapiens)
Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)
H2O [cytosol]
Diseases of nucleotide metabolism (Homo sapiens)
Nucleotide salvage defects (Homo sapiens)
Defective ADA disrupts (deoxy)adenosine deamination (Homo sapiens)
Defective ADA does not deaminate (deoxy)adenosine (Homo sapiens)
H2O [cytosol]
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective ACY1 causes encephalopathy (Homo sapiens)
Defective ACY1 does not hydrolyse mercapturic acids (Homo sapiens)
H2O [cytosol]
Defective AHCY causes HMAHCHD (Homo sapiens)
Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)
H2O [cytosol]
Defective MAOA causes BRUNS (Homo sapiens)
Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)
H2O [cytosol]
Defective MAT1A causes MATD (Homo sapiens)
Defective MAT1A does not transfer Ado from ATP to L-Met (Homo sapiens)
H2O [cytosol]
Defective OPLAH causes OPLAHD (Homo sapiens)
Defective OPLAH does not hydrolyse OPRO (Homo sapiens)
H2O [cytosol]
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
Calpain cleaves p35 to p25 (Homo sapiens)
H2O [cytosol]
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
H2O [cytosol]
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MAPK mutants (Homo sapiens)
Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)
H2O [cytosol]
Signaling by MRAS-complex mutants (Homo sapiens)
Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
H2O [cytosol]
SHOC2 M1731 mutant abolishes MRAS complex function (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
H2O [cytosol]
PI3K/AKT Signaling in Cancer (Homo sapiens)
PTEN Loss of Function in Cancer (Homo sapiens)
PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)
H2O [cytosol]
Diseases of the neuronal system (Homo sapiens)
Diseases associated with visual transduction (Homo sapiens)
Retinoid cycle disease events (Homo sapiens)
Biosynthesis of A2E, implicated in retinal degradation (Homo sapiens)
A2PE hydrolyses to A2E (Homo sapiens)
H2O [cytosol]
NRPE condenses with atRAL to form A2PE (Homo sapiens)
H2O [cytosol]
Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)
H2O [cytosol]
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective ABCA1 causes TGD (Homo sapiens)
Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)
H2O [cytosol]
Defective ABCA12 causes ARCI4B (Homo sapiens)
Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Defective ABCA3 causes SMDP3 (Homo sapiens)
Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)
H2O [cytosol]
Defective ABCB11 causes PFIC2 and BRIC2 (Homo sapiens)
Defective ABCB11 does not transport bile salts from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Defective ABCB4 causes PFIC3, ICP3 and GBD1 (Homo sapiens)
Defective ABCB4 does not transport PC from plasma membrane to extracellular region (Homo sapiens)
H2O [cytosol]
Defective ABCB6 causes MCOPCB7 (Homo sapiens)
Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix (Homo sapiens)
H2O [cytosol]
Defective ABCC2 causes DJS (Homo sapiens)
Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Defective ABCC6 causes PXE (Homo sapiens)
Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Defective ABCD1 causes ALD (Homo sapiens)
Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)
H2O [cytosol]
Defective ABCD4 causes MAHCJ (Homo sapiens)
Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)
H2O [cytosol]
Defective ABCG5 causes sitosterolemia (Homo sapiens)
Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Defective ABCG8 causes GBD4 and sitosterolemia (Homo sapiens)
Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Defective CFTR causes cystic fibrosis (Homo sapiens)
Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
H2O [cytosol]
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Escape of Mtb from the phagocyte (Homo sapiens)
Phagocyte cell death caused by cytosolic Mtb (Homo sapiens)
CpnT hydrolyses NAD+ (Homo sapiens)
H2O [cytosol]
Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
Mtb iron assimilation by chelation (Homo sapiens)
BfrA stores iron (Homo sapiens)
H2O [cytosol]
BfrB stores iron (Homo sapiens)
H2O [cytosol]
Tolerance by Mtb to nitric oxide produced by macrophages (Homo sapiens)
MscR reduces nitrosomycothiol to ammonia (Homo sapiens)
H2O [cytosol]
Nitrogen dioxide is reduced to NO by F420 (Homo sapiens)
H2O [cytosol]
Peroxynitrite is reduced by AhpE (Homo sapiens)
H2O [cytosol]
Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)
H2O [cytosol]
Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)
H2O [cytosol]
Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
AhpC reduces H2O2 (Homo sapiens)
H2O [cytosol]
AhpC reduces peroxidated lipids (Homo sapiens)
H2O [cytosol]
KatG reduces H2O2 (Homo sapiens)
H2O [cytosol]
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of apoptosis (Homo sapiens)
PtpA dephosphorylates GSK3A (Homo sapiens)
H2O [cytosol]
Suppression of phagosomal maturation (Homo sapiens)
Prevention of phagosomal-lysosomal fusion (Homo sapiens)
PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)
H2O [cytosol]
SapM dephosphorylates PI3P (Homo sapiens)
H2O [cytosol]
ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)
H2O [cytosol]
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
H2O [cytosol]
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
APOBEC3G mediated resistance to HIV-1 infection (Homo sapiens)
Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)
H2O [cytosol]
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Maturation of hRSV A proteins (Homo sapiens)
P:PP1 dephosphorylates M2-1 (Homo sapiens)
H2O [cytosol]
Respiratory syncytial virus genome transcription (Homo sapiens)
L protein acts as a cap N7 methyltransferase to modify RSV mRNAs (Homo sapiens)
H2O [cytosol]
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-1 genome (Homo sapiens)
nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
H2O [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
H2O [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
H2O [cytosol]
Transcription of SARS-CoV-1 sgRNAs (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
H2O [cytosol]
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Maturation of replicase proteins (Homo sapiens)
3CLp cleaves nsp6-11 (Homo sapiens)
H2O [cytosol]
3CLp cleaves pp1a (Homo sapiens)
H2O [cytosol]
3CLp cleaves pp1ab (Homo sapiens)
H2O [cytosol]
nsp1-4 cleaves itself (Homo sapiens)
H2O [cytosol]
nsp3 cleaves nsp1-4 (Homo sapiens)
H2O [cytosol]
nsp3-4 cleaves itself (Homo sapiens)
H2O [cytosol]
pp1a cleaves itself (Homo sapiens)
H2O [cytosol]
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
SARS-CoV-2 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-2 genome (Homo sapiens)
nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
H2O [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
H2O [cytosol]
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
H2O [cytosol]
Transcription of SARS-CoV-2 sgRNAs (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)
H2O [cytosol]
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Maturation of replicase proteins (Homo sapiens)
3CLp cleaves nsp6-11 (Homo sapiens)
H2O [cytosol]
3CLp cleaves pp1a (Homo sapiens)
H2O [cytosol]
3CLp cleaves pp1ab (Homo sapiens)
H2O [cytosol]
nsp1-4 cleaves itself (Homo sapiens)
H2O [cytosol]
nsp3 cleaves nsp1-4 (Homo sapiens)
H2O [cytosol]
nsp3-4 cleaves itself (Homo sapiens)
H2O [cytosol]
pp1a cleaves itself (Homo sapiens)
H2O [cytosol]
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)
H2O [cytosol]
SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)
H2O [cytosol]
SARS-CoV-2 nsp3 cleaves IRF3 (Homo sapiens)
H2O [cytosol]
SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)
H2O [cytosol]
SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)
H2O [cytosol]
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir metabolism (Homo sapiens)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)
H2O [cytosol]
Abacavir transmembrane transport (Homo sapiens)
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
H2O [cytosol]
Aspirin ADME (Homo sapiens)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)
H2O [cytosol]
Atorvastatin ADME (Homo sapiens)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
H2O [cytosol]
PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV (Homo sapiens)
H2O [cytosol]
PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
H2O [cytosol]
Azathioprine ADME (Homo sapiens)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Homo sapiens)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Homo sapiens)
H2O [cytosol]
Ciprofloxacin ADME (Homo sapiens)
ABCG2 transports Cipro from hepatic cell to extracellular space (Homo sapiens)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Homo sapiens)
H2O [cytosol]
Cipro is oxidized to oxo-Cipro (Homo sapiens)
H2O [cytosol]
Paracetamol ADME (Homo sapiens)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Homo sapiens)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)
H2O [cytosol]
Prednisone ADME (Homo sapiens)
ABCB1 transports PREDN,PREDL out of hepatic cells (Homo sapiens)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Homo sapiens)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)
H2O [cytosol]
Ribavirin ADME (Homo sapiens)
ADA deamidates RBV (Homo sapiens)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Homo sapiens)
H2O [cytosol]
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
H2O [cytosol]
PRDX1 overoxidizes (Homo sapiens)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Homo sapiens)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
H2O [cytosol]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Arachidonate production from DAG (Homo sapiens)
2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Homo sapiens)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
ABCC4 accumulation of dense granule contents (Homo sapiens)
H2O [cytosol]
Platelet homeostasis (Homo sapiens)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)
H2O [cytosol]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Disassembly of COPII coated vesicle (Homo sapiens)
H2O [cytosol]
Transport of Antigen peptide in to ER (Homo sapiens)
H2O [cytosol]
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)
H2O [cytosol]
Costimulation by the CD28 family (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
Dephosphorylation of AKT by PP2A (Homo sapiens)
H2O [cytosol]
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
H2O [cytosol]
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Homo sapiens)
H2O [cytosol]
Generation of second messenger molecules (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Homo sapiens)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
H2O [cytosol]
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
PTPRJ dephosphorylates active FLT3 (Homo sapiens)
H2O [cytosol]
Growth hormone receptor signaling (Homo sapiens)
PTP1B dephosphorylates GHR (Homo sapiens)
H2O [cytosol]
PTP1B dephosphorylates JAK2 (Homo sapiens)
H2O [cytosol]
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
OAS antiviral response (Homo sapiens)
PDE12 cleaves 2'-5' oligoadenylates (Homo sapiens)
H2O [cytosol]
Viral 2',5'-PDE cleaves 2'-5' oligoadenylates (Homo sapiens)
H2O [cytosol]
Interferon alpha/beta signaling (Homo sapiens)
Regulation of IFNA/IFNB signaling (Homo sapiens)
Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Homo sapiens)
H2O [cytosol]
Interferon gamma signaling (Homo sapiens)
Regulation of IFNG signaling (Homo sapiens)
Dephosphorylation of JAKs by PTPs (Homo sapiens)
H2O [cytosol]
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
H2O [cytosol]
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Ion influx/efflux at host-pathogen interface (Homo sapiens)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)
H2O [cytosol]
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
H2O [cytosol]
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
Regulation by TREX1 (Homo sapiens)
Viral DNA cleavage by TREX1 (Homo sapiens)
H2O [cytosol]
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Homo sapiens)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
H2O [cytosol]
Conversion of PA into DAG by PAP-1 (Homo sapiens)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Homo sapiens)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Homo sapiens)
H2O [cytosol]
ROS and RNS production in phagocytes (Homo sapiens)
Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)
H2O [cytosol]
Hydroxyl-initiated lipid peroxidation (Homo sapiens)
H2O [cytosol]
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
H2O [cytosol]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
Cytosolic H2O2 decarboxylates PYR to acetate (Homo sapiens)
H2O [cytosol]
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)
H2O [cytosol]
Regulation of pyruvate metabolism (Homo sapiens)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Homo sapiens)
H2O [cytosol]
Biological oxidations (Homo sapiens)
Aflatoxin activation and detoxification (Homo sapiens)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)
H2O [cytosol]
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)
H2O [cytosol]
AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)
H2O [cytosol]
AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)
H2O [cytosol]
Phase I - Functionalization of compounds (Homo sapiens)
AADAC deacetylates PHEN (Homo sapiens)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)
H2O [cytosol]
Amine Oxidase reactions (Homo sapiens)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Homo sapiens)
MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Homo sapiens)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Homo sapiens)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Homo sapiens)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Eicosanoids (Homo sapiens)
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)
H2O [cytosol]
Endogenous sterols (Homo sapiens)
CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Homo sapiens)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Homo sapiens)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Homo sapiens)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Homo sapiens)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
H2O [cytosol]
Vitamins (Homo sapiens)
CYP26C1 4-hydroxylates 9cRA (Homo sapiens)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)
H2O [cytosol]
Ethanol oxidation (Homo sapiens)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)
H2O [cytosol]
Phase II - Conjugation of compounds (Homo sapiens)
Cytosolic sulfonation of small molecules (Homo sapiens)
ABHD14B hydrolyses PNPB (Homo sapiens)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)
H2O [cytosol]
Glucuronidation (Homo sapiens)
Formation of the active cofactor, UDP-glucuronate (Homo sapiens)
UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)
H2O [cytosol]
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)
H2O [cytosol]
Methylation (Homo sapiens)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Homo sapiens)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)
H2O [cytosol]
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)
H2O [cytosol]
I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 (Homo sapiens)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Homo sapiens)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Homo sapiens)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Homo sapiens)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)
H2O [cytosol]
Integration of energy metabolism (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
H2O [cytosol]
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
H2O [cytosol]
Metabolism of amino acids and derivatives (Homo sapiens)
Aspartate and asparagine metabolism (Homo sapiens)
ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)
H2O [cytosol]
Carnitine synthesis (Homo sapiens)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)
H2O [cytosol]
Creatine metabolism (Homo sapiens)
phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)
H2O [cytosol]
Histidine catabolism (Homo sapiens)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Homo sapiens)
H2O [cytosol]
Metabolism of polyamines (Homo sapiens)
Agmatine biosynthesis (Homo sapiens)
Agmatine + H2O <=> putrescine + urea (Homo sapiens)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)
H2O [cytosol]
Tyrosine catabolism (Homo sapiens)
FAH cleaves 4FAA (Homo sapiens)
H2O [cytosol]
Selenoamino acid metabolism (Homo sapiens)
Formation of selenosugars for excretion (Homo sapiens)
MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)
H2O [cytosol]
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se (Homo sapiens)
PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)
H2O [cytosol]
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)
H2O [cytosol]
SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
H2O [cytosol]
Metabolism of ingested MeSeO2H into MeSeH (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
AdeSeHCys is hydrolysed to SeHCys by AHCY (Homo sapiens)
H2O [cytosol]
Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)
H2O [cytosol]
MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)
H2O [cytosol]
MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)
H2O [cytosol]
SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)
H2O [cytosol]
SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)
H2O [cytosol]
SeMet is converted to AdoSeMet by MAT (Homo sapiens)
H2O [cytosol]
Selenocysteine synthesis (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
H2O [cytosol]
SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)
H2O [cytosol]
Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)
H2O [cytosol]
Serine biosynthesis (Homo sapiens)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)
H2O [cytosol]
Sulfur amino acid metabolism (Homo sapiens)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)
H2O [cytosol]
Cysteine formation from homocysteine (Homo sapiens)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)
H2O [cytosol]
Degradation of cysteine and homocysteine (Homo sapiens)
Cysteine is degraded to serine and H2S (Homo sapiens)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
H2O [cytosol]
Methionine salvage pathway (Homo sapiens)
Acireductone is created (Homo sapiens)
H2O [cytosol]
Dehydration of methylthio-ribulose-P (Homo sapiens)
H2O [cytosol]
Threonine catabolism (Homo sapiens)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)
H2O [cytosol]
Tryptophan catabolism (Homo sapiens)
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)
H2O [cytosol]
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)
H2O [cytosol]
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)
H2O [cytosol]
AFMID hydrolyses NFK to L-KYN (Homo sapiens)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)
H2O [cytosol]
Urea cycle (Homo sapiens)
arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)
H2O [cytosol]
Metabolism of carbohydrates (Homo sapiens)
Fructose metabolism (Homo sapiens)
Fructose catabolism (Homo sapiens)
ALDH1A1 oxidises GA to DGA (Homo sapiens)
H2O [cytosol]
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Homo sapiens)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Homo sapiens)
H2O [cytosol]
Glycolysis (Homo sapiens)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)
H2O [cytosol]
PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
H2O [cytosol]
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)
H2O [cytosol]
Glycogen metabolism (Homo sapiens)
Glycogen synthesis (Homo sapiens)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Homo sapiens)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Homo sapiens)
H2O [cytosol]
Pentose phosphate pathway (Homo sapiens)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)
H2O [cytosol]
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of D-series resolvins (Homo sapiens)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Homo sapiens)
H2O [cytosol]
Biosynthesis of DHA-derived sulfido conjugates (Homo sapiens)
Biosynthesis of maresin conjugates in tissue regeneration (MCTR) (Homo sapiens)
DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)
H2O [cytosol]
GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)
H2O [cytosol]
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) (Homo sapiens)
GGT hydrolyses PCTR1 to PCTR2 (Homo sapiens)
H2O [cytosol]
GGT hydrolyses PCTR2 to PCTR3 (Homo sapiens)
H2O [cytosol]
GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)
H2O [cytosol]
GGT hydrolyses RCTR2 to RCTR3 (Homo sapiens)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Homo sapiens)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)
H2O [cytosol]
Biosynthesis of maresins (Homo sapiens)
Biosynthesis of maresin-like SPMs (Homo sapiens)
CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)
H2O [cytosol]
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)
H2O [cytosol]
CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
H2O [cytosol]
Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (Homo sapiens)
H2O [cytosol]
Non-enzymatic hydrolysis hydrolyses 13(S),14(S)-epoxy-DHA to 7-epi-MaR1 (Homo sapiens)
H2O [cytosol]
Biosynthesis of protectins (Homo sapiens)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)
H2O [cytosol]
Biosynthesis of DPA-derived SPMs (Homo sapiens)
Biosynthesis of DPAn-3 SPMs (Homo sapiens)
Biosynthesis of DPAn-3-derived maresins (Homo sapiens)
Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA (Homo sapiens)
H2O [cytosol]
Biosynthesis of DPAn-3-derived protectins and resolvins (Homo sapiens)
Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA (Homo sapiens)
H2O [cytosol]
Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Homo sapiens)
Biosynthesis of E-series 18(R)-resolvins (Homo sapiens)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Homo sapiens)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Homo sapiens)
H2O [cytosol]
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives (Homo sapiens)
PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)
H2O [cytosol]
δ12-PGJ3 spontaneously dehydrates to 15d-PGJ3 (Homo sapiens)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
H2O [cytosol]
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
FAAH hydrolyses AEA to AA and ETA (Homo sapiens)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Homo sapiens)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)
H2O [cytosol]
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)
H2O [cytosol]
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)
H2O [cytosol]
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Homo sapiens)
HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH (Homo sapiens)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)
H2O [cytosol]
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
H2O [cytosol]
EXD4 is converted to EXE4 by DPEP (Homo sapiens)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Homo sapiens)
H2O [cytosol]
LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)
H2O [cytosol]
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)
H2O [cytosol]
PGE2 is dehydrated to PGA2 (Homo sapiens)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Homo sapiens)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Homo sapiens)
OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer (Homo sapiens)
H2O [cytosol]
SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Homo sapiens)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Homo sapiens)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)
H2O [cytosol]
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
H2O [cytosol]
Synthesis of bile acids and bile salts (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
H2O [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Homo sapiens)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
H2O [cytosol]
Cholesterol biosynthesis (Homo sapiens)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Homo sapiens)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Homo sapiens)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Homo sapiens)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)
H2O [cytosol]
Squalene is oxidized to its epoxide (Homo sapiens)
H2O [cytosol]
Metabolism of steroid hormones (Homo sapiens)
Androgen biosynthesis (Homo sapiens)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Homo sapiens)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)
H2O [cytosol]
Estrogen biosynthesis (Homo sapiens)
CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)
H2O [cytosol]
Glucocorticoid biosynthesis (Homo sapiens)
CYP17A1 17-hydroxylates PREG (Homo sapiens)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Homo sapiens)
H2O [cytosol]
Mineralocorticoid biosynthesis (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Homo sapiens)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Homo sapiens)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
H2O [cytosol]
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodeling of DAG and TAG (Homo sapiens)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Homo sapiens)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Homo sapiens)
H2O [cytosol]
Acyl chain remodelling of PC (Homo sapiens)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Homo sapiens)
H2O [cytosol]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)
H2O [cytosol]
Acyl chain remodelling of PE (Homo sapiens)
ABHD4 hydrolyses NAPE (Homo sapiens)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)
H2O [cytosol]
Acyl chain remodelling of PG (Homo sapiens)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Homo sapiens)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)
H2O [cytosol]
Acyl chain remodelling of PI (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)
H2O [cytosol]
Acyl chain remodelling of PS (Homo sapiens)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Homo sapiens)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)
H2O [cytosol]
Hydrolysis of LPC (Homo sapiens)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
H2O [cytosol]
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
H2O [cytosol]
GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)
H2O [cytosol]
Hydrolysis of LPE (Homo sapiens)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
H2O [cytosol]
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
H2O [cytosol]
GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)
H2O [cytosol]
Synthesis of PA (Homo sapiens)
DDHD1,2 hydrolyse PA (Homo sapiens)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Homo sapiens)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Homo sapiens)
H2O [cytosol]
Synthesis of PC (Homo sapiens)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Homo sapiens)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)
H2O [cytosol]
Synthesis of PE (Homo sapiens)
PA is dephosphorylated to DAG by LPIN (Homo sapiens)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)
H2O [cytosol]
PI Metabolism (Homo sapiens)
Glycerophospholipid catabolism (Homo sapiens)
GDE1 hydrolyzes GroPIns (Homo sapiens)
H2O [cytosol]
GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)
H2O [cytosol]
GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)
H2O [cytosol]
GDPD5 hydrolyzes GPCho (Homo sapiens)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)
H2O [cytosol]
PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Homo sapiens)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Homo sapiens)
H2O [cytosol]
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid catabolism (Homo sapiens)
ASAH2 hydrolyzes ceramide (plasma membrane) (Homo sapiens)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Homo sapiens)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Homo sapiens)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Homo sapiens)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Homo sapiens)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Homo sapiens)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Homo sapiens)
H2O [cytosol]
Sphingolipid catabolism (Homo sapiens)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Homo sapiens)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Homo sapiens)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Homo sapiens)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Homo sapiens)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Homo sapiens)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Homo sapiens)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Homo sapiens)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Homo sapiens)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Homo sapiens)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Homo sapiens)
H2O [cytosol]
PPM1L dephosphorylates multiphospho-CERT1-2 (Homo sapiens)
H2O [cytosol]
Triglyceride metabolism (Homo sapiens)
Triglyceride biosynthesis (Homo sapiens)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)
H2O [cytosol]
Triglyceride catabolism (Homo sapiens)
2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)
H2O [cytosol]
PNPLA4 hydrolyzes TAG (Homo sapiens)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Homo sapiens)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Homo sapiens)
H2O [cytosol]
cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)
H2O [cytosol]
diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)
H2O [cytosol]
phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)
H2O [cytosol]
phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)
H2O [cytosol]
triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)
H2O [cytosol]
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
DCTPP1 hydrolyses 5idCTP (Homo sapiens)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Homo sapiens)
H2O [cytosol]
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
H2O [cytosol]
FAICAR => IMP + H2O (Homo sapiens)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
H2O [cytosol]
Pyrimidine biosynthesis (Homo sapiens)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Homo sapiens)
H2O [cytosol]
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Homo sapiens)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Homo sapiens)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Homo sapiens)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Homo sapiens)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Homo sapiens)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Homo sapiens)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Homo sapiens)
H2O [cytosol]
Pyrimidine catabolism (Homo sapiens)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)
H2O [cytosol]
Nucleotide salvage (Homo sapiens)
Purine salvage (Homo sapiens)
ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Homo sapiens)
H2O [cytosol]
Pyrimidine salvage (Homo sapiens)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Homo sapiens)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)
H2O [cytosol]
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
4 PBGs bind to form HMB (Homo sapiens)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Homo sapiens)
H2O [cytosol]
HMBL spontaneously transforms to URO1 (Homo sapiens)
H2O [cytosol]
UROS transforms HMB to URO3 (Homo sapiens)
H2O [cytosol]
Heme degradation (Homo sapiens)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
H2O [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)
H2O [cytosol]
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
A REH hydrolses atREs to atROL and FAs (Homo sapiens)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Transport of RCbl within the body (Homo sapiens)
ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Homo sapiens)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Homo sapiens)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Homo sapiens)
H2O [cytosol]
Metabolism of folate and pterines (Homo sapiens)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Homo sapiens)
Cyclisation of GTP to precursor Z (Homo sapiens)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Homo sapiens)
H2O [cytosol]
Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)
H2O [cytosol]
Nicotinate metabolism (Homo sapiens)
ACS transforms to QUIN non-enzymatically (Homo sapiens)
H2O [cytosol]
NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Homo sapiens)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Homo sapiens)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Homo sapiens)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
PANK4 hydrolyzes PPANT to pantetheine (Homo sapiens)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Homo sapiens)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Homo sapiens)
H2O [cytosol]
Vitamin C (ascorbate) metabolism (Homo sapiens)
2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)
H2O [cytosol]
DeHA hydrolyses to 2,3-DKG (Homo sapiens)
H2O [cytosol]
DeHA hydrolyses to threonate and oxalate (Homo sapiens)
H2O [cytosol]
Pyrophosphate hydrolysis (Homo sapiens)
LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
H2O [cytosol]
Reversible hydration of carbon dioxide (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)
H2O [cytosol]
Metabolism of RNA (Homo sapiens)
Deadenylation-dependent mRNA decay (Homo sapiens)
Deadenylation of mRNA (Homo sapiens)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
H2O [cytosol]
PARN deadenylates mRNA (Homo sapiens)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Homo sapiens)
DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Homo sapiens)
5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)
H2O [cytosol]
DCP1-DCP2 complex decaps mRNA (Homo sapiens)
H2O [cytosol]
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
GDP-fucose biosynthesis (Homo sapiens)
GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)
H2O [cytosol]
Sialic acid metabolism (Homo sapiens)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Homo sapiens)
DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)
H2O [cytosol]
Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
PP6 dephosphorylates SEC24 (Homo sapiens)
H2O [cytosol]
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
H2O [cytosol]
SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)
H2O [cytosol]
Deubiquitination (Homo sapiens)
Josephin domain DUBs (Homo sapiens)
ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
H2O [cytosol]
ATXN3 family cleave Ub chains (Homo sapiens)
H2O [cytosol]
Metalloprotease DUBs (Homo sapiens)
BRISC complex deubiquitinates NLRP3 (Homo sapiens)
H2O [cytosol]
Ovarian tumor domain proteases (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
H2O [cytosol]
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)
H2O [cytosol]
UCH proteinases (Homo sapiens)
UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Homo sapiens)
H2O [cytosol]
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
H2O [cytosol]
Ub-specific processing proteases (Homo sapiens)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Homo sapiens)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Homo sapiens)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Homo sapiens)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Homo sapiens)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Homo sapiens)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
H2O [cytosol]
USP5 cleaves polyubiquitin (Homo sapiens)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Homo sapiens)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Homo sapiens)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Hypusine synthesis from eIF5A-lysine (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
H2O [cytosol]
Neddylation (Homo sapiens)
UCHL3, SENP8 cleave NEDD8 (Homo sapiens)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Homo sapiens)
Synthesis of glycosylphosphatidylinositol (GPI) (Homo sapiens)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)
H2O [cytosol]
Protein repair (Homo sapiens)
Methionine is oxidised to methionine sulfoxide (Homo sapiens)
H2O [cytosol]
Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)
H2O [cytosol]
Surfactant metabolism (Homo sapiens)
ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)
H2O [cytosol]
Translation (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
APEH hydrolyses NAc-Ser-protein (Homo sapiens)
H2O [cytosol]
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
H2O [cytosol]
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
H2O [cytosol]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)
H2O [cytosol]
Physiological factors (Homo sapiens)
CES1 hydrolyses sacubitril to sacubitrilat (Homo sapiens)
H2O [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Dopamine clearance from the synaptic cleft (Homo sapiens)
Enzymatic degradation of Dopamine by monoamine oxidase (Homo sapiens)
MAOA:FAD deaminates DA to DOPAC (Homo sapiens)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Homo sapiens)
MAOA:FAD deaminates 3MT to HVA (Homo sapiens)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Homo sapiens)
Metabolism of serotonin (Homo sapiens)
MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
H2O [cytosol]
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
PPM1F dephosphorylates CAMK1 (Homo sapiens)
H2O [cytosol]
PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
H2O [cytosol]
Neurotransmitter release cycle (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Catabolism of Noradrenaline (Homo sapiens)
H2O [cytosol]
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
VxPx cargo-targeting to cilium (Homo sapiens)
ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
H2O [cytosol]
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BAD and translocation to mitochondria (Homo sapiens)
Activation of BAD by calcineurin (Homo sapiens)
H2O [cytosol]
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)
H2O [cytosol]
USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)
H2O [cytosol]
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
H2O [cytosol]
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
A REH hydrolses atREs to atROL and FAs (Homo sapiens)
H2O [cytosol]
The canonical retinoid cycle in rods (twilight vision) (Homo sapiens)
11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)
H2O [cytosol]
ABCA4 mediates atRAL transport (Homo sapiens)
H2O [cytosol]
ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)
H2O [cytosol]
Biosynthesis of A2E, implicated in retinal degradation (Homo sapiens)
A2PE hydrolyses to A2E (Homo sapiens)
H2O [cytosol]
NRPE condenses with atRAL to form A2PE (Homo sapiens)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)
H2O [cytosol]
The phototransduction cascade (Homo sapiens)
Activation of the phototransduction cascade (Homo sapiens)
PDE6 hydrolyses cGMP to GMP (Homo sapiens)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Homo sapiens)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Homo sapiens)
A REH hydrolyses 11cRE to 11cROL (Homo sapiens)
H2O [cytosol]
OPN1LW binds 11cRAL (Homo sapiens)
H2O [cytosol]
OPN1MW binds 11cRAL (Homo sapiens)
H2O [cytosol]
OPN1SW binds 11cRAL (Homo sapiens)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)
H2O [cytosol]
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Ceramide signalling (Homo sapiens)
Production of ceramide which can activate JNK and other targets (Homo sapiens)
H2O [cytosol]
Integrin signaling (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
H2O [cytosol]
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
H2O [cytosol]
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
H2O [cytosol]
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PHLPP dephosphorylates S473 in AKT (Homo sapiens)
H2O [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Homo sapiens)
H2O [cytosol]
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)
H2O [cytosol]
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)
H2O [cytosol]
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Homo sapiens)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Homo sapiens)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)
H2O [cytosol]
RAF activation (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Homo sapiens)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Homo sapiens)
H2O [cytosol]
RAS processing (Homo sapiens)
RAS proteins are depalmitoylated (Homo sapiens)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Homo sapiens)
H2O [cytosol]
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
H2O [cytosol]
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phospholipase C gamma (PLCG) (Homo sapiens)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
H2O [cytosol]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Homo sapiens)
H2O [cytosol]
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Homo sapiens)
H2O [cytosol]
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
H2O [cytosol]
phospho-PLA2 pathway (Homo sapiens)
Hydrolysis of phosphatidylcholine (Homo sapiens)
H2O [cytosol]
Inactivation of PLC beta (Homo sapiens)
H2O [cytosol]
PIP2 hydrolysis (Homo sapiens)
H2O [cytosol]
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Arachidonate production from DAG (Homo sapiens)
2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Homo sapiens)
H2O [cytosol]
G alpha (s) signalling events (Homo sapiens)
PDE3A hydrolyses cAMP to AMP (Homo sapiens)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Homo sapiens)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Homo sapiens)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Homo sapiens)
H2O [cytosol]
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
H2O [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Down-Regulation (Homo sapiens)
PTPN1 dephosphorylates PTK6 (Homo sapiens)
H2O [cytosol]
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
ESTG binding induces ESR depalmitoylation (Homo sapiens)
H2O [cytosol]
Signaling by Retinoic Acid (Homo sapiens)
RA biosynthesis pathway (Homo sapiens)
ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Homo sapiens)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Homo sapiens)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
MDK and PTN in ALK signaling (Homo sapiens)
PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Homo sapiens)
H2O [cytosol]
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Homo sapiens)
H2O [cytosol]
PTPN3 dephosphorylates EPS15 (Homo sapiens)
H2O [cytosol]
GAB1 signalosome (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Homo sapiens)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
H2O [cytosol]
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)
H2O [cytosol]
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
Insulin receptor de-phosphorylation (Homo sapiens)
H2O [cytosol]
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PKB-mediated events (Homo sapiens)
PDE3B signalling (Homo sapiens)
p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)
H2O [cytosol]
Signaling by MET (Homo sapiens)
Negative regulation of MET activity (Homo sapiens)
PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)
H2O [cytosol]
PTPRJ dephosphorylates MET (Homo sapiens)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Homo sapiens)
H2O [cytosol]
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Retrograde neurotrophin signalling (Homo sapiens)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
H2O [cytosol]
Signaling by NTRK3 (TRKC) (Homo sapiens)
Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)
H2O [cytosol]
Signaling by PDGF (Homo sapiens)
PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PKB-mediated events (Homo sapiens)
PDE3B signalling (Homo sapiens)
p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)
H2O [cytosol]
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Miro GTPase Cycle (Homo sapiens)
RHOT1 GTPase cycle (Homo sapiens)
RHOT1 hydrolyzes GTP (Homo sapiens)
H2O [cytosol]
RHOT2 GTPase cycle (Homo sapiens)
RHOT2 hydrolyzes GTP (Homo sapiens)
H2O [cytosol]
RHOBTB3 ATPase cycle (Homo sapiens)
RHOBTB3 hydrolyzes ATP (Homo sapiens)
H2O [cytosol]
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
H2O [cytosol]
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
H2O [cytosol]
RHO GTPases activate PAKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
H2O [cytosol]
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
H2O [cytosol]
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
H2O [cytosol]
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
H2O [cytosol]
RAC2 GTPase cycle (Homo sapiens)
RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)
H2O [cytosol]
RAC3 GTPase cycle (Homo sapiens)
RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)
H2O [cytosol]
RHOA GTPase cycle (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
H2O [cytosol]
RHOB GTPase cycle (Homo sapiens)
RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)
H2O [cytosol]
RHOC GTPase cycle (Homo sapiens)
RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)
H2O [cytosol]
RHOD GTPase cycle (Homo sapiens)
RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)
H2O [cytosol]
RHOF GTPase cycle (Homo sapiens)
RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)
H2O [cytosol]
RHOG GTPase cycle (Homo sapiens)
RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)
H2O [cytosol]
RHOJ GTPase cycle (Homo sapiens)
RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)
H2O [cytosol]
RHOQ GTPase cycle (Homo sapiens)
RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)
H2O [cytosol]
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
H2O [cytosol]
PP1 dephosphorylates TGFBR1 (Homo sapiens)
H2O [cytosol]
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
H2O [cytosol]
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Homo sapiens)
H2O [cytosol]
TCF dependent signaling in response to WNT (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
H2O [cytosol]
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABC transporters in lipid homeostasis (Homo sapiens)
ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)
H2O [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Homo sapiens)
H2O [cytosol]
ABCAs mediate lipid efflux (Homo sapiens)
H2O [cytosol]
ABCAs mediate lipid influx (Homo sapiens)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Homo sapiens)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
ABCA4 mediates atRAL transport (Homo sapiens)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
HCO3- transport through ion channel (Homo sapiens)
H2O [cytosol]
Mitochondrial ABC transporters (Homo sapiens)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)
H2O [cytosol]
The ABCC family mediates organic anion transport (Homo sapiens)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
H2O [cytosol]
Aquaporin-mediated transport (Homo sapiens)
Passive transport by Aquaporins (Homo sapiens)
Aquaporins passively transport water into cells (Homo sapiens)
H2O [cytosol]
Aquaporins passively transport water out of cells (Homo sapiens)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
Aquaporin-1 passively transports water into cell (Homo sapiens)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Homo sapiens)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Homo sapiens)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Homo sapiens)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)
H2O [cytosol]
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Homo sapiens)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)
H2O [cytosol]
Iron uptake and transport (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
H2O [cytosol]
Transferrin endocytosis and recycling (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Homo sapiens)
Erythrocytes take up carbon dioxide and release oxygen (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
HDL assembly (Homo sapiens)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)
H2O [cytosol]
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Homo sapiens)
H2O [cytosol]
Plasma lipoprotein remodeling (Homo sapiens)
HDL remodeling (Homo sapiens)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
H2O [cytosol]
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
H2O [cytosol]
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
PP6 dephosphorylates SEC24 (Homo sapiens)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-independent Golgi-to-ER retrograde traffic (Homo sapiens)
PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)
H2O [cytosol]
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Homo sapiens)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)
H2O [cytosol]
Autophagy (Mus musculus)
Macroautophagy (Mus musculus)
Selective autophagy (Mus musculus)
Pexophagy (Mus musculus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)
H2O [cytosol]
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
M Phase (Mus musculus)
Mitotic Metaphase and Anaphase (Mus musculus)
Mitotic Anaphase (Mus musculus)
Nuclear Envelope (NE) Reassembly (Mus musculus)
Initiation of Nuclear Envelope (NE) Reformation (Mus musculus)
ANKLE2 is deacetylated by SIRT2 (Mus musculus)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Mus musculus)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Mus musculus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Mus musculus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)
H2O [cytosol]
Mitotic Prometaphase (Mus musculus)
Condensation of Prometaphase Chromosomes (Mus musculus)
Dephosphorylation of CK2-modified condensin I (Mus musculus)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Mus musculus)
PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Mus musculus)
H2O [cytosol]
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
Cyclin A/B1/B2 associated events during G2/M transition (Mus musculus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)
H2O [cytosol]
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Mus musculus)
Dephosphorylation of phospho-Cdh1 (Mus musculus)
H2O [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Cytoprotection by HMOX1 (Mus musculus)
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Mus musculus)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Mus musculus)
H2O [cytosol]
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Mus musculus)
Nuclear events mediated by NFE2L2 (Mus musculus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Mus musculus)
PRDX1 overoxidizes (Mus musculus)
H2O [cytosol]
Cellular response to heat stress (Mus musculus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)
H2O [cytosol]
Chromatin organization (Mus musculus)
Chromatin modifying enzymes (Mus musculus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Mus musculus)
H2O [cytosol]
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
EPH-Ephrin signaling (Mus musculus)
EPHB-mediated forward signaling (Mus musculus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)
H2O [cytosol]
L1CAM interactions (Mus musculus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Mus musculus)
H2O [cytosol]
Semaphorin interactions (Mus musculus)
Sema4D in semaphorin signaling (Mus musculus)
Sema4D mediated inhibition of cell attachment and migration (Mus musculus)
Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)
H2O [cytosol]
Signaling by ROBO receptors (Mus musculus)
Regulation of expression of SLITs and ROBOs (Mus musculus)
USP33 deubiquitinates ROBO1 (Mus musculus)
H2O [cytosol]
SLIT2:ROBO1 increases RHOA activity (Mus musculus)
MYO9B inactivates RHOA (Mus musculus)
H2O [cytosol]
Drug ADME (Mus musculus)
Abacavir ADME (Mus musculus)
Abacavir metabolism (Mus musculus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Mus musculus)
H2O [cytosol]
Aspirin ADME (Mus musculus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)
H2O [cytosol]
Atorvastatin ADME (Mus musculus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
H2O [cytosol]
Azathioprine ADME (Mus musculus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Mus musculus)
H2O [cytosol]
Ciprofloxacin ADME (Mus musculus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Mus musculus)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Mus musculus)
H2O [cytosol]
Paracetamol ADME (Mus musculus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Mus musculus)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Mus musculus)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Mus musculus)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Mus musculus)
H2O [cytosol]
Prednisone ADME (Mus musculus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Mus musculus)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Mus musculus)
H2O [cytosol]
Ribavirin ADME (Mus musculus)
ADA deamidates RBV (Mus musculus)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)
H2O [cytosol]
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Metabolic Genes (Mus musculus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
H2O [cytosol]
PRDX1 overoxidizes (Mus musculus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
H2O [cytosol]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Effects of PIP2 hydrolysis (Mus musculus)
Arachidonate production from DAG (Mus musculus)
2-AG hydrolysis to arachidonate by MAGL (Mus musculus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Mus musculus)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
ABCC4 accumulation of dense granule contents (Mus musculus)
H2O [cytosol]
Platelet homeostasis (Mus musculus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)
H2O [cytosol]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Mus musculus)
Disassembly of COPII coated vesicle (Mus musculus)
H2O [cytosol]
Transport of Antigen peptide in to ER (Mus musculus)
H2O [cytosol]
Costimulation by the CD28 family (Mus musculus)
CTLA4 inhibitory signaling (Mus musculus)
Dephosphorylation of AKT by PP2A (Mus musculus)
H2O [cytosol]
MHC class II antigen presentation (Mus musculus)
Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)
H2O [cytosol]
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Mus musculus)
H2O [cytosol]
Generation of second messenger molecules (Mus musculus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Mus musculus)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Mus musculus)
PTPN22 dephosphorylates ZAP70 (Mus musculus)
H2O [cytosol]
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
Negative regulation of FLT3 (Mus musculus)
PTPRJ dephosphorylates active FLT3 (Mus musculus)
H2O [cytosol]
Growth hormone receptor signaling (Mus musculus)
PTP1B dephosphorylates GHR (Mus musculus)
H2O [cytosol]
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
OAS antiviral response (Mus musculus)
PDE12 cleaves 2'-5' oligoadenylates (Mus musculus)
H2O [cytosol]
Interferon alpha/beta signaling (Mus musculus)
Regulation of IFNA/IFNB signaling (Mus musculus)
Dephosphorylation of JAK1 by SHP1 (Mus musculus)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Mus musculus)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Mus musculus)
H2O [cytosol]
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Innate Immune System (Mus musculus)
Antimicrobial peptides (Mus musculus)
Ion influx/efflux at host-pathogen interface (Mus musculus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)
H2O [cytosol]
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
CLEC7A (Dectin-1) induces NFAT activation (Mus musculus)
Calcineurin binds and dephosphorylates NFAT (Mus musculus)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Calcineurin binds and dephosphorylates NFAT (Mus musculus)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Mus musculus)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Mus musculus)
Role of phospholipids in phagocytosis (Mus musculus)
Conversion of PA into DAG by PAP-1 (Mus musculus)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Mus musculus)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Mus musculus)
H2O [cytosol]
Toll-like Receptor Cascades (Mus musculus)
Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
MyD88-independent TLR4 cascade (Mus musculus)
TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
MyD88 cascade initiated on plasma membrane (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
MyD88 dependent cascade initiated on endosome (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
Regulation of NF-kappa B signaling (Mus musculus)
USP14 deubiquitinates NLRC5 (Mus musculus)
H2O [cytosol]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Pyruvate metabolism (Mus musculus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)
H2O [cytosol]
Regulation of pyruvate metabolism (Mus musculus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Mus musculus)
H2O [cytosol]
Biological oxidations (Mus musculus)
Aflatoxin activation and detoxification (Mus musculus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
H2O [cytosol]
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)
H2O [cytosol]
Phase I - Functionalization of compounds (Mus musculus)
AADAC deacetylates PHEN (Mus musculus)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)
H2O [cytosol]
Amine Oxidase reactions (Mus musculus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Mus musculus)
MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Mus musculus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Mus musculus)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Mus musculus)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Mus musculus)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Mus musculus)
Eicosanoids (Mus musculus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Mus musculus)
H2O [cytosol]
Endogenous sterols (Mus musculus)
CYP19A1 hydroxylates ANDST to E1 (Mus musculus)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Mus musculus)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Mus musculus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Mus musculus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Mus musculus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Mus musculus)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
H2O [cytosol]
Vitamins (Mus musculus)
CYP26C1 4-hydroxylates 9cRA (Mus musculus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Mus musculus)
H2O [cytosol]
Ethanol oxidation (Mus musculus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)
H2O [cytosol]
Phase II - Conjugation of compounds (Mus musculus)
Cytosolic sulfonation of small molecules (Mus musculus)
ABHD14B hydrolyses PNPB (Mus musculus)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)
H2O [cytosol]
Glucuronidation (Mus musculus)
Formation of the active cofactor, UDP-glucuronate (Mus musculus)
UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)
H2O [cytosol]
Glutathione conjugation (Mus musculus)
Glutathione synthesis and recycling (Mus musculus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
H2O [cytosol]
Methylation (Mus musculus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Mus musculus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)
H2O [cytosol]
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP2, IP, and Ins in the cytosol (Mus musculus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Mus musculus)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Mus musculus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Mus musculus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)
H2O [cytosol]
Integration of energy metabolism (Mus musculus)
Regulation of insulin secretion (Mus musculus)
Acetylcholine regulates insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Mus musculus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
H2O [cytosol]
Metabolism of amino acids and derivatives (Mus musculus)
Aspartate and asparagine metabolism (Mus musculus)
ASPA deacetylates NAA to acetate and L-aspartate (Mus musculus)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Mus musculus)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)
H2O [cytosol]
Carnitine synthesis (Mus musculus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)
H2O [cytosol]
Histidine catabolism (Mus musculus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)
H2O [cytosol]
Metabolism of polyamines (Mus musculus)
Agmatine biosynthesis (Mus musculus)
Agmatine + H2O <=> putrescine + urea (Mus musculus)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Phenylalanine metabolism (Mus musculus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)
H2O [cytosol]
Tyrosine catabolism (Mus musculus)
FAH cleaves 4FAA (Mus musculus)
H2O [cytosol]
Selenoamino acid metabolism (Mus musculus)
Metabolism of ingested MeSeO2H into MeSeH (Mus musculus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Mus musculus)
SeMet is converted to AdoSeMet by MAT (Mus musculus)
H2O [cytosol]
Selenocysteine synthesis (Mus musculus)
SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)
H2O [cytosol]
Serine biosynthesis (Mus musculus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Mus musculus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)
H2O [cytosol]
Sulfur amino acid metabolism (Mus musculus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)
H2O [cytosol]
Cysteine formation from homocysteine (Mus musculus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Mus musculus)
H2O [cytosol]
Degradation of cysteine and homocysteine (Mus musculus)
Cysteine is degraded to serine and H2S (Mus musculus)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Mus musculus)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Mus musculus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
H2O [cytosol]
Methionine salvage pathway (Mus musculus)
Acireductone is created (Mus musculus)
H2O [cytosol]
Threonine catabolism (Mus musculus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Mus musculus)
H2O [cytosol]
Tryptophan catabolism (Mus musculus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)
H2O [cytosol]
Urea cycle (Mus musculus)
arginine + H2O => ornithine + urea [ARG1] (Mus musculus)
H2O [cytosol]
Metabolism of carbohydrates (Mus musculus)
Fructose metabolism (Mus musculus)
Fructose catabolism (Mus musculus)
ALDH1A1 oxidises GA to DGA (Mus musculus)
H2O [cytosol]
Glucose metabolism (Mus musculus)
Gluconeogenesis (Mus musculus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Mus musculus)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Mus musculus)
H2O [cytosol]
Glycolysis (Mus musculus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Mus musculus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)
H2O [cytosol]
Glycogen metabolism (Mus musculus)
Glycogen synthesis (Mus musculus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Mus musculus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Mus musculus)
H2O [cytosol]
Pentose phosphate pathway (Mus musculus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)
H2O [cytosol]
Metabolism of lipids (Mus musculus)
Biosynthesis of specialized proresolving mediators (SPMs) (Mus musculus)
Biosynthesis of DHA-derived SPMs (Mus musculus)
Biosynthesis of D-series resolvins (Mus musculus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Mus musculus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Mus musculus)
H2O [cytosol]
Biosynthesis of maresins (Mus musculus)
Biosynthesis of maresin-like SPMs (Mus musculus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)
H2O [cytosol]
Biosynthesis of protectins (Mus musculus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Mus musculus)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Mus musculus)
Biosynthesis of E-series 18(R)-resolvins (Mus musculus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Mus musculus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Mus musculus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Mus musculus)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Mus musculus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)
H2O [cytosol]
Fatty acid metabolism (Mus musculus)
Arachidonic acid metabolism (Mus musculus)
FAAH hydrolyses AEA to AA and ETA (Mus musculus)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Mus musculus)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Mus musculus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Mus musculus)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)
H2O [cytosol]
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Mus musculus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Mus musculus)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Mus musculus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Mus musculus)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Mus musculus)
SCD desaturates ST-CoA to OLE-CoA (Mus musculus)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Mus musculus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Mus musculus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)
H2O [cytosol]
Metabolism of steroids (Mus musculus)
Bile acid and bile salt metabolism (Mus musculus)
Recycling of bile acids and salts (Mus musculus)
ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
H2O [cytosol]
Synthesis of bile acids and bile salts (Mus musculus)
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
H2O [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Mus musculus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Mus musculus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Mus musculus)
27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Mus musculus)
ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Mus musculus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
H2O [cytosol]
Cholesterol biosynthesis (Mus musculus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Mus musculus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Mus musculus)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Mus musculus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Mus musculus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)
H2O [cytosol]
Squalene is oxidized to its epoxide (Mus musculus)
H2O [cytosol]
Metabolism of steroid hormones (Mus musculus)
Androgen biosynthesis (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Mus musculus)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)
H2O [cytosol]
Estrogen biosynthesis (Mus musculus)
CYP19A1 hydroxylates ANDST to E1 (Mus musculus)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Mus musculus)
H2O [cytosol]
Glucocorticoid biosynthesis (Mus musculus)
CYP17A1 17-hydroxylates PREG (Mus musculus)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Mus musculus)
H2O [cytosol]
Mineralocorticoid biosynthesis (Mus musculus)
CYP21A2 21-hydroxylates PROG (Mus musculus)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)
H2O [cytosol]
Phospholipid metabolism (Mus musculus)
Glycerophospholipid biosynthesis (Mus musculus)
Acyl chain remodeling of DAG and TAG (Mus musculus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)
H2O [cytosol]
Acyl chain remodelling of PC (Mus musculus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Mus musculus)
H2O [cytosol]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Mus musculus)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Mus musculus)
H2O [cytosol]
Acyl chain remodelling of PE (Mus musculus)
ABHD4 hydrolyses NAPE (Mus musculus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Mus musculus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Mus musculus)
H2O [cytosol]
Acyl chain remodelling of PG (Mus musculus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Mus musculus)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Mus musculus)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Mus musculus)
H2O [cytosol]
Acyl chain remodelling of PI (Mus musculus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)
H2O [cytosol]
Acyl chain remodelling of PS (Mus musculus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Mus musculus)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)
H2O [cytosol]
Hydrolysis of LPC (Mus musculus)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)
H2O [cytosol]
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)
H2O [cytosol]
Hydrolysis of LPE (Mus musculus)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)
H2O [cytosol]
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)
H2O [cytosol]
Synthesis of PA (Mus musculus)
DDHD1,2 hydrolyse PA (Mus musculus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Mus musculus)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)
H2O [cytosol]
Synthesis of PC (Mus musculus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Mus musculus)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)
H2O [cytosol]
Synthesis of PE (Mus musculus)
PA is dephosphorylated to DAG by LPIN (Mus musculus)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)
H2O [cytosol]
PI Metabolism (Mus musculus)
Glycerophospholipid catabolism (Mus musculus)
GDE1 hydrolyzes GroPIns (Mus musculus)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Mus musculus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Mus musculus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Mus musculus)
H2O [cytosol]
Sphingolipid metabolism (Mus musculus)
Glycosphingolipid metabolism (Mus musculus)
Glycosphingolipid catabolism (Mus musculus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Mus musculus)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Mus musculus)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Mus musculus)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Mus musculus)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Mus musculus)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Mus musculus)
H2O [cytosol]
Sphingolipid catabolism (Mus musculus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Mus musculus)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Mus musculus)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Mus musculus)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Mus musculus)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Mus musculus)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Mus musculus)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Mus musculus)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Mus musculus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Mus musculus)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Mus musculus)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Mus musculus)
H2O [cytosol]
Triglyceride metabolism (Mus musculus)
Triglyceride biosynthesis (Mus musculus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)
H2O [cytosol]
Triglyceride catabolism (Mus musculus)
PNPLA5 hydrolyzes TAG (Mus musculus)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Mus musculus)
eNOS activation (Mus musculus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)
H2O [cytosol]
Metabolism of nucleotides (Mus musculus)
Interconversion of nucleotide di- and triphosphates (Mus musculus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Mus musculus)
H2O [cytosol]
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
H2O [cytosol]
FAICAR => IMP + H2O (Mus musculus)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
H2O [cytosol]
Pyrimidine biosynthesis (Mus musculus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Mus musculus)
H2O [cytosol]
Nucleotide catabolism (Mus musculus)
Purine catabolism (Mus musculus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Mus musculus)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Mus musculus)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Mus musculus)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Mus musculus)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Mus musculus)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Mus musculus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Mus musculus)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Mus musculus)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Mus musculus)
H2O [cytosol]
Pyrimidine catabolism (Mus musculus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Mus musculus)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)
H2O [cytosol]
Nucleotide salvage (Mus musculus)
Purine salvage (Mus musculus)
ADA catalyzes the deamination of (deoxy)adenosine (Mus musculus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)
H2O [cytosol]
Pyrimidine salvage (Mus musculus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)
H2O [cytosol]
Metabolism of porphyrins (Mus musculus)
Heme biosynthesis (Mus musculus)
4 PBGs bind to form HMB (Mus musculus)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Mus musculus)
H2O [cytosol]
UROS transforms HMB to URO3 (Mus musculus)
H2O [cytosol]
Heme degradation (Mus musculus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
H2O [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Mus musculus)
Transport of RCbl within the body (Mus musculus)
ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Mus musculus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)
H2O [cytosol]
Metabolism of folate and pterines (Mus musculus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Mus musculus)
Cyclisation of GTP to precursor Z (Mus musculus)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Mus musculus)
H2O [cytosol]
Nicotinate metabolism (Mus musculus)
NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Mus musculus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Mus musculus)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Mus musculus)
PANK4 hydrolyzes PPANT to pantetheine (Mus musculus)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Mus musculus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Mus musculus)
H2O [cytosol]
Pyrophosphate hydrolysis (Mus musculus)
LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
H2O [cytosol]
Reversible hydration of carbon dioxide (Mus musculus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)
H2O [cytosol]
Metabolism of RNA (Mus musculus)
Deadenylation-dependent mRNA decay (Mus musculus)
Deadenylation of mRNA (Mus musculus)
CCR4-NOT complex deadenylates mRNA (Mus musculus)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)
H2O [cytosol]
PARN deadenylates mRNA (Mus musculus)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Mus musculus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Mus musculus)
DCP1-DCP2 complex decaps mRNA (Mus musculus)
H2O [cytosol]
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Asparagine N-linked glycosylation (Mus musculus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Mus musculus)
Synthesis of substrates in N-glycan biosythesis (Mus musculus)
GDP-fucose biosynthesis (Mus musculus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)
H2O [cytosol]
Sialic acid metabolism (Mus musculus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Mus musculus)
DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Mus musculus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Mus musculus)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Mus musculus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Mus musculus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Mus musculus)
ER to Golgi Anterograde Transport (Mus musculus)
COPII-mediated vesicle transport (Mus musculus)
PP6 dephosphorylates SEC24 (Mus musculus)
H2O [cytosol]
Deubiquitination (Mus musculus)
Josephin domain DUBs (Mus musculus)
ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)
H2O [cytosol]
ATXN3 family cleave Ub chains (Mus musculus)
H2O [cytosol]
Metalloprotease DUBs (Mus musculus)
BRISC complex deubiquitinates NLRP3 (Mus musculus)
H2O [cytosol]
Ovarian tumor domain proteases (Mus musculus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)
H2O [cytosol]
UCH proteinases (Mus musculus)
UCHL1, UCHL3 cleave ubiquitin adducts (Mus musculus)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Mus musculus)
H2O [cytosol]
Ub-specific processing proteases (Mus musculus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Mus musculus)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Mus musculus)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Mus musculus)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Mus musculus)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Mus musculus)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Mus musculus)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Mus musculus)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Mus musculus)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Mus musculus)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Mus musculus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)
H2O [cytosol]
USP5 cleaves polyubiquitin (Mus musculus)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Mus musculus)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Mus musculus)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
Hypusine synthesis from eIF5A-lysine (Mus musculus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)
H2O [cytosol]
Neddylation (Mus musculus)
UCHL3, SENP8 cleave NEDD8 (Mus musculus)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Mus musculus)
Synthesis of glycosylphosphatidylinositol (GPI) (Mus musculus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)
H2O [cytosol]
Surfactant metabolism (Mus musculus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)
H2O [cytosol]
Translation (Mus musculus)
Eukaryotic Translation Termination (Mus musculus)
APEH hydrolyses NAc-Ser-protein (Mus musculus)
H2O [cytosol]
tRNA Aminoacylation (Mus musculus)
Cytosolic tRNA aminoacylation (Mus musculus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
H2O [cytosol]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Ion homeostasis (Mus musculus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)
H2O [cytosol]
Physiological factors (Mus musculus)
CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)
H2O [cytosol]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter clearance (Mus musculus)
Dopamine clearance from the synaptic cleft (Mus musculus)
Enzymatic degradation of Dopamine by monoamine oxidase (Mus musculus)
MAOA:FAD deaminates DA to DOPAC (Mus musculus)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Mus musculus)
MAOA:FAD deaminates 3MT to HVA (Mus musculus)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Mus musculus)
Metabolism of serotonin (Mus musculus)
MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
H2O [cytosol]
Neurotransmitter release cycle (Mus musculus)
Norepinephrine Neurotransmitter Release Cycle (Mus musculus)
Catabolism of Noradrenaline (Mus musculus)
H2O [cytosol]
Organelle biogenesis and maintenance (Mus musculus)
Cilium Assembly (Mus musculus)
Cargo trafficking to the periciliary membrane (Mus musculus)
VxPx cargo-targeting to cilium (Mus musculus)
ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)
H2O [cytosol]
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Intrinsic Pathway for Apoptosis (Mus musculus)
Activation of BH3-only proteins (Mus musculus)
Activation of BAD and translocation to mitochondria (Mus musculus)
Activation of BAD by calcineurin (Mus musculus)
H2O [cytosol]
Protein localization (Mus musculus)
Peroxisomal protein import (Mus musculus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)
H2O [cytosol]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
The canonical retinoid cycle in rods (twilight vision) (Mus musculus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Mus musculus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Mus musculus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)
H2O [cytosol]
The phototransduction cascade (Mus musculus)
Activation of the phototransduction cascade (Mus musculus)
PDE6 hydrolyses cGMP to GMP (Mus musculus)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Mus musculus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Mus musculus)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Mus musculus)
OPN1LW binds 11cRAL (Mus musculus)
H2O [cytosol]
OPN1MW binds 11cRAL (Mus musculus)
H2O [cytosol]
OPN1SW binds 11cRAL (Mus musculus)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)
H2O [cytosol]
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
H2O [cytosol]
Intracellular signaling by second messengers (Mus musculus)
DAG and IP3 signaling (Mus musculus)
CaM pathway (Mus musculus)
Calmodulin induced events (Mus musculus)
Cam-PDE 1 activation (Mus musculus)
cAMP hydrolysis by Cam-PDE 1 (Mus musculus)
H2O [cytosol]
PIP3 activates AKT signaling (Mus musculus)
Negative regulation of the PI3K/AKT network (Mus musculus)
PHLPP dephosphorylates S473 in AKT (Mus musculus)
H2O [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Mus musculus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Mus musculus)
H2O [cytosol]
PTEN Regulation (Mus musculus)
Regulation of PTEN stability and activity (Mus musculus)
USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)
H2O [cytosol]
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF-independent MAPK1/3 activation (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)
H2O [cytosol]
RAF/MAP kinase cascade (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Mus musculus)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Mus musculus)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Mus musculus)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)
H2O [cytosol]
RAF activation (Mus musculus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Mus musculus)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Mus musculus)
H2O [cytosol]
RAS processing (Mus musculus)
RAS proteins are depalmitoylated (Mus musculus)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Mus musculus)
H2O [cytosol]
MTOR signalling (Mus musculus)
Energy dependent regulation of mTOR by LKB1-AMPK (Mus musculus)
AMPK is dephosphorylated (Mus musculus)
H2O [cytosol]
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Opioid Signalling (Mus musculus)
DARPP-32 events (Mus musculus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Mus musculus)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Mus musculus)
H2O [cytosol]
G-protein mediated events (Mus musculus)
PLC beta mediated events (Mus musculus)
Ca-dependent events (Mus musculus)
CaM pathway (Mus musculus)
Calmodulin induced events (Mus musculus)
Cam-PDE 1 activation (Mus musculus)
cAMP hydrolysis by Cam-PDE 1 (Mus musculus)
H2O [cytosol]
phospho-PLA2 pathway (Mus musculus)
Hydrolysis of phosphatidylcholine (Mus musculus)
H2O [cytosol]
Inactivation of PLC beta (Mus musculus)
H2O [cytosol]
PIP2 hydrolysis (Mus musculus)
H2O [cytosol]
G alpha (q) signalling events (Mus musculus)
Effects of PIP2 hydrolysis (Mus musculus)
Arachidonate production from DAG (Mus musculus)
2-AG hydrolysis to arachidonate by MAGL (Mus musculus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Mus musculus)
H2O [cytosol]
G alpha (s) signalling events (Mus musculus)
PDE3A hydrolyses cAMP to AMP (Mus musculus)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Mus musculus)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Mus musculus)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Mus musculus)
H2O [cytosol]
Signaling by Hedgehog (Mus musculus)
Hedgehog ligand biogenesis (Mus musculus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)
H2O [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Mus musculus)
Signaling by PTK6 (Mus musculus)
PTK6 Down-Regulation (Mus musculus)
PTPN1 dephosphorylates PTK6 (Mus musculus)
H2O [cytosol]
Signaling by Nuclear Receptors (Mus musculus)
Signaling by Retinoic Acid (Mus musculus)
RA biosynthesis pathway (Mus musculus)
ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Mus musculus)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Mus musculus)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
MDK and PTN in ALK signaling (Mus musculus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Mus musculus)
H2O [cytosol]
Signaling by EGFR (Mus musculus)
EGFR downregulation (Mus musculus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Mus musculus)
H2O [cytosol]
PTPN3 dephosphorylates EPS15 (Mus musculus)
H2O [cytosol]
GAB1 signalosome (Mus musculus)
Dephosphorylation of Gab1 by SHP2 (Mus musculus)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Mus musculus)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Mus musculus)
H2O [cytosol]
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Mus musculus)
H2O [cytosol]
Signaling by Insulin receptor (Mus musculus)
Insulin receptor recycling (Mus musculus)
Insulin receptor de-phosphorylation (Mus musculus)
H2O [cytosol]
Insulin receptor signalling cascade (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PKB-mediated events (Mus musculus)
PDE3B signalling (Mus musculus)
p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)
H2O [cytosol]
Signaling by MET (Mus musculus)
Negative regulation of MET activity (Mus musculus)
PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)
H2O [cytosol]
PTPRJ dephosphorylates MET (Mus musculus)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Mus musculus)
H2O [cytosol]
Signaling by PDGF (Mus musculus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PKB-mediated events (Mus musculus)
PDE3B signalling (Mus musculus)
p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Miro GTPase Cycle (Mus musculus)
RHOT1 GTPase cycle (Mus musculus)
RHOT1 hydrolyzes GTP (Mus musculus)
H2O [cytosol]
RHOT2 GTPase cycle (Mus musculus)
RHOT2 hydrolyzes GTP (Mus musculus)
H2O [cytosol]
RHOBTB3 ATPase cycle (Mus musculus)
RHOBTB3 hydrolyzes ATP (Mus musculus)
H2O [cytosol]
Signaling by Rho GTPases (Mus musculus)
RHO GTPase Effectors (Mus musculus)
RHO GTPases Activate Formins (Mus musculus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)
H2O [cytosol]
RHO GTPase cycle (Mus musculus)
CDC42 GTPase cycle (Mus musculus)
CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)
H2O [cytosol]
RAC1 GTPase cycle (Mus musculus)
RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)
H2O [cytosol]
RAC2 GTPase cycle (Mus musculus)
RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)
H2O [cytosol]
RAC3 GTPase cycle (Mus musculus)
RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)
H2O [cytosol]
RHOA GTPase cycle (Mus musculus)
RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)
H2O [cytosol]
RHOB GTPase cycle (Mus musculus)
RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)
H2O [cytosol]
RHOC GTPase cycle (Mus musculus)
RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)
H2O [cytosol]
RHOD GTPase cycle (Mus musculus)
RHOD GAPs stimulate RHOD GTPase activity (Mus musculus)
H2O [cytosol]
RHOF GTPase cycle (Mus musculus)
RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)
H2O [cytosol]
RHOG GTPase cycle (Mus musculus)
RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)
H2O [cytosol]
RHOJ GTPase cycle (Mus musculus)
RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)
H2O [cytosol]
RHOQ GTPase cycle (Mus musculus)
RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)
H2O [cytosol]
Signaling by TGFB family members (Mus musculus)
Signaling by TGF-beta Receptor Complex (Mus musculus)
TGF-beta receptor signaling activates SMADs (Mus musculus)
Downregulation of TGF-beta receptor signaling (Mus musculus)
MTMR4 dephosphorylates SMAD2/3 (Mus musculus)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
H2O [cytosol]
Signaling by WNT (Mus musculus)
Beta-catenin independent WNT signaling (Mus musculus)
Ca2+ pathway (Mus musculus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Mus musculus)
H2O [cytosol]
TCF dependent signaling in response to WNT (Mus musculus)
Regulation of FZD by ubiquitination (Mus musculus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)
H2O [cytosol]
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
ABC transporters in lipid homeostasis (Mus musculus)
ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)
H2O [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)
H2O [cytosol]
ABCAs mediate lipid efflux (Mus musculus)
H2O [cytosol]
ABCAs mediate lipid influx (Mus musculus)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Mus musculus)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
ABCA4 mediates atRAL transport (Mus musculus)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
HCO3- transport through ion channel (Mus musculus)
H2O [cytosol]
Mitochondrial ABC transporters (Mus musculus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)
H2O [cytosol]
The ABCC family mediates organic anion transport (Mus musculus)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)
H2O [cytosol]
Aquaporin-mediated transport (Mus musculus)
Passive transport by Aquaporins (Mus musculus)
Aquaporins passively transport water into cells (Mus musculus)
H2O [cytosol]
Aquaporins passively transport water out of cells (Mus musculus)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Mus musculus)
Aquaporin-1 passively transports water into cell (Mus musculus)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Mus musculus)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Mus musculus)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Mus musculus)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Mus musculus)
H2O [cytosol]
Ion channel transport (Mus musculus)
Ion transport by P-type ATPases (Mus musculus)
ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)
H2O [cytosol]
Iron uptake and transport (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
H2O [cytosol]
Transferrin endocytosis and recycling (Mus musculus)
Acidification of Tf:TfR1 containing endosome (Mus musculus)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Mus musculus)
Erythrocytes take up carbon dioxide and release oxygen (Mus musculus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Mus musculus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
Plasma lipoprotein assembly (Mus musculus)
HDL assembly (Mus musculus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)
H2O [cytosol]
Plasma lipoprotein clearance (Mus musculus)
LDL clearance (Mus musculus)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Mus musculus)
H2O [cytosol]
Plasma lipoprotein remodeling (Mus musculus)
HDL remodeling (Mus musculus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)
H2O [cytosol]
Vesicle-mediated transport (Mus musculus)
Membrane Trafficking (Mus musculus)
Clathrin-mediated endocytosis (Mus musculus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
H2O [cytosol]
ER to Golgi Anterograde Transport (Mus musculus)
COPII-mediated vesicle transport (Mus musculus)
PP6 dephosphorylates SEC24 (Mus musculus)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Mus musculus)
Golgi-to-ER retrograde transport (Mus musculus)
COPI-independent Golgi-to-ER retrograde traffic (Mus musculus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Mus musculus)
H2O [cytosol]
Rab regulation of trafficking (Mus musculus)
TBC/RABGAPs (Mus musculus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)
H2O [cytosol]
Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
Chorismate via Shikimate Pathway (Mycobacterium tuberculosis)
DHAP from Ery4P and PEP (Mycobacterium tuberculosis)
H2O [cytosol]
Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)
H2O [cytosol]
Dimycocersyl phthiocerol biosynthesis (Mycobacterium tuberculosis)
Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)
H2O [cytosol]
Mycothiol metabolism (Mycobacterium tuberculosis)
Mycothiol biosynthesis (Mycobacterium tuberculosis)
acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate (Mycobacterium tuberculosis)
H2O [cytosol]
acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)
H2O [cytosol]
acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)
H2O [cytosol]
Mycothiol catabolism (Mycobacterium tuberculosis)
mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)
H2O [cytosol]
Mycothiol-dependent detoxification (Mycobacterium tuberculosis)
formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)
H2O [cytosol]
mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)
H2O [cytosol]
Sulfur compound metabolism (Mycobacterium tuberculosis)
Sulfate assimilation (Mycobacterium tuberculosis)
APS is phosphorylated to PAPS (Mycobacterium tuberculosis)
H2O [cytosol]
PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)
H2O [cytosol]
sulfate uptake in the cytosol (Mycobacterium tuberculosis)
H2O [cytosol]
Sulfur amino acid metabolism (Mycobacterium tuberculosis)
Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)
H2O [cytosol]
Cysteine synthesis from O-acetylserine (Mycobacterium tuberculosis)
sulfite is reduced to sulfide (Mycobacterium tuberculosis)
H2O [cytosol]
Cysteine synthesis from O-phosphoserine (Mycobacterium tuberculosis)
cleavage of L-cysteine from carrier protein (Mycobacterium tuberculosis)
H2O [cytosol]
Trehalose biosynthesis (Mycobacterium tuberculosis)
Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose (Mycobacterium tuberculosis)
H2O [cytosol]
Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)
H2O [cytosol]
Cell Cycle (Plasmodium falciparum)
Cell Cycle, Mitotic (Plasmodium falciparum)
M Phase (Plasmodium falciparum)
Mitotic Prometaphase (Plasmodium falciparum)
Condensation of Prometaphase Chromosomes (Plasmodium falciparum)
Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Plasmodium falciparum)
PPP1CC dephosphorylates PLK1 (Plasmodium falciparum)
H2O [cytosol]
Cellular responses to stimuli (Plasmodium falciparum)
Cellular responses to stress (Plasmodium falciparum)
Cellular response to chemical stress (Plasmodium falciparum)
Detoxification of Reactive Oxygen Species (Plasmodium falciparum)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Plasmodium falciparum)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Plasmodium falciparum)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Plasmodium falciparum)
H2O [cytosol]
Cellular response to heat stress (Plasmodium falciparum)
Regulation of HSF1-mediated heat shock response (Plasmodium falciparum)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Plasmodium falciparum)
H2O [cytosol]
Drug ADME (Plasmodium falciparum)
Azathioprine ADME (Plasmodium falciparum)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)
H2O [cytosol]
Ciprofloxacin ADME (Plasmodium falciparum)
ABCG2 transports Cipro from hepatic cell to extracellular space (Plasmodium falciparum)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Plasmodium falciparum)
H2O [cytosol]
Paracetamol ADME (Plasmodium falciparum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Plasmodium falciparum)
H2O [cytosol]
Prednisone ADME (Plasmodium falciparum)
ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Plasmodium falciparum)
H2O [cytosol]
Ribavirin ADME (Plasmodium falciparum)
ADA deamidates RBV (Plasmodium falciparum)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)
H2O [cytosol]
Gene expression (Transcription) (Plasmodium falciparum)
RNA Polymerase II Transcription (Plasmodium falciparum)
Generic Transcription Pathway (Plasmodium falciparum)
Transcriptional Regulation by TP53 (Plasmodium falciparum)
TP53 Regulates Metabolic Genes (Plasmodium falciparum)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Plasmodium falciparum)
H2O [cytosol]
Hemostasis (Plasmodium falciparum)
Platelet activation, signaling and aggregation (Plasmodium falciparum)
Effects of PIP2 hydrolysis (Plasmodium falciparum)
Arachidonate production from DAG (Plasmodium falciparum)
2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Plasmodium falciparum)
Platelet degranulation (Plasmodium falciparum)
ABCC4 accumulation of dense granule contents (Plasmodium falciparum)
H2O [cytosol]
Immune System (Plasmodium falciparum)
Adaptive Immune System (Plasmodium falciparum)
TCR signaling (Plasmodium falciparum)
Generation of second messenger molecules (Plasmodium falciparum)
PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)
H2O [cytosol]
Innate Immune System (Plasmodium falciparum)
C-type lectin receptors (CLRs) (Plasmodium falciparum)
CLEC7A (Dectin-1) signaling (Plasmodium falciparum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)
H2O [cytosol]
Metabolism (Plasmodium falciparum)
Aerobic respiration and respiratory electron transport (Plasmodium falciparum)
Pyruvate metabolism (Plasmodium falciparum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)
H2O [cytosol]
Biological oxidations (Plasmodium falciparum)
Phase II - Conjugation of compounds (Plasmodium falciparum)
Methylation (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
H2O [cytosol]
Inositol phosphate metabolism (Plasmodium falciparum)
Synthesis of IP2, IP, and Ins in the cytosol (Plasmodium falciparum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Plasmodium falciparum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Plasmodium falciparum)
H2O [cytosol]
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Aspartate and asparagine metabolism (Plasmodium falciparum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Plasmodium falciparum)
Phenylalanine metabolism (Plasmodium falciparum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)
H2O [cytosol]
Selenoamino acid metabolism (Plasmodium falciparum)
Metabolism of ingested MeSeO2H into MeSeH (Plasmodium falciparum)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Plasmodium falciparum)
SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)
H2O [cytosol]
Selenocysteine synthesis (Plasmodium falciparum)
SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)
H2O [cytosol]
Sulfur amino acid metabolism (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
H2O [cytosol]
Urea cycle (Plasmodium falciparum)
arginine + H2O => ornithine + urea [ARG1] (Plasmodium falciparum)
H2O [cytosol]
Metabolism of carbohydrates (Plasmodium falciparum)
Glucose metabolism (Plasmodium falciparum)
Gluconeogenesis (Plasmodium falciparum)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Plasmodium falciparum)
H2O [cytosol]
Glycolysis (Plasmodium falciparum)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Plasmodium falciparum)
H2O [cytosol]
Metabolism of lipids (Plasmodium falciparum)
Biosynthesis of specialized proresolving mediators (SPMs) (Plasmodium falciparum)
Biosynthesis of DHA-derived SPMs (Plasmodium falciparum)
Biosynthesis of D-series resolvins (Plasmodium falciparum)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Plasmodium falciparum)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Plasmodium falciparum)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Plasmodium falciparum)
Biosynthesis of E-series 18(R)-resolvins (Plasmodium falciparum)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Plasmodium falciparum)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Plasmodium falciparum)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Plasmodium falciparum)
H2O [cytosol]
Fatty acid metabolism (Plasmodium falciparum)
Arachidonic acid metabolism (Plasmodium falciparum)
Synthesis of 12-eicosatetraenoic acid derivatives (Plasmodium falciparum)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Plasmodium falciparum)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Plasmodium falciparum)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Plasmodium falciparum)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Plasmodium falciparum)
SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Plasmodium falciparum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Plasmodium falciparum)
H2O [cytosol]
Metabolism of steroids (Plasmodium falciparum)
Bile acid and bile salt metabolism (Plasmodium falciparum)
Recycling of bile acids and salts (Plasmodium falciparum)
ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
Synthesis of bile acids and bile salts (Plasmodium falciparum)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Plasmodium falciparum)
ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
Cholesterol biosynthesis (Plasmodium falciparum)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Plasmodium falciparum)
H2O [cytosol]
Phospholipid metabolism (Plasmodium falciparum)
Glycerophospholipid biosynthesis (Plasmodium falciparum)
Acyl chain remodeling of DAG and TAG (Plasmodium falciparum)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Plasmodium falciparum)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Plasmodium falciparum)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)
H2O [cytosol]
Synthesis of PA (Plasmodium falciparum)
DDHD1,2 hydrolyse PA (Plasmodium falciparum)
H2O [cytosol]
Synthesis of PC (Plasmodium falciparum)
PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)
H2O [cytosol]
Synthesis of PE (Plasmodium falciparum)
PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)
H2O [cytosol]
PI Metabolism (Plasmodium falciparum)
Synthesis of PIPs at the ER membrane (Plasmodium falciparum)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Plasmodium falciparum)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Plasmodium falciparum)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Plasmodium falciparum)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
Sphingolipid metabolism (Plasmodium falciparum)
Glycosphingolipid metabolism (Plasmodium falciparum)
Glycosphingolipid catabolism (Plasmodium falciparum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Plasmodium falciparum)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Plasmodium falciparum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)
H2O [cytosol]
Triglyceride metabolism (Plasmodium falciparum)
Triglyceride biosynthesis (Plasmodium falciparum)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)
H2O [cytosol]
Triglyceride catabolism (Plasmodium falciparum)
PNPLA4 hydrolyzes TAG (Plasmodium falciparum)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Plasmodium falciparum)
H2O [cytosol]
Metabolism of nucleotides (Plasmodium falciparum)
Interconversion of nucleotide di- and triphosphates (Plasmodium falciparum)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)
H2O [cytosol]
Nucleotide biosynthesis (Plasmodium falciparum)
Purine ribonucleoside monophosphate biosynthesis (Plasmodium falciparum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
H2O [cytosol]
Pyrimidine biosynthesis (Plasmodium falciparum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)
H2O [cytosol]
Nucleotide catabolism (Plasmodium falciparum)
Purine catabolism (Plasmodium falciparum)
ITPA hydrolyses ITP to IMP (Plasmodium falciparum)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Plasmodium falciparum)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Plasmodium falciparum)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Plasmodium falciparum)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)
H2O [cytosol]
Nucleotide salvage (Plasmodium falciparum)
Purine salvage (Plasmodium falciparum)
ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Plasmodium falciparum)
H2O [cytosol]
Metabolism of porphyrins (Plasmodium falciparum)
Heme biosynthesis (Plasmodium falciparum)
4 PBGs bind to form HMB (Plasmodium falciparum)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)
H2O [cytosol]
Heme degradation (Plasmodium falciparum)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Metabolism of folate and pterines (Plasmodium falciparum)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
H2O [cytosol]
Nicotinate metabolism (Plasmodium falciparum)
NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Plasmodium falciparum)
2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Plasmodium falciparum)
PANK4 hydrolyzes PPANT to pantetheine (Plasmodium falciparum)
H2O [cytosol]
Pyrophosphate hydrolysis (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
H2O [cytosol]
Reversible hydration of carbon dioxide (Plasmodium falciparum)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Plasmodium falciparum)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Plasmodium falciparum)
H2O [cytosol]
Metabolism of RNA (Plasmodium falciparum)
Deadenylation-dependent mRNA decay (Plasmodium falciparum)
mRNA decay by 5' to 3' exoribonuclease (Plasmodium falciparum)
DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)
H2O [cytosol]
Metabolism of proteins (Plasmodium falciparum)
Post-translational protein modification (Plasmodium falciparum)
Asparagine N-linked glycosylation (Plasmodium falciparum)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Plasmodium falciparum)
Synthesis of substrates in N-glycan biosythesis (Plasmodium falciparum)
GDP-fucose biosynthesis (Plasmodium falciparum)
GMDS dehydrates GDP-Man to GDP-DHDMan (Plasmodium falciparum)
H2O [cytosol]
Deubiquitination (Plasmodium falciparum)
Josephin domain DUBs (Plasmodium falciparum)
ATXN3 deubiquitinates polyUb-PARK2 (Plasmodium falciparum)
H2O [cytosol]
ATXN3 family cleave Ub chains (Plasmodium falciparum)
H2O [cytosol]
UCH proteinases (Plasmodium falciparum)
UCHL1, UCHL3 cleave ubiquitin adducts (Plasmodium falciparum)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)
H2O [cytosol]
Ub-specific processing proteases (Plasmodium falciparum)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Plasmodium falciparum)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Plasmodium falciparum)
Hypusine synthesis from eIF5A-lysine (Plasmodium falciparum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)
H2O [cytosol]
Neddylation (Plasmodium falciparum)
UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Plasmodium falciparum)
Synthesis of glycosylphosphatidylinositol (GPI) (Plasmodium falciparum)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)
H2O [cytosol]
Surfactant metabolism (Plasmodium falciparum)
ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)
H2O [cytosol]
Translation (Plasmodium falciparum)
Eukaryotic Translation Termination (Plasmodium falciparum)
APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)
H2O [cytosol]
tRNA Aminoacylation (Plasmodium falciparum)
Cytosolic tRNA aminoacylation (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
H2O [cytosol]
Sensory Perception (Plasmodium falciparum)
Visual phototransduction (Plasmodium falciparum)
The canonical retinoid cycle in rods (twilight vision) (Plasmodium falciparum)
ABCA4 mediates atRAL transport (Plasmodium falciparum)
H2O [cytosol]
Signal Transduction (Plasmodium falciparum)
Intracellular signaling by second messengers (Plasmodium falciparum)
DAG and IP3 signaling (Plasmodium falciparum)
CaM pathway (Plasmodium falciparum)
Calmodulin induced events (Plasmodium falciparum)
Cam-PDE 1 activation (Plasmodium falciparum)
cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)
H2O [cytosol]
MAPK family signaling cascades (Plasmodium falciparum)
MAPK1/MAPK3 signaling (Plasmodium falciparum)
RAF-independent MAPK1/3 activation (Plasmodium falciparum)
Cytosolic DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
H2O [cytosol]
RAF/MAP kinase cascade (Plasmodium falciparum)
Negative regulation of MAPK pathway (Plasmodium falciparum)
Cytosolic DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Plasmodium falciparum)
H2O [cytosol]
Signaling by GPCR (Plasmodium falciparum)
GPCR downstream signalling (Plasmodium falciparum)
G alpha (i) signalling events (Plasmodium falciparum)
Opioid Signalling (Plasmodium falciparum)
DARPP-32 events (Plasmodium falciparum)
PDE4A,C,D hydrolyse cAMP (Plasmodium falciparum)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Plasmodium falciparum)
H2O [cytosol]
G-protein mediated events (Plasmodium falciparum)
PLC beta mediated events (Plasmodium falciparum)
Ca-dependent events (Plasmodium falciparum)
CaM pathway (Plasmodium falciparum)
Calmodulin induced events (Plasmodium falciparum)
Cam-PDE 1 activation (Plasmodium falciparum)
cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)
H2O [cytosol]
G alpha (q) signalling events (Plasmodium falciparum)
Effects of PIP2 hydrolysis (Plasmodium falciparum)
Arachidonate production from DAG (Plasmodium falciparum)
2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)
H2O [cytosol]
G alpha (s) signalling events (Plasmodium falciparum)
PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Plasmodium falciparum)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Plasmodium falciparum)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Plasmodium falciparum)
Signaling by Insulin receptor (Plasmodium falciparum)
Insulin receptor signalling cascade (Plasmodium falciparum)
IRS-mediated signalling (Plasmodium falciparum)
PI3K Cascade (Plasmodium falciparum)
PKB-mediated events (Plasmodium falciparum)
PDE3B signalling (Plasmodium falciparum)
p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Plasmodium falciparum)
IGF1R signaling cascade (Plasmodium falciparum)
IRS-related events triggered by IGF1R (Plasmodium falciparum)
IRS-mediated signalling (Plasmodium falciparum)
PI3K Cascade (Plasmodium falciparum)
PKB-mediated events (Plasmodium falciparum)
PDE3B signalling (Plasmodium falciparum)
p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
H2O [cytosol]
Transport of small molecules (Plasmodium falciparum)
ABC-family proteins mediated transport (Plasmodium falciparum)
ABC transporters in lipid homeostasis (Plasmodium falciparum)
ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)
H2O [cytosol]
ABCAs mediate lipid efflux (Plasmodium falciparum)
H2O [cytosol]
ABCAs mediate lipid influx (Plasmodium falciparum)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
ABCA4 mediates atRAL transport (Plasmodium falciparum)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
HCO3- transport through ion channel (Plasmodium falciparum)
H2O [cytosol]
Mitochondrial ABC transporters (Plasmodium falciparum)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Plasmodium falciparum)
H2O [cytosol]
The ABCC family mediates organic anion transport (Plasmodium falciparum)
H2O [cytosol]
Aquaporin-mediated transport (Plasmodium falciparum)
Passive transport by Aquaporins (Plasmodium falciparum)
Aquaporins passively transport water into cells (Plasmodium falciparum)
H2O [cytosol]
Aquaporins passively transport water out of cells (Plasmodium falciparum)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Plasmodium falciparum)
Aquaporin-1 passively transports water into cell (Plasmodium falciparum)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Plasmodium falciparum)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Plasmodium falciparum)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)
H2O [cytosol]
Ion channel transport (Plasmodium falciparum)
Ion transport by P-type ATPases (Plasmodium falciparum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Plasmodium falciparum)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Plasmodium falciparum)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)
H2O [cytosol]
Iron uptake and transport (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
H2O [cytosol]
Transferrin endocytosis and recycling (Plasmodium falciparum)
Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Plasmodium falciparum)
Erythrocytes take up carbon dioxide and release oxygen (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Plasmodium falciparum)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Plasmodium falciparum)
H2O [cytosol]
Vesicle-mediated transport (Plasmodium falciparum)
Membrane Trafficking (Plasmodium falciparum)
Rab regulation of trafficking (Plasmodium falciparum)
TBC/RABGAPs (Plasmodium falciparum)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
H2O [cytosol]
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
Selective autophagy (Rattus norvegicus)
Pexophagy (Rattus norvegicus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
H2O [cytosol]
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
M Phase (Rattus norvegicus)
Mitotic Metaphase and Anaphase (Rattus norvegicus)
Mitotic Anaphase (Rattus norvegicus)
Nuclear Envelope (NE) Reassembly (Rattus norvegicus)
Initiation of Nuclear Envelope (NE) Reformation (Rattus norvegicus)
ANKLE2 is deacetylated by SIRT2 (Rattus norvegicus)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Rattus norvegicus)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Rattus norvegicus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Rattus norvegicus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)
H2O [cytosol]
Mitotic Prometaphase (Rattus norvegicus)
Condensation of Prometaphase Chromosomes (Rattus norvegicus)
Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Rattus norvegicus)
H2O [cytosol]
Mitotic G2-G2/M phases (Rattus norvegicus)
G2/M Transition (Rattus norvegicus)
Cyclin A/B1/B2 associated events during G2/M transition (Rattus norvegicus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)
H2O [cytosol]
Regulation of mitotic cell cycle (Rattus norvegicus)
APC/C-mediated degradation of cell cycle proteins (Rattus norvegicus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Rattus norvegicus)
Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)
H2O [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
Cytoprotection by HMOX1 (Rattus norvegicus)
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Rattus norvegicus)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Rattus norvegicus)
H2O [cytosol]
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Rattus norvegicus)
Nuclear events mediated by NFE2L2 (Rattus norvegicus)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Rattus norvegicus)
PRDX1 overoxidizes (Rattus norvegicus)
H2O [cytosol]
Cellular response to heat stress (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)
H2O [cytosol]
Chromatin organization (Rattus norvegicus)
Chromatin modifying enzymes (Rattus norvegicus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)
H2O [cytosol]
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPHB-mediated forward signaling (Rattus norvegicus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)
H2O [cytosol]
L1CAM interactions (Rattus norvegicus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Rattus norvegicus)
H2O [cytosol]
Semaphorin interactions (Rattus norvegicus)
Sema4D in semaphorin signaling (Rattus norvegicus)
Sema4D mediated inhibition of cell attachment and migration (Rattus norvegicus)
Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)
H2O [cytosol]
Signaling by ROBO receptors (Rattus norvegicus)
SLIT2:ROBO1 increases RHOA activity (Rattus norvegicus)
MYO9B inactivates RHOA (Rattus norvegicus)
H2O [cytosol]
Drug ADME (Rattus norvegicus)
Aspirin ADME (Rattus norvegicus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)
H2O [cytosol]
Atorvastatin ADME (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
H2O [cytosol]
Azathioprine ADME (Rattus norvegicus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Rattus norvegicus)
H2O [cytosol]
Ciprofloxacin ADME (Rattus norvegicus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Rattus norvegicus)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Rattus norvegicus)
H2O [cytosol]
Paracetamol ADME (Rattus norvegicus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Rattus norvegicus)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Rattus norvegicus)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Rattus norvegicus)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Rattus norvegicus)
H2O [cytosol]
Prednisone ADME (Rattus norvegicus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)
H2O [cytosol]
Ribavirin ADME (Rattus norvegicus)
ADA deamidates RBV (Rattus norvegicus)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Rattus norvegicus)
H2O [cytosol]
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
H2O [cytosol]
PRDX1 overoxidizes (Rattus norvegicus)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Rattus norvegicus)
H2O [cytosol]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Effects of PIP2 hydrolysis (Rattus norvegicus)
Arachidonate production from DAG (Rattus norvegicus)
2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Rattus norvegicus)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
ABCC4 accumulation of dense granule contents (Rattus norvegicus)
H2O [cytosol]
Platelet homeostasis (Rattus norvegicus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)
H2O [cytosol]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Rattus norvegicus)
Disassembly of COPII coated vesicle (Rattus norvegicus)
H2O [cytosol]
Transport of Antigen peptide in to ER (Rattus norvegicus)
H2O [cytosol]
Costimulation by the CD28 family (Rattus norvegicus)
CTLA4 inhibitory signaling (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
H2O [cytosol]
MHC class II antigen presentation (Rattus norvegicus)
Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)
H2O [cytosol]
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
H2O [cytosol]
Generation of second messenger molecules (Rattus norvegicus)
PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Rattus norvegicus)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Rattus norvegicus)
PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
H2O [cytosol]
Cytokine Signaling in Immune system (Rattus norvegicus)
Growth hormone receptor signaling (Rattus norvegicus)
PTP1B dephosphorylates GHR (Rattus norvegicus)
H2O [cytosol]
Interferon Signaling (Rattus norvegicus)
Antiviral mechanism by IFN-stimulated genes (Rattus norvegicus)
OAS antiviral response (Rattus norvegicus)
PDE12 cleaves 2'-5' oligoadenylates (Rattus norvegicus)
H2O [cytosol]
Interferon alpha/beta signaling (Rattus norvegicus)
Regulation of IFNA/IFNB signaling (Rattus norvegicus)
Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
H2O [cytosol]
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Innate Immune System (Rattus norvegicus)
Antimicrobial peptides (Rattus norvegicus)
Ion influx/efflux at host-pathogen interface (Rattus norvegicus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)
H2O [cytosol]
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
CLEC7A (Dectin-1) induces NFAT activation (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Role of phospholipids in phagocytosis (Rattus norvegicus)
Conversion of PA into DAG by PAP-1 (Rattus norvegicus)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Rattus norvegicus)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Rattus norvegicus)
H2O [cytosol]
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
H2O [cytosol]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Pyruvate metabolism (Rattus norvegicus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)
H2O [cytosol]
Regulation of pyruvate metabolism (Rattus norvegicus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Rattus norvegicus)
H2O [cytosol]
Biological oxidations (Rattus norvegicus)
Aflatoxin activation and detoxification (Rattus norvegicus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
H2O [cytosol]
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)
H2O [cytosol]
Phase I - Functionalization of compounds (Rattus norvegicus)
AADAC deacetylates PHEN (Rattus norvegicus)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)
H2O [cytosol]
Amine Oxidase reactions (Rattus norvegicus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Rattus norvegicus)
MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Rattus norvegicus)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Rattus norvegicus)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Rattus norvegicus)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Rattus norvegicus)
Eicosanoids (Rattus norvegicus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)
H2O [cytosol]
Endogenous sterols (Rattus norvegicus)
CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Rattus norvegicus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
H2O [cytosol]
Vitamins (Rattus norvegicus)
CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)
H2O [cytosol]
Ethanol oxidation (Rattus norvegicus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)
H2O [cytosol]
Phase II - Conjugation of compounds (Rattus norvegicus)
Cytosolic sulfonation of small molecules (Rattus norvegicus)
ABHD14B hydrolyses PNPB (Rattus norvegicus)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)
H2O [cytosol]
Glucuronidation (Rattus norvegicus)
Formation of the active cofactor, UDP-glucuronate (Rattus norvegicus)
UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)
H2O [cytosol]
Glutathione conjugation (Rattus norvegicus)
Glutathione synthesis and recycling (Rattus norvegicus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Rattus norvegicus)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
H2O [cytosol]
Methylation (Rattus norvegicus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)
H2O [cytosol]
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IP2, IP, and Ins in the cytosol (Rattus norvegicus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Rattus norvegicus)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Rattus norvegicus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Rattus norvegicus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)
H2O [cytosol]
Integration of energy metabolism (Rattus norvegicus)
Regulation of insulin secretion (Rattus norvegicus)
Acetylcholine regulates insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Rattus norvegicus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
H2O [cytosol]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Aspartate and asparagine metabolism (Rattus norvegicus)
ASPA deacetylates NAA to acetate and L-aspartate (Rattus norvegicus)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)
H2O [cytosol]
Carnitine synthesis (Rattus norvegicus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)
H2O [cytosol]
Histidine catabolism (Rattus norvegicus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Rattus norvegicus)
H2O [cytosol]
Metabolism of polyamines (Rattus norvegicus)
Agmatine biosynthesis (Rattus norvegicus)
Agmatine + H2O <=> putrescine + urea (Rattus norvegicus)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Phenylalanine metabolism (Rattus norvegicus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)
H2O [cytosol]
Tyrosine catabolism (Rattus norvegicus)
FAH cleaves 4FAA (Rattus norvegicus)
H2O [cytosol]
Selenoamino acid metabolism (Rattus norvegicus)
Metabolism of ingested MeSeO2H into MeSeH (Rattus norvegicus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)
H2O [cytosol]
MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)
H2O [cytosol]
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Rattus norvegicus)
SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)
H2O [cytosol]
Selenocysteine synthesis (Rattus norvegicus)
SEPHS2 phosphorylates H2Se to form SELP (Rattus norvegicus)
H2O [cytosol]
Serine biosynthesis (Rattus norvegicus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)
H2O [cytosol]
Sulfur amino acid metabolism (Rattus norvegicus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)
H2O [cytosol]
Cysteine formation from homocysteine (Rattus norvegicus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)
H2O [cytosol]
Degradation of cysteine and homocysteine (Rattus norvegicus)
Cysteine is degraded to serine and H2S (Rattus norvegicus)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
H2O [cytosol]
Methionine salvage pathway (Rattus norvegicus)
Acireductone is created (Rattus norvegicus)
H2O [cytosol]
Threonine catabolism (Rattus norvegicus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Rattus norvegicus)
H2O [cytosol]
Tryptophan catabolism (Rattus norvegicus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)
H2O [cytosol]
Urea cycle (Rattus norvegicus)
arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)
H2O [cytosol]
Metabolism of carbohydrates (Rattus norvegicus)
Fructose metabolism (Rattus norvegicus)
Fructose catabolism (Rattus norvegicus)
ALDH1A1 oxidises GA to DGA (Rattus norvegicus)
H2O [cytosol]
Glucose metabolism (Rattus norvegicus)
Gluconeogenesis (Rattus norvegicus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Rattus norvegicus)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Rattus norvegicus)
H2O [cytosol]
Glycolysis (Rattus norvegicus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Rattus norvegicus)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Rattus norvegicus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)
H2O [cytosol]
Glycogen metabolism (Rattus norvegicus)
Glycogen synthesis (Rattus norvegicus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Rattus norvegicus)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Rattus norvegicus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Rattus norvegicus)
H2O [cytosol]
Pentose phosphate pathway (Rattus norvegicus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)
H2O [cytosol]
Metabolism of lipids (Rattus norvegicus)
Biosynthesis of specialized proresolving mediators (SPMs) (Rattus norvegicus)
Biosynthesis of DHA-derived SPMs (Rattus norvegicus)
Biosynthesis of D-series resolvins (Rattus norvegicus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Rattus norvegicus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Rattus norvegicus)
H2O [cytosol]
Biosynthesis of maresins (Rattus norvegicus)
Biosynthesis of maresin-like SPMs (Rattus norvegicus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)
H2O [cytosol]
Biosynthesis of protectins (Rattus norvegicus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Rattus norvegicus)
Biosynthesis of E-series 18(R)-resolvins (Rattus norvegicus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Rattus norvegicus)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Rattus norvegicus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Rattus norvegicus)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Rattus norvegicus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)
H2O [cytosol]
Fatty acid metabolism (Rattus norvegicus)
Arachidonic acid metabolism (Rattus norvegicus)
FAAH hydrolyses AEA to AA and ETA (Rattus norvegicus)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Rattus norvegicus)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Rattus norvegicus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Rattus norvegicus)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Rattus norvegicus)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)
H2O [cytosol]
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Rattus norvegicus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Rattus norvegicus)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Rattus norvegicus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Rattus norvegicus)
SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Rattus norvegicus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Rattus norvegicus)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Rattus norvegicus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)
H2O [cytosol]
Metabolism of steroids (Rattus norvegicus)
Bile acid and bile salt metabolism (Rattus norvegicus)
Recycling of bile acids and salts (Rattus norvegicus)
ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
H2O [cytosol]
Synthesis of bile acids and bile salts (Rattus norvegicus)
CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
H2O [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Rattus norvegicus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Rattus norvegicus)
27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Rattus norvegicus)
ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
H2O [cytosol]
Cholesterol biosynthesis (Rattus norvegicus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Rattus norvegicus)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Rattus norvegicus)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Rattus norvegicus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Rattus norvegicus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)
H2O [cytosol]
Squalene is oxidized to its epoxide (Rattus norvegicus)
H2O [cytosol]
Metabolism of steroid hormones (Rattus norvegicus)
Androgen biosynthesis (Rattus norvegicus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)
H2O [cytosol]
Estrogen biosynthesis (Rattus norvegicus)
CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)
H2O [cytosol]
Glucocorticoid biosynthesis (Rattus norvegicus)
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Rattus norvegicus)
H2O [cytosol]
Mineralocorticoid biosynthesis (Rattus norvegicus)
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)
H2O [cytosol]
Phospholipid metabolism (Rattus norvegicus)
Glycerophospholipid biosynthesis (Rattus norvegicus)
Acyl chain remodeling of DAG and TAG (Rattus norvegicus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)
H2O [cytosol]
Acyl chain remodelling of PC (Rattus norvegicus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Rattus norvegicus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Rattus norvegicus)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Rattus norvegicus)
H2O [cytosol]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)
H2O [cytosol]
Acyl chain remodelling of PE (Rattus norvegicus)
ABHD4 hydrolyses NAPE (Rattus norvegicus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)
H2O [cytosol]
Acyl chain remodelling of PG (Rattus norvegicus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Rattus norvegicus)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Rattus norvegicus)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Rattus norvegicus)
H2O [cytosol]
Acyl chain remodelling of PI (Rattus norvegicus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)
H2O [cytosol]
Acyl chain remodelling of PS (Rattus norvegicus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)
H2O [cytosol]
Hydrolysis of LPC (Rattus norvegicus)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)
H2O [cytosol]
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)
H2O [cytosol]
Hydrolysis of LPE (Rattus norvegicus)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)
H2O [cytosol]
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)
H2O [cytosol]
Synthesis of PA (Rattus norvegicus)
DDHD1,2 hydrolyse PA (Rattus norvegicus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Rattus norvegicus)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Rattus norvegicus)
H2O [cytosol]
Synthesis of PC (Rattus norvegicus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Rattus norvegicus)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)
H2O [cytosol]
Synthesis of PE (Rattus norvegicus)
PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Rattus norvegicus)
H2O [cytosol]
PI Metabolism (Rattus norvegicus)
Glycerophospholipid catabolism (Rattus norvegicus)
GDE1 hydrolyzes GroPIns (Rattus norvegicus)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
H2O [cytosol]
Sphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid catabolism (Rattus norvegicus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Rattus norvegicus)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Rattus norvegicus)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Rattus norvegicus)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Rattus norvegicus)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Rattus norvegicus)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Rattus norvegicus)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Rattus norvegicus)
H2O [cytosol]
Sphingolipid catabolism (Rattus norvegicus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Rattus norvegicus)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Rattus norvegicus)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Rattus norvegicus)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Rattus norvegicus)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Rattus norvegicus)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Rattus norvegicus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Rattus norvegicus)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Rattus norvegicus)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Rattus norvegicus)
H2O [cytosol]
Triglyceride metabolism (Rattus norvegicus)
Triglyceride biosynthesis (Rattus norvegicus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)
H2O [cytosol]
Triglyceride catabolism (Rattus norvegicus)
PNPLA4 hydrolyzes TAG (Rattus norvegicus)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Rattus norvegicus)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Rattus norvegicus)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
eNOS activation (Rattus norvegicus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)
H2O [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Interconversion of nucleotide di- and triphosphates (Rattus norvegicus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)
H2O [cytosol]
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
H2O [cytosol]
FAICAR => IMP + H2O (Rattus norvegicus)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
H2O [cytosol]
Pyrimidine biosynthesis (Rattus norvegicus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)
H2O [cytosol]
Nucleotide catabolism (Rattus norvegicus)
Purine catabolism (Rattus norvegicus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Rattus norvegicus)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Rattus norvegicus)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Rattus norvegicus)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Rattus norvegicus)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Rattus norvegicus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Rattus norvegicus)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Rattus norvegicus)
H2O [cytosol]
Pyrimidine catabolism (Rattus norvegicus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Rattus norvegicus)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)
H2O [cytosol]
Nucleotide salvage (Rattus norvegicus)
Purine salvage (Rattus norvegicus)
ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Rattus norvegicus)
H2O [cytosol]
Pyrimidine salvage (Rattus norvegicus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)
H2O [cytosol]
Metabolism of porphyrins (Rattus norvegicus)
Heme biosynthesis (Rattus norvegicus)
4 PBGs bind to form HMB (Rattus norvegicus)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)
H2O [cytosol]
UROS transforms HMB to URO3 (Rattus norvegicus)
H2O [cytosol]
Heme degradation (Rattus norvegicus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
H2O [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Rattus norvegicus)
Transport of RCbl within the body (Rattus norvegicus)
ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)
H2O [cytosol]
Metabolism of folate and pterines (Rattus norvegicus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Rattus norvegicus)
Cyclisation of GTP to precursor Z (Rattus norvegicus)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)
H2O [cytosol]
Nicotinate metabolism (Rattus norvegicus)
NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Rattus norvegicus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Rattus norvegicus)
2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Rattus norvegicus)
PANK4 hydrolyzes PPANT to pantetheine (Rattus norvegicus)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Rattus norvegicus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Rattus norvegicus)
H2O [cytosol]
Pyrophosphate hydrolysis (Rattus norvegicus)
LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
H2O [cytosol]
Reversible hydration of carbon dioxide (Rattus norvegicus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)
H2O [cytosol]
Metabolism of RNA (Rattus norvegicus)
Deadenylation-dependent mRNA decay (Rattus norvegicus)
Deadenylation of mRNA (Rattus norvegicus)
PAN2-PAN3 complex partially deadenylates mRNA (Rattus norvegicus)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Rattus norvegicus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Rattus norvegicus)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Rattus norvegicus)
DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)
H2O [cytosol]
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Rattus norvegicus)
Synthesis of substrates in N-glycan biosythesis (Rattus norvegicus)
GDP-fucose biosynthesis (Rattus norvegicus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Rattus norvegicus)
H2O [cytosol]
Sialic acid metabolism (Rattus norvegicus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Rattus norvegicus)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Rattus norvegicus)
DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Rattus norvegicus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Rattus norvegicus)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Rattus norvegicus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Rattus norvegicus)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Rattus norvegicus)
ER to Golgi Anterograde Transport (Rattus norvegicus)
COPII-mediated vesicle transport (Rattus norvegicus)
PP6 dephosphorylates SEC24 (Rattus norvegicus)
H2O [cytosol]
Deubiquitination (Rattus norvegicus)
Josephin domain DUBs (Rattus norvegicus)
ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)
H2O [cytosol]
ATXN3 family cleave Ub chains (Rattus norvegicus)
H2O [cytosol]
Metalloprotease DUBs (Rattus norvegicus)
BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)
H2O [cytosol]
Ovarian tumor domain proteases (Rattus norvegicus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Rattus norvegicus)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)
H2O [cytosol]
UCH proteinases (Rattus norvegicus)
UCHL1, UCHL3 cleave ubiquitin adducts (Rattus norvegicus)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)
H2O [cytosol]
Ub-specific processing proteases (Rattus norvegicus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Rattus norvegicus)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Rattus norvegicus)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Rattus norvegicus)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Rattus norvegicus)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Rattus norvegicus)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)
H2O [cytosol]
USP5 cleaves polyubiquitin (Rattus norvegicus)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Rattus norvegicus)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Rattus norvegicus)
Hypusine synthesis from eIF5A-lysine (Rattus norvegicus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)
H2O [cytosol]
Neddylation (Rattus norvegicus)
UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Rattus norvegicus)
Synthesis of glycosylphosphatidylinositol (GPI) (Rattus norvegicus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)
H2O [cytosol]
Surfactant metabolism (Rattus norvegicus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)
H2O [cytosol]
Translation (Rattus norvegicus)
Eukaryotic Translation Termination (Rattus norvegicus)
APEH hydrolyses NAc-Ser-protein (Rattus norvegicus)
H2O [cytosol]
tRNA Aminoacylation (Rattus norvegicus)
Cytosolic tRNA aminoacylation (Rattus norvegicus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
H2O [cytosol]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Ion homeostasis (Rattus norvegicus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)
H2O [cytosol]
Physiological factors (Rattus norvegicus)
CES1 hydrolyses sacubitril to sacubitrilat (Rattus norvegicus)
H2O [cytosol]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter clearance (Rattus norvegicus)
Dopamine clearance from the synaptic cleft (Rattus norvegicus)
Enzymatic degradation of Dopamine by monoamine oxidase (Rattus norvegicus)
MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Rattus norvegicus)
MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Rattus norvegicus)
Metabolism of serotonin (Rattus norvegicus)
MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
H2O [cytosol]
Neurotransmitter release cycle (Rattus norvegicus)
Norepinephrine Neurotransmitter Release Cycle (Rattus norvegicus)
Catabolism of Noradrenaline (Rattus norvegicus)
H2O [cytosol]
Organelle biogenesis and maintenance (Rattus norvegicus)
Cilium Assembly (Rattus norvegicus)
Cargo trafficking to the periciliary membrane (Rattus norvegicus)
VxPx cargo-targeting to cilium (Rattus norvegicus)
ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)
H2O [cytosol]
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Intrinsic Pathway for Apoptosis (Rattus norvegicus)
Activation of BH3-only proteins (Rattus norvegicus)
Activation of BAD and translocation to mitochondria (Rattus norvegicus)
Activation of BAD by calcineurin (Rattus norvegicus)
H2O [cytosol]
Sensory Perception (Rattus norvegicus)
Visual phototransduction (Rattus norvegicus)
The canonical retinoid cycle in rods (twilight vision) (Rattus norvegicus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Rattus norvegicus)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)
H2O [cytosol]
The phototransduction cascade (Rattus norvegicus)
Activation of the phototransduction cascade (Rattus norvegicus)
PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Rattus norvegicus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Rattus norvegicus)
OPN1LW binds 11cRAL (Rattus norvegicus)
H2O [cytosol]
OPN1MW binds 11cRAL (Rattus norvegicus)
H2O [cytosol]
OPN1SW binds 11cRAL (Rattus norvegicus)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)
H2O [cytosol]
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
H2O [cytosol]
Intracellular signaling by second messengers (Rattus norvegicus)
DAG and IP3 signaling (Rattus norvegicus)
CaM pathway (Rattus norvegicus)
Calmodulin induced events (Rattus norvegicus)
Cam-PDE 1 activation (Rattus norvegicus)
cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)
H2O [cytosol]
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)
H2O [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Rattus norvegicus)
H2O [cytosol]
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN stability and activity (Rattus norvegicus)
USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)
H2O [cytosol]
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF-independent MAPK1/3 activation (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)
H2O [cytosol]
RAF/MAP kinase cascade (Rattus norvegicus)
Negative regulation of MAPK pathway (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Rattus norvegicus)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)
H2O [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)
H2O [cytosol]
RAF activation (Rattus norvegicus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Rattus norvegicus)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Rattus norvegicus)
H2O [cytosol]
RAS processing (Rattus norvegicus)
RAS proteins are depalmitoylated (Rattus norvegicus)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Rattus norvegicus)
H2O [cytosol]
MTOR signalling (Rattus norvegicus)
Energy dependent regulation of mTOR by LKB1-AMPK (Rattus norvegicus)
AMPK is dephosphorylated (Rattus norvegicus)
H2O [cytosol]
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
DARPP-32 events (Rattus norvegicus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Rattus norvegicus)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)
H2O [cytosol]
G-protein mediated events (Rattus norvegicus)
PLC beta mediated events (Rattus norvegicus)
Ca-dependent events (Rattus norvegicus)
CaM pathway (Rattus norvegicus)
Calmodulin induced events (Rattus norvegicus)
Cam-PDE 1 activation (Rattus norvegicus)
cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)
H2O [cytosol]
phospho-PLA2 pathway (Rattus norvegicus)
Hydrolysis of phosphatidylcholine (Rattus norvegicus)
H2O [cytosol]
Inactivation of PLC beta (Rattus norvegicus)
H2O [cytosol]
PIP2 hydrolysis (Rattus norvegicus)
H2O [cytosol]
G alpha (q) signalling events (Rattus norvegicus)
Effects of PIP2 hydrolysis (Rattus norvegicus)
Arachidonate production from DAG (Rattus norvegicus)
2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Rattus norvegicus)
H2O [cytosol]
G alpha (s) signalling events (Rattus norvegicus)
PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Rattus norvegicus)
H2O [cytosol]
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog ligand biogenesis (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)
H2O [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PTK6 (Rattus norvegicus)
PTK6 Down-Regulation (Rattus norvegicus)
PTPN1 dephosphorylates PTK6 (Rattus norvegicus)
H2O [cytosol]
Signaling by Nuclear Receptors (Rattus norvegicus)
Signaling by Retinoic Acid (Rattus norvegicus)
RA biosynthesis pathway (Rattus norvegicus)
ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Rattus norvegicus)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
MDK and PTN in ALK signaling (Rattus norvegicus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
H2O [cytosol]
Signaling by EGFR (Rattus norvegicus)
EGFR downregulation (Rattus norvegicus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Rattus norvegicus)
H2O [cytosol]
PTPN3 dephosphorylates EPS15 (Rattus norvegicus)
H2O [cytosol]
GAB1 signalosome (Rattus norvegicus)
Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
H2O [cytosol]
Signaling by ERBB2 (Rattus norvegicus)
Downregulation of ERBB2 signaling (Rattus norvegicus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)
H2O [cytosol]
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor recycling (Rattus norvegicus)
Insulin receptor de-phosphorylation (Rattus norvegicus)
H2O [cytosol]
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PKB-mediated events (Rattus norvegicus)
PDE3B signalling (Rattus norvegicus)
p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
H2O [cytosol]
Signaling by MET (Rattus norvegicus)
Negative regulation of MET activity (Rattus norvegicus)
PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)
H2O [cytosol]
PTPRJ dephosphorylates MET (Rattus norvegicus)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Rattus norvegicus)
H2O [cytosol]
Signaling by PDGF (Rattus norvegicus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PKB-mediated events (Rattus norvegicus)
PDE3B signalling (Rattus norvegicus)
p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Miro GTPase Cycle (Rattus norvegicus)
RHOT2 GTPase cycle (Rattus norvegicus)
RHOT2 hydrolyzes GTP (Rattus norvegicus)
H2O [cytosol]
RHOBTB3 ATPase cycle (Rattus norvegicus)
RHOBTB3 hydrolyzes ATP (Rattus norvegicus)
H2O [cytosol]
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate Formins (Rattus norvegicus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)
H2O [cytosol]
RHO GTPase cycle (Rattus norvegicus)
CDC42 GTPase cycle (Rattus norvegicus)
CDC42 GAPs stimulate CDC42 GTPase activity (Rattus norvegicus)
H2O [cytosol]
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)
H2O [cytosol]
RAC2 GTPase cycle (Rattus norvegicus)
RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)
H2O [cytosol]
RHOA GTPase cycle (Rattus norvegicus)
RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)
H2O [cytosol]
RHOB GTPase cycle (Rattus norvegicus)
RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)
H2O [cytosol]
RHOD GTPase cycle (Rattus norvegicus)
RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)
H2O [cytosol]
RHOF GTPase cycle (Rattus norvegicus)
RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)
H2O [cytosol]
RHOG GTPase cycle (Rattus norvegicus)
RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)
H2O [cytosol]
RHOJ GTPase cycle (Rattus norvegicus)
RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)
H2O [cytosol]
RHOQ GTPase cycle (Rattus norvegicus)
RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)
H2O [cytosol]
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
TGF-beta receptor signaling activates SMADs (Rattus norvegicus)
Downregulation of TGF-beta receptor signaling (Rattus norvegicus)
MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)
H2O [cytosol]
Signaling by WNT (Rattus norvegicus)
Beta-catenin independent WNT signaling (Rattus norvegicus)
Ca2+ pathway (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)
H2O [cytosol]
TCF dependent signaling in response to WNT (Rattus norvegicus)
Regulation of FZD by ubiquitination (Rattus norvegicus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)
H2O [cytosol]
Transport of small molecules (Rattus norvegicus)
ABC-family proteins mediated transport (Rattus norvegicus)
ABC transporters in lipid homeostasis (Rattus norvegicus)
ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)
H2O [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)
H2O [cytosol]
ABCAs mediate lipid efflux (Rattus norvegicus)
H2O [cytosol]
ABCAs mediate lipid influx (Rattus norvegicus)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Rattus norvegicus)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
HCO3- transport through ion channel (Rattus norvegicus)
H2O [cytosol]
Mitochondrial ABC transporters (Rattus norvegicus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)
H2O [cytosol]
The ABCC family mediates organic anion transport (Rattus norvegicus)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)
H2O [cytosol]
Aquaporin-mediated transport (Rattus norvegicus)
Passive transport by Aquaporins (Rattus norvegicus)
Aquaporins passively transport water into cells (Rattus norvegicus)
H2O [cytosol]
Aquaporins passively transport water out of cells (Rattus norvegicus)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Rattus norvegicus)
Aquaporin-1 passively transports water into cell (Rattus norvegicus)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Rattus norvegicus)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Rattus norvegicus)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Rattus norvegicus)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Rattus norvegicus)
H2O [cytosol]
Ion channel transport (Rattus norvegicus)
Ion transport by P-type ATPases (Rattus norvegicus)
ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)
H2O [cytosol]
Iron uptake and transport (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
H2O [cytosol]
Transferrin endocytosis and recycling (Rattus norvegicus)
Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Rattus norvegicus)
Erythrocytes take up carbon dioxide and release oxygen (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Rattus norvegicus)
Plasma lipoprotein assembly (Rattus norvegicus)
HDL assembly (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
H2O [cytosol]
Plasma lipoprotein clearance (Rattus norvegicus)
LDL clearance (Rattus norvegicus)
NCEH1 hydrolyzes cholesterol esters (Rattus norvegicus)
H2O [cytosol]
Plasma lipoprotein remodeling (Rattus norvegicus)
HDL remodeling (Rattus norvegicus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)
H2O [cytosol]
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
H2O [cytosol]
ER to Golgi Anterograde Transport (Rattus norvegicus)
COPII-mediated vesicle transport (Rattus norvegicus)
PP6 dephosphorylates SEC24 (Rattus norvegicus)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Rattus norvegicus)
Golgi-to-ER retrograde transport (Rattus norvegicus)
COPI-independent Golgi-to-ER retrograde traffic (Rattus norvegicus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)
H2O [cytosol]
Rab regulation of trafficking (Rattus norvegicus)
TBC/RABGAPs (Rattus norvegicus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
H2O [cytosol]
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
M Phase (Saccharomyces cerevisiae)
Mitotic Metaphase and Anaphase (Saccharomyces cerevisiae)
Mitotic Anaphase (Saccharomyces cerevisiae)
Nuclear Envelope (NE) Reassembly (Saccharomyces cerevisiae)
Postmitotic nuclear pore complex (NPC) reformation (Saccharomyces cerevisiae)
RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)
H2O [cytosol]
Mitotic Prometaphase (Saccharomyces cerevisiae)
Condensation of Prometaphase Chromosomes (Saccharomyces cerevisiae)
Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Saccharomyces cerevisiae)
PPP1CC dephosphorylates PLK1 (Saccharomyces cerevisiae)
H2O [cytosol]
Regulation of mitotic cell cycle (Saccharomyces cerevisiae)
APC/C-mediated degradation of cell cycle proteins (Saccharomyces cerevisiae)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Saccharomyces cerevisiae)
Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)
H2O [cytosol]
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
Detoxification of Reactive Oxygen Species (Saccharomyces cerevisiae)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Saccharomyces cerevisiae)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Saccharomyces cerevisiae)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
Nuclear events mediated by NFE2L2 (Saccharomyces cerevisiae)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Saccharomyces cerevisiae)
PRDX1 overoxidizes (Saccharomyces cerevisiae)
H2O [cytosol]
Cellular response to heat stress (Saccharomyces cerevisiae)
Regulation of HSF1-mediated heat shock response (Saccharomyces cerevisiae)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
Drug ADME (Saccharomyces cerevisiae)
Aspirin ADME (Saccharomyces cerevisiae)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)
H2O [cytosol]
Azathioprine ADME (Saccharomyces cerevisiae)
GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)
H2O [cytosol]
Ciprofloxacin ADME (Saccharomyces cerevisiae)
ABCG2 transports Cipro from hepatic cell to extracellular space (Saccharomyces cerevisiae)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Saccharomyces cerevisiae)
H2O [cytosol]
Paracetamol ADME (Saccharomyces cerevisiae)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Saccharomyces cerevisiae)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)
H2O [cytosol]
Ribavirin ADME (Saccharomyces cerevisiae)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)
H2O [cytosol]
Gene expression (Transcription) (Saccharomyces cerevisiae)
RNA Polymerase II Transcription (Saccharomyces cerevisiae)
Generic Transcription Pathway (Saccharomyces cerevisiae)
Transcriptional Regulation by TP53 (Saccharomyces cerevisiae)
TP53 Regulates Metabolic Genes (Saccharomyces cerevisiae)
PRDX1 overoxidizes (Saccharomyces cerevisiae)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Saccharomyces cerevisiae)
H2O [cytosol]
Hemostasis (Saccharomyces cerevisiae)
Platelet activation, signaling and aggregation (Saccharomyces cerevisiae)
Effects of PIP2 hydrolysis (Saccharomyces cerevisiae)
Arachidonate production from DAG (Saccharomyces cerevisiae)
2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)
H2O [cytosol]
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Costimulation by the CD28 family (Saccharomyces cerevisiae)
CTLA4 inhibitory signaling (Saccharomyces cerevisiae)
Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)
H2O [cytosol]
TCR signaling (Saccharomyces cerevisiae)
Downstream TCR signaling (Saccharomyces cerevisiae)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
H2O [cytosol]
Generation of second messenger molecules (Saccharomyces cerevisiae)
PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)
H2O [cytosol]
Innate Immune System (Saccharomyces cerevisiae)
C-type lectin receptors (CLRs) (Saccharomyces cerevisiae)
CLEC7A (Dectin-1) signaling (Saccharomyces cerevisiae)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Saccharomyces cerevisiae)
Role of phospholipids in phagocytosis (Saccharomyces cerevisiae)
Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Pyruvate metabolism (Saccharomyces cerevisiae)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)
H2O [cytosol]
Biological oxidations (Saccharomyces cerevisiae)
Phase I - Functionalization of compounds (Saccharomyces cerevisiae)
ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Saccharomyces cerevisiae)
Endogenous sterols (Saccharomyces cerevisiae)
CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)
H2O [cytosol]
Ethanol oxidation (Saccharomyces cerevisiae)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)
H2O [cytosol]
Phase II - Conjugation of compounds (Saccharomyces cerevisiae)
Glutathione conjugation (Saccharomyces cerevisiae)
Glutathione synthesis and recycling (Saccharomyces cerevisiae)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Saccharomyces cerevisiae)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
H2O [cytosol]
Methylation (Saccharomyces cerevisiae)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
H2O [cytosol]
Inositol phosphate metabolism (Saccharomyces cerevisiae)
Synthesis of IP2, IP, and Ins in the cytosol (Saccharomyces cerevisiae)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Saccharomyces cerevisiae)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Saccharomyces cerevisiae)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
Integration of energy metabolism (Saccharomyces cerevisiae)
Regulation of insulin secretion (Saccharomyces cerevisiae)
Acetylcholine regulates insulin secretion (Saccharomyces cerevisiae)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Saccharomyces cerevisiae)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Saccharomyces cerevisiae)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Aspartate and asparagine metabolism (Saccharomyces cerevisiae)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Saccharomyces cerevisiae)
Phenylalanine metabolism (Saccharomyces cerevisiae)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)
H2O [cytosol]
Selenoamino acid metabolism (Saccharomyces cerevisiae)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Saccharomyces cerevisiae)
SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)
H2O [cytosol]
Serine biosynthesis (Saccharomyces cerevisiae)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Saccharomyces cerevisiae)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Saccharomyces cerevisiae)
H2O [cytosol]
Sulfur amino acid metabolism (Saccharomyces cerevisiae)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)
H2O [cytosol]
Cysteine formation from homocysteine (Saccharomyces cerevisiae)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Saccharomyces cerevisiae)
H2O [cytosol]
Degradation of cysteine and homocysteine (Saccharomyces cerevisiae)
Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Saccharomyces cerevisiae)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
H2O [cytosol]
Methionine salvage pathway (Saccharomyces cerevisiae)
Acireductone is created (Saccharomyces cerevisiae)
H2O [cytosol]
Threonine catabolism (Saccharomyces cerevisiae)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Saccharomyces cerevisiae)
H2O [cytosol]
Tryptophan catabolism (Saccharomyces cerevisiae)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)
H2O [cytosol]
Urea cycle (Saccharomyces cerevisiae)
arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Fructose metabolism (Saccharomyces cerevisiae)
Fructose catabolism (Saccharomyces cerevisiae)
ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)
H2O [cytosol]
Glucose metabolism (Saccharomyces cerevisiae)
Gluconeogenesis (Saccharomyces cerevisiae)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Saccharomyces cerevisiae)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Saccharomyces cerevisiae)
H2O [cytosol]
Glycolysis (Saccharomyces cerevisiae)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Saccharomyces cerevisiae)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Glycogen metabolism (Saccharomyces cerevisiae)
Glycogen synthesis (Saccharomyces cerevisiae)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Saccharomyces cerevisiae)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Saccharomyces cerevisiae)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Saccharomyces cerevisiae)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Saccharomyces cerevisiae)
H2O [cytosol]
Pentose phosphate pathway (Saccharomyces cerevisiae)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of lipids (Saccharomyces cerevisiae)
Biosynthesis of specialized proresolving mediators (SPMs) (Saccharomyces cerevisiae)
Biosynthesis of DHA-derived SPMs (Saccharomyces cerevisiae)
Biosynthesis of D-series resolvins (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Saccharomyces cerevisiae)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)
H2O [cytosol]
Biosynthesis of protectins (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Saccharomyces cerevisiae)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Saccharomyces cerevisiae)
Biosynthesis of E-series 18(R)-resolvins (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Saccharomyces cerevisiae)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Saccharomyces cerevisiae)
H2O [cytosol]
Fatty acid metabolism (Saccharomyces cerevisiae)
Arachidonic acid metabolism (Saccharomyces cerevisiae)
Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Saccharomyces cerevisiae)
LTA4 is hydolysed to LTB4 by LTA4H (Saccharomyces cerevisiae)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Saccharomyces cerevisiae)
SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Saccharomyces cerevisiae)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of steroids (Saccharomyces cerevisiae)
Bile acid and bile salt metabolism (Saccharomyces cerevisiae)
Recycling of bile acids and salts (Saccharomyces cerevisiae)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of bile acids and bile salts (Saccharomyces cerevisiae)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Saccharomyces cerevisiae)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
H2O [cytosol]
Cholesterol biosynthesis (Saccharomyces cerevisiae)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Saccharomyces cerevisiae)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Saccharomyces cerevisiae)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Saccharomyces cerevisiae)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)
H2O [cytosol]
Phospholipid metabolism (Saccharomyces cerevisiae)
Glycerophospholipid biosynthesis (Saccharomyces cerevisiae)
Acyl chain remodeling of DAG and TAG (Saccharomyces cerevisiae)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Saccharomyces cerevisiae)
H2O [cytosol]
Acyl chain remodelling of PC (Saccharomyces cerevisiae)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Saccharomyces cerevisiae)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Saccharomyces cerevisiae)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)
H2O [cytosol]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)
H2O [cytosol]
Acyl chain remodelling of PE (Saccharomyces cerevisiae)
ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Saccharomyces cerevisiae)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)
H2O [cytosol]
Acyl chain remodelling of PG (Saccharomyces cerevisiae)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Saccharomyces cerevisiae)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Saccharomyces cerevisiae)
H2O [cytosol]
Acyl chain remodelling of PI (Saccharomyces cerevisiae)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)
H2O [cytosol]
Acyl chain remodelling of PS (Saccharomyces cerevisiae)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Saccharomyces cerevisiae)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Saccharomyces cerevisiae)
H2O [cytosol]
Hydrolysis of LPC (Saccharomyces cerevisiae)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)
H2O [cytosol]
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)
H2O [cytosol]
Hydrolysis of LPE (Saccharomyces cerevisiae)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)
H2O [cytosol]
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PA (Saccharomyces cerevisiae)
DDHD1,2 hydrolyse PA (Saccharomyces cerevisiae)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Saccharomyces cerevisiae)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Saccharomyces cerevisiae)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PC (Saccharomyces cerevisiae)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PE (Saccharomyces cerevisiae)
PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)
H2O [cytosol]
PI Metabolism (Saccharomyces cerevisiae)
Glycerophospholipid catabolism (Saccharomyces cerevisiae)
PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Saccharomyces cerevisiae)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Saccharomyces cerevisiae)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
H2O [cytosol]
Sphingolipid metabolism (Saccharomyces cerevisiae)
Glycosphingolipid metabolism (Saccharomyces cerevisiae)
Glycosphingolipid catabolism (Saccharomyces cerevisiae)
ENPP7 hydrolyzes sphingomyelin (Saccharomyces cerevisiae)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Saccharomyces cerevisiae)
H2O [cytosol]
Sphingolipid catabolism (Saccharomyces cerevisiae)
ACER3 hydrolyzes phytoceramide (Saccharomyces cerevisiae)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Saccharomyces cerevisiae)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Saccharomyces cerevisiae)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Saccharomyces cerevisiae)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Saccharomyces cerevisiae)
H2O [cytosol]
Triglyceride metabolism (Saccharomyces cerevisiae)
Triglyceride biosynthesis (Saccharomyces cerevisiae)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of nucleotides (Saccharomyces cerevisiae)
Interconversion of nucleotide di- and triphosphates (Saccharomyces cerevisiae)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Saccharomyces cerevisiae)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Saccharomyces cerevisiae)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)
H2O [cytosol]
Nucleotide biosynthesis (Saccharomyces cerevisiae)
Purine ribonucleoside monophosphate biosynthesis (Saccharomyces cerevisiae)
FAICAR => IMP + H2O (Saccharomyces cerevisiae)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Pyrimidine biosynthesis (Saccharomyces cerevisiae)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)
H2O [cytosol]
Nucleotide catabolism (Saccharomyces cerevisiae)
Purine catabolism (Saccharomyces cerevisiae)
Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Saccharomyces cerevisiae)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Saccharomyces cerevisiae)
H2O [cytosol]
Nucleotide salvage (Saccharomyces cerevisiae)
Purine salvage (Saccharomyces cerevisiae)
AMP + H2O => IMP + NH4+ (AMPD) (Saccharomyces cerevisiae)
H2O [cytosol]
Pyrimidine salvage (Saccharomyces cerevisiae)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of porphyrins (Saccharomyces cerevisiae)
Heme biosynthesis (Saccharomyces cerevisiae)
4 PBGs bind to form HMB (Saccharomyces cerevisiae)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)
H2O [cytosol]
UROS transforms HMB to URO3 (Saccharomyces cerevisiae)
H2O [cytosol]
Heme degradation (Saccharomyces cerevisiae)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of cofactors (Saccharomyces cerevisiae)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Saccharomyces cerevisiae)
GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Saccharomyces cerevisiae)
Transport of RCbl within the body (Saccharomyces cerevisiae)
ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of folate and pterines (Saccharomyces cerevisiae)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
H2O [cytosol]
Nicotinate metabolism (Saccharomyces cerevisiae)
NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Saccharomyces cerevisiae)
2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Saccharomyces cerevisiae)
PANK4 hydrolyzes PPANT to pantetheine (Saccharomyces cerevisiae)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Saccharomyces cerevisiae)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)
H2O [cytosol]
Pyrophosphate hydrolysis (Saccharomyces cerevisiae)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of RNA (Saccharomyces cerevisiae)
Deadenylation-dependent mRNA decay (Saccharomyces cerevisiae)
Deadenylation of mRNA (Saccharomyces cerevisiae)
PAN2-PAN3 complex partially deadenylates mRNA (Saccharomyces cerevisiae)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Saccharomyces cerevisiae)
DCPS scavenges the 7-methylguanosine cap of mRNA (Saccharomyces cerevisiae)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Saccharomyces cerevisiae)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Saccharomyces cerevisiae)
DCP1-DCP2 complex decaps mRNA (Saccharomyces cerevisiae)
H2O [cytosol]
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Asparagine N-linked glycosylation (Saccharomyces cerevisiae)
Transport to the Golgi and subsequent modification (Saccharomyces cerevisiae)
ER to Golgi Anterograde Transport (Saccharomyces cerevisiae)
COPII-mediated vesicle transport (Saccharomyces cerevisiae)
PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)
H2O [cytosol]
Deubiquitination (Saccharomyces cerevisiae)
UCH proteinases (Saccharomyces cerevisiae)
UCHL1, UCHL3 cleave ubiquitin adducts (Saccharomyces cerevisiae)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)
H2O [cytosol]
Ub-specific processing proteases (Saccharomyces cerevisiae)
USP10 deubiquitinates SNX3, CFTR (Saccharomyces cerevisiae)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Saccharomyces cerevisiae)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Saccharomyces cerevisiae)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Saccharomyces cerevisiae)
Hypusine synthesis from eIF5A-lysine (Saccharomyces cerevisiae)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)
H2O [cytosol]
Neddylation (Saccharomyces cerevisiae)
UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Saccharomyces cerevisiae)
Synthesis of glycosylphosphatidylinositol (GPI) (Saccharomyces cerevisiae)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Saccharomyces cerevisiae)
H2O [cytosol]
Translation (Saccharomyces cerevisiae)
tRNA Aminoacylation (Saccharomyces cerevisiae)
Cytosolic tRNA aminoacylation (Saccharomyces cerevisiae)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)
H2O [cytosol]
Signal Transduction (Saccharomyces cerevisiae)
Intracellular signaling by second messengers (Saccharomyces cerevisiae)
PIP3 activates AKT signaling (Saccharomyces cerevisiae)
Negative regulation of the PI3K/AKT network (Saccharomyces cerevisiae)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Saccharomyces cerevisiae)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Saccharomyces cerevisiae)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
H2O [cytosol]
MAPK family signaling cascades (Saccharomyces cerevisiae)
MAPK1/MAPK3 signaling (Saccharomyces cerevisiae)
RAF/MAP kinase cascade (Saccharomyces cerevisiae)
Negative regulation of MAPK pathway (Saccharomyces cerevisiae)
PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)
H2O [cytosol]
RAS processing (Saccharomyces cerevisiae)
USP17L2 deubiquitinates RCE1 (Saccharomyces cerevisiae)
H2O [cytosol]
Signaling by GPCR (Saccharomyces cerevisiae)
GPCR downstream signalling (Saccharomyces cerevisiae)
G alpha (i) signalling events (Saccharomyces cerevisiae)
Opioid Signalling (Saccharomyces cerevisiae)
G-protein mediated events (Saccharomyces cerevisiae)
PLC beta mediated events (Saccharomyces cerevisiae)
Ca-dependent events (Saccharomyces cerevisiae)
phospho-PLA2 pathway (Saccharomyces cerevisiae)
Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)
H2O [cytosol]
Inactivation of PLC beta (Saccharomyces cerevisiae)
H2O [cytosol]
PIP2 hydrolysis (Saccharomyces cerevisiae)
H2O [cytosol]
G alpha (q) signalling events (Saccharomyces cerevisiae)
Effects of PIP2 hydrolysis (Saccharomyces cerevisiae)
Arachidonate production from DAG (Saccharomyces cerevisiae)
2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)
H2O [cytosol]
Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
Signaling by Retinoic Acid (Saccharomyces cerevisiae)
RA biosynthesis pathway (Saccharomyces cerevisiae)
ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Saccharomyces cerevisiae)
Miro GTPase Cycle (Saccharomyces cerevisiae)
RHOT1 GTPase cycle (Saccharomyces cerevisiae)
RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)
H2O [cytosol]
RHOT2 GTPase cycle (Saccharomyces cerevisiae)
RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)
H2O [cytosol]
Signaling by Rho GTPases (Saccharomyces cerevisiae)
RHO GTPase cycle (Saccharomyces cerevisiae)
CDC42 GTPase cycle (Saccharomyces cerevisiae)
CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
RHOA GTPase cycle (Saccharomyces cerevisiae)
RHOA GAPs stimulate RHOA GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
RHOB GTPase cycle (Saccharomyces cerevisiae)
RHOB GAPs stimulate RHOB GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
RHOC GTPase cycle (Saccharomyces cerevisiae)
RHOC GAPs stimulate RHOC GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
RHOD GTPase cycle (Saccharomyces cerevisiae)
RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
RHOF GTPase cycle (Saccharomyces cerevisiae)
RHOF GAPs stimulate RHOF GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
RHOJ GTPase cycle (Saccharomyces cerevisiae)
RHOJ GAPs stimulate RHOJ GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
RHOQ GTPase cycle (Saccharomyces cerevisiae)
RHOQ GAPs stimulate RHOQ GTPase activity (Saccharomyces cerevisiae)
H2O [cytosol]
Transport of small molecules (Saccharomyces cerevisiae)
ABC-family proteins mediated transport (Saccharomyces cerevisiae)
ABC transporters in lipid homeostasis (Saccharomyces cerevisiae)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Saccharomyces cerevisiae)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Saccharomyces cerevisiae)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Saccharomyces cerevisiae)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)
H2O [cytosol]
Aquaporin-mediated transport (Saccharomyces cerevisiae)
Passive transport by Aquaporins (Saccharomyces cerevisiae)
Aquaporins passively transport water into cells (Saccharomyces cerevisiae)
H2O [cytosol]
Aquaporins passively transport water out of cells (Saccharomyces cerevisiae)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Saccharomyces cerevisiae)
Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)
H2O [cytosol]
Ion channel transport (Saccharomyces cerevisiae)
Ion transport by P-type ATPases (Saccharomyces cerevisiae)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Saccharomyces cerevisiae)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Saccharomyces cerevisiae)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Saccharomyces cerevisiae)
H2O [cytosol]
Iron uptake and transport (Saccharomyces cerevisiae)
ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)
H2O [cytosol]
Transferrin endocytosis and recycling (Saccharomyces cerevisiae)
Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Saccharomyces cerevisiae)
Plasma lipoprotein remodeling (Saccharomyces cerevisiae)
HDL remodeling (Saccharomyces cerevisiae)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Saccharomyces cerevisiae)
H2O [cytosol]
Vesicle-mediated transport (Saccharomyces cerevisiae)
Membrane Trafficking (Saccharomyces cerevisiae)
ER to Golgi Anterograde Transport (Saccharomyces cerevisiae)
COPII-mediated vesicle transport (Saccharomyces cerevisiae)
PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Saccharomyces cerevisiae)
Golgi-to-ER retrograde transport (Saccharomyces cerevisiae)
COPI-independent Golgi-to-ER retrograde traffic (Saccharomyces cerevisiae)
PLA2s hydrolyze phospholipids at the Golgi membrane (Saccharomyces cerevisiae)
H2O [cytosol]
Rab regulation of trafficking (Saccharomyces cerevisiae)
TBC/RABGAPs (Saccharomyces cerevisiae)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)
H2O [cytosol]
Autophagy (Schizosaccharomyces pombe)
Macroautophagy (Schizosaccharomyces pombe)
Selective autophagy (Schizosaccharomyces pombe)
Pexophagy (Schizosaccharomyces pombe)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Schizosaccharomyces pombe)
H2O [cytosol]
Cell Cycle (Schizosaccharomyces pombe)
Cell Cycle, Mitotic (Schizosaccharomyces pombe)
M Phase (Schizosaccharomyces pombe)
Mitotic Metaphase and Anaphase (Schizosaccharomyces pombe)
Mitotic Anaphase (Schizosaccharomyces pombe)
Nuclear Envelope (NE) Reassembly (Schizosaccharomyces pombe)
Postmitotic nuclear pore complex (NPC) reformation (Schizosaccharomyces pombe)
RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)
H2O [cytosol]
Mitotic Prometaphase (Schizosaccharomyces pombe)
Condensation of Prometaphase Chromosomes (Schizosaccharomyces pombe)
Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Schizosaccharomyces pombe)
PPP1CC dephosphorylates PLK1 (Schizosaccharomyces pombe)
H2O [cytosol]
Regulation of mitotic cell cycle (Schizosaccharomyces pombe)
APC/C-mediated degradation of cell cycle proteins (Schizosaccharomyces pombe)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Schizosaccharomyces pombe)
Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)
H2O [cytosol]
Cellular responses to stimuli (Schizosaccharomyces pombe)
Cellular responses to stress (Schizosaccharomyces pombe)
Cellular response to chemical stress (Schizosaccharomyces pombe)
Detoxification of Reactive Oxygen Species (Schizosaccharomyces pombe)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Schizosaccharomyces pombe)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Schizosaccharomyces pombe)
Nuclear events mediated by NFE2L2 (Schizosaccharomyces pombe)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Schizosaccharomyces pombe)
PRDX1 overoxidizes (Schizosaccharomyces pombe)
H2O [cytosol]
Cellular response to heat stress (Schizosaccharomyces pombe)
Regulation of HSF1-mediated heat shock response (Schizosaccharomyces pombe)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
Drug ADME (Schizosaccharomyces pombe)
Aspirin ADME (Schizosaccharomyces pombe)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)
H2O [cytosol]
Azathioprine ADME (Schizosaccharomyces pombe)
GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)
H2O [cytosol]
Paracetamol ADME (Schizosaccharomyces pombe)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Schizosaccharomyces pombe)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Schizosaccharomyces pombe)
H2O [cytosol]
Prednisone ADME (Schizosaccharomyces pombe)
ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Schizosaccharomyces pombe)
H2O [cytosol]
Ribavirin ADME (Schizosaccharomyces pombe)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)
H2O [cytosol]
Gene expression (Transcription) (Schizosaccharomyces pombe)
RNA Polymerase II Transcription (Schizosaccharomyces pombe)
Generic Transcription Pathway (Schizosaccharomyces pombe)
Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
TP53 Regulates Metabolic Genes (Schizosaccharomyces pombe)
PRDX1 overoxidizes (Schizosaccharomyces pombe)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)
H2O [cytosol]
Hemostasis (Schizosaccharomyces pombe)
Platelet activation, signaling and aggregation (Schizosaccharomyces pombe)
Effects of PIP2 hydrolysis (Schizosaccharomyces pombe)
Arachidonate production from DAG (Schizosaccharomyces pombe)
2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)
H2O [cytosol]
Platelet homeostasis (Schizosaccharomyces pombe)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Schizosaccharomyces pombe)
H2O [cytosol]
Immune System (Schizosaccharomyces pombe)
Adaptive Immune System (Schizosaccharomyces pombe)
Class I MHC mediated antigen processing & presentation (Schizosaccharomyces pombe)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Schizosaccharomyces pombe)
Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)
H2O [cytosol]
Costimulation by the CD28 family (Schizosaccharomyces pombe)
CTLA4 inhibitory signaling (Schizosaccharomyces pombe)
Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
H2O [cytosol]
TCR signaling (Schizosaccharomyces pombe)
Downstream TCR signaling (Schizosaccharomyces pombe)
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
H2O [cytosol]
Generation of second messenger molecules (Schizosaccharomyces pombe)
PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)
H2O [cytosol]
Innate Immune System (Schizosaccharomyces pombe)
C-type lectin receptors (CLRs) (Schizosaccharomyces pombe)
CLEC7A (Dectin-1) signaling (Schizosaccharomyces pombe)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Schizosaccharomyces pombe)
Role of phospholipids in phagocytosis (Schizosaccharomyces pombe)
Conversion of PA into DAG by PAP-1 (Schizosaccharomyces pombe)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Pyruvate metabolism (Schizosaccharomyces pombe)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)
H2O [cytosol]
Biological oxidations (Schizosaccharomyces pombe)
Phase I - Functionalization of compounds (Schizosaccharomyces pombe)
AADAC deacetylates PHEN (Schizosaccharomyces pombe)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Schizosaccharomyces pombe)
Endogenous sterols (Schizosaccharomyces pombe)
CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)
H2O [cytosol]
Ethanol oxidation (Schizosaccharomyces pombe)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)
H2O [cytosol]
Phase II - Conjugation of compounds (Schizosaccharomyces pombe)
Glutathione conjugation (Schizosaccharomyces pombe)
Glutathione synthesis and recycling (Schizosaccharomyces pombe)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)
H2O [cytosol]
Methylation (Schizosaccharomyces pombe)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)
H2O [cytosol]
Inositol phosphate metabolism (Schizosaccharomyces pombe)
Synthesis of IP2, IP, and Ins in the cytosol (Schizosaccharomyces pombe)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Schizosaccharomyces pombe)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Schizosaccharomyces pombe)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
Integration of energy metabolism (Schizosaccharomyces pombe)
Regulation of insulin secretion (Schizosaccharomyces pombe)
Acetylcholine regulates insulin secretion (Schizosaccharomyces pombe)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Schizosaccharomyces pombe)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Schizosaccharomyces pombe)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Aspartate and asparagine metabolism (Schizosaccharomyces pombe)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Schizosaccharomyces pombe)
Phenylalanine metabolism (Schizosaccharomyces pombe)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)
H2O [cytosol]
Selenoamino acid metabolism (Schizosaccharomyces pombe)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Schizosaccharomyces pombe)
SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)
H2O [cytosol]
Serine biosynthesis (Schizosaccharomyces pombe)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Schizosaccharomyces pombe)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)
H2O [cytosol]
Sulfur amino acid metabolism (Schizosaccharomyces pombe)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)
H2O [cytosol]
Cysteine formation from homocysteine (Schizosaccharomyces pombe)
PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)
H2O [cytosol]
Degradation of cysteine and homocysteine (Schizosaccharomyces pombe)
Cysteine is degraded to serine and H2S (Schizosaccharomyces pombe)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)
H2O [cytosol]
Methionine salvage pathway (Schizosaccharomyces pombe)
Acireductone is created (Schizosaccharomyces pombe)
H2O [cytosol]
Urea cycle (Schizosaccharomyces pombe)
arginine + H2O => ornithine + urea [ARG1] (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Fructose metabolism (Schizosaccharomyces pombe)
Fructose catabolism (Schizosaccharomyces pombe)
ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)
H2O [cytosol]
Glucose metabolism (Schizosaccharomyces pombe)
Gluconeogenesis (Schizosaccharomyces pombe)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Schizosaccharomyces pombe)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Schizosaccharomyces pombe)
H2O [cytosol]
Glycolysis (Schizosaccharomyces pombe)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Schizosaccharomyces pombe)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Schizosaccharomyces pombe)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Schizosaccharomyces pombe)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)
H2O [cytosol]
Pentose phosphate pathway (Schizosaccharomyces pombe)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of lipids (Schizosaccharomyces pombe)
Biosynthesis of specialized proresolving mediators (SPMs) (Schizosaccharomyces pombe)
Biosynthesis of DHA-derived SPMs (Schizosaccharomyces pombe)
Biosynthesis of D-series resolvins (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Schizosaccharomyces pombe)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Schizosaccharomyces pombe)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)
H2O [cytosol]
Biosynthesis of protectins (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Schizosaccharomyces pombe)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Schizosaccharomyces pombe)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Schizosaccharomyces pombe)
Biosynthesis of E-series 18(R)-resolvins (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)
H2O [cytosol]
Fatty acid metabolism (Schizosaccharomyces pombe)
Arachidonic acid metabolism (Schizosaccharomyces pombe)
Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Schizosaccharomyces pombe)
LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Schizosaccharomyces pombe)
SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Schizosaccharomyces pombe)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Schizosaccharomyces pombe)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of steroids (Schizosaccharomyces pombe)
Bile acid and bile salt metabolism (Schizosaccharomyces pombe)
Recycling of bile acids and salts (Schizosaccharomyces pombe)
ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of bile acids and bile salts (Schizosaccharomyces pombe)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Schizosaccharomyces pombe)
ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
Cholesterol biosynthesis (Schizosaccharomyces pombe)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Schizosaccharomyces pombe)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Schizosaccharomyces pombe)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)
H2O [cytosol]
Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)
H2O [cytosol]
Phospholipid metabolism (Schizosaccharomyces pombe)
Glycerophospholipid biosynthesis (Schizosaccharomyces pombe)
Acyl chain remodeling of DAG and TAG (Schizosaccharomyces pombe)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Schizosaccharomyces pombe)
H2O [cytosol]
Acyl chain remodelling of PC (Schizosaccharomyces pombe)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Schizosaccharomyces pombe)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Schizosaccharomyces pombe)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)
H2O [cytosol]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)
H2O [cytosol]
Acyl chain remodelling of PE (Schizosaccharomyces pombe)
ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Schizosaccharomyces pombe)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Schizosaccharomyces pombe)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Schizosaccharomyces pombe)
H2O [cytosol]
Acyl chain remodelling of PG (Schizosaccharomyces pombe)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Schizosaccharomyces pombe)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Schizosaccharomyces pombe)
H2O [cytosol]
Acyl chain remodelling of PI (Schizosaccharomyces pombe)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)
H2O [cytosol]
Acyl chain remodelling of PS (Schizosaccharomyces pombe)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Schizosaccharomyces pombe)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Schizosaccharomyces pombe)
H2O [cytosol]
Hydrolysis of LPC (Schizosaccharomyces pombe)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)
H2O [cytosol]
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)
H2O [cytosol]
Hydrolysis of LPE (Schizosaccharomyces pombe)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)
H2O [cytosol]
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PA (Schizosaccharomyces pombe)
DDHD1,2 hydrolyse PA (Schizosaccharomyces pombe)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PC (Schizosaccharomyces pombe)
PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PE (Schizosaccharomyces pombe)
PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)
H2O [cytosol]
PI Metabolism (Schizosaccharomyces pombe)
Glycerophospholipid catabolism (Schizosaccharomyces pombe)
PNPLA6 hydrolyzes LysoPtdCho (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Schizosaccharomyces pombe)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
H2O [cytosol]
Sphingolipid metabolism (Schizosaccharomyces pombe)
Glycosphingolipid metabolism (Schizosaccharomyces pombe)
Glycosphingolipid catabolism (Schizosaccharomyces pombe)
ENPP7 hydrolyzes sphingomyelin (Schizosaccharomyces pombe)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Schizosaccharomyces pombe)
H2O [cytosol]
Sphingolipid catabolism (Schizosaccharomyces pombe)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Schizosaccharomyces pombe)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Schizosaccharomyces pombe)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Schizosaccharomyces pombe)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Schizosaccharomyces pombe)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Schizosaccharomyces pombe)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Schizosaccharomyces pombe)
H2O [cytosol]
Triglyceride metabolism (Schizosaccharomyces pombe)
Triglyceride biosynthesis (Schizosaccharomyces pombe)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of nucleotides (Schizosaccharomyces pombe)
Interconversion of nucleotide di- and triphosphates (Schizosaccharomyces pombe)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)
H2O [cytosol]
Nucleotide biosynthesis (Schizosaccharomyces pombe)
Purine ribonucleoside monophosphate biosynthesis (Schizosaccharomyces pombe)
FAICAR => IMP + H2O (Schizosaccharomyces pombe)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Pyrimidine biosynthesis (Schizosaccharomyces pombe)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)
H2O [cytosol]
Nucleotide catabolism (Schizosaccharomyces pombe)
Purine catabolism (Schizosaccharomyces pombe)
Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Schizosaccharomyces pombe)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)
H2O [cytosol]
Pyrimidine catabolism (Schizosaccharomyces pombe)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Schizosaccharomyces pombe)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Schizosaccharomyces pombe)
H2O [cytosol]
Nucleotide salvage (Schizosaccharomyces pombe)
Purine salvage (Schizosaccharomyces pombe)
AMP + H2O => IMP + NH4+ (AMPD) (Schizosaccharomyces pombe)
H2O [cytosol]
Pyrimidine salvage (Schizosaccharomyces pombe)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of porphyrins (Schizosaccharomyces pombe)
Heme biosynthesis (Schizosaccharomyces pombe)
4 PBGs bind to form HMB (Schizosaccharomyces pombe)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)
H2O [cytosol]
UROS transforms HMB to URO3 (Schizosaccharomyces pombe)
H2O [cytosol]
Heme degradation (Schizosaccharomyces pombe)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Schizosaccharomyces pombe)
GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Schizosaccharomyces pombe)
Transport of RCbl within the body (Schizosaccharomyces pombe)
ABCC1 transports cytosolic RCbl to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of folate and pterines (Schizosaccharomyces pombe)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
H2O [cytosol]
Nicotinate metabolism (Schizosaccharomyces pombe)
NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Schizosaccharomyces pombe)
PANK4 hydrolyzes PPANT to pantetheine (Schizosaccharomyces pombe)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Schizosaccharomyces pombe)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)
H2O [cytosol]
Pyrophosphate hydrolysis (Schizosaccharomyces pombe)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of RNA (Schizosaccharomyces pombe)
Deadenylation-dependent mRNA decay (Schizosaccharomyces pombe)
mRNA decay by 3' to 5' exoribonuclease (Schizosaccharomyces pombe)
DCPS scavenges the 7-methylguanosine cap of mRNA (Schizosaccharomyces pombe)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Schizosaccharomyces pombe)
H2O [cytosol]
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Asparagine N-linked glycosylation (Schizosaccharomyces pombe)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Schizosaccharomyces pombe)
Synthesis of substrates in N-glycan biosythesis (Schizosaccharomyces pombe)
Synthesis of Dolichyl-phosphate (Schizosaccharomyces pombe)
DOLPP1 dephosphorylates DOLDP to DOLP (Schizosaccharomyces pombe)
H2O [cytosol]
Deubiquitination (Schizosaccharomyces pombe)
UCH proteinases (Schizosaccharomyces pombe)
UCHL1, UCHL3 cleave ubiquitin adducts (Schizosaccharomyces pombe)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)
H2O [cytosol]
Ub-specific processing proteases (Schizosaccharomyces pombe)
USP10 deubiquitinates SNX3, CFTR (Schizosaccharomyces pombe)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Schizosaccharomyces pombe)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Schizosaccharomyces pombe)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Schizosaccharomyces pombe)
H2O [cytosol]
USP5 cleaves polyubiquitin (Schizosaccharomyces pombe)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Schizosaccharomyces pombe)
Hypusine synthesis from eIF5A-lysine (Schizosaccharomyces pombe)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)
H2O [cytosol]
Neddylation (Schizosaccharomyces pombe)
UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Schizosaccharomyces pombe)
Synthesis of glycosylphosphatidylinositol (GPI) (Schizosaccharomyces pombe)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)
H2O [cytosol]
Translation (Schizosaccharomyces pombe)
tRNA Aminoacylation (Schizosaccharomyces pombe)
Cytosolic tRNA aminoacylation (Schizosaccharomyces pombe)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)
H2O [cytosol]
Signal Transduction (Schizosaccharomyces pombe)
Intracellular signaling by second messengers (Schizosaccharomyces pombe)
PIP3 activates AKT signaling (Schizosaccharomyces pombe)
Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Schizosaccharomyces pombe)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
H2O [cytosol]
PTEN Regulation (Schizosaccharomyces pombe)
Regulation of PTEN stability and activity (Schizosaccharomyces pombe)
USP13 and OTUD3 deubiquitinate PTEN (Schizosaccharomyces pombe)
H2O [cytosol]
MAPK family signaling cascades (Schizosaccharomyces pombe)
MAPK1/MAPK3 signaling (Schizosaccharomyces pombe)
RAF/MAP kinase cascade (Schizosaccharomyces pombe)
Negative regulation of MAPK pathway (Schizosaccharomyces pombe)
PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)
H2O [cytosol]
RAS processing (Schizosaccharomyces pombe)
USP17L2 deubiquitinates RCE1 (Schizosaccharomyces pombe)
H2O [cytosol]
Signaling by GPCR (Schizosaccharomyces pombe)
GPCR downstream signalling (Schizosaccharomyces pombe)
G alpha (i) signalling events (Schizosaccharomyces pombe)
Opioid Signalling (Schizosaccharomyces pombe)
G-protein mediated events (Schizosaccharomyces pombe)
PLC beta mediated events (Schizosaccharomyces pombe)
Ca-dependent events (Schizosaccharomyces pombe)
phospho-PLA2 pathway (Schizosaccharomyces pombe)
Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)
H2O [cytosol]
Inactivation of PLC beta (Schizosaccharomyces pombe)
H2O [cytosol]
PIP2 hydrolysis (Schizosaccharomyces pombe)
H2O [cytosol]
G alpha (q) signalling events (Schizosaccharomyces pombe)
Effects of PIP2 hydrolysis (Schizosaccharomyces pombe)
Arachidonate production from DAG (Schizosaccharomyces pombe)
2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)
H2O [cytosol]
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
Signaling by Retinoic Acid (Schizosaccharomyces pombe)
RA biosynthesis pathway (Schizosaccharomyces pombe)
ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Schizosaccharomyces pombe)
Miro GTPase Cycle (Schizosaccharomyces pombe)
RHOT1 GTPase cycle (Schizosaccharomyces pombe)
RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)
H2O [cytosol]
RHOT2 GTPase cycle (Schizosaccharomyces pombe)
RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)
H2O [cytosol]
Signaling by Rho GTPases (Schizosaccharomyces pombe)
RHO GTPase cycle (Schizosaccharomyces pombe)
CDC42 GTPase cycle (Schizosaccharomyces pombe)
CDC42 GAPs stimulate CDC42 GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
RHOA GTPase cycle (Schizosaccharomyces pombe)
RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
RHOB GTPase cycle (Schizosaccharomyces pombe)
RHOB GAPs stimulate RHOB GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
RHOC GTPase cycle (Schizosaccharomyces pombe)
RHOC GAPs stimulate RHOC GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
RHOD GTPase cycle (Schizosaccharomyces pombe)
RHOD GAPs stimulate RHOD GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
RHOF GTPase cycle (Schizosaccharomyces pombe)
RHOF GAPs stimulate RHOF GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
RHOJ GTPase cycle (Schizosaccharomyces pombe)
RHOJ GAPs stimulate RHOJ GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
RHOQ GTPase cycle (Schizosaccharomyces pombe)
RHOQ GAPs stimulate RHOQ GTPase activity (Schizosaccharomyces pombe)
H2O [cytosol]
Transport of small molecules (Schizosaccharomyces pombe)
ABC-family proteins mediated transport (Schizosaccharomyces pombe)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Schizosaccharomyces pombe)
H2O [cytosol]
Mitochondrial ABC transporters (Schizosaccharomyces pombe)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Schizosaccharomyces pombe)
H2O [cytosol]
The ABCC family mediates organic anion transport (Schizosaccharomyces pombe)
H2O [cytosol]
Aquaporin-mediated transport (Schizosaccharomyces pombe)
Passive transport by Aquaporins (Schizosaccharomyces pombe)
Aquaporins passively transport water into cells (Schizosaccharomyces pombe)
H2O [cytosol]
Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Schizosaccharomyces pombe)
Aquaporin-3 passively transports water out of cell (Schizosaccharomyces pombe)
H2O [cytosol]
Ion channel transport (Schizosaccharomyces pombe)
Ion transport by P-type ATPases (Schizosaccharomyces pombe)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Schizosaccharomyces pombe)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Schizosaccharomyces pombe)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Schizosaccharomyces pombe)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)
H2O [cytosol]
Iron uptake and transport (Schizosaccharomyces pombe)
Transferrin endocytosis and recycling (Schizosaccharomyces pombe)
Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Schizosaccharomyces pombe)
Plasma lipoprotein clearance (Schizosaccharomyces pombe)
LDL clearance (Schizosaccharomyces pombe)
NCEH1 hydrolyzes cholesterol esters (Schizosaccharomyces pombe)
H2O [cytosol]
Vesicle-mediated transport (Schizosaccharomyces pombe)
Membrane Trafficking (Schizosaccharomyces pombe)
Intra-Golgi and retrograde Golgi-to-ER traffic (Schizosaccharomyces pombe)
Golgi-to-ER retrograde transport (Schizosaccharomyces pombe)
COPI-independent Golgi-to-ER retrograde traffic (Schizosaccharomyces pombe)
PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)
H2O [cytosol]
Rab regulation of trafficking (Schizosaccharomyces pombe)
TBC/RABGAPs (Schizosaccharomyces pombe)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)
H2O [cytosol]
Autophagy (Sus scrofa)
Macroautophagy (Sus scrofa)
Selective autophagy (Sus scrofa)
Pexophagy (Sus scrofa)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)
H2O [cytosol]
Cell Cycle (Sus scrofa)
Cell Cycle, Mitotic (Sus scrofa)
M Phase (Sus scrofa)
Mitotic Metaphase and Anaphase (Sus scrofa)
Mitotic Anaphase (Sus scrofa)
Nuclear Envelope (NE) Reassembly (Sus scrofa)
Initiation of Nuclear Envelope (NE) Reformation (Sus scrofa)
ANKLE2 is deacetylated by SIRT2 (Sus scrofa)
H2O [cytosol]
PP2A dephosphorylates BANF1 (Sus scrofa)
H2O [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Sus scrofa)
RAN stimulates fusion of nuclear envelope (NE) membranes (Sus scrofa)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Sus scrofa)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Sus scrofa)
H2O [cytosol]
Mitotic Prometaphase (Sus scrofa)
Condensation of Prometaphase Chromosomes (Sus scrofa)
Dephosphorylation of CK2-modified condensin I (Sus scrofa)
H2O [cytosol]
Resolution of Sister Chromatid Cohesion (Sus scrofa)
PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Sus scrofa)
H2O [cytosol]
Mitotic G2-G2/M phases (Sus scrofa)
G2/M Transition (Sus scrofa)
Cyclin A/B1/B2 associated events during G2/M transition (Sus scrofa)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)
H2O [cytosol]
Regulation of mitotic cell cycle (Sus scrofa)
APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Sus scrofa)
Dephosphorylation of phospho-Cdh1 (Sus scrofa)
H2O [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
Cytoprotection by HMOX1 (Sus scrofa)
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Sus scrofa)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)
H2O [cytosol]
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)
H2O [cytosol]
PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)
H2O [cytosol]
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Sus scrofa)
Nuclear events mediated by NFE2L2 (Sus scrofa)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Sus scrofa)
PRDX1 overoxidizes (Sus scrofa)
H2O [cytosol]
Cellular response to heat stress (Sus scrofa)
Regulation of HSF1-mediated heat shock response (Sus scrofa)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Sus scrofa)
H2O [cytosol]
Chromatin organization (Sus scrofa)
Chromatin modifying enzymes (Sus scrofa)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)
H2O [cytosol]
Developmental Biology (Sus scrofa)
Nervous system development (Sus scrofa)
Axon guidance (Sus scrofa)
EPH-Ephrin signaling (Sus scrofa)
EPHB-mediated forward signaling (Sus scrofa)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)
H2O [cytosol]
L1CAM interactions (Sus scrofa)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Sus scrofa)
H2O [cytosol]
Semaphorin interactions (Sus scrofa)
Sema4D in semaphorin signaling (Sus scrofa)
Sema4D mediated inhibition of cell attachment and migration (Sus scrofa)
Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)
H2O [cytosol]
Signaling by ROBO receptors (Sus scrofa)
SLIT2:ROBO1 increases RHOA activity (Sus scrofa)
MYO9B inactivates RHOA (Sus scrofa)
H2O [cytosol]
Drug ADME (Sus scrofa)
Abacavir ADME (Sus scrofa)
Abacavir metabolism (Sus scrofa)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Sus scrofa)
H2O [cytosol]
Aspirin ADME (Sus scrofa)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)
H2O [cytosol]
Atorvastatin ADME (Sus scrofa)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Sus scrofa)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
H2O [cytosol]
Azathioprine ADME (Sus scrofa)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Sus scrofa)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Sus scrofa)
H2O [cytosol]
Ciprofloxacin ADME (Sus scrofa)
ABCG2 transports Cipro from hepatic cell to extracellular space (Sus scrofa)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Sus scrofa)
H2O [cytosol]
Paracetamol ADME (Sus scrofa)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Sus scrofa)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Sus scrofa)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Sus scrofa)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Sus scrofa)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)
H2O [cytosol]
GGT dimers hydrolyse APAP-SG (Sus scrofa)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Sus scrofa)
H2O [cytosol]
Prednisone ADME (Sus scrofa)
ABCB1 transports PREDN,PREDL out of hepatic cells (Sus scrofa)
H2O [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Sus scrofa)
H2O [cytosol]
ABCB1 transports xenobiotics out of the cell (Sus scrofa)
H2O [cytosol]
CYP3A4 oxidizes PREDN,PREDL (Sus scrofa)
H2O [cytosol]
Ribavirin ADME (Sus scrofa)
ADA deamidates RBV (Sus scrofa)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Sus scrofa)
H2O [cytosol]
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
TP53 Regulates Metabolic Genes (Sus scrofa)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
H2O [cytosol]
PRDX1 overoxidizes (Sus scrofa)
H2O [cytosol]
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Sus scrofa)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)
H2O [cytosol]
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Effects of PIP2 hydrolysis (Sus scrofa)
Arachidonate production from DAG (Sus scrofa)
2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Sus scrofa)
H2O [cytosol]
Platelet Aggregation (Plug Formation) (Sus scrofa)
Integrin signaling (Sus scrofa)
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
H2O [cytosol]
Response to elevated platelet cytosolic Ca2+ (Sus scrofa)
Platelet degranulation (Sus scrofa)
ABCC4 accumulation of dense granule contents (Sus scrofa)
H2O [cytosol]
Platelet homeostasis (Sus scrofa)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Sus scrofa)
H2O [cytosol]
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Sus scrofa)
Disassembly of COPII coated vesicle (Sus scrofa)
H2O [cytosol]
Transport of Antigen peptide in to ER (Sus scrofa)
H2O [cytosol]
MHC class II antigen presentation (Sus scrofa)
Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)
H2O [cytosol]
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Sus scrofa)
H2O [cytosol]
Generation of second messenger molecules (Sus scrofa)
PLC-gamma1 hydrolyses PIP2 (Sus scrofa)
H2O [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Sus scrofa)
Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)
H2O [cytosol]
Inactivation of LCK by PTPN22 (Sus scrofa)
H2O [cytosol]
Translocation of ZAP-70 to Immunological synapse (Sus scrofa)
PTPN22 dephosphorylates ZAP70 (Sus scrofa)
H2O [cytosol]
Cytokine Signaling in Immune system (Sus scrofa)
Growth hormone receptor signaling (Sus scrofa)
PTP1B dephosphorylates GHR (Sus scrofa)
H2O [cytosol]
Interferon Signaling (Sus scrofa)
Antiviral mechanism by IFN-stimulated genes (Sus scrofa)
OAS antiviral response (Sus scrofa)
PDE12 cleaves 2'-5' oligoadenylates (Sus scrofa)
H2O [cytosol]
Interferon alpha/beta signaling (Sus scrofa)
Regulation of IFNA/IFNB signaling (Sus scrofa)
Dephosphorylation of JAK1 by SHP1 (Sus scrofa)
H2O [cytosol]
Dephosphorylation of STAT1 by SHP2 (Sus scrofa)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Sus scrofa)
H2O [cytosol]
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Innate Immune System (Sus scrofa)
Antimicrobial peptides (Sus scrofa)
Ion influx/efflux at host-pathogen interface (Sus scrofa)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)
H2O [cytosol]
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
CLEC7A (Dectin-1) induces NFAT activation (Sus scrofa)
Calcineurin binds and dephosphorylates NFAT (Sus scrofa)
H2O [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Calcineurin binds and dephosphorylates NFAT (Sus scrofa)
H2O [cytosol]
Hydrolysis of PIP2 by PLCG (Sus scrofa)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Role of phospholipids in phagocytosis (Sus scrofa)
Conversion of PA into DAG by PAP-1 (Sus scrofa)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Sus scrofa)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Sus scrofa)
H2O [cytosol]
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
USP14 deubiquitinates NLRC5 (Sus scrofa)
H2O [cytosol]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Pyruvate metabolism (Sus scrofa)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)
H2O [cytosol]
Regulation of pyruvate metabolism (Sus scrofa)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Sus scrofa)
H2O [cytosol]
Biological oxidations (Sus scrofa)
Aflatoxin activation and detoxification (Sus scrofa)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Sus scrofa)
H2O [cytosol]
CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Sus scrofa)
H2O [cytosol]
Phase I - Functionalization of compounds (Sus scrofa)
AADAC deacetylates PHEN (Sus scrofa)
H2O [cytosol]
ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)
H2O [cytosol]
Amine Oxidase reactions (Sus scrofa)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Sus scrofa)
MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)
H2O [cytosol]
MAOB:FAD oxidatively deaminates TYR (Sus scrofa)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)
H2O [cytosol]
BPHL hydrolyses VACV to ACV (Sus scrofa)
H2O [cytosol]
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Sus scrofa)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Sus scrofa)
Eicosanoids (Sus scrofa)
CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)
H2O [cytosol]
Endogenous sterols (Sus scrofa)
CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)
H2O [cytosol]
CYP1B1 4-hydroxylates EST17b (Sus scrofa)
H2O [cytosol]
CYP21A2 21-hydroxylates PROG (Sus scrofa)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Sus scrofa)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Sus scrofa)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Sus scrofa)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
H2O [cytosol]
Vitamins (Sus scrofa)
CYP26C1 4-hydroxylates 9cRA (Sus scrofa)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)
H2O [cytosol]
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Sus scrofa)
H2O [cytosol]
Ethanol oxidation (Sus scrofa)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)
H2O [cytosol]
Phase II - Conjugation of compounds (Sus scrofa)
Cytosolic sulfonation of small molecules (Sus scrofa)
ABHD14B hydrolyses PNPB (Sus scrofa)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)
H2O [cytosol]
Glucuronidation (Sus scrofa)
Formation of the active cofactor, UDP-glucuronate (Sus scrofa)
UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)
H2O [cytosol]
Glutathione conjugation (Sus scrofa)
Glutathione synthesis and recycling (Sus scrofa)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)
H2O [cytosol]
Methylation (Sus scrofa)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)
H2O [cytosol]
Inositol phosphate metabolism (Sus scrofa)
Synthesis of IP2, IP, and Ins in the cytosol (Sus scrofa)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Sus scrofa)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
H2O [cytosol]
MIOX oxidises Ins to GlcA (Sus scrofa)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Sus scrofa)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Sus scrofa)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)
H2O [cytosol]
Integration of energy metabolism (Sus scrofa)
Regulation of insulin secretion (Sus scrofa)
Acetylcholine regulates insulin secretion (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
H2O [cytosol]
Free fatty acids regulate insulin secretion (Sus scrofa)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
H2O [cytosol]
Metabolism of amino acids and derivatives (Sus scrofa)
Aspartate and asparagine metabolism (Sus scrofa)
ASPA deacetylates NAA to acetate and L-aspartate (Sus scrofa)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)
H2O [cytosol]
Carnitine synthesis (Sus scrofa)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)
H2O [cytosol]
Histidine catabolism (Sus scrofa)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)
H2O [cytosol]
Metabolism of polyamines (Sus scrofa)
Agmatine biosynthesis (Sus scrofa)
Agmatine + H2O <=> putrescine + urea (Sus scrofa)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Phenylalanine metabolism (Sus scrofa)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)
H2O [cytosol]
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)
H2O [cytosol]
Tyrosine catabolism (Sus scrofa)
FAH cleaves 4FAA (Sus scrofa)
H2O [cytosol]
Selenoamino acid metabolism (Sus scrofa)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Sus scrofa)
SeMet is converted to AdoSeMet by MAT (Sus scrofa)
H2O [cytosol]
Selenocysteine synthesis (Sus scrofa)
SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)
H2O [cytosol]
Serine biosynthesis (Sus scrofa)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Sus scrofa)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Sus scrofa)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Sus scrofa)
H2O [cytosol]
Sulfur amino acid metabolism (Sus scrofa)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)
H2O [cytosol]
Cysteine formation from homocysteine (Sus scrofa)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)
H2O [cytosol]
PXLP-K212-CTH cleaves L-Cystathionine (Sus scrofa)
H2O [cytosol]
Degradation of cysteine and homocysteine (Sus scrofa)
Cysteine is degraded to serine and H2S (Sus scrofa)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Sus scrofa)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)
H2O [cytosol]
Methionine salvage pathway (Sus scrofa)
Acireductone is created (Sus scrofa)
H2O [cytosol]
Threonine catabolism (Sus scrofa)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Sus scrofa)
H2O [cytosol]
Tryptophan catabolism (Sus scrofa)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Sus scrofa)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)
H2O [cytosol]
Urea cycle (Sus scrofa)
arginine + H2O => ornithine + urea [ARG1] (Sus scrofa)
H2O [cytosol]
Metabolism of carbohydrates (Sus scrofa)
Fructose metabolism (Sus scrofa)
Fructose catabolism (Sus scrofa)
ALDH1A1 oxidises GA to DGA (Sus scrofa)
H2O [cytosol]
Glucose metabolism (Sus scrofa)
Gluconeogenesis (Sus scrofa)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Sus scrofa)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Sus scrofa)
H2O [cytosol]
Glycolysis (Sus scrofa)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Sus scrofa)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)
H2O [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Sus scrofa)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)
H2O [cytosol]
Glycogen metabolism (Sus scrofa)
Glycogen synthesis (Sus scrofa)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Sus scrofa)
H2O [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Sus scrofa)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Sus scrofa)
H2O [cytosol]
Pentose phosphate pathway (Sus scrofa)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)
H2O [cytosol]
Metabolism of lipids (Sus scrofa)
Biosynthesis of specialized proresolving mediators (SPMs) (Sus scrofa)
Biosynthesis of DHA-derived SPMs (Sus scrofa)
Biosynthesis of D-series resolvins (Sus scrofa)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Sus scrofa)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Sus scrofa)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Sus scrofa)
H2O [cytosol]
Biosynthesis of maresins (Sus scrofa)
Biosynthesis of maresin-like SPMs (Sus scrofa)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)
H2O [cytosol]
Biosynthesis of protectins (Sus scrofa)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Sus scrofa)
Biosynthesis of E-series 18(R)-resolvins (Sus scrofa)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Sus scrofa)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Sus scrofa)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Sus scrofa)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Sus scrofa)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Sus scrofa)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)
H2O [cytosol]
Fatty acid metabolism (Sus scrofa)
Arachidonic acid metabolism (Sus scrofa)
FAAH hydrolyses AEA to AA and ETA (Sus scrofa)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Sus scrofa)
H2O [cytosol]
Synthesis of 12-eicosatetraenoic acid derivatives (Sus scrofa)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)
H2O [cytosol]
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Sus scrofa)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Sus scrofa)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)
H2O [cytosol]
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Sus scrofa)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Sus scrofa)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Sus scrofa)
SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)
H2O [cytosol]
SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Sus scrofa)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Sus scrofa)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Sus scrofa)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)
H2O [cytosol]
Metabolism of steroids (Sus scrofa)
Bile acid and bile salt metabolism (Sus scrofa)
Recycling of bile acids and salts (Sus scrofa)
ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
H2O [cytosol]
Synthesis of bile acids and bile salts (Sus scrofa)
CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
H2O [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Sus scrofa)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Sus scrofa)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Sus scrofa)
27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Sus scrofa)
ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Sus scrofa)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
H2O [cytosol]
Cholesterol biosynthesis (Sus scrofa)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)
H2O [cytosol]
CYP51A1 demethylates LNSOL (Sus scrofa)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Sus scrofa)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Sus scrofa)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)
H2O [cytosol]
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)
H2O [cytosol]
Squalene is oxidized to its epoxide (Sus scrofa)
H2O [cytosol]
Metabolism of steroid hormones (Sus scrofa)
Androgen biosynthesis (Sus scrofa)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Sus scrofa)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)
H2O [cytosol]
Estrogen biosynthesis (Sus scrofa)
CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)
H2O [cytosol]
Glucocorticoid biosynthesis (Sus scrofa)
CYP17A1 17-hydroxylates PREG (Sus scrofa)
H2O [cytosol]
CYP21A2 oxidises 17HPROG (Sus scrofa)
H2O [cytosol]
Mineralocorticoid biosynthesis (Sus scrofa)
CYP21A2 21-hydroxylates PROG (Sus scrofa)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
H2O [cytosol]
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)
H2O [cytosol]
Phospholipid metabolism (Sus scrofa)
Glycerophospholipid biosynthesis (Sus scrofa)
Acyl chain remodeling of DAG and TAG (Sus scrofa)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)
H2O [cytosol]
Acyl chain remodelling of PC (Sus scrofa)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Sus scrofa)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Sus scrofa)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)
H2O [cytosol]
Acyl chain remodelling of PE (Sus scrofa)
ABHD4 hydrolyses NAPE (Sus scrofa)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)
H2O [cytosol]
Acyl chain remodelling of PG (Sus scrofa)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Sus scrofa)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Sus scrofa)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Sus scrofa)
H2O [cytosol]
Acyl chain remodelling of PI (Sus scrofa)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)
H2O [cytosol]
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)
H2O [cytosol]
Acyl chain remodelling of PS (Sus scrofa)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Sus scrofa)
H2O [cytosol]
Hydrolysis of LPC (Sus scrofa)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)
H2O [cytosol]
Synthesis of PA (Sus scrofa)
DDHD1,2 hydrolyse PA (Sus scrofa)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)
H2O [cytosol]
Synthesis of PC (Sus scrofa)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Sus scrofa)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Sus scrofa)
H2O [cytosol]
Synthesis of PE (Sus scrofa)
PA is dephosphorylated to DAG by LPIN (Sus scrofa)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Sus scrofa)
H2O [cytosol]
PI Metabolism (Sus scrofa)
Glycerophospholipid catabolism (Sus scrofa)
GDE1 hydrolyzes GroPIns (Sus scrofa)
H2O [cytosol]
PNPLA6 hydrolyzes LysoPtdCho (Sus scrofa)
H2O [cytosol]
Synthesis of PIPs at the ER membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)
H2O [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Sus scrofa)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Sus scrofa)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)
H2O [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Sus scrofa)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Sus scrofa)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Sus scrofa)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Sus scrofa)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Sus scrofa)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Sus scrofa)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Sus scrofa)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Sus scrofa)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Sus scrofa)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Sus scrofa)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Sus scrofa)
H2O [cytosol]
Sphingolipid metabolism (Sus scrofa)
Glycosphingolipid metabolism (Sus scrofa)
Glycosphingolipid catabolism (Sus scrofa)
ASAH2 hydrolyzes ceramide (plasma membrane) (Sus scrofa)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Sus scrofa)
H2O [cytosol]
GBA2 hydrolyzes GlcCer (plasma membrane) (Sus scrofa)
H2O [cytosol]
GBA3 hydrolyzes GlcCer (cytosol) (Sus scrofa)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Sus scrofa)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Sus scrofa)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Sus scrofa)
H2O [cytosol]
Sphingolipid catabolism (Sus scrofa)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Sus scrofa)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Sus scrofa)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Sus scrofa)
H2O [cytosol]
ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Sus scrofa)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Sus scrofa)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Sus scrofa)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Sus scrofa)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Sus scrofa)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Sus scrofa)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Sus scrofa)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Sus scrofa)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Sus scrofa)
H2O [cytosol]
Triglyceride metabolism (Sus scrofa)
Triglyceride biosynthesis (Sus scrofa)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)
H2O [cytosol]
Triglyceride catabolism (Sus scrofa)
PNPLA4 hydrolyzes TAG (Sus scrofa)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Sus scrofa)
H2O [cytosol]
Metabolism of nucleotides (Sus scrofa)
Interconversion of nucleotide di- and triphosphates (Sus scrofa)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)
H2O [cytosol]
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)
H2O [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Sus scrofa)
H2O [cytosol]
Nucleotide biosynthesis (Sus scrofa)
Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
H2O [cytosol]
FAICAR => IMP + H2O (Sus scrofa)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
H2O [cytosol]
Pyrimidine biosynthesis (Sus scrofa)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Sus scrofa)
H2O [cytosol]
Nucleotide catabolism (Sus scrofa)
Purine catabolism (Sus scrofa)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Sus scrofa)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Sus scrofa)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Sus scrofa)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)
H2O [cytosol]
DNPH1 hydrolyses dGMP (Sus scrofa)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Sus scrofa)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Sus scrofa)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Sus scrofa)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Sus scrofa)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Sus scrofa)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Sus scrofa)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Sus scrofa)
H2O [cytosol]
Pyrimidine catabolism (Sus scrofa)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)
H2O [cytosol]
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)
H2O [cytosol]
5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)
H2O [cytosol]
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)
H2O [cytosol]
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)
H2O [cytosol]
Nucleotide salvage (Sus scrofa)
Purine salvage (Sus scrofa)
ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Sus scrofa)
H2O [cytosol]
Pyrimidine salvage (Sus scrofa)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)
H2O [cytosol]
Metabolism of porphyrins (Sus scrofa)
Heme biosynthesis (Sus scrofa)
4 PBGs bind to form HMB (Sus scrofa)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Sus scrofa)
H2O [cytosol]
UROS transforms HMB to URO3 (Sus scrofa)
H2O [cytosol]
Heme degradation (Sus scrofa)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
H2O [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of cofactors (Sus scrofa)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Sus scrofa)
GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Sus scrofa)
Transport of RCbl within the body (Sus scrofa)
ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)
H2O [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Sus scrofa)
H2O [cytosol]
Uptake of dietary cobalamins into enterocytes (Sus scrofa)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)
H2O [cytosol]
Metabolism of folate and pterines (Sus scrofa)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Sus scrofa)
Cyclisation of GTP to precursor Z (Sus scrofa)
H2O [cytosol]
Molybdenum ion transfer onto molybdopterin (Sus scrofa)
H2O [cytosol]
Nicotinate metabolism (Sus scrofa)
NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Sus scrofa)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Sus scrofa)
2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
H2O [cytosol]
2xTRAP hydrolyzes FMN to RIB (Sus scrofa)
H2O [cytosol]
Vitamin B5 (pantothenate) metabolism (Sus scrofa)
PANK4 hydrolyzes PPANT to pantetheine (Sus scrofa)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Sus scrofa)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Sus scrofa)
H2O [cytosol]
Pyrophosphate hydrolysis (Sus scrofa)
LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)
H2O [cytosol]
Reversible hydration of carbon dioxide (Sus scrofa)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)
H2O [cytosol]
Metabolism of RNA (Sus scrofa)
Deadenylation-dependent mRNA decay (Sus scrofa)
Deadenylation of mRNA (Sus scrofa)
CCR4-NOT complex deadenylates mRNA (Sus scrofa)
H2O [cytosol]
PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)
H2O [cytosol]
PARN deadenylates mRNA (Sus scrofa)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Sus scrofa)
DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Sus scrofa)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Sus scrofa)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Sus scrofa)
DCP1-DCP2 complex decaps mRNA (Sus scrofa)
H2O [cytosol]
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Asparagine N-linked glycosylation (Sus scrofa)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Sus scrofa)
Synthesis of substrates in N-glycan biosythesis (Sus scrofa)
GDP-fucose biosynthesis (Sus scrofa)
GMDS dehydrates GDP-Man to GDP-DHDMan (Sus scrofa)
H2O [cytosol]
Sialic acid metabolism (Sus scrofa)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Sus scrofa)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Sus scrofa)
DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Sus scrofa)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Sus scrofa)
H2O [cytosol]
Synthesis of dolichyl-phosphate-glucose (Sus scrofa)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Sus scrofa)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Sus scrofa)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Sus scrofa)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Sus scrofa)
ER to Golgi Anterograde Transport (Sus scrofa)
COPII-mediated vesicle transport (Sus scrofa)
PP6 dephosphorylates SEC24 (Sus scrofa)
H2O [cytosol]
Deubiquitination (Sus scrofa)
Josephin domain DUBs (Sus scrofa)
ATXN3 family cleave Ub chains (Sus scrofa)
H2O [cytosol]
Metalloprotease DUBs (Sus scrofa)
BRISC complex deubiquitinates NLRP3 (Sus scrofa)
H2O [cytosol]
Ovarian tumor domain proteases (Sus scrofa)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)
H2O [cytosol]
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)
H2O [cytosol]
UCH proteinases (Sus scrofa)
UCHL1, UCHL3 cleave ubiquitin adducts (Sus scrofa)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Sus scrofa)
H2O [cytosol]
Ub-specific processing proteases (Sus scrofa)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)
H2O [cytosol]
USP10 deubiquitinates SNX3, CFTR (Sus scrofa)
H2O [cytosol]
USP11 deubiquitinates NFKBIA (Sus scrofa)
H2O [cytosol]
USP13 deubiquitinates BECN1,USP10 (Sus scrofa)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)
H2O [cytosol]
USP19 deubiquitinates RNF123 (Sus scrofa)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Sus scrofa)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Sus scrofa)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Sus scrofa)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)
H2O [cytosol]
USP5 cleaves polyubiquitin (Sus scrofa)
H2O [cytosol]
USP8 deubiquitinates RNF128 (Sus scrofa)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Sus scrofa)
H2O [cytosol]
USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Sus scrofa)
Hypusine synthesis from eIF5A-lysine (Sus scrofa)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)
H2O [cytosol]
Neddylation (Sus scrofa)
UCHL3, SENP8 cleave NEDD8 (Sus scrofa)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Sus scrofa)
Synthesis of glycosylphosphatidylinositol (GPI) (Sus scrofa)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)
H2O [cytosol]
Surfactant metabolism (Sus scrofa)
ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)
H2O [cytosol]
Translation (Sus scrofa)
Eukaryotic Translation Termination (Sus scrofa)
APEH hydrolyses NAc-Ser-protein (Sus scrofa)
H2O [cytosol]
tRNA Aminoacylation (Sus scrofa)
Cytosolic tRNA aminoacylation (Sus scrofa)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)
H2O [cytosol]
Muscle contraction (Sus scrofa)
Cardiac conduction (Sus scrofa)
Ion homeostasis (Sus scrofa)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)
H2O [cytosol]
Physiological factors (Sus scrofa)
CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)
H2O [cytosol]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter clearance (Sus scrofa)
Dopamine clearance from the synaptic cleft (Sus scrofa)
Enzymatic degradation of Dopamine by monoamine oxidase (Sus scrofa)
MAOA:FAD deaminates DA to DOPAC (Sus scrofa)
H2O [cytosol]
Enzymatic degradation of dopamine by COMT (Sus scrofa)
MAOA:FAD deaminates 3MT to HVA (Sus scrofa)
H2O [cytosol]
Serotonin clearance from the synaptic cleft (Sus scrofa)
Metabolism of serotonin (Sus scrofa)
MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)
H2O [cytosol]
Neurotransmitter release cycle (Sus scrofa)
Norepinephrine Neurotransmitter Release Cycle (Sus scrofa)
Catabolism of Noradrenaline (Sus scrofa)
H2O [cytosol]
Organelle biogenesis and maintenance (Sus scrofa)
Cilium Assembly (Sus scrofa)
Cargo trafficking to the periciliary membrane (Sus scrofa)
VxPx cargo-targeting to cilium (Sus scrofa)
ASAP1 stimulates GTPase activity of ARF4 (Sus scrofa)
H2O [cytosol]
Programmed Cell Death (Sus scrofa)
Apoptosis (Sus scrofa)
Intrinsic Pathway for Apoptosis (Sus scrofa)
Activation of BH3-only proteins (Sus scrofa)
Activation of BAD and translocation to mitochondria (Sus scrofa)
Activation of BAD by calcineurin (Sus scrofa)
H2O [cytosol]
Protein localization (Sus scrofa)
Peroxisomal protein import (Sus scrofa)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Sus scrofa)
H2O [cytosol]
Sensory Perception (Sus scrofa)
Visual phototransduction (Sus scrofa)
The canonical retinoid cycle in rods (twilight vision) (Sus scrofa)
11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)
H2O [cytosol]
ABCA4 mediates atRAL transport (Sus scrofa)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)
H2O [cytosol]
The phototransduction cascade (Sus scrofa)
Activation of the phototransduction cascade (Sus scrofa)
PDE6 hydrolyses cGMP to GMP (Sus scrofa)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Sus scrofa)
GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)
H2O [cytosol]
PP2A dephosphorylates p-RHO to RHO (Sus scrofa)
H2O [cytosol]
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Sus scrofa)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Sus scrofa)
OPN1LW binds 11cRAL (Sus scrofa)
H2O [cytosol]
OPN1MW binds 11cRAL (Sus scrofa)
H2O [cytosol]
OPN1SW binds 11cRAL (Sus scrofa)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)
H2O [cytosol]
Signal Transduction (Sus scrofa)
Integrin signaling (Sus scrofa)
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
H2O [cytosol]
Intracellular signaling by second messengers (Sus scrofa)
DAG and IP3 signaling (Sus scrofa)
CaM pathway (Sus scrofa)
Calmodulin induced events (Sus scrofa)
Cam-PDE 1 activation (Sus scrofa)
cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)
H2O [cytosol]
PIP3 activates AKT signaling (Sus scrofa)
Negative regulation of the PI3K/AKT network (Sus scrofa)
PTEN dephosphorylates PIP3 (Sus scrofa)
H2O [cytosol]
PTEN Regulation (Sus scrofa)
Regulation of PTEN stability and activity (Sus scrofa)
USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)
H2O [cytosol]
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF-independent MAPK1/3 activation (Sus scrofa)
Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)
H2O [cytosol]
RAF/MAP kinase cascade (Sus scrofa)
Negative regulation of MAPK pathway (Sus scrofa)
Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)
H2O [cytosol]
PP2A dephosphorylates RAF1 (Sus scrofa)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Sus scrofa)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Sus scrofa)
H2O [cytosol]
RAF activation (Sus scrofa)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)
H2O [cytosol]
PP2A dephosphorylates KSR1 (Sus scrofa)
H2O [cytosol]
PP2A dephosphorylates inactive RAFs (Sus scrofa)
H2O [cytosol]
RAS processing (Sus scrofa)
RAS proteins are depalmitoylated (Sus scrofa)
H2O [cytosol]
USP17L2 deubiquitinates RCE1 (Sus scrofa)
H2O [cytosol]
MTOR signalling (Sus scrofa)
Energy dependent regulation of mTOR by LKB1-AMPK (Sus scrofa)
AMPK is dephosphorylated (Sus scrofa)
H2O [cytosol]
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Opioid Signalling (Sus scrofa)
DARPP-32 events (Sus scrofa)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Sus scrofa)
H2O [cytosol]
PDE4A,C,D hydrolyse cAMP (Sus scrofa)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Sus scrofa)
H2O [cytosol]
G-protein mediated events (Sus scrofa)
PLC beta mediated events (Sus scrofa)
Ca-dependent events (Sus scrofa)
CaM pathway (Sus scrofa)
Calmodulin induced events (Sus scrofa)
Cam-PDE 1 activation (Sus scrofa)
cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)
H2O [cytosol]
phospho-PLA2 pathway (Sus scrofa)
Hydrolysis of phosphatidylcholine (Sus scrofa)
H2O [cytosol]
Inactivation of PLC beta (Sus scrofa)
H2O [cytosol]
PIP2 hydrolysis (Sus scrofa)
H2O [cytosol]
G alpha (q) signalling events (Sus scrofa)
Effects of PIP2 hydrolysis (Sus scrofa)
Arachidonate production from DAG (Sus scrofa)
2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Sus scrofa)
H2O [cytosol]
G alpha (s) signalling events (Sus scrofa)
PDE3A hydrolyses cAMP to AMP (Sus scrofa)
H2O [cytosol]
PDE3B hydrolyses cAMP to AMP (Sus scrofa)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Sus scrofa)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Sus scrofa)
H2O [cytosol]
Signaling by Hedgehog (Sus scrofa)
Hedgehog ligand biogenesis (Sus scrofa)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)
H2O [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PTK6 (Sus scrofa)
PTK6 Down-Regulation (Sus scrofa)
PTPN1 dephosphorylates PTK6 (Sus scrofa)
H2O [cytosol]
Signaling by Nuclear Receptors (Sus scrofa)
Signaling by Retinoic Acid (Sus scrofa)
RA biosynthesis pathway (Sus scrofa)
ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Sus scrofa)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Sus scrofa)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
MDK and PTN in ALK signaling (Sus scrofa)
PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)
H2O [cytosol]
PTPN6 dephosphorylates JAK3 (Sus scrofa)
H2O [cytosol]
Signaling by EGFR (Sus scrofa)
EGFR downregulation (Sus scrofa)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Sus scrofa)
H2O [cytosol]
PTPN3 dephosphorylates EPS15 (Sus scrofa)
H2O [cytosol]
GAB1 signalosome (Sus scrofa)
Dephosphorylation of Gab1 by SHP2 (Sus scrofa)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Sus scrofa)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)
H2O [cytosol]
Sustained activation of SRC kinase by SHP2 (Sus scrofa)
H2O [cytosol]
Signaling by ERBB2 (Sus scrofa)
Downregulation of ERBB2 signaling (Sus scrofa)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)
H2O [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Sus scrofa)
H2O [cytosol]
Signaling by Insulin receptor (Sus scrofa)
Insulin receptor recycling (Sus scrofa)
Insulin receptor de-phosphorylation (Sus scrofa)
H2O [cytosol]
Insulin receptor signalling cascade (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PKB-mediated events (Sus scrofa)
PDE3B signalling (Sus scrofa)
p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)
H2O [cytosol]
Signaling by MET (Sus scrofa)
Negative regulation of MET activity (Sus scrofa)
PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)
H2O [cytosol]
USP8 deubiquitinates LRIG1 (Sus scrofa)
H2O [cytosol]
Signaling by PDGF (Sus scrofa)
PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
IGF1R signaling cascade (Sus scrofa)
IRS-related events triggered by IGF1R (Sus scrofa)
IRS-mediated signalling (Sus scrofa)
PI3K Cascade (Sus scrofa)
PKB-mediated events (Sus scrofa)
PDE3B signalling (Sus scrofa)
p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Miro GTPase Cycle (Sus scrofa)
RHOT1 GTPase cycle (Sus scrofa)
RHOT1 hydrolyzes GTP (Sus scrofa)
H2O [cytosol]
RHOT2 GTPase cycle (Sus scrofa)
RHOT2 hydrolyzes GTP (Sus scrofa)
H2O [cytosol]
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases Activate Formins (Sus scrofa)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)
H2O [cytosol]
RHO GTPase cycle (Sus scrofa)
CDC42 GTPase cycle (Sus scrofa)
CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)
H2O [cytosol]
RAC1 GTPase cycle (Sus scrofa)
RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)
H2O [cytosol]
RAC2 GTPase cycle (Sus scrofa)
RAC2 GAPs stimulate RAC2 GTPase activity (Sus scrofa)
H2O [cytosol]
RAC3 GTPase cycle (Sus scrofa)
RAC3 GAPs stimulate RAC3 GTPase activity (Sus scrofa)
H2O [cytosol]
RHOA GTPase cycle (Sus scrofa)
RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)
H2O [cytosol]
RHOB GTPase cycle (Sus scrofa)
RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)
H2O [cytosol]
RHOC GTPase cycle (Sus scrofa)
RHOC GAPs stimulate RHOC GTPase activity (Sus scrofa)
H2O [cytosol]
RHOD GTPase cycle (Sus scrofa)
RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)
H2O [cytosol]
RHOF GTPase cycle (Sus scrofa)
RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)
H2O [cytosol]
RHOG GTPase cycle (Sus scrofa)
RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)
H2O [cytosol]
RHOJ GTPase cycle (Sus scrofa)
RHOJ GAPs stimulate RHOJ GTPase activity (Sus scrofa)
H2O [cytosol]
RHOQ GTPase cycle (Sus scrofa)
RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)
H2O [cytosol]
Signaling by TGFB family members (Sus scrofa)
Signaling by TGF-beta Receptor Complex (Sus scrofa)
TGF-beta receptor signaling activates SMADs (Sus scrofa)
Downregulation of TGF-beta receptor signaling (Sus scrofa)
MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)
H2O [cytosol]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Sus scrofa)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Sus scrofa)
USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)
H2O [cytosol]
Signaling by WNT (Sus scrofa)
Beta-catenin independent WNT signaling (Sus scrofa)
Ca2+ pathway (Sus scrofa)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Sus scrofa)
H2O [cytosol]
PDE6 hydrolyses cGMP to GMP (Sus scrofa)
H2O [cytosol]
TCF dependent signaling in response to WNT (Sus scrofa)
Regulation of FZD by ubiquitination (Sus scrofa)
USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)
H2O [cytosol]
USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)
H2O [cytosol]
Transport of small molecules (Sus scrofa)
ABC-family proteins mediated transport (Sus scrofa)
ABC transporters in lipid homeostasis (Sus scrofa)
ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)
H2O [cytosol]
ABCA7:Apo1A-mediated phospholipid efflux (Sus scrofa)
H2O [cytosol]
ABCAs mediate lipid efflux (Sus scrofa)
H2O [cytosol]
ABCAs mediate lipid influx (Sus scrofa)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Sus scrofa)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)
H2O [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
ABCA4 mediates atRAL transport (Sus scrofa)
H2O [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Sus scrofa)
H2O [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Sus scrofa)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
HCO3- transport through ion channel (Sus scrofa)
H2O [cytosol]
Mitochondrial ABC transporters (Sus scrofa)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Sus scrofa)
H2O [cytosol]
The ABCC family mediates organic anion transport (Sus scrofa)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Sus scrofa)
H2O [cytosol]
Aquaporin-mediated transport (Sus scrofa)
Passive transport by Aquaporins (Sus scrofa)
Aquaporins passively transport water into cells (Sus scrofa)
H2O [cytosol]
Aquaporins passively transport water out of cells (Sus scrofa)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Sus scrofa)
Aquaporin-1 passively transports water into cell (Sus scrofa)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Sus scrofa)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Sus scrofa)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Sus scrofa)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Sus scrofa)
H2O [cytosol]
Ion channel transport (Sus scrofa)
Ion transport by P-type ATPases (Sus scrofa)
ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Sus scrofa)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Sus scrofa)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Sus scrofa)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)
H2O [cytosol]
Iron uptake and transport (Sus scrofa)
ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
H2O [cytosol]
Transferrin endocytosis and recycling (Sus scrofa)
Acidification of Tf:TfR1 containing endosome (Sus scrofa)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Sus scrofa)
Erythrocytes take up carbon dioxide and release oxygen (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Sus scrofa)
Plasma lipoprotein assembly (Sus scrofa)
HDL assembly (Sus scrofa)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Sus scrofa)
H2O [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Sus scrofa)
H2O [cytosol]
Plasma lipoprotein clearance (Sus scrofa)
LDL clearance (Sus scrofa)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)
H2O [cytosol]
NCEH1 hydrolyzes cholesterol esters (Sus scrofa)
H2O [cytosol]
Plasma lipoprotein remodeling (Sus scrofa)
HDL remodeling (Sus scrofa)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)
H2O [cytosol]
Vesicle-mediated transport (Sus scrofa)
Membrane Trafficking (Sus scrofa)
Clathrin-mediated endocytosis (Sus scrofa)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
H2O [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
H2O [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
H2O [cytosol]
ER to Golgi Anterograde Transport (Sus scrofa)
COPII-mediated vesicle transport (Sus scrofa)
PP6 dephosphorylates SEC24 (Sus scrofa)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Sus scrofa)
Golgi-to-ER retrograde transport (Sus scrofa)
COPI-independent Golgi-to-ER retrograde traffic (Sus scrofa)
PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)
H2O [cytosol]
Rab regulation of trafficking (Sus scrofa)
TBC/RABGAPs (Sus scrofa)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)
H2O [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Sus scrofa)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)
H2O [cytosol]
Cell Cycle (Xenopus tropicalis)
Cell Cycle, Mitotic (Xenopus tropicalis)
M Phase (Xenopus tropicalis)
Mitotic Metaphase and Anaphase (Xenopus tropicalis)
Mitotic Anaphase (Xenopus tropicalis)
Nuclear Envelope (NE) Reassembly (Xenopus tropicalis)
Postmitotic nuclear pore complex (NPC) reformation (Xenopus tropicalis)
RAN stimulates fusion of nuclear envelope (NE) membranes (Xenopus tropicalis)
H2O [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Xenopus tropicalis)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Xenopus tropicalis)
H2O [cytosol]
Mitotic Prometaphase (Xenopus tropicalis)
Resolution of Sister Chromatid Cohesion (Xenopus tropicalis)
PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)
H2O [cytosol]
PPP1CC dephosphorylates PLK1 (Xenopus tropicalis)
H2O [cytosol]
Mitotic G2-G2/M phases (Xenopus tropicalis)
G2/M Transition (Xenopus tropicalis)
Cyclin A/B1/B2 associated events during G2/M transition (Xenopus tropicalis)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Xenopus tropicalis)
H2O [cytosol]
Regulation of mitotic cell cycle (Xenopus tropicalis)
APC/C-mediated degradation of cell cycle proteins (Xenopus tropicalis)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Xenopus tropicalis)
Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)
H2O [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to chemical stress (Xenopus tropicalis)
Cytoprotection by HMOX1 (Xenopus tropicalis)
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
H2O [cytosol]
Detoxification of Reactive Oxygen Species (Xenopus tropicalis)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)
H2O [cytosol]
KEAP1-NFE2L2 pathway (Xenopus tropicalis)
Nuclear events mediated by NFE2L2 (Xenopus tropicalis)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Xenopus tropicalis)
PRDX1 overoxidizes (Xenopus tropicalis)
H2O [cytosol]
Cellular response to heat stress (Xenopus tropicalis)
Regulation of HSF1-mediated heat shock response (Xenopus tropicalis)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Xenopus tropicalis)
H2O [cytosol]
Chromatin organization (Xenopus tropicalis)
Chromatin modifying enzymes (Xenopus tropicalis)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Xenopus tropicalis)
H2O [cytosol]
Developmental Biology (Xenopus tropicalis)
Nervous system development (Xenopus tropicalis)
Axon guidance (Xenopus tropicalis)
EPH-Ephrin signaling (Xenopus tropicalis)
EPHB-mediated forward signaling (Xenopus tropicalis)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)
H2O [cytosol]
Semaphorin interactions (Xenopus tropicalis)
Sema4D in semaphorin signaling (Xenopus tropicalis)
Sema4D mediated inhibition of cell attachment and migration (Xenopus tropicalis)
Inactivation of Rho-GTP by p190RhoGAP (Xenopus tropicalis)
H2O [cytosol]
Signaling by ROBO receptors (Xenopus tropicalis)
SLIT2:ROBO1 increases RHOA activity (Xenopus tropicalis)
MYO9B inactivates RHOA (Xenopus tropicalis)
H2O [cytosol]
Drug ADME (Xenopus tropicalis)
Abacavir ADME (Xenopus tropicalis)
Abacavir metabolism (Xenopus tropicalis)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)
H2O [cytosol]
Aspirin ADME (Xenopus tropicalis)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Xenopus tropicalis)
H2O [cytosol]
Atorvastatin ADME (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
H2O [cytosol]
CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)
H2O [cytosol]
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)
H2O [cytosol]
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
H2O [cytosol]
Azathioprine ADME (Xenopus tropicalis)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)
H2O [cytosol]
GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
H2O [cytosol]
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)
H2O [cytosol]
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)
H2O [cytosol]
XDH oxidises 6MP to 6TU (Xenopus tropicalis)
H2O [cytosol]
Ciprofloxacin ADME (Xenopus tropicalis)
ABCG2 transports Cipro from hepatic cell to extracellular space (Xenopus tropicalis)
H2O [cytosol]
ABCG2 transports Cipro from intestinal cell to extracellular space (Xenopus tropicalis)
H2O [cytosol]
Paracetamol ADME (Xenopus tropicalis)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)
H2O [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)
H2O [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)
H2O [cytosol]
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Xenopus tropicalis)
H2O [cytosol]
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Xenopus tropicalis)
H2O [cytosol]
CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)
H2O [cytosol]
GSTs transfer GSH to NAPQI to form APAP-SG (Xenopus tropicalis)
H2O [cytosol]
Prednisone ADME (Xenopus tropicalis)
CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)
H2O [cytosol]
Ribavirin ADME (Xenopus tropicalis)
ADA deamidates RBV (Xenopus tropicalis)
H2O [cytosol]
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)
H2O [cytosol]
NT5C2 tetramer dephosphorylates RBV-MP (Xenopus tropicalis)
H2O [cytosol]
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional Regulation by TP53 (Xenopus tropicalis)
TP53 Regulates Metabolic Genes (Xenopus tropicalis)
PRDX1 overoxidizes (Xenopus tropicalis)
H2O [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)
H2O [cytosol]
Hemostasis (Xenopus tropicalis)
Platelet activation, signaling and aggregation (Xenopus tropicalis)
Effects of PIP2 hydrolysis (Xenopus tropicalis)
Arachidonate production from DAG (Xenopus tropicalis)
2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)
H2O [cytosol]
Platelet homeostasis (Xenopus tropicalis)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Xenopus tropicalis)
H2O [cytosol]
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
TCR signaling (Xenopus tropicalis)
Downstream TCR signaling (Xenopus tropicalis)
Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
H2O [cytosol]
Generation of second messenger molecules (Xenopus tropicalis)
PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)
H2O [cytosol]
Cytokine Signaling in Immune system (Xenopus tropicalis)
Interferon Signaling (Xenopus tropicalis)
Interferon alpha/beta signaling (Xenopus tropicalis)
Regulation of IFNA/IFNB signaling (Xenopus tropicalis)
Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)
H2O [cytosol]
Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)
H2O [cytosol]
Signaling by Interleukins (Xenopus tropicalis)
Interleukin-1 family signaling (Xenopus tropicalis)
Interleukin-1 signaling (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Innate Immune System (Xenopus tropicalis)
Antimicrobial peptides (Xenopus tropicalis)
Ion influx/efflux at host-pathogen interface (Xenopus tropicalis)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Xenopus tropicalis)
H2O [cytosol]
C-type lectin receptors (CLRs) (Xenopus tropicalis)
CLEC7A (Dectin-1) signaling (Xenopus tropicalis)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)
H2O [cytosol]
Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
H2O [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Xenopus tropicalis)
Role of phospholipids in phagocytosis (Xenopus tropicalis)
Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)
H2O [cytosol]
Hydrolysis of PC to PA by PLD (Xenopus tropicalis)
H2O [cytosol]
Production of AA by iPLA2 upon FCGR activation (Xenopus tropicalis)
H2O [cytosol]
Toll-like Receptor Cascades (Xenopus tropicalis)
Toll Like Receptor 10 (TLR10) Cascade (Xenopus tropicalis)
MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Toll Like Receptor 3 (TLR3) Cascade (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
MyD88-independent TLR4 cascade (Xenopus tropicalis)
TRIF (TICAM1)-mediated TLR4 signaling (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Toll Like Receptor 5 (TLR5) Cascade (Xenopus tropicalis)
MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
TAK1-dependent IKK and NF-kappa-B activation (Xenopus tropicalis)
Regulation of NF-kappa B signaling (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
H2O [cytosol]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Pyruvate metabolism (Xenopus tropicalis)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)
H2O [cytosol]
Biological oxidations (Xenopus tropicalis)
Aflatoxin activation and detoxification (Xenopus tropicalis)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
H2O [cytosol]
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
H2O [cytosol]
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)
H2O [cytosol]
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)
H2O [cytosol]
CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)
H2O [cytosol]
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)
H2O [cytosol]
Phase I - Functionalization of compounds (Xenopus tropicalis)
Amine Oxidase reactions (Xenopus tropicalis)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Xenopus tropicalis)
MAOB:FAD oxidatively deaminates TYR (Xenopus tropicalis)
H2O [cytosol]
MAOB:FAD oxidatively deaminates of PEA (Xenopus tropicalis)
H2O [cytosol]
CMBL hydrolyses OM to OLMS (Xenopus tropicalis)
H2O [cytosol]
Cytochrome P450 - arranged by substrate type (Xenopus tropicalis)
Eicosanoids (Xenopus tropicalis)
CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)
H2O [cytosol]
CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)
H2O [cytosol]
Endogenous sterols (Xenopus tropicalis)
CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)
H2O [cytosol]
CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)
H2O [cytosol]
CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
H2O [cytosol]
Sterols are 12-hydroxylated by CYP8B1 (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
H2O [cytosol]
Vitamins (Xenopus tropicalis)
CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)
H2O [cytosol]
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)
H2O [cytosol]
Ethanol oxidation (Xenopus tropicalis)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)
H2O [cytosol]
MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)
H2O [cytosol]
Phase II - Conjugation of compounds (Xenopus tropicalis)
Cytosolic sulfonation of small molecules (Xenopus tropicalis)
ABHD14B hydrolyses PNPB (Xenopus tropicalis)
H2O [cytosol]
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)
H2O [cytosol]
Glucuronidation (Xenopus tropicalis)
Formation of the active cofactor, UDP-glucuronate (Xenopus tropicalis)
UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)
H2O [cytosol]
Glutathione conjugation (Xenopus tropicalis)
Glutathione synthesis and recycling (Xenopus tropicalis)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Xenopus tropicalis)
H2O [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)
H2O [cytosol]
Methylation (Xenopus tropicalis)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)
H2O [cytosol]
GSTO1 dimer reduces methylarsonate to methylarsonite (Xenopus tropicalis)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)
H2O [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Xenopus tropicalis)
H2O [cytosol]
Inositol phosphate metabolism (Xenopus tropicalis)
Synthesis of IP2, IP, and Ins in the cytosol (Xenopus tropicalis)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Xenopus tropicalis)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)
H2O [cytosol]
Synthesis of pyrophosphates in the cytosol (Xenopus tropicalis)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)
H2O [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)
H2O [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)
H2O [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)
H2O [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)
H2O [cytosol]
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Aspartate and asparagine metabolism (Xenopus tropicalis)
ASPA deacetylates NAA to acetate and L-aspartate (Xenopus tropicalis)
H2O [cytosol]
ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)
H2O [cytosol]
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)
H2O [cytosol]
Carnitine synthesis (Xenopus tropicalis)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)
H2O [cytosol]
Histidine catabolism (Xenopus tropicalis)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)
H2O [cytosol]
urocanate + H2O => 4-imidazolone-5-propionate (Xenopus tropicalis)
H2O [cytosol]
Metabolism of polyamines (Xenopus tropicalis)
Agmatine biosynthesis (Xenopus tropicalis)
Agmatine + H2O <=> putrescine + urea (Xenopus tropicalis)
H2O [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Phenylalanine metabolism (Xenopus tropicalis)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)
H2O [cytosol]
Tyrosine catabolism (Xenopus tropicalis)
FAH cleaves 4FAA (Xenopus tropicalis)
H2O [cytosol]
Selenoamino acid metabolism (Xenopus tropicalis)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Xenopus tropicalis)
SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)
H2O [cytosol]
Serine biosynthesis (Xenopus tropicalis)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)
H2O [cytosol]
PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)
H2O [cytosol]
Sulfur amino acid metabolism (Xenopus tropicalis)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)
H2O [cytosol]
Cysteine formation from homocysteine (Xenopus tropicalis)
PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)
H2O [cytosol]
Degradation of cysteine and homocysteine (Xenopus tropicalis)
Cysteine is degraded to serine and H2S (Xenopus tropicalis)
H2O [cytosol]
FMO1:FAD oxidizes HTAU to TAU (Xenopus tropicalis)
H2O [cytosol]
Homocysteine is degraded to oxobutanoate and H2S (Xenopus tropicalis)
H2O [cytosol]
MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)
H2O [cytosol]
Methionine salvage pathway (Xenopus tropicalis)
Acireductone is created (Xenopus tropicalis)
H2O [cytosol]
Threonine catabolism (Xenopus tropicalis)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)
H2O [cytosol]
Tryptophan catabolism (Xenopus tropicalis)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)
H2O [cytosol]
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)
H2O [cytosol]
Urea cycle (Xenopus tropicalis)
arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)
H2O [cytosol]
Metabolism of carbohydrates (Xenopus tropicalis)
Fructose metabolism (Xenopus tropicalis)
Fructose catabolism (Xenopus tropicalis)
ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)
H2O [cytosol]
Glucose metabolism (Xenopus tropicalis)
Gluconeogenesis (Xenopus tropicalis)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Xenopus tropicalis)
H2O [cytosol]
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Xenopus tropicalis)
H2O [cytosol]
Glycolysis (Xenopus tropicalis)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)
H2O [cytosol]
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)
H2O [cytosol]
Lysosomal oligosaccharide catabolism (Xenopus tropicalis)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Xenopus tropicalis)
H2O [cytosol]
Pentose phosphate pathway (Xenopus tropicalis)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)
H2O [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Biosynthesis of specialized proresolving mediators (SPMs) (Xenopus tropicalis)
Biosynthesis of DHA-derived SPMs (Xenopus tropicalis)
Biosynthesis of D-series resolvins (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)
H2O [cytosol]
Biosynthesis of aspirin-triggered D-series resolvins (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Xenopus tropicalis)
H2O [cytosol]
Biosynthesis of maresins (Xenopus tropicalis)
Biosynthesis of maresin-like SPMs (Xenopus tropicalis)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)
H2O [cytosol]
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)
H2O [cytosol]
CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)
H2O [cytosol]
Biosynthesis of protectins (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Xenopus tropicalis)
H2O [cytosol]
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)
H2O [cytosol]
Biosynthesis of EPA-derived SPMs (Xenopus tropicalis)
Biosynthesis of E-series 18(R)-resolvins (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)
H2O [cytosol]
Biosynthesis of E-series 18(S)-resolvins (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)
H2O [cytosol]
Synthesis of Lipoxins (LX) (Xenopus tropicalis)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)
H2O [cytosol]
Fatty acid metabolism (Xenopus tropicalis)
Arachidonic acid metabolism (Xenopus tropicalis)
FAAH hydrolyses AEA to AA and ETA (Xenopus tropicalis)
H2O [cytosol]
Hydrolysis of phosphatidylcholine (Xenopus tropicalis)
H2O [cytosol]
Synthesis of 15-eicosatetraenoic acid derivatives (Xenopus tropicalis)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)
H2O [cytosol]
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Xenopus tropicalis)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
H2O [cytosol]
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
H2O [cytosol]
5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)
H2O [cytosol]
CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)
H2O [cytosol]
LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)
H2O [cytosol]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (Xenopus tropicalis)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)
H2O [cytosol]
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)
H2O [cytosol]
EET(1) is hydrolysed to DHET(1) by EPHX2 (Xenopus tropicalis)
H2O [cytosol]
Fatty acyl-CoA biosynthesis (Xenopus tropicalis)
SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)
H2O [cytosol]
Synthesis of very long-chain fatty acyl-CoAs (Xenopus tropicalis)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)
H2O [cytosol]
ACSL3,4 ligate CoA to AA to form AA-CoA (Xenopus tropicalis)
H2O [cytosol]
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)
H2O [cytosol]
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)
H2O [cytosol]
Mitochondrial Fatty Acid Beta-Oxidation (Xenopus tropicalis)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)
H2O [cytosol]
Metabolism of steroids (Xenopus tropicalis)
Bile acid and bile salt metabolism (Xenopus tropicalis)
Recycling of bile acids and salts (Xenopus tropicalis)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
H2O [cytosol]
Synthesis of bile acids and bile salts (Xenopus tropicalis)
CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
H2O [cytosol]
Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)
H2O [cytosol]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Xenopus tropicalis)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
H2O [cytosol]
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
H2O [cytosol]
CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)
H2O [cytosol]
CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
H2O [cytosol]
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
H2O [cytosol]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Xenopus tropicalis)
27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)
H2O [cytosol]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Xenopus tropicalis)
CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)
H2O [cytosol]
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
H2O [cytosol]
Cholesterol biosynthesis (Xenopus tropicalis)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
H2O [cytosol]
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
H2O [cytosol]
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)
H2O [cytosol]
Cholesterol biosynthesis via desmosterol (Xenopus tropicalis)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)
H2O [cytosol]
Cholesterol biosynthesis via lathosterol (Xenopus tropicalis)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)
H2O [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Xenopus tropicalis)
H2O [cytosol]
Squalene is oxidized to its epoxide (Xenopus tropicalis)
H2O [cytosol]
Metabolism of steroid hormones (Xenopus tropicalis)
Androgen biosynthesis (Xenopus tropicalis)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
H2O [cytosol]
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
H2O [cytosol]
CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)
H2O [cytosol]
CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)
H2O [cytosol]
Estrogen biosynthesis (Xenopus tropicalis)
CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)
H2O [cytosol]
CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)
H2O [cytosol]
Glucocorticoid biosynthesis (Xenopus tropicalis)
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
H2O [cytosol]
Vitamin D (calciferol) metabolism (Xenopus tropicalis)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)
H2O [cytosol]
Phospholipid metabolism (Xenopus tropicalis)
Glycerophospholipid biosynthesis (Xenopus tropicalis)
Acyl chain remodeling of DAG and TAG (Xenopus tropicalis)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)
H2O [cytosol]
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Xenopus tropicalis)
H2O [cytosol]
TAG is hydrolyzed to DAG by PNPLA2/3 (Xenopus tropicalis)
H2O [cytosol]
Acyl chain remodelling of PC (Xenopus tropicalis)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Xenopus tropicalis)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)
H2O [cytosol]
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Xenopus tropicalis)
H2O [cytosol]
THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)
H2O [cytosol]
Acyl chain remodelling of PE (Xenopus tropicalis)
ABHD4 hydrolyses NAPE (Xenopus tropicalis)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Xenopus tropicalis)
H2O [cytosol]
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)
H2O [cytosol]
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)
H2O [cytosol]
Acyl chain remodelling of PG (Xenopus tropicalis)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)
H2O [cytosol]
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Xenopus tropicalis)
H2O [cytosol]
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Xenopus tropicalis)
H2O [cytosol]
Acyl chain remodelling of PI (Xenopus tropicalis)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Xenopus tropicalis)
H2O [cytosol]
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Xenopus tropicalis)
H2O [cytosol]
Acyl chain remodelling of PS (Xenopus tropicalis)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)
H2O [cytosol]
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Xenopus tropicalis)
H2O [cytosol]
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)
H2O [cytosol]
Hydrolysis of LPC (Xenopus tropicalis)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)
H2O [cytosol]
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)
H2O [cytosol]
Synthesis of PA (Xenopus tropicalis)
DDHD1,2 hydrolyse PA (Xenopus tropicalis)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)
H2O [cytosol]
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)
H2O [cytosol]
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)
H2O [cytosol]
PC is hydrolyzed to PA and choline by PLD1/2 (Xenopus tropicalis)
H2O [cytosol]
Synthesis of PC (Xenopus tropicalis)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Xenopus tropicalis)
H2O [cytosol]
PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)
H2O [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Xenopus tropicalis)
H2O [cytosol]
Synthesis of PE (Xenopus tropicalis)
PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)
H2O [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Xenopus tropicalis)
H2O [cytosol]
PI Metabolism (Xenopus tropicalis)
Glycerophospholipid catabolism (Xenopus tropicalis)
GDE1 hydrolyzes GroPIns (Xenopus tropicalis)
H2O [cytosol]
Synthesis of PIPs at the Golgi membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)
H2O [cytosol]
Synthesis of PIPs at the early endosome membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Xenopus tropicalis)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Xenopus tropicalis)
H2O [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Xenopus tropicalis)
H2O [cytosol]
Synthesis of PIPs at the late endosome membrane (Xenopus tropicalis)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)
H2O [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)
H2O [cytosol]
Synthesis of PIPs at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
H2O [cytosol]
Sphingolipid metabolism (Xenopus tropicalis)
Glycosphingolipid metabolism (Xenopus tropicalis)
Glycosphingolipid catabolism (Xenopus tropicalis)
ASAH2 hydrolyzes ceramide (plasma membrane) (Xenopus tropicalis)
H2O [cytosol]
ENPP7 hydrolyzes sphingomyelin (Xenopus tropicalis)
H2O [cytosol]
NEU2 cleaves GM3 to form LacCer (cytosol) (Xenopus tropicalis)
H2O [cytosol]
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Xenopus tropicalis)
H2O [cytosol]
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Xenopus tropicalis)
H2O [cytosol]
Sphingolipid catabolism (Xenopus tropicalis)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Xenopus tropicalis)
H2O [cytosol]
ACER2 hydrolyzes ceramide (Golgi) (Xenopus tropicalis)
H2O [cytosol]
ACER3 hydrolyzes phytoceramide (Xenopus tropicalis)
H2O [cytosol]
ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)
H2O [cytosol]
ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)
H2O [cytosol]
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Xenopus tropicalis)
H2O [cytosol]
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Xenopus tropicalis)
H2O [cytosol]
Sphingolipid de novo biosynthesis (Xenopus tropicalis)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)
H2O [cytosol]
DEGS1 dehydrogenates dihydroceramide (Xenopus tropicalis)
H2O [cytosol]
DEGS2 oxygenates dihydroceramide (Xenopus tropicalis)
H2O [cytosol]
FA2H hydroxylates 1,2-saturated fatty acids (Xenopus tropicalis)
H2O [cytosol]
Triglyceride metabolism (Xenopus tropicalis)
Triglyceride biosynthesis (Xenopus tropicalis)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)
H2O [cytosol]
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)
H2O [cytosol]
Triglyceride catabolism (Xenopus tropicalis)
PNPLA4 hydrolyzes TAG (Xenopus tropicalis)
H2O [cytosol]
PNPLA4 hydrolyzes retinyl palmitate (Xenopus tropicalis)
H2O [cytosol]
PNPLA5 hydrolyzes TAG (Xenopus tropicalis)
H2O [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Xenopus tropicalis)
eNOS activation (Xenopus tropicalis)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)
H2O [cytosol]
Metabolism of nucleotides (Xenopus tropicalis)
Interconversion of nucleotide di- and triphosphates (Xenopus tropicalis)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)
H2O [cytosol]
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)
H2O [cytosol]
dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)
H2O [cytosol]
Nucleotide biosynthesis (Xenopus tropicalis)
Purine ribonucleoside monophosphate biosynthesis (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
H2O [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)
H2O [cytosol]
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)
H2O [cytosol]
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
H2O [cytosol]
Pyrimidine biosynthesis (Xenopus tropicalis)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)
H2O [cytosol]
CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)
H2O [cytosol]
Nucleotide catabolism (Xenopus tropicalis)
Purine catabolism (Xenopus tropicalis)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Xenopus tropicalis)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)
H2O [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)
H2O [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Xenopus tropicalis)
H2O [cytosol]
Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)
H2O [cytosol]
ITPA hydrolyses ITP to IMP (Xenopus tropicalis)
H2O [cytosol]
ITPA hydrolyses XTP to XMP (Xenopus tropicalis)
H2O [cytosol]
ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)
H2O [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Xenopus tropicalis)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
H2O [cytosol]
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)
H2O [cytosol]
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)
H2O [cytosol]
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)
H2O [cytosol]
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)
H2O [cytosol]
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
H2O [cytosol]
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)
H2O [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
H2O [cytosol]
XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)
H2O [cytosol]
XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)
H2O [cytosol]
XDH oxidizes hypoxanthine to form xanthine (Xenopus tropicalis)
H2O [cytosol]
XDH oxidizes xanthine to form urate (Xenopus tropicalis)
H2O [cytosol]
Pyrimidine catabolism (Xenopus tropicalis)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Xenopus tropicalis)
H2O [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)
H2O [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Xenopus tropicalis)
H2O [cytosol]
Nucleotide salvage (Xenopus tropicalis)
Purine salvage (Xenopus tropicalis)
ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)
H2O [cytosol]
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)
H2O [cytosol]
AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)
H2O [cytosol]
Pyrimidine salvage (Xenopus tropicalis)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)
H2O [cytosol]
HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)
H2O [cytosol]
Metabolism of porphyrins (Xenopus tropicalis)
Heme biosynthesis (Xenopus tropicalis)
4 PBGs bind to form HMB (Xenopus tropicalis)
H2O [cytosol]
ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
H2O [cytosol]
ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)
H2O [cytosol]
UROS transforms HMB to URO3 (Xenopus tropicalis)
H2O [cytosol]
Heme degradation (Xenopus tropicalis)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)
H2O [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
H2O [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of cofactors (Xenopus tropicalis)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Xenopus tropicalis)
GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)
H2O [cytosol]
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Xenopus tropicalis)
Transport of RCbl within the body (Xenopus tropicalis)
ABCC1 transports cytosolic RCbl to extracellular region (Xenopus tropicalis)
H2O [cytosol]
Metabolism of folate and pterines (Xenopus tropicalis)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)
H2O [cytosol]
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
H2O [cytosol]
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
H2O [cytosol]
Molybdenum cofactor biosynthesis (Xenopus tropicalis)
Cyclisation of GTP to precursor Z (Xenopus tropicalis)
H2O [cytosol]
Vitamin B1 (thiamin) metabolism (Xenopus tropicalis)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)
H2O [cytosol]
Vitamin B2 (riboflavin) metabolism (Xenopus tropicalis)
2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
H2O [cytosol]
Vitamin B6 activation to pyridoxal phosphate (Xenopus tropicalis)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)
H2O [cytosol]
AOX1 oxidises PXL to PDXate (Xenopus tropicalis)
H2O [cytosol]
Pyrophosphate hydrolysis (Xenopus tropicalis)
LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)
H2O [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)
H2O [cytosol]
Reversible hydration of carbon dioxide (Xenopus tropicalis)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)
H2O [cytosol]
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)
H2O [cytosol]
Metabolism of RNA (Xenopus tropicalis)
Deadenylation-dependent mRNA decay (Xenopus tropicalis)
Deadenylation of mRNA (Xenopus tropicalis)
CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)
H2O [cytosol]
PARN deadenylates mRNA (Xenopus tropicalis)
H2O [cytosol]
mRNA decay by 3' to 5' exoribonuclease (Xenopus tropicalis)
DCPS scavenges the 7-methylguanosine cap of mRNA (Xenopus tropicalis)
H2O [cytosol]
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)
H2O [cytosol]
NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)
H2O [cytosol]
mRNA decay by 5' to 3' exoribonuclease (Xenopus tropicalis)
DCP1-DCP2 complex decaps mRNA (Xenopus tropicalis)
H2O [cytosol]
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Asparagine N-linked glycosylation (Xenopus tropicalis)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Xenopus tropicalis)
Synthesis of substrates in N-glycan biosythesis (Xenopus tropicalis)
GDP-fucose biosynthesis (Xenopus tropicalis)
GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)
H2O [cytosol]
Sialic acid metabolism (Xenopus tropicalis)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)
H2O [cytosol]
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)
H2O [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Xenopus tropicalis)
H2O [cytosol]
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)
H2O [cytosol]
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)
H2O [cytosol]
Synthesis of Dolichyl-phosphate (Xenopus tropicalis)
DOLPP1 dephosphorylates DOLDP to DOLP (Xenopus tropicalis)
H2O [cytosol]
Synthesis of UDP-N-acetyl-glucosamine (Xenopus tropicalis)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Xenopus tropicalis)
H2O [cytosol]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Xenopus tropicalis)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Xenopus tropicalis)
H2O [cytosol]
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Xenopus tropicalis)
H2O [cytosol]
Transport to the Golgi and subsequent modification (Xenopus tropicalis)
ER to Golgi Anterograde Transport (Xenopus tropicalis)
COPII-mediated vesicle transport (Xenopus tropicalis)
PP6 dephosphorylates SEC24 (Xenopus tropicalis)
H2O [cytosol]
Deubiquitination (Xenopus tropicalis)
Josephin domain DUBs (Xenopus tropicalis)
ATXN3 family cleave Ub chains (Xenopus tropicalis)
H2O [cytosol]
Metalloprotease DUBs (Xenopus tropicalis)
BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)
H2O [cytosol]
Ovarian tumor domain proteases (Xenopus tropicalis)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Xenopus tropicalis)
H2O [cytosol]
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Xenopus tropicalis)
H2O [cytosol]
UCH proteinases (Xenopus tropicalis)
UCHL1, UCHL3 cleave ubiquitin adducts (Xenopus tropicalis)
H2O [cytosol]
UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)
H2O [cytosol]
Ub-specific processing proteases (Xenopus tropicalis)
USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)
H2O [cytosol]
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)
H2O [cytosol]
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Xenopus tropicalis)
H2O [cytosol]
USP18 deubiquitinates TAK1:TAB1 (Xenopus tropicalis)
H2O [cytosol]
USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)
H2O [cytosol]
USP21 deubiquitinates RIPK1,DDX58 (Xenopus tropicalis)
H2O [cytosol]
USP25 deubiquitinates DDX58 (Xenopus tropicalis)
H2O [cytosol]
USP30 deubiquitinates Ub-MOM proteins (Xenopus tropicalis)
H2O [cytosol]
USP33 deubiquitinates CCP110,ARRB (Xenopus tropicalis)
H2O [cytosol]
USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)
H2O [cytosol]
USP8 deubiquitinates STAM2:HGS (Xenopus tropicalis)
H2O [cytosol]
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Xenopus tropicalis)
Hypusine synthesis from eIF5A-lysine (Xenopus tropicalis)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)
H2O [cytosol]
Neddylation (Xenopus tropicalis)
UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)
H2O [cytosol]
Post-translational modification: synthesis of GPI-anchored proteins (Xenopus tropicalis)
Synthesis of glycosylphosphatidylinositol (GPI) (Xenopus tropicalis)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)
H2O [cytosol]
Surfactant metabolism (Xenopus tropicalis)
ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)
H2O [cytosol]
Translation (Xenopus tropicalis)
Eukaryotic Translation Termination (Xenopus tropicalis)
APEH hydrolyses NAc-Ser-protein (Xenopus tropicalis)
H2O [cytosol]
tRNA Aminoacylation (Xenopus tropicalis)
Cytosolic tRNA aminoacylation (Xenopus tropicalis)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)
H2O [cytosol]
Muscle contraction (Xenopus tropicalis)
Cardiac conduction (Xenopus tropicalis)
Ion homeostasis (Xenopus tropicalis)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)
H2O [cytosol]
Physiological factors (Xenopus tropicalis)
CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)
H2O [cytosol]
Programmed Cell Death (Xenopus tropicalis)
Apoptosis (Xenopus tropicalis)
Intrinsic Pathway for Apoptosis (Xenopus tropicalis)
Activation of BH3-only proteins (Xenopus tropicalis)
Activation of BAD and translocation to mitochondria (Xenopus tropicalis)
Activation of BAD by calcineurin (Xenopus tropicalis)
H2O [cytosol]
Protein localization (Xenopus tropicalis)
Peroxisomal protein import (Xenopus tropicalis)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Xenopus tropicalis)
H2O [cytosol]
Sensory Perception (Xenopus tropicalis)
Visual phototransduction (Xenopus tropicalis)
The canonical retinoid cycle in rods (twilight vision) (Xenopus tropicalis)
ABCA4 mediates atRAL transport (Xenopus tropicalis)
H2O [cytosol]
CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)
H2O [cytosol]
RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)
H2O [cytosol]
The phototransduction cascade (Xenopus tropicalis)
Activation of the phototransduction cascade (Xenopus tropicalis)
PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)
H2O [cytosol]
Inactivation, recovery and regulation of the phototransduction cascade (Xenopus tropicalis)
GNAT1-GTP hydrolyses its bound GTP to GDP (Xenopus tropicalis)
H2O [cytosol]
The retinoid cycle in cones (daylight vision) (Xenopus tropicalis)
OPN1LW binds 11cRAL (Xenopus tropicalis)
H2O [cytosol]
OPN1MW binds 11cRAL (Xenopus tropicalis)
H2O [cytosol]
OPN1SW binds 11cRAL (Xenopus tropicalis)
H2O [cytosol]
at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)
H2O [cytosol]
Signal Transduction (Xenopus tropicalis)
Intracellular signaling by second messengers (Xenopus tropicalis)
DAG and IP3 signaling (Xenopus tropicalis)
CaM pathway (Xenopus tropicalis)
Calmodulin induced events (Xenopus tropicalis)
Cam-PDE 1 activation (Xenopus tropicalis)
cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)
H2O [cytosol]
PIP3 activates AKT signaling (Xenopus tropicalis)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
H2O [cytosol]
PTEN Regulation (Xenopus tropicalis)
Regulation of PTEN stability and activity (Xenopus tropicalis)
USP13 and OTUD3 deubiquitinate PTEN (Xenopus tropicalis)
H2O [cytosol]
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF-independent MAPK1/3 activation (Xenopus tropicalis)
Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
H2O [cytosol]
RAF/MAP kinase cascade (Xenopus tropicalis)
Negative regulation of MAPK pathway (Xenopus tropicalis)
Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
H2O [cytosol]
Nuclear DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
H2O [cytosol]
PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)
H2O [cytosol]
PTPN3 dephosphorylates MAPK12 (Xenopus tropicalis)
H2O [cytosol]
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Opioid Signalling (Xenopus tropicalis)
DARPP-32 events (Xenopus tropicalis)
PDE4A,C,D hydrolyse cAMP (Xenopus tropicalis)
H2O [cytosol]
p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)
H2O [cytosol]
G-protein mediated events (Xenopus tropicalis)
PLC beta mediated events (Xenopus tropicalis)
Ca-dependent events (Xenopus tropicalis)
CaM pathway (Xenopus tropicalis)
Calmodulin induced events (Xenopus tropicalis)
Cam-PDE 1 activation (Xenopus tropicalis)
cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)
H2O [cytosol]
phospho-PLA2 pathway (Xenopus tropicalis)
Hydrolysis of phosphatidylcholine (Xenopus tropicalis)
H2O [cytosol]
Inactivation of PLC beta (Xenopus tropicalis)
H2O [cytosol]
PIP2 hydrolysis (Xenopus tropicalis)
H2O [cytosol]
G alpha (q) signalling events (Xenopus tropicalis)
Effects of PIP2 hydrolysis (Xenopus tropicalis)
Arachidonate production from DAG (Xenopus tropicalis)
2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)
H2O [cytosol]
ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)
H2O [cytosol]
G alpha (s) signalling events (Xenopus tropicalis)
PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
H2O [cytosol]
PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)
H2O [cytosol]
cAMP degradation by Phosphodiesterases (Xenopus tropicalis)
H2O [cytosol]
Signaling by Hedgehog (Xenopus tropicalis)
Hedgehog ligand biogenesis (Xenopus tropicalis)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)
H2O [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by PTK6 (Xenopus tropicalis)
PTK6 Down-Regulation (Xenopus tropicalis)
PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)
H2O [cytosol]
Signaling by Nuclear Receptors (Xenopus tropicalis)
Signaling by Retinoic Acid (Xenopus tropicalis)
RA biosynthesis pathway (Xenopus tropicalis)
ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)
H2O [cytosol]
ALDHs oxidise atRAL to atRA (Xenopus tropicalis)
H2O [cytosol]
CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)
H2O [cytosol]
CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)
H2O [cytosol]
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by EGFR (Xenopus tropicalis)
EGFR downregulation (Xenopus tropicalis)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Xenopus tropicalis)
H2O [cytosol]
GAB1 signalosome (Xenopus tropicalis)
Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)
H2O [cytosol]
Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)
H2O [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)
H2O [cytosol]
Signaling by ERBB2 (Xenopus tropicalis)
Downregulation of ERBB2 signaling (Xenopus tropicalis)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)
H2O [cytosol]
Signaling by Insulin receptor (Xenopus tropicalis)
Insulin receptor recycling (Xenopus tropicalis)
Insulin receptor de-phosphorylation (Xenopus tropicalis)
H2O [cytosol]
Insulin receptor signalling cascade (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PKB-mediated events (Xenopus tropicalis)
PDE3B signalling (Xenopus tropicalis)
p-S295-PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
H2O [cytosol]
Signaling by MET (Xenopus tropicalis)
Negative regulation of MET activity (Xenopus tropicalis)
PTPN1 and PTPN2 dephosphorylate MET (Xenopus tropicalis)
H2O [cytosol]
Signaling by PDGF (Xenopus tropicalis)
PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)
H2O [cytosol]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Xenopus tropicalis)
IGF1R signaling cascade (Xenopus tropicalis)
IRS-related events triggered by IGF1R (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PKB-mediated events (Xenopus tropicalis)
PDE3B signalling (Xenopus tropicalis)
p-S295-PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
H2O [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
Miro GTPase Cycle (Xenopus tropicalis)
RHOT2 GTPase cycle (Xenopus tropicalis)
RHOT2 hydrolyzes GTP (Xenopus tropicalis)
H2O [cytosol]
Signaling by Rho GTPases (Xenopus tropicalis)
RHO GTPase cycle (Xenopus tropicalis)
CDC42 GTPase cycle (Xenopus tropicalis)
CDC42 GAPs stimulate CDC42 GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RAC1 GTPase cycle (Xenopus tropicalis)
RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RAC2 GTPase cycle (Xenopus tropicalis)
RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RAC3 GTPase cycle (Xenopus tropicalis)
RAC3 GAPs stimulate RAC3 GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RHOA GTPase cycle (Xenopus tropicalis)
RHOA GAPs stimulate RHOA GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RHOB GTPase cycle (Xenopus tropicalis)
RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RHOD GTPase cycle (Xenopus tropicalis)
RHOD GAPs stimulate RHOD GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RHOF GTPase cycle (Xenopus tropicalis)
RHOF GAPs stimulate RHOF GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RHOG GTPase cycle (Xenopus tropicalis)
RHOG GAPs stimulate RHOG GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RHOJ GTPase cycle (Xenopus tropicalis)
RHOJ GAPs stimulate RHOJ GTPase activity (Xenopus tropicalis)
H2O [cytosol]
RHOQ GTPase cycle (Xenopus tropicalis)
RHOQ GAPs stimulate RHOQ GTPase activity (Xenopus tropicalis)
H2O [cytosol]
Signaling by TGFB family members (Xenopus tropicalis)
Signaling by TGF-beta Receptor Complex (Xenopus tropicalis)
TGF-beta receptor signaling activates SMADs (Xenopus tropicalis)
Downregulation of TGF-beta receptor signaling (Xenopus tropicalis)
MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)
H2O [cytosol]
Signaling by WNT (Xenopus tropicalis)
Beta-catenin independent WNT signaling (Xenopus tropicalis)
Ca2+ pathway (Xenopus tropicalis)
PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)
H2O [cytosol]
TCF dependent signaling in response to WNT (Xenopus tropicalis)
Regulation of FZD by ubiquitination (Xenopus tropicalis)
USP8 deubiquitinates FZD to potentiate WNT signaling (Xenopus tropicalis)
H2O [cytosol]
Transport of small molecules (Xenopus tropicalis)
ABC-family proteins mediated transport (Xenopus tropicalis)
ABC transporters in lipid homeostasis (Xenopus tropicalis)
ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)
H2O [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)
H2O [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Xenopus tropicalis)
H2O [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)
H2O [cytosol]
ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)
H2O [cytosol]
ABCA4 mediates atRAL transport (Xenopus tropicalis)
H2O [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)
H2O [cytosol]
HCO3- transport through ion channel (Xenopus tropicalis)
H2O [cytosol]
Mitochondrial ABC transporters (Xenopus tropicalis)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)
H2O [cytosol]
The ABCC family mediates organic anion transport (Xenopus tropicalis)
H2O [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)
H2O [cytosol]
Aquaporin-mediated transport (Xenopus tropicalis)
Passive transport by Aquaporins (Xenopus tropicalis)
Aquaporins passively transport water into cells (Xenopus tropicalis)
H2O [cytosol]
Aquaporins passively transport water out of cells (Xenopus tropicalis)
H2O [cytosol]
Vasopressin regulates renal water homeostasis via Aquaporins (Xenopus tropicalis)
Aquaporin-1 passively transports water into cell (Xenopus tropicalis)
H2O [cytosol]
Aquaporin-1 passively transports water out of cell (Xenopus tropicalis)
H2O [cytosol]
Aquaporin-3 passively transports water out of cell (Xenopus tropicalis)
H2O [cytosol]
Aquaporin-4 passively transports water out of cell (Xenopus tropicalis)
H2O [cytosol]
p-S256-Aquaporin-2 passively transports water into cell (Xenopus tropicalis)
H2O [cytosol]
Ion channel transport (Xenopus tropicalis)
Ion transport by P-type ATPases (Xenopus tropicalis)
ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
H2O [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)
H2O [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)
H2O [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)
H2O [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)
H2O [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Xenopus tropicalis)
H2O [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
H2O [cytosol]
ATP7A transports cytosolic Cu2+ to extracellular region (Xenopus tropicalis)
H2O [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)
H2O [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Xenopus tropicalis)
H2O [cytosol]
Iron uptake and transport (Xenopus tropicalis)
ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
H2O [cytosol]
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
H2O [cytosol]
Transferrin endocytosis and recycling (Xenopus tropicalis)
Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)
H2O [cytosol]
O2/CO2 exchange in erythrocytes (Xenopus tropicalis)
Erythrocytes take up carbon dioxide and release oxygen (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)
H2O [cytosol]
Erythrocytes take up oxygen and release carbon dioxide (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)
H2O [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Xenopus tropicalis)
Plasma lipoprotein remodeling (Xenopus tropicalis)
HDL remodeling (Xenopus tropicalis)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)
H2O [cytosol]
Vesicle-mediated transport (Xenopus tropicalis)
Membrane Trafficking (Xenopus tropicalis)
ER to Golgi Anterograde Transport (Xenopus tropicalis)
COPII-mediated vesicle transport (Xenopus tropicalis)
PP6 dephosphorylates SEC24 (Xenopus tropicalis)
H2O [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Xenopus tropicalis)
Golgi-to-ER retrograde transport (Xenopus tropicalis)
COPI-independent Golgi-to-ER retrograde traffic (Xenopus tropicalis)
PLA2s hydrolyze phospholipids at the Golgi membrane (Xenopus tropicalis)
H2O [cytosol]
Rab regulation of trafficking (Xenopus tropicalis)
TBC/RABGAPs (Xenopus tropicalis)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Xenopus tropicalis)
H2O [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)
H2O [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Xenopus tropicalis)
H2O [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)
H2O [cytosol]
External Reference Information
External Reference
water [ChEBI:15377]
Participates
as an input of
ceramide + H2O => stearate + sphingosine [endoplasmic reticulum] (Gallus gallus)
phytoceramide + H2O => stearate + phytosphingosine (Gallus gallus)
fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)
hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)
xanthine + H2O + NAD+ => urate + NADH + H+ (Gallus gallus)
inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate (Gallus gallus)
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)
5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate (Gallus gallus)
inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)
4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 (Gallus gallus)
fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)
phosphoenolpyruvate + H2O <=> 2-phosphoglycerate (Gallus gallus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PLA2s hydrolyze phospholipids at the Golgi membrane (Saccharomyces cerevisiae)
PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)
PLA2s hydrolyze phospholipids at the Golgi membrane (Caenorhabditis elegans)
PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)
PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Xenopus tropicalis)
PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)
PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)
PLA2s hydrolyze phospholipids at the Golgi membrane (Bos taurus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)
PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Mus musculus)
PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Canis familiaris)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Drosophila melanogaster)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Xenopus tropicalis)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Homo sapiens)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Dictyostelium discoideum)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Caenorhabditis elegans)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Xenopus tropicalis)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Danio rerio)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)
TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Gallus gallus)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Sus scrofa)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Canis familiaris)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Mus musculus)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Canis familiaris)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)
TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)
ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)
ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)
ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)
ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)
ALDHs oxidise atRAL to atRA (Drosophila melanogaster)
ALDHs oxidise atRAL to atRA (Gallus gallus)
ALDHs oxidise atRAL to atRA (Xenopus tropicalis)
ALDHs oxidise atRAL to atRA (Danio rerio)
ALDHs oxidise atRAL to atRA (Sus scrofa)
ALDHs oxidise atRAL to atRA (Bos taurus)
ALDHs oxidise atRAL to atRA (Canis familiaris)
ALDHs oxidise atRAL to atRA (Rattus norvegicus)
ALDHs oxidise atRAL to atRA (Mus musculus)
ALDHs oxidise atRAL to atRA (Homo sapiens)
Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Mus musculus)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)
RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)
RHOT1 hydrolyzes GTP (Dictyostelium discoideum)
RHOT1 hydrolyzes GTP (Caenorhabditis elegans)
RHOT1 hydrolyzes GTP (Drosophila melanogaster)
RHOT1 hydrolyzes GTP (Gallus gallus)
RHOT1 hydrolyzes GTP (Danio rerio)
RHOT1 hydrolyzes GTP (Sus scrofa)
RHOT1 hydrolyzes GTP (Bos taurus)
RHOT1 hydrolyzes GTP (Canis familiaris)
RHOT1 hydrolyzes GTP (Mus musculus)
RHOT1 hydrolyzes GTP (Homo sapiens)
RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)
RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)
RHOT2 hydrolyzes GTP (Dictyostelium discoideum)
RHOT2 hydrolyzes GTP (Caenorhabditis elegans)
RHOT2 hydrolyzes GTP (Drosophila melanogaster)
RHOT2 hydrolyzes GTP (Gallus gallus)
RHOT2 hydrolyzes GTP (Xenopus tropicalis)
RHOT2 hydrolyzes GTP (Danio rerio)
RHOT2 hydrolyzes GTP (Sus scrofa)
RHOT2 hydrolyzes GTP (Bos taurus)
RHOT2 hydrolyzes GTP (Rattus norvegicus)
RHOT2 hydrolyzes GTP (Mus musculus)
RHOT2 hydrolyzes GTP (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Saccharomyces cerevisiae)
RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)
RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)
RHOA GAPs stimulate RHOA GTPase activity (Gallus gallus)
RHOA GAPs stimulate RHOA GTPase activity (Xenopus tropicalis)
RHOA GAPs stimulate RHOA GTPase activity (Danio rerio)
RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)
RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)
RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)
RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)
RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
RHOC GAPs stimulate RHOC GTPase activity (Saccharomyces cerevisiae)
RHOC GAPs stimulate RHOC GTPase activity (Schizosaccharomyces pombe)
RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)
RHOC GAPs stimulate RHOC GTPase activity (Sus scrofa)
RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)
RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)
RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)
RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)
RHOQ GAPs stimulate RHOQ GTPase activity (Saccharomyces cerevisiae)
RHOQ GAPs stimulate RHOQ GTPase activity (Schizosaccharomyces pombe)
RHOQ GAPs stimulate RHOQ GTPase activity (Dictyostelium discoideum)
RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)
RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)
RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)
RHOQ GAPs stimulate RHOQ GTPase activity (Xenopus tropicalis)
RHOQ GAPs stimulate RHOQ GTPase activity (Danio rerio)
RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)
RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)
RHOQ GAPs stimulate RHOQ GTPase activity (Canis familiaris)
RHOQ GAPs stimulate RHOQ GTPase activity (Rattus norvegicus)
RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)
RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)
CDC42 GAPs stimulate CDC42 GTPase activity (Schizosaccharomyces pombe)
CDC42 GAPs stimulate CDC42 GTPase activity (Dictyostelium discoideum)
CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)
CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)
CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)
CDC42 GAPs stimulate CDC42 GTPase activity (Xenopus tropicalis)
CDC42 GAPs stimulate CDC42 GTPase activity (Danio rerio)
CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)
CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)
CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)
CDC42 GAPs stimulate CDC42 GTPase activity (Rattus norvegicus)
CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)
RAC2 GAPs stimulate RAC2 GTPase activity (Caenorhabditis elegans)
RAC2 GAPs stimulate RAC2 GTPase activity (Drosophila melanogaster)
RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)
RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)
RAC2 GAPs stimulate RAC2 GTPase activity (Danio rerio)
RAC2 GAPs stimulate RAC2 GTPase activity (Sus scrofa)
RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)
RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)
RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)
RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)
RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)
RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)
RHOD GAPs stimulate RHOD GTPase activity (Schizosaccharomyces pombe)
RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)
RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)
RHOD GAPs stimulate RHOD GTPase activity (Gallus gallus)
RHOD GAPs stimulate RHOD GTPase activity (Xenopus tropicalis)
RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)
RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)
RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)
RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)
RHOD GAPs stimulate RHOD GTPase activity (Rattus norvegicus)
RHOD GAPs stimulate RHOD GTPase activity (Mus musculus)
RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Dictyostelium discoideum)
RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)
RAC1 GAPs stimulate RAC1 GTPase activity (Drosophila melanogaster)
RAC1 GAPs stimulate RAC1 GTPase activity (Gallus gallus)
RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)
RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)
RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)
RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)
RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)
RAC1 GAPs stimulate RAC1 GTPase activity (Rattus norvegicus)
RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RHOF GAPs stimulate RHOF GTPase activity (Saccharomyces cerevisiae)
RHOF GAPs stimulate RHOF GTPase activity (Schizosaccharomyces pombe)
RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)
RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)
RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)
RHOF GAPs stimulate RHOF GTPase activity (Xenopus tropicalis)
RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)
RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)
RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)
RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)
RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)
RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)
RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)
RHOB GAPs stimulate RHOB GTPase activity (Saccharomyces cerevisiae)
RHOB GAPs stimulate RHOB GTPase activity (Schizosaccharomyces pombe)
RHOB GAPs stimulate RHOB GTPase activity (Caenorhabditis elegans)
RHOB GAPs stimulate RHOB GTPase activity (Drosophila melanogaster)
RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)
RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)
RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)
RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)
RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)
RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)
RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)
RHOG GAPs stimulate RHOG GTPase activity (Caenorhabditis elegans)
RHOG GAPs stimulate RHOG GTPase activity (Drosophila melanogaster)
RHOG GAPs stimulate RHOG GTPase activity (Gallus gallus)
RHOG GAPs stimulate RHOG GTPase activity (Xenopus tropicalis)
RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)
RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)
RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)
RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)
RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)
RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)
RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)
RHOJ GAPs stimulate RHOJ GTPase activity (Saccharomyces cerevisiae)
RHOJ GAPs stimulate RHOJ GTPase activity (Schizosaccharomyces pombe)
RHOJ GAPs stimulate RHOJ GTPase activity (Dictyostelium discoideum)
RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)
RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)
RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)
RHOJ GAPs stimulate RHOJ GTPase activity (Xenopus tropicalis)
RHOJ GAPs stimulate RHOJ GTPase activity (Sus scrofa)
RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)
RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)
RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)
RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)
RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)
RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)
RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)
RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)
RAC3 GAPs stimulate RAC3 GTPase activity (Gallus gallus)
RAC3 GAPs stimulate RAC3 GTPase activity (Xenopus tropicalis)
RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)
RAC3 GAPs stimulate RAC3 GTPase activity (Sus scrofa)
RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)
RAC3 GAPs stimulate RAC3 GTPase activity (Canis familiaris)
RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)
RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)
RHOBTB3 hydrolyzes ATP (Dictyostelium discoideum)
RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)
RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)
RHOBTB3 hydrolyzes ATP (Gallus gallus)
RHOBTB3 hydrolyzes ATP (Bos taurus)
RHOBTB3 hydrolyzes ATP (Canis familiaris)
RHOBTB3 hydrolyzes ATP (Rattus norvegicus)
RHOBTB3 hydrolyzes ATP (Mus musculus)
RHOBTB3 hydrolyzes ATP (Homo sapiens)
Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Bos taurus)
GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Caenorhabditis elegans)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Drosophila melanogaster)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Gallus gallus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Xenopus tropicalis)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Sus scrofa)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Bos taurus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)
USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)
ASAP1 stimulates GTPase activity of ARF4 (Drosophila melanogaster)
ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)
ASAP1 stimulates GTPase activity of ARF4 (Danio rerio)
ASAP1 stimulates GTPase activity of ARF4 (Sus scrofa)
ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)
ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)
ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)
ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)
ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)
Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)
Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose (Mycobacterium tuberculosis)
DHAP from Ery4P and PEP (Mycobacterium tuberculosis)
mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)
formylmycothiol hydrolyzes into mycothiol and formate (Mycobacterium tuberculosis)
acetylglucosamine-inositol-phosphate is dephosphorylated (Mycobacterium tuberculosis)
acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)
mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)
Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)
cleavage of L-cysteine from carrier protein (Mycobacterium tuberculosis)
APS is phosphorylated to PAPS (Mycobacterium tuberculosis)
PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)
sulfate uptake in the cytosol (Mycobacterium tuberculosis)
CES1 hydrolyses sacubitril to sacubitrilat (Dictyostelium discoideum)
CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)
CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)
CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)
CES1 hydrolyses sacubitril to sacubitrilat (Xenopus tropicalis)
CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)
CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)
CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)
CES1 hydrolyses sacubitril to sacubitrilat (Canis familiaris)
CES1 hydrolyses sacubitril to sacubitrilat (Rattus norvegicus)
CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)
CES1 hydrolyses sacubitril to sacubitrilat (Homo sapiens)
APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)
APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)
APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)
APEH hydrolyses NAc-Ser-protein (Gallus gallus)
APEH hydrolyses NAc-Ser-protein (Xenopus tropicalis)
APEH hydrolyses NAc-Ser-protein (Sus scrofa)
APEH hydrolyses NAc-Ser-protein (Bos taurus)
APEH hydrolyses NAc-Ser-protein (Canis familiaris)
APEH hydrolyses NAc-Ser-protein (Rattus norvegicus)
APEH hydrolyses NAc-Ser-protein (Mus musculus)
APEH hydrolyses NAc-Ser-protein (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Bos taurus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Rattus norvegicus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Mus musculus)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Xenopus tropicalis)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Danio rerio)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Sus scrofa)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Bos taurus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Gallus gallus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Xenopus tropicalis)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Mus musculus)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)
USP30 deubiquitinates Ub-MOM proteins (Schizosaccharomyces pombe)
USP30 deubiquitinates Ub-MOM proteins (Caenorhabditis elegans)
USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)
USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)
USP30 deubiquitinates Ub-MOM proteins (Xenopus tropicalis)
USP30 deubiquitinates Ub-MOM proteins (Danio rerio)
USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)
USP30 deubiquitinates Ub-MOM proteins (Bos taurus)
USP30 deubiquitinates Ub-MOM proteins (Canis familiaris)
USP30 deubiquitinates Ub-MOM proteins (Rattus norvegicus)
USP30 deubiquitinates Ub-MOM proteins (Mus musculus)
USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
USP5 cleaves polyubiquitin (Schizosaccharomyces pombe)
USP5 cleaves polyubiquitin (Dictyostelium discoideum)
USP5 cleaves polyubiquitin (Drosophila melanogaster)
USP5 cleaves polyubiquitin (Gallus gallus)
USP5 cleaves polyubiquitin (Danio rerio)
USP5 cleaves polyubiquitin (Sus scrofa)
USP5 cleaves polyubiquitin (Bos taurus)
USP5 cleaves polyubiquitin (Canis familiaris)
USP5 cleaves polyubiquitin (Rattus norvegicus)
USP5 cleaves polyubiquitin (Mus musculus)
USP5 cleaves polyubiquitin (Homo sapiens)
USP10 deubiquitinates SNX3, CFTR (Saccharomyces cerevisiae)
USP10 deubiquitinates SNX3, CFTR (Schizosaccharomyces pombe)
USP10 deubiquitinates SNX3, CFTR (Gallus gallus)
USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)
USP10 deubiquitinates SNX3, CFTR (Sus scrofa)
USP10 deubiquitinates SNX3, CFTR (Canis familiaris)
USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)
USP10 deubiquitinates SNX3, CFTR (Mus musculus)
USP10 deubiquitinates SNX3, CFTR (Homo sapiens)
USP21 deubiquitinates RIPK1,DDX58 (Dictyostelium discoideum)
USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)
USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)
USP21 deubiquitinates RIPK1,DDX58 (Xenopus tropicalis)
USP21 deubiquitinates RIPK1,DDX58 (Sus scrofa)
USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)
USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)
USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)
USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)
USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)
USP13 deubiquitinates BECN1,USP10 (Schizosaccharomyces pombe)
USP13 deubiquitinates BECN1,USP10 (Dictyostelium discoideum)
USP13 deubiquitinates BECN1,USP10 (Drosophila melanogaster)
USP13 deubiquitinates BECN1,USP10 (Gallus gallus)
USP13 deubiquitinates BECN1,USP10 (Danio rerio)
USP13 deubiquitinates BECN1,USP10 (Sus scrofa)
USP13 deubiquitinates BECN1,USP10 (Bos taurus)
USP13 deubiquitinates BECN1,USP10 (Canis familiaris)
USP13 deubiquitinates BECN1,USP10 (Rattus norvegicus)
USP13 deubiquitinates BECN1,USP10 (Mus musculus)
USP13 deubiquitinates BECN1,USP10 (Homo sapiens)
USP11 deubiquitinates NFKBIA (Sus scrofa)
USP11 deubiquitinates NFKBIA (Bos taurus)
USP11 deubiquitinates NFKBIA (Canis familiaris)
USP11 deubiquitinates NFKBIA (Rattus norvegicus)
USP11 deubiquitinates NFKBIA (Mus musculus)
USP11 deubiquitinates NFKBIA (Homo sapiens)
USP33 deubiquitinates CCP110,ARRB (Drosophila melanogaster)
USP33 deubiquitinates CCP110,ARRB (Gallus gallus)
USP33 deubiquitinates CCP110,ARRB (Xenopus tropicalis)
USP33 deubiquitinates CCP110,ARRB (Sus scrofa)
USP33 deubiquitinates CCP110,ARRB (Bos taurus)
USP33 deubiquitinates CCP110,ARRB (Canis familiaris)
USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)
USP33 deubiquitinates CCP110,ARRB (Mus musculus)
USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Plasmodium falciparum)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Caenorhabditis elegans)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Drosophila melanogaster)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Bos taurus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Homo sapiens)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)
USP25 deubiquitinates DDX58 (Saccharomyces cerevisiae)
USP25 deubiquitinates DDX58 (Dictyostelium discoideum)
USP25 deubiquitinates DDX58 (Caenorhabditis elegans)
USP25 deubiquitinates DDX58 (Xenopus tropicalis)
USP25 deubiquitinates DDX58 (Sus scrofa)
USP25 deubiquitinates DDX58 (Bos taurus)
USP25 deubiquitinates DDX58 (Rattus norvegicus)
USP25 deubiquitinates DDX58 (Mus musculus)
USP25 deubiquitinates DDX58 (Homo sapiens)
USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)
USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)
USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)
USP20, USP33 deubiquitinate ADRB2 (Danio rerio)
USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)
USP20, USP33 deubiquitinate ADRB2 (Bos taurus)
USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)
USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)
USP20, USP33 deubiquitinate ADRB2 (Mus musculus)
USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)
USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)
USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)
USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)
USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)
USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)
USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)
USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)
USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)
USP19 deubiquitinates RNF123 (Dictyostelium discoideum)
USP19 deubiquitinates RNF123 (Gallus gallus)
USP19 deubiquitinates RNF123 (Sus scrofa)
USP19 deubiquitinates RNF123 (Bos taurus)
USP19 deubiquitinates RNF123 (Canis familiaris)
USP19 deubiquitinates RNF123 (Rattus norvegicus)
USP19 deubiquitinates RNF123 (Mus musculus)
USP19 deubiquitinates RNF123 (Homo sapiens)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Saccharomyces cerevisiae)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Schizosaccharomyces pombe)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Xenopus tropicalis)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Danio rerio)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Canis familiaris)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Mus musculus)
USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)
USP8 deubiquitinates STAM2:HGS (Gallus gallus)
USP8 deubiquitinates STAM2:HGS (Xenopus tropicalis)
USP8 deubiquitinates STAM2:HGS (Sus scrofa)
USP8 deubiquitinates STAM2:HGS (Bos taurus)
USP8 deubiquitinates STAM2:HGS (Canis familiaris)
USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)
USP8 deubiquitinates STAM2:HGS (Mus musculus)
USP8 deubiquitinates STAM2:HGS (Homo sapiens)
USP8 deubiquitinates RNF128 (Drosophila melanogaster)
USP8 deubiquitinates RNF128 (Gallus gallus)
USP8 deubiquitinates RNF128 (Sus scrofa)
USP8 deubiquitinates RNF128 (Bos taurus)
USP8 deubiquitinates RNF128 (Canis familiaris)
USP8 deubiquitinates RNF128 (Rattus norvegicus)
USP8 deubiquitinates RNF128 (Mus musculus)
USP8 deubiquitinates RNF128 (Homo sapiens)
USP18 deubiquitinates TAK1:TAB1 (Gallus gallus)
USP18 deubiquitinates TAK1:TAB1 (Xenopus tropicalis)
USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)
USP18 deubiquitinates TAK1:TAB1 (Bos taurus)
USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)
USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)
USP18 deubiquitinates TAK1:TAB1 (Mus musculus)
USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)
BRISC complex deubiquitinates NLRP3 (Gallus gallus)
BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)
BRISC complex deubiquitinates NLRP3 (Sus scrofa)
BRISC complex deubiquitinates NLRP3 (Bos taurus)
BRISC complex deubiquitinates NLRP3 (Canis familiaris)
BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)
BRISC complex deubiquitinates NLRP3 (Mus musculus)
BRISC complex deubiquitinates NLRP3 (Homo sapiens)
UCHL1, UCHL3 cleave ubiquitin adducts (Plasmodium falciparum)
UCHL1, UCHL3 cleave ubiquitin adducts (Saccharomyces cerevisiae)
UCHL1, UCHL3 cleave ubiquitin adducts (Schizosaccharomyces pombe)
UCHL1, UCHL3 cleave ubiquitin adducts (Dictyostelium discoideum)
UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)
UCHL1, UCHL3 cleave ubiquitin adducts (Drosophila melanogaster)
UCHL1, UCHL3 cleave ubiquitin adducts (Gallus gallus)
UCHL1, UCHL3 cleave ubiquitin adducts (Xenopus tropicalis)
UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)
UCHL1, UCHL3 cleave ubiquitin adducts (Sus scrofa)
UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)
UCHL1, UCHL3 cleave ubiquitin adducts (Canis familiaris)
UCHL1, UCHL3 cleave ubiquitin adducts (Rattus norvegicus)
UCHL1, UCHL3 cleave ubiquitin adducts (Mus musculus)
UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)
ATXN3 family cleave Ub chains (Plasmodium falciparum)
ATXN3 family cleave Ub chains (Dictyostelium discoideum)
ATXN3 family cleave Ub chains (Caenorhabditis elegans)
ATXN3 family cleave Ub chains (Drosophila melanogaster)
ATXN3 family cleave Ub chains (Gallus gallus)
ATXN3 family cleave Ub chains (Xenopus tropicalis)
ATXN3 family cleave Ub chains (Danio rerio)
ATXN3 family cleave Ub chains (Sus scrofa)
ATXN3 family cleave Ub chains (Bos taurus)
ATXN3 family cleave Ub chains (Canis familiaris)
ATXN3 family cleave Ub chains (Rattus norvegicus)
ATXN3 family cleave Ub chains (Mus musculus)
ATXN3 family cleave Ub chains (Homo sapiens)
ATXN3 deubiquitinates polyUb-PARK2 (Plasmodium falciparum)
ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)
ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)
ATXN3 deubiquitinates polyUb-PARK2 (Canis familiaris)
ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)
ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)
ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Saccharomyces cerevisiae)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Gallus gallus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Bos taurus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Canis familiaris)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)
N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin (Bos taurus)
SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Homo sapiens)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)
Non-enzymatic hydrolysis hydrolyses 13(S),14(S)-epoxy-DHA to 7-epi-MaR1 (Homo sapiens)
Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (Homo sapiens)
GGT hydrolyses RCTR2 to RCTR3 (Homo sapiens)
GGT hydrolyses RCTR1 to RCTR2 (Homo sapiens)
GGT hydrolyses PCTR1 to PCTR2 (Homo sapiens)
GGT hydrolyses PCTR2 to PCTR3 (Homo sapiens)
GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)
DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Mus musculus)
LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Homo sapiens)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Mus musculus)
LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Homo sapiens)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Mus musculus)
LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Mus musculus)
LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)
Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA (Homo sapiens)
Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA (Homo sapiens)
Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Gallus gallus)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Xenopus tropicalis)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Sus scrofa)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Canis familiaris)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Mus musculus)
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Gallus gallus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Xenopus tropicalis)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by the Mtmr2:Sbf2 tetramer at the plasma membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
PI3P is dephosphorylated to PI by the Mtmr2:Sbf2 tetramer at the plasma membrane (Mus musculus)
PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Danio rerio)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Gallus gallus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Homo sapiens)
Pnpla7 hydrolyzes LysoPtdCho (Mus musculus)
PNPLA7 hydrolyzes LysoPtdCho (Homo sapiens)
GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)
GDE1 hydrolyzes GroPIns (Drosophila melanogaster)
GDE1 hydrolyzes GroPIns (Gallus gallus)
GDE1 hydrolyzes GroPIns (Xenopus tropicalis)
GDE1 hydrolyzes GroPIns (Danio rerio)
GDE1 hydrolyzes GroPIns (Sus scrofa)
GDE1 hydrolyzes GroPIns (Bos taurus)
GDE1 hydrolyzes GroPIns (Canis familiaris)
GDE1 hydrolyzes GroPIns (Rattus norvegicus)
GDE1 hydrolyzes GroPIns (Mus musculus)
GDE1 hydrolyzes GroPIns (Homo sapiens)
Gdpd5 hydrolyzes GPCho (Mus musculus)
Gdpd3 hydrolyzes LysoPtdCho (Mus musculus)
GDPD3 hydrolyzes LysoPtdCho (Homo sapiens)
Gdpd1 hydrolyzes LysoPtdCho (Mus musculus)
GDPD1 hydrolyzes LysoPtdCho (Homo sapiens)
PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)
PNPLA6 hydrolyzes LysoPtdCho (Schizosaccharomyces pombe)
PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)
PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)
PNPLA6 hydrolyzes LysoPtdCho (Gallus gallus)
PNPLA6 hydrolyzes LysoPtdCho (Sus scrofa)
PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)
PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)
PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)
PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)
PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)
GDPD5 hydrolyzes GPCho (Homo sapiens)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Drosophila melanogaster)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Gallus gallus)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Canis familiaris)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Danio rerio)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Saccharomyces cerevisiae)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Saccharomyces cerevisiae)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Schizosaccharomyces pombe)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Schizosaccharomyces pombe)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Canis familiaris)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Mus musculus)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Caenorhabditis elegans)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Caenorhabditis elegans)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Drosophila melanogaster)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Drosophila melanogaster)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Gallus gallus)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Gallus gallus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Gallus gallus)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Xenopus tropicalis)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Xenopus tropicalis)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Sus scrofa)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Sus scrofa)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Sus scrofa)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Rattus norvegicus)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Rattus norvegicus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Rattus norvegicus)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Homo sapiens)
PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Mus musculus)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Mus musculus)
PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)
PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Plasmodium falciparum)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Saccharomyces cerevisiae)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Schizosaccharomyces pombe)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Dictyostelium discoideum)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Gallus gallus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Sus scrofa)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Bos taurus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Homo sapiens)
THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)
THEM86B hydrolyses PMCHO, PMETAM (Caenorhabditis elegans)
THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)
THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)
THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)
THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)
THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)
THEM86B hydrolyses PMCHO, PMETAM (Canis familiaris)
THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)
THEM86B hydrolyses PMCHO, PMETAM (Mus musculus)
THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)
DDHD1,2 hydrolyse PA (Plasmodium falciparum)
DDHD1,2 hydrolyse PA (Saccharomyces cerevisiae)
DDHD1,2 hydrolyse PA (Schizosaccharomyces pombe)
DDHD1,2 hydrolyse PA (Dictyostelium discoideum)
DDHD1,2 hydrolyse PA (Gallus gallus)
DDHD1,2 hydrolyse PA (Xenopus tropicalis)
DDHD1,2 hydrolyse PA (Sus scrofa)
DDHD1,2 hydrolyse PA (Bos taurus)
DDHD1,2 hydrolyse PA (Canis familiaris)
DDHD1,2 hydrolyse PA (Rattus norvegicus)
DDHD1,2 hydrolyse PA (Mus musculus)
DDHD1,2 hydrolyse PA (Homo sapiens)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Dictyostelium discoideum)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Gallus gallus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Xenopus tropicalis)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Rattus norvegicus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)
ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)
ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)
ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)
ABHD4 hydrolyses NAPE (Caenorhabditis elegans)
ABHD4 hydrolyses NAPE (Drosophila melanogaster)
ABHD4 hydrolyses NAPE (Xenopus tropicalis)
ABHD4 hydrolyses NAPE (Sus scrofa)
ABHD4 hydrolyses NAPE (Bos taurus)
ABHD4 hydrolyses NAPE (Canis familiaris)
ABHD4 hydrolyses NAPE (Rattus norvegicus)
ABHD4 hydrolyses NAPE (Mus musculus)
ABHD4 hydrolyses NAPE (Homo sapiens)
FAAH hydrolyses AEA to AA and ETA (Caenorhabditis elegans)
FAAH hydrolyses AEA to AA and ETA (Gallus gallus)
FAAH hydrolyses AEA to AA and ETA (Xenopus tropicalis)
FAAH hydrolyses AEA to AA and ETA (Sus scrofa)
FAAH hydrolyses AEA to AA and ETA (Bos taurus)
FAAH hydrolyses AEA to AA and ETA (Canis familiaris)
FAAH hydrolyses AEA to AA and ETA (Rattus norvegicus)
FAAH hydrolyses AEA to AA and ETA (Mus musculus)
FAAH hydrolyses AEA to AA and ETA (Homo sapiens)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Plasmodium falciparum)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Dictyostelium discoideum)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Gallus gallus)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Xenopus tropicalis)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Danio rerio)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Bos taurus)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Canis familiaris)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Mus musculus)
EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)
EXD4 is converted to EXE4 by DPEP (Homo sapiens)
LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)
PNPLA4 hydrolyzes TAG (Plasmodium falciparum)
PNPLA4 hydrolyzes TAG (Gallus gallus)
PNPLA4 hydrolyzes TAG (Xenopus tropicalis)
PNPLA4 hydrolyzes TAG (Sus scrofa)
PNPLA4 hydrolyzes TAG (Bos taurus)
PNPLA4 hydrolyzes TAG (Canis familiaris)
PNPLA4 hydrolyzes TAG (Rattus norvegicus)
PNPLA4 hydrolyzes TAG (Homo sapiens)
PNPLA5 hydrolyzes TAG (Plasmodium falciparum)
PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)
PNPLA5 hydrolyzes TAG (Drosophila melanogaster)
PNPLA5 hydrolyzes TAG (Gallus gallus)
PNPLA5 hydrolyzes TAG (Xenopus tropicalis)
PNPLA5 hydrolyzes TAG (Danio rerio)
PNPLA5 hydrolyzes TAG (Canis familiaris)
PNPLA5 hydrolyzes TAG (Rattus norvegicus)
PNPLA5 hydrolyzes TAG (Mus musculus)
PNPLA5 hydrolyzes TAG (Homo sapiens)
phosphorylated perilipin + H2O -> perilipin + orthophosphate (Rattus norvegicus)
phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)
cholesterol ester + H2O -> cholesterol + fatty acid (Rattus norvegicus)
cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)
2-acylglycerol + H2O -> glycerol + fatty acid (Rattus norvegicus)
2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)
diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Rattus norvegicus)
triacylglycerol + H2O -> diacylglycerol + fatty acid (Rattus norvegicus)
triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)
diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)
PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)
PNPLA4 hydrolyzes retinyl palmitate (Gallus gallus)
PNPLA4 hydrolyzes retinyl palmitate (Xenopus tropicalis)
PNPLA4 hydrolyzes retinyl palmitate (Sus scrofa)
PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)
PNPLA4 hydrolyzes retinyl palmitate (Canis familiaris)
PNPLA4 hydrolyzes retinyl palmitate (Rattus norvegicus)
PNPLA4 hydrolyzes retinyl palmitate (Homo sapiens)
phosphorylated HSL + H2O -> HSL + orthophosphate (Rattus norvegicus)
phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Saccharomyces cerevisiae)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Schizosaccharomyces pombe)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Gallus gallus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Homo sapiens)
I(1,3)P2 is dephosphorylated into I1P by Mtmr7 (Mus musculus)
I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)
I(1,3)P2 is dephosphorylated into I1P by Mtmr7:Mtmr9 (Mus musculus)
I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9 (Homo sapiens)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Dictyostelium discoideum)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Gallus gallus)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Sus scrofa)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Gallus gallus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Gallus gallus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Danio rerio)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Sus scrofa)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Homo sapiens)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Plasmodium falciparum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Schizosaccharomyces pombe)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Gallus gallus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Gallus gallus)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Xenopus tropicalis)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Sus scrofa)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Rattus norvegicus)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Mus musculus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Dictyostelium discoideum)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Drosophila melanogaster)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Gallus gallus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Rattus norvegicus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Plasmodium falciparum)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Caenorhabditis elegans)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Drosophila melanogaster)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Gallus gallus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Danio rerio)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Bos taurus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Mus musculus)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)
Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)
Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)
Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)
Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol (Mus musculus)
CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
PTP1B dephosphorylates GHR (Gallus gallus)
PTP1B dephosphorylates GHR (Danio rerio)
PTP1B dephosphorylates GHR (Sus scrofa)
PTP1B dephosphorylates GHR (Bos taurus)
PTP1B dephosphorylates GHR (Canis familiaris)
PTP1B dephosphorylates GHR (Rattus norvegicus)
PTP1B dephosphorylates GHR (Mus musculus)
PTP1B dephosphorylates GHR (Homo sapiens)
PTP1B dephosphorylates JAK2 (Homo sapiens)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Schizosaccharomyces pombe)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Xenopus tropicalis)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Sus scrofa)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Bos taurus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Canis familiaris)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)
PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
ABCC4 accumulation of dense granule contents (Plasmodium falciparum)
ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Drosophila melanogaster)
ABCC4 accumulation of dense granule contents (Gallus gallus)
ABCC4 accumulation of dense granule contents (Danio rerio)
ABCC4 accumulation of dense granule contents (Sus scrofa)
ABCC4 accumulation of dense granule contents (Bos taurus)
ABCC4 accumulation of dense granule contents (Canis familiaris)
ABCC4 accumulation of dense granule contents (Rattus norvegicus)
ABCC4 accumulation of dense granule contents (Mus musculus)
ABCC4 accumulation of dense granule contents (Homo sapiens)
ABCG2 transports Cipro from intestinal cell to extracellular space (Plasmodium falciparum)
ABCG2 transports Cipro from intestinal cell to extracellular space (Saccharomyces cerevisiae)
ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)
ABCG2 transports Cipro from intestinal cell to extracellular space (Caenorhabditis elegans)
ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)
ABCG2 transports Cipro from intestinal cell to extracellular space (Xenopus tropicalis)
ABCG2 transports Cipro from intestinal cell to extracellular space (Sus scrofa)
ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)
ABCG2 transports Cipro from intestinal cell to extracellular space (Canis familiaris)
ABCG2 transports Cipro from intestinal cell to extracellular space (Rattus norvegicus)
ABCG2 transports Cipro from intestinal cell to extracellular space (Mus musculus)
ABCG2 transports Cipro from intestinal cell to extracellular space (Homo sapiens)
ABCG2 transports Cipro from hepatic cell to extracellular space (Plasmodium falciparum)
ABCG2 transports Cipro from hepatic cell to extracellular space (Saccharomyces cerevisiae)
ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)
ABCG2 transports Cipro from hepatic cell to extracellular space (Caenorhabditis elegans)
ABCG2 transports Cipro from hepatic cell to extracellular space (Drosophila melanogaster)
ABCG2 transports Cipro from hepatic cell to extracellular space (Xenopus tropicalis)
ABCG2 transports Cipro from hepatic cell to extracellular space (Sus scrofa)
ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)
ABCG2 transports Cipro from hepatic cell to extracellular space (Rattus norvegicus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Mus musculus)
ABCG2 transports Cipro from hepatic cell to extracellular space (Homo sapiens)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Sus scrofa)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Xenopus tropicalis)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
XDH oxidises 6MP to 6TU (Dictyostelium discoideum)
XDH oxidises 6MP to 6TU (Caenorhabditis elegans)
XDH oxidises 6MP to 6TU (Drosophila melanogaster)
XDH oxidises 6MP to 6TU (Gallus gallus)
XDH oxidises 6MP to 6TU (Xenopus tropicalis)
XDH oxidises 6MP to 6TU (Sus scrofa)
XDH oxidises 6MP to 6TU (Bos taurus)
XDH oxidises 6MP to 6TU (Canis familiaris)
XDH oxidises 6MP to 6TU (Rattus norvegicus)
XDH oxidises 6MP to 6TU (Mus musculus)
XDH oxidises 6MP to 6TU (Homo sapiens)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Plasmodium falciparum)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Mus musculus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Plasmodium falciparum)
GMPS dimer transforms 6TXMP to 6TGMP (Saccharomyces cerevisiae)
GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)
GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)
GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)
GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)
GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)
GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)
GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)
GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)
GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)
GMPS dimer transforms 6TXMP to 6TGMP (Rattus norvegicus)
GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Caenorhabditis elegans)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Gallus gallus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Xenopus tropicalis)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Danio rerio)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Bos taurus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Rattus norvegicus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)
IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Homo sapiens)
GMPS dimer transforms 6TXMP to 6TGMP (Homo sapiens)
PON1,3 hydrolyse 2-OH-ATVL to 2-OH-ATV (Homo sapiens)
PON1,3 hydrolyse ATVL to ATV (Caenorhabditis elegans)
PON1,3 hydrolyse ATVL to ATV (Gallus gallus)
PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)
PON1,3 hydrolyse ATVL to ATV (Danio rerio)
PON1,3 hydrolyse ATVL to ATV (Sus scrofa)
PON1,3 hydrolyse ATVL to ATV (Bos taurus)
PON1,3 hydrolyse ATVL to ATV (Canis familiaris)
PON1,3 hydrolyse ATVL to ATV (Rattus norvegicus)
PON1,3 hydrolyse ATVL to ATV (Mus musculus)
PON1,3 hydrolyse ATVL to ATV (Homo sapiens)
PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Xenopus tropicalis)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Danio rerio)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Sus scrofa)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Plasmodium falciparum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Saccharomyces cerevisiae)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Schizosaccharomyces pombe)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Xenopus tropicalis)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Sus scrofa)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Rattus norvegicus)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Mus musculus)
GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)
GGT dimers hydrolyse APAP-SG (Schizosaccharomyces pombe)
GGT dimers hydrolyse APAP-SG (Caenorhabditis elegans)
GGT dimers hydrolyse APAP-SG (Drosophila melanogaster)
GGT dimers hydrolyse APAP-SG (Gallus gallus)
GGT dimers hydrolyse APAP-SG (Sus scrofa)
GGT dimers hydrolyse APAP-SG (Bos taurus)
GGT dimers hydrolyse APAP-SG (Canis familiaris)
GGT dimers hydrolyse APAP-SG (Rattus norvegicus)
GGT dimers hydrolyse APAP-SG (Mus musculus)
GGT dimers hydrolyse APAP-SG (Homo sapiens)
CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Plasmodium falciparum)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Sus scrofa)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)
ADA deamidates RBV (Plasmodium falciparum)
ADA deamidates RBV (Dictyostelium discoideum)
ADA deamidates RBV (Caenorhabditis elegans)
ADA deamidates RBV (Gallus gallus)
ADA deamidates RBV (Xenopus tropicalis)
ADA deamidates RBV (Danio rerio)
ADA deamidates RBV (Sus scrofa)
ADA deamidates RBV (Bos taurus)
ADA deamidates RBV (Canis familiaris)
ADA deamidates RBV (Rattus norvegicus)
ADA deamidates RBV (Mus musculus)
ADA deamidates RBV (Homo sapiens)
NT5C2 tetramer dephosphorylates RBV-MP (Dictyostelium discoideum)
NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)
NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)
NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)
NT5C2 tetramer dephosphorylates RBV-MP (Xenopus tropicalis)
NT5C2 tetramer dephosphorylates RBV-MP (Sus scrofa)
NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)
NT5C2 tetramer dephosphorylates RBV-MP (Canis familiaris)
NT5C2 tetramer dephosphorylates RBV-MP (Rattus norvegicus)
NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Drosophila melanogaster)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Gallus gallus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Xenopus tropicalis)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Sus scrofa)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Bos taurus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Canis familiaris)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)
ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)
NT5C2 tetramer dephosphorylates RBV-MP (Homo sapiens)
ABCB1 transports xenobiotics out of the cell (Plasmodium falciparum)
ABCB1 transports xenobiotics out of the cell (Schizosaccharomyces pombe)
ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)
ABCB1 transports xenobiotics out of the cell (Gallus gallus)
ABCB1 transports xenobiotics out of the cell (Sus scrofa)
ABCB1 transports xenobiotics out of the cell (Bos taurus)
ABCB1 transports xenobiotics out of the cell (Canis familiaris)
ABCB1 transports xenobiotics out of the cell (Rattus norvegicus)
ABCB1 transports xenobiotics out of the cell (Mus musculus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)
ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)
ABCB1 transports PREDN,PREDL out of hepatic cells (Dictyostelium discoideum)
ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Sus scrofa)
ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)
ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)
ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)
ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)
ABCB1 transports PREDN,PREDL out of kidney cells (Dictyostelium discoideum)
ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)
ABCB1 transports PREDN,PREDL out of kidney cells (Sus scrofa)
ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)
ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)
ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)
ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)
ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)
ABCB1 transports PREDN,PREDL out of hepatic cells (Homo sapiens)
ABCB1 transports xenobiotics out of the cell (Homo sapiens)
MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)
MAOA:FAD deaminates DA to DOPAC (Gallus gallus)
MAOA:FAD deaminates DA to DOPAC (Sus scrofa)
MAOA:FAD deaminates DA to DOPAC (Bos taurus)
MAOA:FAD deaminates DA to DOPAC (Canis familiaris)
MAOA:FAD deaminates DA to DOPAC (Rattus norvegicus)
MAOA:FAD deaminates DA to DOPAC (Mus musculus)
MAOA:FAD deaminates DA to DOPAC (Homo sapiens)
MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)
MAOA:FAD deaminates 3MT to HVA (Gallus gallus)
MAOA:FAD deaminates 3MT to HVA (Sus scrofa)
MAOA:FAD deaminates 3MT to HVA (Bos taurus)
MAOA:FAD deaminates 3MT to HVA (Canis familiaris)
MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)
MAOA:FAD deaminates 3MT to HVA (Mus musculus)
MAOA:FAD deaminates 3MT to HVA (Homo sapiens)
Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix (Homo sapiens)
Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)
Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)
Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)
Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)
Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)
Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)
Defective ABCB11 does not transport bile salts from cytosol to extracellular region (Homo sapiens)
Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)
Defective ABCB4 does not transport PC from plasma membrane to extracellular region (Homo sapiens)
Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)
Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)
Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35) (Mus musculus)
Calpain cleaves p35 to p25 (Homo sapiens)
Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)
PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)
PDE6 hydrolyses cGMP to GMP (Sus scrofa)
PDE6 hydrolyses cGMP to GMP (Bos taurus)
PDE6 hydrolyses cGMP to GMP (Canis familiaris)
PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Xenopus tropicalis)
GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)
GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)
GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)
PDE6 hydrolyses cGMP to GMP (Homo sapiens)
PDE6 hydrolyses cGMP to GMP (Mus musculus)
A2PE hydrolyses to A2E (Homo sapiens)
at-retinyl is hydrolysed from R* to release atRAL (Caenorhabditis elegans)
at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)
at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)
at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)
at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)
at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)
at-retinyl is hydrolysed from R* to release atRAL (Canis familiaris)
at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)
at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)
An REH hydrolyses 11cRE to 11cROL (Gallus gallus)
A REH hydrolyses 11cRE to 11cROL (Homo sapiens)
at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)
A REH hydrolses atREs to atROL and FAs (Homo sapiens)
Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)
Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)
Defective ADA does not deaminate (deoxy)adenosine (Homo sapiens)
Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)
Defective ACY1 does not hydrolyse mercapturic acids (Homo sapiens)
Defective OPLAH does not hydrolyse OPRO (Homo sapiens)
ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)
ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)
ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)
ABCB11 transports bile salts from cytosol to extracellular region (Gallus gallus)
ABCB11 transports bile salts from cytosol to extracellular region (Sus scrofa)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)
ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)
ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)
ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)
Defective AHCY does not hydrolyse AdoHcy (Homo sapiens)
Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)
AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)
AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Caenorhabditis elegans)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Gallus gallus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Sus scrofa)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Canis familiaris)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
ACY1:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)
Defective MAT1A does not transfer Ado from ATP to L-Met (Homo sapiens)
AADAC deacetylates PHEN (Schizosaccharomyces pombe)
AADAC deacetylates PHEN (Dictyostelium discoideum)
AADAC deacetylates PHEN (Caenorhabditis elegans)
AADAC deacetylates PHEN (Gallus gallus)
AADAC deacetylates PHEN (Sus scrofa)
AADAC deacetylates PHEN (Bos taurus)
AADAC deacetylates PHEN (Canis familiaris)
AADAC deacetylates PHEN (Rattus norvegicus)
AADAC deacetylates PHEN (Mus musculus)
AADAC deacetylates PHEN (Homo sapiens)
ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)
ALDH8A1 oxidises 9cRAL to 9cRA (Caenorhabditis elegans)
ALDH8A1 oxidises 9cRAL to 9cRA (Gallus gallus)
ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)
ALDH8A1 oxidises 9cRAL to 9cRA (Danio rerio)
ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)
ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)
ALDH8A1 oxidises 9cRAL to 9cRA (Canis familiaris)
ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)
ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)
ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)
HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH (Homo sapiens)
LTA4 is hydolysed to LTB4 by LTA4H (Saccharomyces cerevisiae)
LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)
LTA4 is hydolysed to LTB4 by LTA4H (Dictyostelium discoideum)
LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)
LTA4 is hydolysed to LTB4 by LTA4H (Drosophila melanogaster)
LTA4 is hydolysed to LTB4 by LTA4H (Gallus gallus)
LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)
LTA4 is hydolysed to LTB4 by LTA4H (Danio rerio)
LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)
LTA4 is hydolysed to LTB4 by LTA4H (Bos taurus)
LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)
LTA4 is hydolysed to LTB4 by LTA4H (Rattus norvegicus)
LTA4 is hydolysed to LTB4 by LTA4H (Mus musculus)
LTA4 is hydolysed to LTB4 by LTA4H (Homo sapiens)
BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)
BPHL hydrolyses VACV to ACV (Drosophila melanogaster)
BPHL hydrolyses VACV to ACV (Gallus gallus)
BPHL hydrolyses VACV to ACV (Sus scrofa)
BPHL hydrolyses VACV to ACV (Bos taurus)
BPHL hydrolyses VACV to ACV (Canis familiaris)
BPHL hydrolyses VACV to ACV (Rattus norvegicus)
BPHL hydrolyses VACV to ACV (Mus musculus)
BPHL hydrolyses VACV to ACV (Homo sapiens)
MAOB:FAD oxidatively deaminates of PEA (Dictyostelium discoideum)
MAOB:FAD oxidatively deaminates of PEA (Gallus gallus)
MAOB:FAD oxidatively deaminates of PEA (Xenopus tropicalis)
MAOB:FAD oxidatively deaminates of PEA (Danio rerio)
MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)
MAOB:FAD oxidatively deaminates of PEA (Bos taurus)
MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)
MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)
MAOB:FAD oxidatively deaminates of PEA (Mus musculus)
MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)
MAOA:FAD oxidatively deaminates of 5HT (Dictyostelium discoideum)
MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)
MAOA:FAD oxidatively deaminates of 5HT (Sus scrofa)
MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)
MAOA:FAD oxidatively deaminates of 5HT (Canis familiaris)
MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)
MAOA:FAD oxidatively deaminates of 5HT (Mus musculus)
MAOA:FAD oxidatively deaminates of 5HT (Homo sapiens)
MAOB:FAD oxidatively deaminates TYR (Dictyostelium discoideum)
MAOB:FAD oxidatively deaminates TYR (Gallus gallus)
MAOB:FAD oxidatively deaminates TYR (Xenopus tropicalis)
MAOB:FAD oxidatively deaminates TYR (Danio rerio)
MAOB:FAD oxidatively deaminates TYR (Sus scrofa)
MAOB:FAD oxidatively deaminates TYR (Bos taurus)
MAOB:FAD oxidatively deaminates TYR (Canis familiaris)
MAOB:FAD oxidatively deaminates TYR (Rattus norvegicus)
MAOB:FAD oxidatively deaminates TYR (Mus musculus)
MAOB:FAD oxidatively deaminates TYR (Homo sapiens)
ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)
ALD3A1 oxidises 4HPCP to CXPA (Dictyostelium discoideum)
ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)
ALD3A1 oxidises 4HPCP to CXPA (Drosophila melanogaster)
ALD3A1 oxidises 4HPCP to CXPA (Gallus gallus)
ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)
ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)
ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)
ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)
ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)
ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)
ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Gallus gallus)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Sus scrofa)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Mus musculus)
EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)
CMBL hydrolyses OM to OLMS (Gallus gallus)
CMBL hydrolyses OM to OLMS (Xenopus tropicalis)
CMBL hydrolyses OM to OLMS (Danio rerio)
CMBL hydrolyses OM to OLMS (Sus scrofa)
CMBL hydrolyses OM to OLMS (Bos taurus)
CMBL hydrolyses OM to OLMS (Canis familiaris)
CMBL hydrolyses OM to OLMS (Rattus norvegicus)
CMBL hydrolyses OM to OLMS (Mus musculus)
CMBL hydrolyses OM to OLMS (Homo sapiens)
Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)
2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)
2xTRAP hydrolyzes FMN to RIB (Gallus gallus)
2xTRAP hydrolyzes FMN to RIB (Danio rerio)
2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)
2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)
2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)
2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)
2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)
2xENPP1 hydrolyzes FAD to FMN (Danio rerio)
2xTRAP hydrolyzes FMN to RIB (Sus scrofa)
2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)
2xTRAP hydrolyzes FMN to RIB (Bos taurus)
2xENPP1 hydrolyzes FAD to FMN (Bos taurus)
2xTRAP hydrolyzes FMN to RIB (Canis familiaris)
2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)
2xTRAP hydrolyzes FMN to RIB (Rattus norvegicus)
2xENPP1 hydrolyzes FAD to FMN (Rattus norvegicus)
2xTRAP hydrolyzes FMN to RIB (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Mus musculus)
2xENPP1 hydrolyzes FAD to FMN (Homo sapiens)
2xTRAP hydrolyzes FMN to RIB (Homo sapiens)
PANK4 hydrolyzes PPANT to pantetheine (Plasmodium falciparum)
PANK4 hydrolyzes PPANT to pantetheine (Saccharomyces cerevisiae)
PANK4 hydrolyzes PPANT to pantetheine (Schizosaccharomyces pombe)
PANK4 hydrolyzes PPANT to pantetheine (Dictyostelium discoideum)
PANK4 hydrolyzes PPANT to pantetheine (Caenorhabditis elegans)
PANK4 hydrolyzes PPANT to pantetheine (Gallus gallus)
PANK4 hydrolyzes PPANT to pantetheine (Sus scrofa)
PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)
PANK4 hydrolyzes PPANT to pantetheine (Canis familiaris)
PANK4 hydrolyzes PPANT to pantetheine (Rattus norvegicus)
PANK4 hydrolyzes PPANT to pantetheine (Mus musculus)
PANK4 hydrolyzes PPANT to pantetheine (Homo sapiens)
DeHA hydrolyses to threonate and oxalate (Homo sapiens)
2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)
DeHA hydrolyses to 2,3-DKG (Homo sapiens)
Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)
Molybdenum ion transfer onto molybdopterin (Caenorhabditis elegans)
Molybdenum ion transfer onto molybdopterin (Drosophila melanogaster)
Molybdenum ion transfer onto molybdopterin (Gallus gallus)
Molybdenum ion transfer onto molybdopterin (Sus scrofa)
Molybdenum ion transfer onto molybdopterin (Bos taurus)
Molybdenum ion transfer onto molybdopterin (Canis familiaris)
Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)
Molybdenum ion transfer onto molybdopterin (Mus musculus)
Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)
Molybdenum ion transfer onto molybdopterin (Homo sapiens)
Cyclisation of GTP to precursor Z (Dictyostelium discoideum)
Cyclisation of GTP to precursor Z (Caenorhabditis elegans)
Cyclisation of GTP to precursor Z (Drosophila melanogaster)
Cyclisation of GTP to precursor Z (Gallus gallus)
Cyclisation of GTP to precursor Z (Xenopus tropicalis)
Cyclisation of GTP to precursor Z (Sus scrofa)
Cyclisation of GTP to precursor Z (Bos taurus)
Cyclisation of GTP to precursor Z (Canis familiaris)
Cyclisation of GTP to precursor Z (Rattus norvegicus)
Cyclisation of GTP to precursor Z (Mus musculus)
Cyclisation of GTP to precursor Z (Homo sapiens)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Dictyostelium discoideum)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Caenorhabditis elegans)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Drosophila melanogaster)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Gallus gallus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Bos taurus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)
2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)
AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)
AOX1 oxidises PXL to PDXate (Caenorhabditis elegans)
AOX1 oxidises PXL to PDXate (Drosophila melanogaster)
AOX1 oxidises PXL to PDXate (Gallus gallus)
AOX1 oxidises PXL to PDXate (Xenopus tropicalis)
AOX1 oxidises PXL to PDXate (Danio rerio)
AOX1 oxidises PXL to PDXate (Sus scrofa)
AOX1 oxidises PXL to PDXate (Bos taurus)
AOX1 oxidises PXL to PDXate (Rattus norvegicus)
AOX1 oxidises PXL to PDXate (Mus musculus)
AOX1 oxidises PXL to PDXate (Homo sapiens)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Homo sapiens)
PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)
PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)
PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)
PTPN6 dephosphorylates JAK3 (Sus scrofa)
PTPN6 dephosphorylates JAK3 (Bos taurus)
PTPN6 dephosphorylates JAK3 (Canis familiaris)
PTPN6 dephosphorylates JAK3 (Rattus norvegicus)
PTPN6 dephosphorylates JAK3 (Mus musculus)
PTPN6 dephosphorylates JAK3 (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Mus musculus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
PTEN cancer mutants do not dephosphorylate PIP3 (Homo sapiens)
PTPRJ dephosphorylates active FLT3 (Bos taurus)
PTPRJ dephosphorylates active FLT3 (Canis familiaris)
PTPRJ dephosphorylates active FLT3 (Mus musculus)
PTPRJ dephosphorylates active FLT3 (Homo sapiens)
L protein acts as a cap N7 methyltransferase to modify RSV mRNAs (Homo sapiens)
P:PP1 dephosphorylates M2-1 (Homo sapiens)
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Mus musculus)
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Mus musculus)
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Sus scrofa)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Bos taurus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Canis familiaris)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Mus musculus)
abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)
CpnT hydrolyses NAD+ (Homo sapiens)
PtpA dephosphorylates GSK3A (Homo sapiens)
ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)
SapM dephosphorylates PI3P (Homo sapiens)
PtpA:Ub dephosphorylates p-Y133-VPS33B (Homo sapiens)
PIP2 hydrolysis (Rattus norvegicus)
PIP2 hydrolysis (Homo sapiens)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Homo sapiens)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Danio rerio)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Sus scrofa)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Canis familiaris)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Rattus norvegicus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Mus musculus)
LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)
MYO9B inactivates RHOA (Caenorhabditis elegans)
MYO9B inactivates RHOA (Gallus gallus)
MYO9B inactivates RHOA (Xenopus tropicalis)
MYO9B inactivates RHOA (Sus scrofa)
MYO9B inactivates RHOA (Bos taurus)
MYO9B inactivates RHOA (Canis familiaris)
MYO9B inactivates RHOA (Rattus norvegicus)
MYO9B inactivates RHOA (Mus musculus)
MYO9B inactivates RHOA (Homo sapiens)
Inactivation of RAC1 (Homo sapiens)
Inactivation of CDC42 (Homo sapiens)
USP33 deubiquitinates ROBO1 (Drosophila melanogaster)
USP33 deubiquitinates ROBO1 (Bos taurus)
USP33 deubiquitinates ROBO1 (Mus musculus)
USP33 deubiquitinates ROBO1 (Homo sapiens)
AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote (Homo sapiens)
CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA (Homo sapiens)
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)
DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Xenopus tropicalis)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Mus musculus)
PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Homo sapiens)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Gallus gallus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Mus musculus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Saccharomyces cerevisiae)
OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)
OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)
OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Caenorhabditis elegans)
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Drosophila melanogaster)
OPLAH hydrolyses OPRO to L-Glu (Drosophila melanogaster)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Xenopus tropicalis)
OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)
OPLAH hydrolyses OPRO to L-Glu (Danio rerio)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)
OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Canis familiaris)
OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Caenorhabditis elegans)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Drosophila melanogaster)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Xenopus tropicalis)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Sus scrofa)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Canis familiaris)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Mus musculus)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)
ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Rattus norvegicus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Rattus norvegicus)
OPLAH hydrolyses OPRO to L-Glu (Rattus norvegicus)
OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)
OPLAH hydrolyses OPRO to L-Glu (Mus musculus)
CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Gallus gallus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)
ABHD14B hydrolyses PNPB (Caenorhabditis elegans)
ABHD14B hydrolyses PNPB (Gallus gallus)
ABHD14B hydrolyses PNPB (Xenopus tropicalis)
ABHD14B hydrolyses PNPB (Danio rerio)
ABHD14B hydrolyses PNPB (Sus scrofa)
ABHD14B hydrolyses PNPB (Bos taurus)
ABHD14B hydrolyses PNPB (Canis familiaris)
ABHD14B hydrolyses PNPB (Rattus norvegicus)
ABHD14B hydrolyses PNPB (Mus musculus)
ABHD14B hydrolyses PNPB (Homo sapiens)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Plasmodium falciparum)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Saccharomyces cerevisiae)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Schizosaccharomyces pombe)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Xenopus tropicalis)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Sus scrofa)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Canis familiaris)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Rattus norvegicus)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)
ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)
ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)
ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)
ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)
ATP13A2 transports cations from cytosol to lysosomal lumen (Gallus gallus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)
ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)
ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)
ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Mus musculus)
ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)
ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)
ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)
ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)
ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Plasmodium falciparum)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Saccharomyces cerevisiae)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Schizosaccharomyces pombe)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Drosophila melanogaster)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)
ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Xenopus tropicalis)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Canis familiaris)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)
ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)
ATP7A transports cytosolic Cu2+ to extracellular region (Xenopus tropicalis)
ATP7A transports cytosolic Cu2+ to extracellular region (Danio rerio)
ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)
ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)
ATP7A transports cytosolic Cu2+ to extracellular region (Rattus norvegicus)
ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)
ATP7A transports cytosolic Cu2+ to extracellular region (Homo sapiens)
ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)
ATP4A:ATP4B exchanges K+ for H+ (Sus scrofa)
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
ATP4A:ATP4B exchanges K+ for H+ (Canis familiaris)
ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)
ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)
ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Saccharomyces cerevisiae)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Gallus gallus)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Xenopus tropicalis)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Danio rerio)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Mus musculus)
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Plasmodium falciparum)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Dictyostelium discoideum)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Gallus gallus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Xenopus tropicalis)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Danio rerio)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Canis familiaris)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Rattus norvegicus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Mus musculus)
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Schizosaccharomyces pombe)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Sus scrofa)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Mus musculus)
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Homo sapiens)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Sus scrofa)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Sus scrofa)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)
NCEH1 hydrolyzes cholesterol esters (Schizosaccharomyces pombe)
NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)
NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)
NCEH1 hydrolyzes cholesterol esters (Gallus gallus)
NCEH1 hydrolyzes cholesterol esters (Danio rerio)
NCEH1 hydrolyzes cholesterol esters (Sus scrofa)
NCEH1 hydrolyzes cholesterol esters (Bos taurus)
NCEH1 hydrolyzes cholesterol esters (Canis familiaris)
NCEH1 hydrolyzes cholesterol esters (Rattus norvegicus)
NCEH1 hydrolyzes cholesterol esters (Mus musculus)
NCEH1 hydrolyzes cholesterol esters (Homo sapiens)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Drosophila melanogaster)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)
CES3 hydrolyses CHEST to CHOL and LCFA(-) (Homo sapiens)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)
ABCA4 mediates atRAL transport (Plasmodium falciparum)
ABCA4 mediates atRAL transport (Dictyostelium discoideum)
ABCA4 mediates atRAL transport (Caenorhabditis elegans)
ABCA4 mediates atRAL transport (Xenopus tropicalis)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Caenorhabditis elegans)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Gallus gallus)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Danio rerio)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Sus scrofa)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Canis familiaris)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Mus musculus)
PP2A dephosphorylates p-RHO to RHO (Caenorhabditis elegans)
PP2A dephosphorylates p-RHO to RHO (Gallus gallus)
PP2A dephosphorylates p-RHO to RHO (Sus scrofa)
PP2A dephosphorylates p-RHO to RHO (Bos taurus)
PP2A dephosphorylates p-RHO to RHO (Canis familiaris)
PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)
PP2A dephosphorylates p-RHO to RHO (Mus musculus)
PP2A dephosphorylates p-RHO to RHO (Homo sapiens)
RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)
RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)
RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)
RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)
RPE65 isomero-hydrolyses atREs to 11cROL (Danio rerio)
RPE65 isomero-hydrolyses atREs to 11cROL (Sus scrofa)
RPE65 isomero-hydrolyses atREs to 11cROL (Bos taurus)
RPE65 isomero-hydrolyses atREs to 11cROL (Canis familiaris)
RPE65 isomero-hydrolyses atREs to 11cROL (Rattus norvegicus)
RPE65 isomero-hydrolyses atREs to 11cROL (Mus musculus)
ABCA4 mediates atRAL transport (Drosophila melanogaster)
ABCA4 mediates atRAL transport (Gallus gallus)
ABCA4 mediates atRAL transport (Sus scrofa)
ABCA4 mediates atRAL transport (Bos taurus)
ABCA4 mediates atRAL transport (Canis familiaris)
ABCA4 mediates atRAL transport (Mus musculus)
NRPE is a substrate for Abca4 (Bos taurus)
ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)
RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)
at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)
ABCA4 mediates atRAL transport (Homo sapiens)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Plasmodium falciparum)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Schizosaccharomyces pombe)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Drosophila melanogaster)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Sus scrofa)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Homo sapiens)
ABCB9 transports peptides from cytosol to lysosomal lumen (Schizosaccharomyces pombe)
ABCB9 transports peptides from cytosol to lysosomal lumen (Caenorhabditis elegans)
ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)
ABCB9 transports peptides from cytosol to lysosomal lumen (Danio rerio)
ABCB9 transports peptides from cytosol to lysosomal lumen (Sus scrofa)
ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
ABCB9 transports peptides from cytosol to lysosomal lumen (Canis familiaris)
ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)
ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)
ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)
CFTR transports Cl- from cytosol to extracellular region (Plasmodium falciparum)
CFTR transports Cl- from cytosol to extracellular region (Dictyostelium discoideum)
CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)
CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)
CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)
CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)
CFTR transports Cl- from cytosol to extracellular region (Danio rerio)
CFTR transports Cl- from cytosol to extracellular region (Sus scrofa)
CFTR transports Cl- from cytosol to extracellular region (Bos taurus)
CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)
CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)
CFTR transports Cl- from cytosol to extracellular region (Mus musculus)
CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Plasmodium falciparum)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Gallus gallus)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Rattus norvegicus)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Homo sapiens)
HCO3- transport through ion channel (Plasmodium falciparum)
HCO3- transport through ion channel (Dictyostelium discoideum)
HCO3- transport through ion channel (Caenorhabditis elegans)
HCO3- transport through ion channel (Drosophila melanogaster)
HCO3- transport through ion channel (Gallus gallus)
HCO3- transport through ion channel (Xenopus tropicalis)
HCO3- transport through ion channel (Danio rerio)
HCO3- transport through ion channel (Sus scrofa)
HCO3- transport through ion channel (Bos taurus)
HCO3- transport through ion channel (Canis familiaris)
HCO3- transport through ion channel (Rattus norvegicus)
HCO3- transport through ion channel (Mus musculus)
HCO3- transport through ion channel (Homo sapiens)
The ABCC family mediates organic anion transport (Plasmodium falciparum)
The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)
The ABCC family mediates organic anion transport (Schizosaccharomyces pombe)
The ABCC family mediates organic anion transport (Dictyostelium discoideum)
The ABCC family mediates organic anion transport (Caenorhabditis elegans)
The ABCC family mediates organic anion transport (Drosophila melanogaster)
The ABCC family mediates organic anion transport (Gallus gallus)
The ABCC family mediates organic anion transport (Xenopus tropicalis)
The ABCC family mediates organic anion transport (Danio rerio)
The ABCC family mediates organic anion transport (Sus scrofa)
The ABCC family mediates organic anion transport (Bos taurus)
The ABCC family mediates organic anion transport (Canis familiaris)
The ABCC family mediates organic anion transport (Rattus norvegicus)
The ABCC family mediates organic anion transport (Mus musculus)
The ABCC family mediates organic anion transport (Homo sapiens)
ABCA7:Apo1A-mediated phospholipid efflux (Sus scrofa)
ABCA7:Apo1A-mediated phospholipid efflux (Canis familiaris)
ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)
ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)
ABCA7:Apo1A-mediated phospholipid efflux (Homo sapiens)
ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)
ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)
ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)
ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)
ABCA12 transports lipids from cytosol to extracellular region (Gallus gallus)
ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)
ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)
ABCA12 transports lipids from cytosol to extracellular region (Rattus norvegicus)
ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)
ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)
ABCG4 may mediate cholesterol efflux (Saccharomyces cerevisiae)
ABCG4 may mediate cholesterol efflux (Dictyostelium discoideum)
ABCG4 may mediate cholesterol efflux (Drosophila melanogaster)
ABCG4 may mediate cholesterol efflux (Gallus gallus)
ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)
ABCG4 may mediate cholesterol efflux (Danio rerio)
ABCG4 may mediate cholesterol efflux (Bos taurus)
ABCG4 may mediate cholesterol efflux (Canis familiaris)
ABCG4 may mediate cholesterol efflux (Rattus norvegicus)
ABCG4 may mediate cholesterol efflux (Mus musculus)
ABCG4 may mediate cholesterol efflux (Homo sapiens)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Saccharomyces cerevisiae)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Gallus gallus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)
ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)
ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)
ABCA3 transports PC, PG from ER membrane to lamellar body (Gallus gallus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)
ABCA3 transports PC, PG from ER membrane to lamellar body (Sus scrofa)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)
ABCA3 transports PC, PG from ER membrane to lamellar body (Rattus norvegicus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Mus musculus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Homo sapiens)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Plasmodium falciparum)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Caenorhabditis elegans)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Canis familiaris)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Rattus norvegicus)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Plasmodium falciparum)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Gallus gallus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Canis familiaris)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Rattus norvegicus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)
ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)
ABCAs mediate lipid efflux (Plasmodium falciparum)
ABCAs mediate lipid efflux (Dictyostelium discoideum)
ABCAs mediate lipid efflux (Gallus gallus)
ABCAs mediate lipid efflux (Sus scrofa)
ABCAs mediate lipid efflux (Rattus norvegicus)
ABCAs mediate lipid efflux (Mus musculus)
ABCAs mediate lipid efflux (Homo sapiens)
ABCAs mediate lipid influx (Plasmodium falciparum)
ABCAs mediate lipid influx (Dictyostelium discoideum)
ABCAs mediate lipid influx (Gallus gallus)
ABCAs mediate lipid influx (Sus scrofa)
ABCAs mediate lipid influx (Rattus norvegicus)
ABCAs mediate lipid influx (Mus musculus)
ABCAs mediate lipid influx (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Sus scrofa)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)
ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)
ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)
ABCB4 transports PC from plasma membrane to extracellular region (Gallus gallus)
ABCB4 transports PC from plasma membrane to extracellular region (Sus scrofa)
ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
ABCB4 transports PC from plasma membrane to extracellular region (Canis familiaris)
ABCB4 transports PC from plasma membrane to extracellular region (Rattus norvegicus)
ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)
ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)
Aquaporin-3 passively transports water out of cell (Plasmodium falciparum)
Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)
Aquaporin-3 passively transports water out of cell (Schizosaccharomyces pombe)
Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)
Aquaporin-3 passively transports water out of cell (Gallus gallus)
Aquaporin-3 passively transports water out of cell (Xenopus tropicalis)
Aquaporin-3 passively transports water out of cell (Danio rerio)
Aquaporin-3 passively transports water out of cell (Sus scrofa)
Aquaporin-3 passively transports water out of cell (Bos taurus)
Aquaporin-3 passively transports water out of cell (Canis familiaris)
Aquaporin-3 passively transports water out of cell (Rattus norvegicus)
Aquaporin-3 passively transports water out of cell (Mus musculus)
Aquaporin-3 passively transports water out of cell (Homo sapiens)
Aquaporin-4 passively transports water out of cell (Plasmodium falciparum)
Aquaporin-4 passively transports water out of cell (Dictyostelium discoideum)
Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)
Aquaporin-4 passively transports water out of cell (Gallus gallus)
Aquaporin-4 passively transports water out of cell (Xenopus tropicalis)
Aquaporin-4 passively transports water out of cell (Sus scrofa)
Aquaporin-4 passively transports water out of cell (Bos taurus)
Aquaporin-4 passively transports water out of cell (Canis familiaris)
Aquaporin-4 passively transports water out of cell (Rattus norvegicus)
Aquaporin-4 passively transports water out of cell (Mus musculus)
Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)
Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)
Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)
Aquaporin-1 passively transports water out of cell (Gallus gallus)
Aquaporin-1 passively transports water out of cell (Xenopus tropicalis)
Aquaporin-1 passively transports water out of cell (Danio rerio)
Aquaporin-1 passively transports water out of cell (Sus scrofa)
Aquaporin-1 passively transports water out of cell (Bos taurus)
Aquaporin-1 passively transports water out of cell (Canis familiaris)
Aquaporin-1 passively transports water out of cell (Rattus norvegicus)
Aquaporin-1 passively transports water out of cell (Mus musculus)
Aquaporin-1 passively transports water out of cell (Homo sapiens)
Aquaporin-4 passively transports water out of cell (Homo sapiens)
Aquaporins passively transport water out of cells (Plasmodium falciparum)
Aquaporins passively transport water out of cells (Saccharomyces cerevisiae)
Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)
Aquaporins passively transport water out of cells (Dictyostelium discoideum)
Aquaporins passively transport water out of cells (Caenorhabditis elegans)
Aquaporins passively transport water out of cells (Drosophila melanogaster)
Aquaporins passively transport water out of cells (Gallus gallus)
Aquaporins passively transport water out of cells (Xenopus tropicalis)
Aquaporins passively transport water out of cells (Danio rerio)
Aquaporins passively transport water out of cells (Sus scrofa)
Aquaporins passively transport water out of cells (Bos taurus)
Aquaporins passively transport water out of cells (Canis familiaris)
Aquaporins passively transport water out of cells (Rattus norvegicus)
Aquaporins passively transport water out of cells (Mus musculus)
Aquaporins passively transport water out of cells (Homo sapiens)
UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)
UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)
UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)
UCHL3, SENP8 cleave NEDD8 (Dictyostelium discoideum)
UCHL3, SENP8 cleave NEDD8 (Caenorhabditis elegans)
UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)
UCHL3, SENP8 cleave NEDD8 (Gallus gallus)
UCHL3, SENP8 cleave NEDD8 (Xenopus tropicalis)
UCHL3, SENP8 cleave NEDD8 (Danio rerio)
UCHL3, SENP8 cleave NEDD8 (Sus scrofa)
UCHL3, SENP8 cleave NEDD8 (Bos taurus)
UCHL3, SENP8 cleave NEDD8 (Canis familiaris)
UCHL3, SENP8 cleave NEDD8 (Rattus norvegicus)
UCHL3, SENP8 cleave NEDD8 (Mus musculus)
UCHL3, SENP8 cleave NEDD8 (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Plasmodium falciparum)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Saccharomyces cerevisiae)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Schizosaccharomyces pombe)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Dictyostelium discoideum)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Xenopus tropicalis)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Sus scrofa)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Rattus norvegicus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Gallus gallus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Danio rerio)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Sus scrofa)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)
UDP-glucose is oxidised to UDP-glucuronate (Caenorhabditis elegans)
UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)
UDP-glucose is oxidised to UDP-glucuronate (Gallus gallus)
UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)
UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)
UDP-glucose is oxidised to UDP-glucuronate (Sus scrofa)
UDP-glucose is oxidised to UDP-glucuronate (Bos taurus)
UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)
UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)
UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)
UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)
4 PBGs bind to form HMB (Plasmodium falciparum)
4 PBGs bind to form HMB (Saccharomyces cerevisiae)
4 PBGs bind to form HMB (Schizosaccharomyces pombe)
4 PBGs bind to form HMB (Drosophila melanogaster)
4 PBGs bind to form HMB (Gallus gallus)
4 PBGs bind to form HMB (Xenopus tropicalis)
4 PBGs bind to form HMB (Sus scrofa)
4 PBGs bind to form HMB (Bos taurus)
4 PBGs bind to form HMB (Canis familiaris)
4 PBGs bind to form HMB (Rattus norvegicus)
4 PBGs bind to form HMB (Mus musculus)
4 PBGs bind to form HMB (Homo sapiens)
3CLp cleaves nsp6-11 (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)
PDE12 cleaves 2'-5' oligoadenylates (Caenorhabditis elegans)
PDE12 cleaves 2'-5' oligoadenylates (Drosophila melanogaster)
PDE12 cleaves 2'-5' oligoadenylates (Gallus gallus)
PDE12 cleaves 2'-5' oligoadenylates (Sus scrofa)
PDE12 cleaves 2'-5' oligoadenylates (Bos taurus)
PDE12 cleaves 2'-5' oligoadenylates (Canis familiaris)
PDE12 cleaves 2'-5' oligoadenylates (Rattus norvegicus)
PDE12 cleaves 2'-5' oligoadenylates (Mus musculus)
PDE12 cleaves 2'-5' oligoadenylates (Homo sapiens)
Viral 2',5'-PDE cleaves 2'-5' oligoadenylates (Homo sapiens)
PTPN12 dephosphorylates PDGFRB at Y1021 (Gallus gallus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)
PTPN12 dephosphorylates PDGFRB at Y1021 (Danio rerio)
PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)
PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)
PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Mus musculus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
Dephosphorylation of AKT by PP2A (Saccharomyces cerevisiae)
Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
Dephosphorylation of AKT by PP2A (Dictyostelium discoideum)
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Drosophila melanogaster)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Mus musculus)
Dephosphorylation of AKT by PP2A (Homo sapiens)
PTPRS dephosphorylates Ntrk3 (Gallus gallus)
PTPRO dephosphorylate NTRK3 (Gallus gallus)
Protein tyrosine phosphatases dephosphorylate NTRK3 (Homo sapiens)
Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)
Translocation of antigenic peptides back to phagosomes via TAP (Gallus gallus)
Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)
Disassembly of COPII coated vesicle (Sus scrofa)
Disassembly of COPII coated vesicle (Bos taurus)
Disassembly of COPII coated vesicle (Canis familiaris)
Disassembly of COPII coated vesicle (Rattus norvegicus)
Disassembly of COPII coated vesicle (Mus musculus)
Disassembly of COPII coated vesicle (Homo sapiens)
Disassembly of COPII coated vesicle (Gallus gallus)
5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast) (Saccharomyces cerevisiae)
DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)
DCP1-DCP2 complex decaps mRNA (Saccharomyces cerevisiae)
DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)
DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)
DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)
DCP1-DCP2 complex decaps mRNA (Xenopus tropicalis)
DCP1-DCP2 complex decaps mRNA (Danio rerio)
DCP1-DCP2 complex decaps mRNA (Sus scrofa)
DCP1-DCP2 complex decaps mRNA (Bos taurus)
DCP1-DCP2 complex decaps mRNA (Canis familiaris)
DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)
DCP1-DCP2 complex decaps mRNA (Mus musculus)
DCP1-DCP2 complex decaps mRNA (Homo sapiens)
5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)
DCP1-DCP2 complex decaps mRNA (Gallus gallus)
NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)
NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)
NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)
NT5C3B hydrolyses 7MGP to 7MG (Sus scrofa)
NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)
NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)
NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)
NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)
NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)
DCPS scavenges the 7-methylguanosine cap of mRNA (Saccharomyces cerevisiae)
DCPS scavenges the 7-methylguanosine cap of mRNA (Schizosaccharomyces pombe)
DCPS scavenges the 7-methylguanosine cap of mRNA (Caenorhabditis elegans)
DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)
DCPS scavenges the 7-methylguanosine cap of mRNA (Xenopus tropicalis)
DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)
DCPS scavenges the 7-methylguanosine cap of mRNA (Bos taurus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)
DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)
DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)
DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)
NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Saccharomyces cerevisiae)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Schizosaccharomyces pombe)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Drosophila melanogaster)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Sus scrofa)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Bos taurus)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Rattus norvegicus)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Homo sapiens)
Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)
PARN deadenylates mRNA (Xenopus tropicalis)
PARN deadenylates mRNA (Sus scrofa)
PARN deadenylates mRNA (Bos taurus)
PARN deadenylates mRNA (Canis familiaris)
PARN deadenylates mRNA (Mus musculus)
PARN deadenylates mRNA (Homo sapiens)
PARN deadenylates mRNA (Gallus gallus)
CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)
CCR4-NOT complex deadenylates mRNA (Sus scrofa)
CCR4-NOT complex deadenylates mRNA (Bos taurus)
CCR4-NOT complex deadenylates mRNA (Canis familiaris)
CCR4-NOT complex deadenylates mRNA (Mus musculus)
CCR4-NOT complex deadenylates mRNA (Homo sapiens)
PAN2-PAN3 complex partially deadenylates mRNA (Saccharomyces cerevisiae)
PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)
PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)
PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)
PAN2-PAN3 complex partially deadenylates mRNA (Rattus norvegicus)
PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)
PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)
PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)
CCR4-NOT complex deadenylates mRNA (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Sus scrofa)
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
Dephosphorylation of JAK1 by SHP1 (Mus musculus)
Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
Dephosphorylation of TYK2 by PTP1B (Gallus gallus)
Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)
Dephosphorylation of TYK2 by PTP1B (Sus scrofa)
Dephosphorylation of TYK2 by PTP1B (Bos taurus)
Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
Dephosphorylation of TYK2 by PTP1B (Mus musculus)
Dephosphorylation of TYK2 by PTP1B (Homo sapiens)
Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
Dephosphorylation of STAT1 by SHP2 (Xenopus tropicalis)
Dephosphorylation of STAT1 by SHP2 (Sus scrofa)
Dephosphorylation of STAT1 by SHP2 (Bos taurus)
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
Dephosphorylation of STAT1 by SHP2 (Mus musculus)
Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
Viral DNA cleavage by TREX1 (Homo sapiens)
HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)
HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)
HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)
HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)
HDHD1:Mg2+ dephosphorylates PURIDP (Gallus gallus)
HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)
HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)
HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)
HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)
HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)
HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)
HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)
HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Caenorhabditis elegans)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Drosophila melanogaster)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Gallus gallus)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Danio rerio)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Sus scrofa)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Canis familiaris)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)
ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Homo sapiens)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Gallus gallus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Sus scrofa)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Canis familiaris)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)
ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)
LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
LHPP:Mg2+ dimer hydrolyses PPi (Gallus gallus)
LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)
LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)
LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)
LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)
LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)
LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)
LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Drosophila melanogaster)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Danio rerio)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Sus scrofa)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Schizosaccharomyces pombe)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Caenorhabditis elegans)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Gallus gallus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Canis familiaris)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Rattus norvegicus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Homo sapiens)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Caenorhabditis elegans)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Gallus gallus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Sus scrofa)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Canis familiaris)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Mus musculus)
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Homo sapiens)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Gallus gallus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Homo sapiens)
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Xenopus tropicalis)
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Canis familiaris)
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Gallus gallus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Danio rerio)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Rattus norvegicus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Mus musculus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Gallus gallus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Xenopus tropicalis)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Canis familiaris)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Sus scrofa)
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Canis familiaris)
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Saccharomyces cerevisiae)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Plasmodium falciparum)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Gallus gallus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Danio rerio)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Rattus norvegicus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)
NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Homo sapiens)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Gallus gallus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Bos taurus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)
NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Plasmodium falciparum)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Gallus gallus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Gallus gallus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Xenopus tropicalis)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Danio rerio)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Bos taurus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Mus musculus)
NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Plasmodium falciparum)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Gallus gallus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Danio rerio)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Sus scrofa)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Rattus norvegicus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)
NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Gallus gallus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Danio rerio)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Mus musculus)
ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Homo sapiens)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Plasmodium falciparum)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Gallus gallus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Danio rerio)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Bos taurus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Mus musculus)
NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Plasmodium falciparum)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Gallus gallus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Bos taurus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Rattus norvegicus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)
NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Gallus gallus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Xenopus tropicalis)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Sus scrofa)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Canis familiaris)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)
ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)
ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)
ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)
ITPA hydrolyses dITP to dIMP (Dictyostelium discoideum)
ITPA hydrolyses dITP to dIMP (Caenorhabditis elegans)
ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)
ITPA hydrolyses dITP to dIMP (Gallus gallus)
ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)
ITPA hydrolyses dITP to dIMP (Danio rerio)
ITPA hydrolyses dITP to dIMP (Sus scrofa)
ITPA hydrolyses dITP to dIMP (Bos taurus)
ITPA hydrolyses dITP to dIMP (Canis familiaris)
ITPA hydrolyses dITP to dIMP (Rattus norvegicus)
ITPA hydrolyses dITP to dIMP (Mus musculus)
ITPA hydrolyses dITP to dIMP (Homo sapiens)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Gallus gallus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Xenopus tropicalis)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Sus scrofa)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)
ITPA hydrolyses ITP to IMP (Plasmodium falciparum)
ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)
ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)
ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)
ITPA hydrolyses ITP to IMP (Caenorhabditis elegans)
ITPA hydrolyses ITP to IMP (Drosophila melanogaster)
ITPA hydrolyses ITP to IMP (Gallus gallus)
ITPA hydrolyses ITP to IMP (Xenopus tropicalis)
ITPA hydrolyses ITP to IMP (Danio rerio)
ITPA hydrolyses ITP to IMP (Sus scrofa)
ITPA hydrolyses ITP to IMP (Bos taurus)
ITPA hydrolyses ITP to IMP (Canis familiaris)
ITPA hydrolyses ITP to IMP (Rattus norvegicus)
ITPA hydrolyses ITP to IMP (Mus musculus)
ITPA hydrolyses ITP to IMP (Homo sapiens)
ITPA hydrolyses XTP to XMP (Plasmodium falciparum)
ITPA hydrolyses XTP to XMP (Saccharomyces cerevisiae)
ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)
ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)
ITPA hydrolyses XTP to XMP (Caenorhabditis elegans)
ITPA hydrolyses XTP to XMP (Drosophila melanogaster)
ITPA hydrolyses XTP to XMP (Gallus gallus)
ITPA hydrolyses XTP to XMP (Xenopus tropicalis)
ITPA hydrolyses XTP to XMP (Danio rerio)
ITPA hydrolyses XTP to XMP (Sus scrofa)
ITPA hydrolyses XTP to XMP (Bos taurus)
ITPA hydrolyses XTP to XMP (Canis familiaris)
ITPA hydrolyses XTP to XMP (Rattus norvegicus)
ITPA hydrolyses XTP to XMP (Mus musculus)
ITPA hydrolyses XTP to XMP (Homo sapiens)
XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)
XDH dehydrogenates xanthine to form urate (Caenorhabditis elegans)
XDH dehydrogenates xanthine to form urate (Drosophila melanogaster)
XDH dehydrogenates xanthine to form urate (Gallus gallus)
XDH dehydrogenates xanthine to form urate (Xenopus tropicalis)
XDH dehydrogenates xanthine to form urate (Sus scrofa)
XDH dehydrogenates xanthine to form urate (Bos taurus)
XDH dehydrogenates xanthine to form urate (Canis familiaris)
XDH dehydrogenates xanthine to form urate (Rattus norvegicus)
XDH dehydrogenates xanthine to form urate (Mus musculus)
XDH dehydrogenates hypoxanthine to form xanthine (Dictyostelium discoideum)
XDH dehydrogenates hypoxanthine to form xanthine (Caenorhabditis elegans)
XDH dehydrogenates hypoxanthine to form xanthine (Drosophila melanogaster)
XDH dehydrogenates hypoxanthine to form xanthine (Gallus gallus)
XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)
XDH dehydrogenates hypoxanthine to form xanthine (Sus scrofa)
XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)
XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)
XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)
XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)
XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)
XDH dehydrogenates xanthine to form urate (Homo sapiens)
Dctpp1 hydrolyses 5idCTP (Mus musculus)
DCTPP1 hydrolyses 5idCTP (Homo sapiens)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Schizosaccharomyces pombe)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Drosophila melanogaster)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Danio rerio)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Sus scrofa)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Dictyostelium discoideum)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Drosophila melanogaster)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Gallus gallus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Rattus norvegicus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Mus musculus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)
dCMP + H2O => dUMP + NH4+ (Gallus gallus)
dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)
dCMP + H2O => dUMP + NH4+ (Danio rerio)
dCMP + H2O => dUMP + NH4+ (Sus scrofa)
dCMP + H2O => dUMP + NH4+ (Bos taurus)
dCMP + H2O => dUMP + NH4+ (Canis familiaris)
dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)
dCMP + H2O => dUMP + NH4+ (Mus musculus)
CAD hexamer transforms L-Gln to CAP (Plasmodium falciparum)
CAD hexamer transforms L-Gln to CAP (Saccharomyces cerevisiae)
CAD hexamer transforms L-Gln to CAP (Schizosaccharomyces pombe)
CAD hexamer transforms L-Gln to CAP (Dictyostelium discoideum)
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)
CAD hexamer transforms L-Gln to CAP (Xenopus tropicalis)
CAD hexamer transforms L-Gln to CAP (Sus scrofa)
CAD hexamer transforms L-Gln to CAP (Bos taurus)
CAD hexamer transforms L-Gln to CAP (Canis familiaris)
CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)
CAD hexamer transforms L-Gln to CAP (Mus musculus)
CAD hexamer transforms L-Gln to CAP (Homo sapiens)
dCMP + H2O => dUMP + NH4+ (Homo sapiens)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Saccharomyces cerevisiae)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Gallus gallus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Saccharomyces cerevisiae)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Gallus gallus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Danio rerio)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Sus scrofa)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Canis familiaris)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Rattus norvegicus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Homo sapiens)
PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)
PP6 dephosphorylates SEC24 (Dictyostelium discoideum)
PP6 dephosphorylates SEC24 (Gallus gallus)
PP6 dephosphorylates SEC24 (Xenopus tropicalis)
PP6 dephosphorylates SEC24 (Sus scrofa)
PP6 dephosphorylates SEC24 (Bos taurus)
PP6 dephosphorylates SEC24 (Canis familiaris)
PP6 dephosphorylates SEC24 (Rattus norvegicus)
PP6 dephosphorylates SEC24 (Mus musculus)
PP6 dephosphorylates SEC24 (Homo sapiens)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Sus scrofa)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Bos taurus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)
NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)
cAMP degradation by Phosphodiesterases (Plasmodium falciparum)
cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)
cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)
cAMP degradation by Phosphodiesterases (Drosophila melanogaster)
cAMP degradation by Phosphodiesterases (Gallus gallus)
cAMP degradation by Phosphodiesterases (Xenopus tropicalis)
cAMP degradation by Phosphodiesterases (Danio rerio)
cAMP degradation by Phosphodiesterases (Sus scrofa)
cAMP degradation by Phosphodiesterases (Bos taurus)
cAMP degradation by Phosphodiesterases (Canis familiaris)
cAMP degradation by Phosphodiesterases (Rattus norvegicus)
cAMP degradation by Phosphodiesterases (Mus musculus)
cAMP degradation by Phosphodiesterases (Homo sapiens)
PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)
PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)
PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)
PDE3A hydrolyses cAMP to AMP (Gallus gallus)
PDE3A hydrolyses cAMP to AMP (Sus scrofa)
PDE3A hydrolyses cAMP to AMP (Bos taurus)
PDE3A hydrolyses cAMP to AMP (Canis familiaris)
PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)
PDE3A hydrolyses cAMP to AMP (Mus musculus)
PDE3A hydrolyses cAMP to AMP (Homo sapiens)
PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
PDE3B hydrolyses cAMP to AMP (Gallus gallus)
PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
PDE3B hydrolyses cAMP to AMP (Sus scrofa)
PDE3B hydrolyses cAMP to AMP (Bos taurus)
PDE3B hydrolyses cAMP to AMP (Canis familiaris)
PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
PDE3B hydrolyses cAMP to AMP (Mus musculus)
PDE3B hydrolyses cAMP to AMP (Homo sapiens)
PDE4A hydrolyses cAMP to AMP (Plasmodium falciparum)
PDE4A hydrolyses cAMP to AMP (Dictyostelium discoideum)
PDE4A hydrolyses cAMP to AMP (Caenorhabditis elegans)
PDE4A hydrolyses cAMP to AMP (Drosophila melanogaster)
PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)
PDE4A hydrolyses cAMP to AMP (Sus scrofa)
PDE4A hydrolyses cAMP to AMP (Bos taurus)
PDE4A hydrolyses cAMP to AMP (Canis familiaris)
PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)
PDE4A hydrolyses cAMP to AMP (Mus musculus)
PDE4A hydrolyses cAMP to AMP (Homo sapiens)
2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)
2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)
2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)
2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)
2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)
2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)
2-AG hydrolysis to arachidonate by MAGL (Danio rerio)
2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)
2-AG hydrolysis to arachidonate by MAGL (Bos taurus)
2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)
2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)
2-AG hydrolysis to arachidonate by MAGL (Mus musculus)
2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)
ABHD6,12 hydrolyse 3AG (Saccharomyces cerevisiae)
ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)
ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)
ABHD6,12 hydrolyse 3AG (Gallus gallus)
ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)
ABHD6,12 hydrolyse 3AG (Danio rerio)
ABHD6,12 hydrolyse 3AG (Sus scrofa)
ABHD6,12 hydrolyse 3AG (Bos taurus)
ABHD6,12 hydrolyse 3AG (Canis familiaris)
ABHD6,12 hydrolyse 3AG (Rattus norvegicus)
ABHD6,12 hydrolyse 3AG (Mus musculus)
ABHD6,12 hydrolyse 3AG (Homo sapiens)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Sus scrofa)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Canis familiaris)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
PDE4A,C,D hydrolyse cAMP (Plasmodium falciparum)
PDE4A,C,D hydrolyse cAMP (Dictyostelium discoideum)
PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)
PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)
PDE4A,C,D hydrolyse cAMP (Gallus gallus)
PDE4A,C,D hydrolyse cAMP (Xenopus tropicalis)
PDE4A,C,D hydrolyse cAMP (Sus scrofa)
PDE4A,C,D hydrolyse cAMP (Bos taurus)
PDE4A,C,D hydrolyse cAMP (Canis familiaris)
PDE4A,C,D hydrolyse cAMP (Rattus norvegicus)
PDE4A,C,D hydrolyse cAMP (Mus musculus)
PDE4A,C,D hydrolyse cAMP (Homo sapiens)
Ppp3 complex dephosphorylates DARPP-32 on T34 (Rattus norvegicus)
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
p-S54-PDE4B hydrolyses cAMP (Plasmodium falciparum)
p-S54-PDE4B hydrolyses cAMP (Dictyostelium discoideum)
p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)
p-S54-PDE4B hydrolyses cAMP (Drosophila melanogaster)
p-S54-PDE4B hydrolyses cAMP (Gallus gallus)
p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)
p-S54-PDE4B hydrolyses cAMP (Sus scrofa)
p-S54-PDE4B hydrolyses cAMP (Bos taurus)
p-S54-PDE4B hydrolyses cAMP (Canis familiaris)
p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)
p-S54-PDE4B hydrolyses cAMP (Mus musculus)
p-S54-PDE4B hydrolyses cAMP (Homo sapiens)
Inactivation of PLC beta (Saccharomyces cerevisiae)
Inactivation of PLC beta (Schizosaccharomyces pombe)
Inactivation of PLC beta (Dictyostelium discoideum)
Inactivation of PLC beta (Caenorhabditis elegans)
Inactivation of PLC beta (Drosophila melanogaster)
Inactivation of PLC beta (Gallus gallus)
Inactivation of PLC beta (Xenopus tropicalis)
Inactivation of PLC beta (Sus scrofa)
Inactivation of PLC beta (Bos taurus)
Inactivation of PLC beta (Canis familiaris)
Inactivation of PLC beta (Rattus norvegicus)
Inactivation of PLC beta (Mus musculus)
Inactivation of PLC beta (Homo sapiens)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Saccharomyces cerevisiae)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Dictyostelium discoideum)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Gallus gallus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Sus scrofa)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Rattus norvegicus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Mus musculus)
LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Homo sapiens)
ASAH2 hydrolyzes ceramide (plasma membrane) (Dictyostelium discoideum)
ASAH2 hydrolyzes ceramide (plasma membrane) (Drosophila melanogaster)
ASAH2 hydrolyzes ceramide (plasma membrane) (Gallus gallus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Xenopus tropicalis)
ASAH2 hydrolyzes ceramide (plasma membrane) (Danio rerio)
ASAH2 hydrolyzes ceramide (plasma membrane) (Sus scrofa)
ASAH2 hydrolyzes ceramide (plasma membrane) (Bos taurus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Canis familiaris)
ASAH2 hydrolyzes ceramide (plasma membrane) (Rattus norvegicus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Mus musculus)
ASAH2 hydrolyzes ceramide (plasma membrane) (Homo sapiens)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Gallus gallus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Xenopus tropicalis)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Danio rerio)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Sus scrofa)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Bos taurus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Canis familiaris)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Rattus norvegicus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Mus musculus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Homo sapiens)
NEU2 cleaves GM3 to form LacCer (cytosol) (Gallus gallus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Xenopus tropicalis)
NEU2 cleaves GM3 to form LacCer (cytosol) (Danio rerio)
NEU2 cleaves GM3 to form LacCer (cytosol) (Sus scrofa)
NEU2 cleaves GM3 to form LacCer (cytosol) (Bos taurus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Canis familiaris)
NEU2 cleaves GM3 to form LacCer (cytosol) (Rattus norvegicus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Mus musculus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Homo sapiens)
GBA3 hydrolyzes GlcCer (cytosol) (Caenorhabditis elegans)
GBA3 hydrolyzes GlcCer (cytosol) (Drosophila melanogaster)
GBA3 hydrolyzes GlcCer (cytosol) (Danio rerio)
GBA3 hydrolyzes GlcCer (cytosol) (Sus scrofa)
GBA3 hydrolyzes GlcCer (cytosol) (Bos taurus)
GBA3 hydrolyzes GlcCer (cytosol) (Canis familiaris)
GBA3 hydrolyzes GlcCer (cytosol) (Rattus norvegicus)
GBA3 hydrolyzes GlcCer (cytosol) (Homo sapiens)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Plasmodium falciparum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Saccharomyces cerevisiae)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Schizosaccharomyces pombe)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Dictyostelium discoideum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Danio rerio)
ENPP7 hydrolyzes sphingomyelin (Saccharomyces cerevisiae)
ENPP7 hydrolyzes sphingomyelin (Schizosaccharomyces pombe)
ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Caenorhabditis elegans)
ENPP7 hydrolyzes sphingomyelin (Caenorhabditis elegans)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Gallus gallus)
ENPP7 hydrolyzes sphingomyelin (Gallus gallus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Xenopus tropicalis)
ENPP7 hydrolyzes sphingomyelin (Xenopus tropicalis)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Sus scrofa)
ENPP7 hydrolyzes sphingomyelin (Sus scrofa)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Bos taurus)
ENPP7 hydrolyzes sphingomyelin (Bos taurus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)
ENPP7 hydrolyzes sphingomyelin (Canis familiaris)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Rattus norvegicus)
ENPP7 hydrolyzes sphingomyelin (Rattus norvegicus)
ENPP7 hydrolyzes sphingomyelin (Homo sapiens)
ENPP7 hydrolyzes sphingomyelin (Mus musculus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Mus musculus)
SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Homo sapiens)
GBA2 hydrolyzes GlcCer (plasma membrane) (Dictyostelium discoideum)
GBA2 hydrolyzes GlcCer (plasma membrane) (Caenorhabditis elegans)
GBA2 hydrolyzes GlcCer (plasma membrane) (Drosophila melanogaster)
GBA2 hydrolyzes GlcCer (plasma membrane) (Gallus gallus)
GBA2 hydrolyzes GlcCer (plasma membrane) (Danio rerio)
GBA2 hydrolyzes GlcCer (plasma membrane) (Sus scrofa)
GBA2 hydrolyzes GlcCer (plasma membrane) (Bos taurus)
GBA2 hydrolyzes GlcCer (plasma membrane) (Canis familiaris)
GBA2 hydrolyzes GlcCer (plasma membrane) (Rattus norvegicus)
GBA2 hydrolyzes GlcCer (plasma membrane) (Mus musculus)
GBA2 hydrolyzes GlcCer (plasma membrane) (Homo sapiens)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Saccharomyces cerevisiae)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Schizosaccharomyces pombe)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Dictyostelium discoideum)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Gallus gallus)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Xenopus tropicalis)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Sus scrofa)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Bos taurus)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Canis familiaris)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Rattus norvegicus)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Mus musculus)
SGPP1,2 dephosphorylate sphingoid-1-phosphates (Homo sapiens)
ACER2 hydrolyzes ceramide (Golgi) (Caenorhabditis elegans)
ACER2 hydrolyzes ceramide (Golgi) (Drosophila melanogaster)
ACER2 hydrolyzes ceramide (Golgi) (Gallus gallus)
ACER2 hydrolyzes ceramide (Golgi) (Xenopus tropicalis)
ACER2 hydrolyzes ceramide (Golgi) (Sus scrofa)
ACER2 hydrolyzes ceramide (Golgi) (Bos taurus)
ACER2 hydrolyzes ceramide (Golgi) (Canis familiaris)
ACER2 hydrolyzes ceramide (Golgi) (Rattus norvegicus)
ACER2 hydrolyzes ceramide (Golgi) (Mus musculus)
PPM1L dephosphorylates multiphospho-CERT1-2 (Drosophila melanogaster)
PPM1L dephosphorylates multiphospho-CERT1-2 (Danio rerio)
PPM1L dephosphorylates multiphospho-CERT1-2 (Bos taurus)
PPM1L dephosphorylates multiphospho-CERT1-2 (Homo sapiens)
ACER2 hydrolyzes ceramide (Golgi) (Homo sapiens)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Plasmodium falciparum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Caenorhabditis elegans)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Gallus gallus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Sus scrofa)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Bos taurus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)
ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Danio rerio)
ALDH3B1 oxidises HXAL to PALM (Saccharomyces cerevisiae)
ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)
ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)
ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)
ALDH3B1 oxidises HXAL to PALM (Gallus gallus)
ALDH3B1 oxidises HXAL to PALM (Xenopus tropicalis)
ALDH3B1 oxidises HXAL to PALM (Danio rerio)
ALDH3B1 oxidises HXAL to PALM (Sus scrofa)
ALDH3B1 oxidises HXAL to PALM (Bos taurus)
ALDH3B1 oxidises HXAL to PALM (Canis familiaris)
ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)
ALDH3B1 oxidises HXAL to PALM (Mus musculus)
ALDH3B1 oxidises HXAL to PALM (Homo sapiens)
ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)
ALDH3A2-1 oxidises HD2NAL to PALM (Dictyostelium discoideum)
ALDH3A2-1 oxidises HD2NAL to PALM (Caenorhabditis elegans)
ALDH3A2-1 oxidises HD2NAL to PALM (Drosophila melanogaster)
ALDH3A2-1 oxidises HD2NAL to PALM (Gallus gallus)
ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)
ALDH3A2-1 oxidises HD2NAL to PALM (Sus scrofa)
ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)
ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)
ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)
ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)
ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)
ALDH3B2 oxidises HXAL to PALM (Saccharomyces cerevisiae)
ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)
ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)
ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)
ALDH3B2 oxidises HXAL to PALM (Gallus gallus)
ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)
ALDH3B2 oxidises HXAL to PALM (Danio rerio)
ALDH3B2 oxidises HXAL to PALM (Sus scrofa)
ALDH3B2 oxidises HXAL to PALM (Bos taurus)
ALDH3B2 oxidises HXAL to PALM (Canis familiaris)
ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)
ALDH3B2 oxidises HXAL to PALM (Mus musculus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Gallus gallus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Gallus gallus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Danio rerio)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Saccharomyces cerevisiae)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Schizosaccharomyces pombe)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Dictyostelium discoideum)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Caenorhabditis elegans)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Caenorhabditis elegans)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Drosophila melanogaster)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Drosophila melanogaster)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Xenopus tropicalis)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Xenopus tropicalis)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Sus scrofa)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Sus scrofa)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Bos taurus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Bos taurus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Canis familiaris)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Canis familiaris)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Rattus norvegicus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Rattus norvegicus)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Mus musculus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Mus musculus)
PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Homo sapiens)
ALDH3B2 oxidises HXAL to PALM (Homo sapiens)
ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Homo sapiens)
ACER3 hydrolyzes phytoceramide (Saccharomyces cerevisiae)
ACER3 hydrolyzes phytoceramide (Dictyostelium discoideum)
ACER3 hydrolyzes phytoceramide (Gallus gallus)
ACER3 hydrolyzes phytoceramide (Xenopus tropicalis)
ACER3 hydrolyzes phytoceramide (Sus scrofa)
ACER3 hydrolyzes phytoceramide (Bos taurus)
ACER3 hydrolyzes phytoceramide (Canis familiaris)
ACER3 hydrolyzes phytoceramide (Rattus norvegicus)
ACER3 hydrolyzes phytoceramide (Mus musculus)
ACER3 hydrolyzes phytoceramide (Homo sapiens)
DOLPP1 dephosphorylates DOLDP to DOLP (Schizosaccharomyces pombe)
DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)
DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)
DOLPP1 dephosphorylates DOLDP to DOLP (Xenopus tropicalis)
DOLPP1 dephosphorylates DOLDP to DOLP (Danio rerio)
DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)
DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)
DOLPP1 dephosphorylates DOLDP to DOLP (Canis familiaris)
DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)
DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)
DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Caenorhabditis elegans)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Xenopus tropicalis)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Danio rerio)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Sus scrofa)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Rattus norvegicus)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Mus musculus)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Mus musculus)
NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Danio rerio)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Sus scrofa)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Canis familiaris)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Rattus norvegicus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Mus musculus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Xenopus tropicalis)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Canis familiaris)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Gallus gallus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Xenopus tropicalis)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Sus scrofa)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Canis familiaris)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)
NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)
Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Xenopus tropicalis)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Drosophila melanogaster)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Xenopus tropicalis)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Sus scrofa)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Bos taurus)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Rattus norvegicus)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Saccharomyces cerevisiae)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Gallus gallus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Xenopus tropicalis)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Sus scrofa)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Rattus norvegicus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Mus musculus)
MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Homo sapiens)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Gallus gallus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Danio rerio)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)
ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Homo sapiens)
phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)
Acireductone is created (Saccharomyces cerevisiae)
Acireductone is created (Schizosaccharomyces pombe)
Acireductone is created (Dictyostelium discoideum)
Acireductone is created (Caenorhabditis elegans)
Acireductone is created (Drosophila melanogaster)
Acireductone is created (Gallus gallus)
Acireductone is created (Xenopus tropicalis)
Acireductone is created (Danio rerio)
Acireductone is created (Sus scrofa)
Acireductone is created (Bos taurus)
Acireductone is created (Canis familiaris)
Acireductone is created (Rattus norvegicus)
Acireductone is created (Mus musculus)
Acireductone is created (Homo sapiens)
Homocysteine is degraded to oxobutanoate and H2S (Saccharomyces cerevisiae)
Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)
Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)
Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)
Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)
Homocysteine is degraded to oxobutanoate and H2S (Gallus gallus)
Homocysteine is degraded to oxobutanoate and H2S (Xenopus tropicalis)
Homocysteine is degraded to oxobutanoate and H2S (Danio rerio)
Homocysteine is degraded to oxobutanoate and H2S (Sus scrofa)
Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)
Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)
Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)
Homocysteine is degraded to oxobutanoate and H2S (Mus musculus)
Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Gallus gallus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)
ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)
Rpl30:Met-tRNAi:mRNA:Secisbp2:Sec-tRNA(Sec):Eefsec:GTP is hydrolysed to Rpl30:Met-tRNAi:mRNA:Secisbp2:Sec and Eefsec:GDP by Eefsec (Rattus norvegicus)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)
SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Drosophila melanogaster)
SEPHS2 phosphorylates H2Se to form SELP (Danio rerio)
SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)
SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)
SEPHS2 phosphorylates H2Se to form SELP (Rattus norvegicus)
SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)
SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)
Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer (Homo sapiens)
MeSeH is hydrolysed to H2Se by methylselenol demethylase (Rattus norvegicus)
MeSec is hydrolysed to MeSeH by PXLP-K211-Cth (Rattus norvegicus)
MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)
Excess SeMet is cleaved into MeSeH by PXLP-K211-Cth (Mus musculus)
Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)
SeCysta is hydrolysed to Sec by PXLP-K211-Cth (Rattus norvegicus)
SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)
MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)
AdeSeHCys is hydrolysed to SeHCys by Ahcy (Rattus norvegicus)
SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)
SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)
SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)
SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
SeMet is converted to AdoSeMet by MAT (Gallus gallus)
SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)
SeMet is converted to AdoSeMet by MAT (Danio rerio)
SeMet is converted to AdoSeMet by MAT (Sus scrofa)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)
SeMet is converted to AdoSeMet by MAT (Mus musculus)
SeMet is converted to AdoSeMet by MAT (Homo sapiens)
AdeSeHCys is hydrolysed to SeHCys by AHCY (Homo sapiens)
MeSebGalNac is hydrolysed to MeSeH and bGalNac (Rattus norvegicus)
MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)
NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)
NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)
NADSYN1 hexamer amidates NAAD to NAD+ (Schizosaccharomyces pombe)
NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)
NADSYN1 hexamer amidates NAAD to NAD+ (Caenorhabditis elegans)
NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)
NADSYN1 hexamer amidates NAAD to NAD+ (Gallus gallus)
NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)
NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)
NADSYN1 hexamer amidates NAAD to NAD+ (Bos taurus)
NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)
NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)
NADSYN1 hexamer amidates NAAD to NAD+ (Mus musculus)
NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Felis catus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Gallus gallus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Sus scrofa)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)
N-formylkynurenine + H2O => kynurenine + formate [mouse] (Mus musculus)
AFMID hydrolyses NFK to L-KYN (Homo sapiens)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Gallus gallus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Bos taurus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Mus musculus)
4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)
urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)
urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)
urocanate + H2O => 4-imidazolone-5-propionate (Gallus gallus)
urocanate + H2O => 4-imidazolone-5-propionate (Xenopus tropicalis)
urocanate + H2O => 4-imidazolone-5-propionate (Danio rerio)
urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)
urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)
urocanate + H2O => 4-imidazolone-5-propionate (Canis familiaris)
urocanate + H2O => 4-imidazolone-5-propionate (Rattus norvegicus)
urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)
urocanate + H2O => 4-imidazolone-5-propionate (Homo sapiens)
Agmatine + H2O <=> putrescine + urea (Gallus gallus)
Agmatine + H2O <=> putrescine + urea (Xenopus tropicalis)
Agmatine + H2O <=> putrescine + urea (Danio rerio)
Agmatine + H2O <=> putrescine + urea (Sus scrofa)
Agmatine + H2O <=> putrescine + urea (Bos taurus)
Agmatine + H2O <=> putrescine + urea (Canis familiaris)
Agmatine + H2O <=> putrescine + urea (Rattus norvegicus)
Agmatine + H2O <=> putrescine + urea (Mus musculus)
Agmatine + H2O <=> putrescine + urea (Homo sapiens)
ASPG hydrolyses L-Asn to L-Asp (Dictyostelium discoideum)
ASPG hydrolyses L-Asn to L-Asp (Caenorhabditis elegans)
ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)
ASPG hydrolyses L-Asn to L-Asp (Gallus gallus)
ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)
ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)
ASPG hydrolyses L-Asn to L-Asp (Bos taurus)
ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)
ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)
ASPG hydrolyses L-Asn to L-Asp (Mus musculus)
ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Dictyostelium discoideum)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Gallus gallus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Rattus norvegicus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Mus musculus)
aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Homo sapiens)
ASPA deacetylates NAA to acetate and L-aspartate (Gallus gallus)
ASPA deacetylates NAA to acetate and L-aspartate (Xenopus tropicalis)
ASPA deacetylates NAA to acetate and L-aspartate (Danio rerio)
ASPA deacetylates NAA to acetate and L-aspartate (Sus scrofa)
ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)
ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)
ASPA deacetylates NAA to acetate and L-aspartate (Rattus norvegicus)
ASPA deacetylates NAA to acetate and L-aspartate (Mus musculus)
ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)
arginine + H2O => ornithine + urea [ARG1] (Plasmodium falciparum)
arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)
arginine + H2O => ornithine + urea [ARG1] (Schizosaccharomyces pombe)
arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)
arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)
arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)
arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)
arginine + H2O => ornithine + urea [ARG1] (Sus scrofa)
arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)
arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)
arginine + H2O => ornithine + urea [ARG1] (Bos taurus)
arginine + H2O => ornithine + urea [ARG1] (Canis familiaris)
arginine + H2O => ornithine + urea [ARG1] (Mus musculus)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Schizosaccharomyces pombe)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Gallus gallus)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Sus scrofa)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Drosophila melanogaster)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Gallus gallus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Danio rerio)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Sus scrofa)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Mus musculus)
5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)
XDH oxidizes xanthine to form urate (Dictyostelium discoideum)
XDH oxidizes xanthine to form urate (Caenorhabditis elegans)
XDH oxidizes xanthine to form urate (Drosophila melanogaster)
XDH oxidizes xanthine to form urate (Gallus gallus)
XDH oxidizes xanthine to form urate (Xenopus tropicalis)
XDH oxidizes xanthine to form urate (Sus scrofa)
XDH oxidizes xanthine to form urate (Bos taurus)
XDH oxidizes xanthine to form urate (Canis familiaris)
XDH oxidizes xanthine to form urate (Rattus norvegicus)
XDH oxidizes xanthine to form urate (Mus musculus)
Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)
Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)
Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)
Guanine + H2O => Xanthine + NH4+ (Gallus gallus)
Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)
Guanine + H2O => Xanthine + NH4+ (Danio rerio)
Guanine + H2O => Xanthine + NH4+ (Sus scrofa)
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)
Guanine + H2O => Xanthine + NH4+ (Mus musculus)
DNPH1 hydrolyses dGMP (Danio rerio)
DNPH1 hydrolyses dGMP (Sus scrofa)
DNPH1 hydrolyses dGMP (Bos taurus)
DNPH1 hydrolyses dGMP (Canis familiaris)
DNPH1 hydrolyses dGMP (Rattus norvegicus)
DNPH1 hydrolyses dGMP (Mus musculus)
DNPH1 hydrolyses dGMP (Homo sapiens)
Guanine + H2O => Xanthine + NH4+ (Homo sapiens)
XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)
XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)
XDH oxidizes hypoxanthine to form xanthine (Drosophila melanogaster)
XDH oxidizes hypoxanthine to form xanthine (Gallus gallus)
XDH oxidizes hypoxanthine to form xanthine (Xenopus tropicalis)
XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)
XDH oxidizes hypoxanthine to form xanthine (Bos taurus)
XDH oxidizes hypoxanthine to form xanthine (Canis familiaris)
XDH oxidizes hypoxanthine to form xanthine (Rattus norvegicus)
XDH oxidizes hypoxanthine to form xanthine (Mus musculus)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Drosophila melanogaster)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Gallus gallus)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Sus scrofa)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)
AMP + H2O => IMP + NH4+ (AMPD) (Plasmodium falciparum)
AMP + H2O => IMP + NH4+ (AMPD) (Saccharomyces cerevisiae)
AMP + H2O => IMP + NH4+ (AMPD) (Schizosaccharomyces pombe)
AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)
AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)
AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)
AMP + H2O => IMP + NH4+ (AMPD) (Gallus gallus)
AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)
AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)
AMP + H2O => IMP + NH4+ (AMPD) (Sus scrofa)
AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)
AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)
AMP + H2O => IMP + NH4+ (AMPD) (Rattus norvegicus)
AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)
AMP + H2O => IMP + NH4+ (AMPD) (Homo sapiens)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)
ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)
ADA catalyzes the deamination of (deoxy)adenosine (Dictyostelium discoideum)
ADA catalyzes the deamination of (deoxy)adenosine (Caenorhabditis elegans)
ADA catalyzes the deamination of (deoxy)adenosine (Gallus gallus)
ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)
ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)
ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)
ADA catalyzes the deamination of (deoxy)adenosine (Bos taurus)
ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)
ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)
ADA catalyzes the deamination of (deoxy)adenosine (Mus musculus)
ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)
XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)
XDH oxidizes xanthine to form urate (Homo sapiens)
Atp7a transfers Cu from Atox1 to Sod3 (Mus musculus)
ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Gallus gallus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)
FAH cleaves 4FAA (Dictyostelium discoideum)
FAH cleaves 4FAA (Caenorhabditis elegans)
FAH cleaves 4FAA (Drosophila melanogaster)
FAH cleaves 4FAA (Gallus gallus)
FAH cleaves 4FAA (Xenopus tropicalis)
FAH cleaves 4FAA (Sus scrofa)
FAH cleaves 4FAA (Bos taurus)
FAH cleaves 4FAA (Rattus norvegicus)
FAH cleaves 4FAA (Mus musculus)
FAH cleaves 4FAA (Homo sapiens)
FAH cleaves 4FAA (Canis familiaris)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Saccharomyces cerevisiae)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Drosophila melanogaster)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Gallus gallus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Gallus gallus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Drosophila melanogaster)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Homo sapiens)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Rattus norvegicus)
ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)
ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)
ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)
ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)
ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)
ALDH1A1 oxidises GA to DGA (Gallus gallus)
ALDH1A1 oxidises GA to DGA (Xenopus tropicalis)
ALDH1A1 oxidises GA to DGA (Sus scrofa)
ALDH1A1 oxidises GA to DGA (Bos taurus)
ALDH1A1 oxidises GA to DGA (Canis familiaris)
ALDH1A1 oxidises GA to DGA (Rattus norvegicus)
ALDH1A1 oxidises GA to DGA (Mus musculus)
ALDH1A1 oxidises GA to DGA (Homo sapiens)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Gallus gallus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Gallus gallus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Xenopus tropicalis)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)
Olah hydrolyzes decanoyl-Fasn dimer to decanoate and Fasn dimer (Rattus norvegicus)
OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer (Homo sapiens)
Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)
Cysteine is degraded to serine and H2S (Schizosaccharomyces pombe)
Cysteine is degraded to serine and H2S (Dictyostelium discoideum)
Cysteine is degraded to serine and H2S (Caenorhabditis elegans)
Cysteine is degraded to serine and H2S (Drosophila melanogaster)
Cysteine is degraded to serine and H2S (Gallus gallus)
Cysteine is degraded to serine and H2S (Xenopus tropicalis)
Cysteine is degraded to serine and H2S (Danio rerio)
Cysteine is degraded to serine and H2S (Sus scrofa)
Cysteine is degraded to serine and H2S (Bos taurus)
Cysteine is degraded to serine and H2S (Canis familiaris)
Cysteine is degraded to serine and H2S (Rattus norvegicus)
Cysteine is degraded to serine and H2S (Mus musculus)
PXLP-K212-CTH cleaves L-Cystathionine (Saccharomyces cerevisiae)
PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)
PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)
PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)
PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)
PXLP-K212-CTH cleaves L-Cystathionine (Gallus gallus)
PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)
PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)
PXLP-K212-CTH cleaves L-Cystathionine (Sus scrofa)
PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)
PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)
PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)
PXLP-K212-CTH cleaves L-Cystathionine (Mus musculus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Saccharomyces cerevisiae)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Caenorhabditis elegans)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Drosophila melanogaster)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Gallus gallus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Sus scrofa)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Canis familiaris)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Dictyostelium discoideum)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Gallus gallus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Xenopus tropicalis)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Sus scrofa)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Rattus norvegicus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Homo sapiens)
AHCY:NAD+ tetramer hydrolyses AdoHcy (Homo sapiens)
PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)
Cysteine is degraded to serine and H2S (Homo sapiens)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Saccharomyces cerevisiae)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Gallus gallus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
Pgp:Mg2+ dimer hydrolyses 3PG to glycerol (Rattus norvegicus)
PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Gallus gallus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Danio rerio)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)
HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Homo sapiens)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Caenorhabditis elegans)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Drosophila melanogaster)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Gallus gallus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Danio rerio)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Sus scrofa)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Bos taurus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Canis familiaris)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Rattus norvegicus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Mus musculus)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Homo sapiens)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Schizosaccharomyces pombe)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Gallus gallus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)
Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Gallus gallus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Sus scrofa)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Homo sapiens)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Xenopus tropicalis)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Sus scrofa)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Canis familiaris)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
PP2A dephosphorylates BANF1 (Caenorhabditis elegans)
PP2A dephosphorylates BANF1 (Drosophila melanogaster)
PP2A dephosphorylates BANF1 (Gallus gallus)
PP2A dephosphorylates BANF1 (Danio rerio)
PP2A dephosphorylates BANF1 (Sus scrofa)
PP2A dephosphorylates BANF1 (Bos taurus)
PP2A dephosphorylates BANF1 (Canis familiaris)
PP2A dephosphorylates BANF1 (Rattus norvegicus)
PP2A dephosphorylates BANF1 (Mus musculus)
PP2A dephosphorylates BANF1 (Homo sapiens)
ANKLE2 is deacetylated by SIRT2 (Drosophila melanogaster)
ANKLE2 is deacetylated by SIRT2 (Gallus gallus)
ANKLE2 is deacetylated by SIRT2 (Danio rerio)
ANKLE2 is deacetylated by SIRT2 (Sus scrofa)
ANKLE2 is deacetylated by SIRT2 (Bos taurus)
ANKLE2 is deacetylated by SIRT2 (Canis familiaris)
ANKLE2 is deacetylated by SIRT2 (Rattus norvegicus)
ANKLE2 is deacetylated by SIRT2 (Mus musculus)
ANKLE2 is deacetylated by SIRT2 (Homo sapiens)
RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)
RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)
RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)
RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)
RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Xenopus tropicalis)
RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)
RAN stimulates fusion of nuclear envelope (NE) membranes (Sus scrofa)
RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Canis familiaris)
RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)
PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)
PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
PPP1CC dephosphorylates PLK1 (Plasmodium falciparum)
PPP1CC dephosphorylates PLK1 (Schizosaccharomyces pombe)
PPP1CC dephosphorylates PLK1 (Dictyostelium discoideum)
PPP1CC dephosphorylates PLK1 (Caenorhabditis elegans)
PPP1CC dephosphorylates PLK1 (Drosophila melanogaster)
PPP1CC dephosphorylates PLK1 (Gallus gallus)
PPP1CC dephosphorylates PLK1 (Xenopus tropicalis)
PPP1CC dephosphorylates PLK1 (Sus scrofa)
PPP1CC dephosphorylates PLK1 (Bos taurus)
PPP1CC dephosphorylates PLK1 (Canis familiaris)
PPP1CC dephosphorylates PLK1 (Rattus norvegicus)
PPP1CC dephosphorylates PLK1 (Mus musculus)
PPP1CC dephosphorylates PLK1 (Homo sapiens)
PPP1CC dephosphorylates PLK1 (Saccharomyces cerevisiae)
Dephosphorylation of CK2-modified condensin I (Plasmodium falciparum)
Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)
Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)
Dephosphorylation of CK2-modified condensin I (Dictyostelium discoideum)
Dephosphorylation of CK2-modified condensin I (Drosophila melanogaster)
Dephosphorylation of CK2-modified condensin I (Gallus gallus)
Dephosphorylation of CK2-modified condensin I (Sus scrofa)
Dephosphorylation of CK2-modified condensin I (Bos taurus)
Dephosphorylation of CK2-modified condensin I (Canis familiaris)
Dephosphorylation of CK2-modified condensin I (Rattus norvegicus)
Dephosphorylation of CK2-modified condensin I (Mus musculus)
Dephosphorylation of CK2-modified condensin I (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT (Sus scrofa)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT (Mus musculus)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Catabolism of Noradrenaline (Dictyostelium discoideum)
Catabolism of Noradrenaline (Gallus gallus)
Catabolism of Noradrenaline (Sus scrofa)
Catabolism of Noradrenaline (Bos taurus)
Catabolism of Noradrenaline (Canis familiaris)
Catabolism of Noradrenaline (Rattus norvegicus)
Catabolism of Noradrenaline (Mus musculus)
Catabolism of Noradrenaline (Homo sapiens)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Xenopus tropicalis)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Danio rerio)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)
PTPN1 and PTPN2 dephosphorylate MET (Xenopus tropicalis)
PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)
PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)
PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)
PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)
PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)
PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)
USP8 deubiquitinates LRIG1 (Sus scrofa)
USP8 deubiquitinates LRIG1 (Bos taurus)
USP8 deubiquitinates LRIG1 (Canis familiaris)
USP8 deubiquitinates LRIG1 (Rattus norvegicus)
USP8 deubiquitinates LRIG1 (Mus musculus)
USP8 deubiquitinates LRIG1 (Homo sapiens)
USP8 deubiquitinates LRIG1 (Gallus gallus)
PTPRJ dephosphorylates MET (Caenorhabditis elegans)
PTPRJ dephosphorylates MET (Bos taurus)
PTPRJ dephosphorylates MET (Canis familiaris)
PTPRJ dephosphorylates MET (Rattus norvegicus)
PTPRJ dephosphorylates MET (Mus musculus)
PTPRJ dephosphorylates MET (Homo sapiens)
PTPRJ dephosphorylates MET (Gallus gallus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)
ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)
ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)
Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)
Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)
Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)
Acidification of Tf:TfR1 containing endosome (Danio rerio)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Gallus gallus)
Acidification of Tf:TfR1 containing endosome (Sus scrofa)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
Acidification of Tf:TfR1 containing endosome (Mus musculus)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)
MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)
MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)
MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)
MAT1A multimers transfer Ado from ATP to L-Met (Gallus gallus)
MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)
MAT1A multimers transfer Ado from ATP to L-Met (Danio rerio)
MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)
MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)
MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Gallus gallus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Canis familiaris)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Homo sapiens)
DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Drosophila melanogaster)
GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)
GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)
GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)
GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)
GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)
GCH1 reduces GTP to dihydroneopterin triphosphate (Gallus gallus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)
GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)
GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)
GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)
ESTG binding induces ESR depalmitoylation (Homo sapiens)
Endocytosis of clathrin-coated vesicle (Rattus norvegicus)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
Production of ceramide which can activate JNK and other targets (Rattus norvegicus)
Production of ceramide which can activate JNK and other targets (Homo sapiens)
Ppm1f dephosphorylates p-T286-CaMKII-alpha (Rattus norvegicus)
PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
Ppm1f dephosphorylates Camk1 (Rattus norvegicus)
PPM1F dephosphorylates CAMK1 (Homo sapiens)
AMPK is dephosphorylated (Caenorhabditis elegans)
AMPK is dephosphorylated (Drosophila melanogaster)
AMPK is dephosphorylated (Gallus gallus)
AMPK is dephosphorylated (Sus scrofa)
AMPK is dephosphorylated (Bos taurus)
AMPK is dephosphorylated (Canis familiaris)
AMPK is dephosphorylated (Rattus norvegicus)
AMPK is dephosphorylated (Homo sapiens)
AMPK is dephosphorylated (Mus musculus)
p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)
p-S295-PDE3B hydrolyses cAMP to AMP (Dictyostelium discoideum)
p-S295-PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)
p-S295-PDE3B hydrolyses cAMP to AMP (Gallus gallus)
p-S295-PDE3B hydrolyses cAMP to AMP (Xenopus tropicalis)
p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)
p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)
p-S295-PDE3B hydrolyses cAMP to AMP (Canis familiaris)
p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)
p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)
p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)
cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)
cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)
cAMP hydrolysis by Cam-PDE 1 (Caenorhabditis elegans)
cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)
cAMP hydrolysis by Cam-PDE 1 (Gallus gallus)
cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)
cAMP hydrolysis by Cam-PDE 1 (Sus scrofa)
cAMP hydrolysis by Cam-PDE 1 (Bos taurus)
cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)
cAMP hydrolysis by Cam-PDE 1 (Rattus norvegicus)
cAMP hydrolysis by Cam-PDE 1 (Mus musculus)
cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Xenopus tropicalis)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Sus scrofa)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Rattus norvegicus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Mus musculus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Homo sapiens)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
PTPN3 dephosphorylates EPS15 (Gallus gallus)
PTPN3 dephosphorylates EPS15 (Sus scrofa)
PTPN3 dephosphorylates EPS15 (Bos taurus)
PTPN3 dephosphorylates EPS15 (Canis familiaris)
PTPN3 dephosphorylates EPS15 (Rattus norvegicus)
PTPN3 dephosphorylates EPS15 (Mus musculus)
PTPN3 dephosphorylates EPS15 (Homo sapiens)
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)
SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
SHP2 dephosphorylates Tyr 992 on EGFR (Rattus norvegicus)
SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)
Dephosphorylation of Gab1 by SHP2 (Sus scrofa)
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
Dephosphorylation of Gab1 by SHP2 (Mus musculus)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
Sustained activation of SRC kinase by SHP2 (Sus scrofa)
Sustained activation of SRC kinase by SHP2 (Bos taurus)
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)
Sustained activation of SRC kinase by SHP2 (Mus musculus)
Dephosphorylation of PAG by SHP2 (Gallus gallus)
Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)
Dephosphorylation of PAG by SHP2 (Sus scrofa)
Dephosphorylation of PAG by SHP2 (Bos taurus)
Dephosphorylation of PAG by SHP2 (Canis familiaris)
Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
Dephosphorylation of PAG by SHP2 (Mus musculus)
Dephosphorylation of PAG by SHP2 (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)
Inactivation of Rho-GTP by p190RhoGAP (Xenopus tropicalis)
Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)
Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)
Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)
Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
Production of AA by iPLA2 upon FCGR activation (Caenorhabditis elegans)
Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)
Production of AA by iPLA2 upon FCGR activation (Gallus gallus)
Production of AA by iPLA2 upon FCGR activation (Xenopus tropicalis)
Production of AA by iPLA2 upon FCGR activation (Sus scrofa)
Production of AA by iPLA2 upon FCGR activation (Bos taurus)
Production of AA by iPLA2 upon FCGR activation (Canis familiaris)
Production of AA by iPLA2 upon FCGR activation (Rattus norvegicus)
Production of AA by iPLA2 upon FCGR activation (Mus musculus)
Production of AA by iPLA2 upon FCGR activation (Homo sapiens)
Conversion of PA into DAG by PAP-1 (Saccharomyces cerevisiae)
Conversion of PA into DAG by PAP-1 (Schizosaccharomyces pombe)
Conversion of PA into DAG by PAP-1 (Dictyostelium discoideum)
Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)
Conversion of PA into DAG by PAP-1 (Gallus gallus)
Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)
Conversion of PA into DAG by PAP-1 (Sus scrofa)
Conversion of PA into DAG by PAP-1 (Bos taurus)
Conversion of PA into DAG by PAP-1 (Canis familiaris)
Conversion of PA into DAG by PAP-1 (Rattus norvegicus)
Conversion of PA into DAG by PAP-1 (Mus musculus)
Conversion of PA into DAG by PAP-1 (Homo sapiens)
Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)
Hydrolysis of PC to PA by PLD (Schizosaccharomyces pombe)
Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)
Hydrolysis of PC to PA by PLD (Caenorhabditis elegans)
Hydrolysis of PC to PA by PLD (Drosophila melanogaster)
Hydrolysis of PC to PA by PLD (Xenopus tropicalis)
Hydrolysis of PC to PA by PLD (Sus scrofa)
Hydrolysis of PC to PA by PLD (Bos taurus)
Hydrolysis of PC to PA by PLD (Canis familiaris)
Hydrolysis of PC to PA by PLD (Rattus norvegicus)
Hydrolysis of PC to PA by PLD (Mus musculus)
Hydrolysis of PC to PA by PLD (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
PTPN1 dephosphorylates PTK6 (Xenopus tropicalis)
PTPN1 dephosphorylates PTK6 (Sus scrofa)
PTPN1 dephosphorylates PTK6 (Bos taurus)
PTPN1 dephosphorylates PTK6 (Rattus norvegicus)
PTPN1 dephosphorylates PTK6 (Mus musculus)
PTPN1 dephosphorylates PTK6 (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Gallus gallus)
USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)
USP34 deubiquitinates AXIN1,AXIN2 (Bos taurus)
USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)
USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)
USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
USP8 deubiquitinates FZD to potentiate WNT signaling (Gallus gallus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Xenopus tropicalis)
USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)
USP8 deubiquitinates FZD to potentiate WNT signaling (Bos taurus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Drosophila melanogaster)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Gallus gallus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Sus scrofa)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Mus musculus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
PDE6 hydrolyses cGMP to GMP (Gallus gallus)
PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)
PDE6 hydrolyses cGMP to GMP (Sus scrofa)
PDE6 hydrolyses cGMP to GMP (Bos taurus)
PDE6 hydrolyses cGMP to GMP (Canis familiaris)
PDE6 hydrolyses cGMP to GMP (Rattus norvegicus)
PDE6 hydrolyses cGMP to GMP (Mus musculus)
PDE6 hydrolyses cGMP to GMP (Homo sapiens)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Sus scrofa)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Danio rerio)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Homo sapiens)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Drosophila melanogaster)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Gallus gallus)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Danio rerio)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Sus scrofa)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Mus musculus)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)
PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)
PP2A dephosphorylates inactive RAFs (Sus scrofa)
PP2A dephosphorylates inactive RAFs (Bos taurus)
PP2A dephosphorylates inactive RAFs (Rattus norvegicus)
PP2A dephosphorylates inactive RAFs (Mus musculus)
PP2A dephosphorylates inactive RAFs (Homo sapiens)
PP2A dephosphorylates RAF1 (Caenorhabditis elegans)
PP2A dephosphorylates RAF1 (Drosophila melanogaster)
PP2A dephosphorylates RAF1 (Sus scrofa)
PP2A dephosphorylates RAF1 (Bos taurus)
PP2A dephosphorylates RAF1 (Canis familiaris)
PP2A dephosphorylates RAF1 (Rattus norvegicus)
PP2A dephosphorylates RAF1 (Mus musculus)
PP5 dephosphorylates RAF1 S338 (Plasmodium falciparum)
PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)
PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)
PP5 dephosphorylates RAF1 S338 (Sus scrofa)
PP5 dephosphorylates RAF1 S338 (Bos taurus)
PP5 dephosphorylates RAF1 S338 (Canis familiaris)
PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)
PP5 dephosphorylates RAF1 S338 (Mus musculus)
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)
PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)
PTPN3 dephosphorylates MAPK12 (Gallus gallus)
PTPN3 dephosphorylates MAPK12 (Xenopus tropicalis)
PTPN3 dephosphorylates MAPK12 (Sus scrofa)
PTPN3 dephosphorylates MAPK12 (Bos taurus)
PTPN3 dephosphorylates MAPK12 (Canis familiaris)
PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)
PTPN3 dephosphorylates MAPK12 (Mus musculus)
PTPN3 dephosphorylates MAPK12 (Homo sapiens)
PTPN7 dephosphorylates p-T,Y-MAPKs (Saccharomyces cerevisiae)
PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)
PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)
PTPN7 dephosphorylates p-T,Y-MAPKs (Drosophila melanogaster)
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Rattus norvegicus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)
PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)
RAS proteins are depalmitoylated (Caenorhabditis elegans)
RAS proteins are depalmitoylated (Drosophila melanogaster)
RAS proteins are depalmitoylated (Gallus gallus)
RAS proteins are depalmitoylated (Danio rerio)
RAS proteins are depalmitoylated (Sus scrofa)
RAS proteins are depalmitoylated (Canis familiaris)
RAS proteins are depalmitoylated (Rattus norvegicus)
RAS proteins are depalmitoylated (Mus musculus)
RAS proteins are depalmitoylated (Homo sapiens)
RAS proteins are depalmitoylated (Bos taurus)
USP17L2 deubiquitinates RCE1 (Saccharomyces cerevisiae)
USP17L2 deubiquitinates RCE1 (Schizosaccharomyces pombe)
USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)
USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)
USP17L2 deubiquitinates RCE1 (Sus scrofa)
USP17L2 deubiquitinates RCE1 (Canis familiaris)
USP17L2 deubiquitinates RCE1 (Rattus norvegicus)
USP17L2 deubiquitinates RCE1 (Mus musculus)
USP17L2 deubiquitinates RCE1 (Homo sapiens)
USP17L2 deubiquitinates RCE1 (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
Inactivation of LCK by PTPN22 (Gallus gallus)
Inactivation of LCK by PTPN22 (Sus scrofa)
Inactivation of LCK by PTPN22 (Bos taurus)
Inactivation of LCK by PTPN22 (Canis familiaris)
Inactivation of LCK by PTPN22 (Mus musculus)
Inactivation of LCK by PTPN22 (Homo sapiens)
Inactivation of LCK by PTPN22 (Rattus norvegicus)
PTPN22 dephosphorylates ZAP70 (Gallus gallus)
PTPN22 dephosphorylates ZAP70 (Sus scrofa)
PTPN22 dephosphorylates ZAP70 (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Mus musculus)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
USP13 and OTUD3 deubiquitinate PTEN (Schizosaccharomyces pombe)
USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)
USP13 and OTUD3 deubiquitinate PTEN (Caenorhabditis elegans)
USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)
USP13 and OTUD3 deubiquitinate PTEN (Gallus gallus)
USP13 and OTUD3 deubiquitinate PTEN (Xenopus tropicalis)
USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)
USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)
USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)
USP13 and OTUD3 deubiquitinate PTEN (Mus musculus)
USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)
PHLPP dephosphorylates S473 in AKT (Drosophila melanogaster)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)
PHLPP dephosphorylates S473 in AKT (Mus musculus)
PHLPP dephosphorylates S473 in AKT (Homo sapiens)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Saccharomyces cerevisiae)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Danio rerio)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)
Activation of BAD by calcineurin (Xenopus tropicalis)
Activation of BAD by calcineurin (Sus scrofa)
Activation of BAD by calcineurin (Bos taurus)
Activation of BAD by calcineurin (Canis familiaris)
Activation of BAD by calcineurin (Rattus norvegicus)
Activation of BAD by calcineurin (Mus musculus)
Activation of BAD by calcineurin (Homo sapiens)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Gallus gallus)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Gallus gallus)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Rattus norvegicus)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Gallus gallus)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Gallus gallus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Canis familiaris)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Rattus norvegicus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Mus musculus)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Mus musculus)
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Homo sapiens)
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)
Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)
Hydrolysis of PIP3 to PI(3,4)P2 (Xenopus tropicalis)
Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Rattus norvegicus)
Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)
Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Bos taurus)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
Nuclear DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)
Nuclear DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
Nuclear DUSPs dephosphorylate MAPKs (Danio rerio)
Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)
Nuclear DUSPs dephosphorylate MAPKs (Bos taurus)
Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)
Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)
Nuclear DUSPs dephosphorylate MAPKs (Mus musculus)
Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Plasmodium falciparum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)
Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)
Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)
Cytosolic DUSPs dephosphorylate MAPKs (Danio rerio)
Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Rattus norvegicus)
Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)
SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)
SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)
SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)
SARS-CoV-2 nsp3 cleaves IRF3 (Homo sapiens)
Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Sus scrofa)
Transport of Antigen peptide in to ER (Bos taurus)
Transport of Antigen peptide in to ER (Rattus norvegicus)
Transport of Antigen peptide in to ER (Mus musculus)
Transport of Antigen peptide in to ER (Homo sapiens)
3CLp cleaves nsp6-11 (Homo sapiens)
nsp3 cleaves nsp1-4 (Homo sapiens)
nsp3-4 cleaves itself (Homo sapiens)
3CLp cleaves pp1ab (Homo sapiens)
pp1a cleaves itself (Homo sapiens)
3CLp cleaves pp1a (Homo sapiens)
nsp1-4 cleaves itself (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)
nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)
3CLp cleaves pp1ab (Homo sapiens)
pp1a cleaves itself (Homo sapiens)
nsp1-4 cleaves itself (Homo sapiens)
nsp3-4 cleaves itself (Homo sapiens)
nsp3 cleaves nsp1-4 (Homo sapiens)
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)
3CLp cleaves pp1a (Homo sapiens)
Dephosphorylation of Jaks by Ptps (Mus musculus)
Dephosphorylation of JAKs by PTPs (Homo sapiens)
Uchl5 deubiquitinates TGFBR1 (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)
MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)
MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)
MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)
MTMR4 dephosphorylates SMAD2/3 (Bos taurus)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)
MTMR4 dephosphorylates SMAD2/3 (Mus musculus)
MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)
PP1CC dephosphorylates TGFBR1 (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)
Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)
Dephosphorylation of phospho-Cdh1 (Danio rerio)
Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)
Dephosphorylation of phospho-Cdh1 (Gallus gallus)
Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)
Dephosphorylation of phospho-Cdh1 (Sus scrofa)
Dephosphorylation of phospho-Cdh1 (Bos taurus)
Dephosphorylation of phospho-Cdh1 (Canis familiaris)
Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)
Dephosphorylation of phospho-Cdh1 (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Caenorhabditis elegans)
USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)
USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)
USP9X (FAM) deubiquitinates SMAD4 (Bos taurus)
USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)
USP9X (FAM) deubiquitinates SMAD4 (Homo sapiens)
USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)
USP14 deubiquitinates NLRC5 (Gallus gallus)
USP14 deubiquitinates NLRC5 (Xenopus tropicalis)
USP14 deubiquitinates NLRC5 (Sus scrofa)
USP14 deubiquitinates NLRC5 (Bos taurus)
USP14 deubiquitinates NLRC5 (Canis familiaris)
USP14 deubiquitinates NLRC5 (Rattus norvegicus)
USP14 deubiquitinates NLRC5 (Mus musculus)
USP14 deubiquitinates NLRC5 (Homo sapiens)
PP2A dephosphorylates KSR1 (Caenorhabditis elegans)
PP2A dephosphorylates KSR1 (Drosophila melanogaster)
PP2A dephosphorylates KSR1 (Sus scrofa)
PP2A dephosphorylates KSR1 (Bos taurus)
PP2A dephosphorylates KSR1 (Rattus norvegicus)
PP2A dephosphorylates KSR1 (Mus musculus)
PP2A dephosphorylates KSR1 (Homo sapiens)
Insulin receptor de-phosphorylation (Drosophila melanogaster)
Insulin receptor de-phosphorylation (Gallus gallus)
Insulin receptor de-phosphorylation (Xenopus tropicalis)
Insulin receptor de-phosphorylation (Sus scrofa)
Insulin receptor de-phosphorylation (Bos taurus)
Insulin receptor de-phosphorylation (Canis familiaris)
Insulin receptor de-phosphorylation (Rattus norvegicus)
Insulin receptor de-phosphorylation (Mus musculus)
Insulin receptor de-phosphorylation (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Saccharomyces cerevisiae)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Schizosaccharomyces pombe)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Xenopus tropicalis)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Saccharomyces cerevisiae)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Schizosaccharomyces pombe)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Drosophila melanogaster)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Gallus gallus)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Gallus gallus)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Gallus gallus)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Xenopus tropicalis)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Xenopus tropicalis)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Xenopus tropicalis)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Danio rerio)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Sus scrofa)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Rattus norvegicus)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Mus musculus)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Saccharomyces cerevisiae)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Gallus gallus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)
Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)
Hydrolysis of phosphatidylcholine (Gallus gallus)
Hydrolysis of phosphatidylcholine (Xenopus tropicalis)
Hydrolysis of phosphatidylcholine (Danio rerio)
Hydrolysis of phosphatidylcholine (Sus scrofa)
Hydrolysis of phosphatidylcholine (Bos taurus)
Hydrolysis of phosphatidylcholine (Canis familiaris)
Hydrolysis of phosphatidylcholine (Rattus norvegicus)
Hydrolysis of phosphatidylcholine (Mus musculus)
Hydrolysis of phosphatidylcholine (Homo sapiens)
PIP2 hydrolysis (Saccharomyces cerevisiae)
PIP2 hydrolysis (Schizosaccharomyces pombe)
PIP2 hydrolysis (Dictyostelium discoideum)
PIP2 hydrolysis (Caenorhabditis elegans)
PIP2 hydrolysis (Drosophila melanogaster)
PIP2 hydrolysis (Gallus gallus)
PIP2 hydrolysis (Xenopus tropicalis)
PIP2 hydrolysis (Sus scrofa)
PIP2 hydrolysis (Bos taurus)
PIP2 hydrolysis (Canis familiaris)
PIP2 hydrolysis (Rattus norvegicus)
PIP2 hydrolysis (Mus musculus)
PIP2 hydrolysis (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Plasmodium falciparum)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)
PTEN dephosphorylates PIP3 (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Saccharomyces cerevisiae)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Saccharomyces cerevisiae)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)
PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Schizosaccharomyces pombe)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Schizosaccharomyces pombe)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Schizosaccharomyces pombe)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Schizosaccharomyces pombe)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)
PTEN dephosphorylates PIP3 (Dictyostelium discoideum)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Caenorhabditis elegans)
PTEN dephosphorylates PIP3 (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)
PTEN dephosphorylates PIP3 (Drosophila melanogaster)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Gallus gallus)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Gallus gallus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Gallus gallus)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Gallus gallus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Gallus gallus)
PTEN dephosphorylates PIP3 (Gallus gallus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Xenopus tropicalis)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Xenopus tropicalis)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Xenopus tropicalis)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Xenopus tropicalis)
PTEN dephosphorylates PIP3 (Danio rerio)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Sus scrofa)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)
PTEN dephosphorylates PIP3 (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Saccharomyces cerevisiae)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Sus scrofa)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Gallus gallus)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Sus scrofa)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Canis familiaris)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Dictyostelium discoideum)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Schizosaccharomyces pombe)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Gallus gallus)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Gallus gallus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Xenopus tropicalis)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Danio rerio)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Sus scrofa)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Schizosaccharomyces pombe)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Drosophila melanogaster)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Gallus gallus)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Gallus gallus)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Gallus gallus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Dictyostelium discoideum)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Drosophila melanogaster)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Gallus gallus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Mus musculus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Saccharomyces cerevisiae)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Schizosaccharomyces pombe)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Gallus gallus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Xenopus tropicalis)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Danio rerio)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Sus scrofa)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Canis familiaris)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Rattus norvegicus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Plasmodium falciparum)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Saccharomyces cerevisiae)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Schizosaccharomyces pombe)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Dictyostelium discoideum)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Caenorhabditis elegans)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Drosophila melanogaster)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Gallus gallus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Xenopus tropicalis)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Danio rerio)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Sus scrofa)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Bos taurus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Canis familiaris)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Rattus norvegicus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Homo sapiens)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Gallus gallus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Sus scrofa)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Canis familiaris)
ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)
ABCC1 transports cytosolic RCbl to extracellular region (Schizosaccharomyces pombe)
ABCC1 transports cytosolic RCbl to extracellular region (Dictyostelium discoideum)
ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)
ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)
ABCC1 transports cytosolic RCbl to extracellular region (Gallus gallus)
ABCC1 transports cytosolic RCbl to extracellular region (Xenopus tropicalis)
ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)
ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)
ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)
ABCC1 transports cytosolic RCbl to extracellular region (Rattus norvegicus)
ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Gallus gallus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Homo sapiens)
ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Homo sapiens)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)
Enolase dimers (ENO1,2,3) convert PEP to 2PG (Mus musculus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Mus musculus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Caenorhabditis elegans)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Gallus gallus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Xenopus tropicalis)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Bos taurus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)
GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Homo sapiens)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Danio rerio)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Sus scrofa)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Rattus norvegicus)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Mus musculus)
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Homo sapiens)
D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)
GPETA is hydrolyzed to ETA and G3P by Gpcpd1 (Mus musculus)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Saccharomyces cerevisiae)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Caenorhabditis elegans)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Drosophila melanogaster)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Gallus gallus)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Danio rerio)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Rattus norvegicus)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Homo sapiens)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Saccharomyces cerevisiae)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Saccharomyces cerevisiae)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Schizosaccharomyces pombe)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Schizosaccharomyces pombe)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Danio rerio)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Canis familiaris)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Caenorhabditis elegans)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Drosophila melanogaster)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Gallus gallus)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Gallus gallus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Gallus gallus)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Xenopus tropicalis)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Sus scrofa)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Homo sapiens)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Mus musculus)
PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Homo sapiens)
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Mus musculus)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Saccharomyces cerevisiae)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Schizosaccharomyces pombe)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Schizosaccharomyces pombe)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Schizosaccharomyces pombe)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Drosophila melanogaster)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Drosophila melanogaster)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Gallus gallus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Gallus gallus)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Gallus gallus)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Xenopus tropicalis)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Danio rerio)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Bos taurus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Canis familiaris)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)
PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Mus musculus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Mus musculus)
PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)
PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)
PETA is dephosphorylated to ETA by PHOSPHO1 (Gallus gallus)
PETA is dephosphorylated to ETA by PHOSPHO1 (Xenopus tropicalis)
PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)
PETA is dephosphorylated to ETA by PHOSPHO1 (Sus scrofa)
PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)
PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)
PETA is dephosphorylated to ETA by PHOSPHO1 (Rattus norvegicus)
PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)
PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)
PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)
PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)
PA is dephosphorylated to DAG by LPIN (Mus musculus)
GPCho is hydrolyzed to Cho and G3P by Gpcpd1 (Mus musculus)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)
1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Saccharomyces cerevisiae)
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Gallus gallus)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Canis familiaris)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)
PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Bos taurus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Bos taurus)
PA is dephosphorylated to DAG by LPIN (Bos taurus)
PCho is dephosphorylated to Cho by PHOSPHO1 (Canis familiaris)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)
PA is dephosphorylated to DAG by LPIN (Canis familiaris)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)
PCho is dephosphorylated to Cho by PHOSPHO1 (Xenopus tropicalis)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Saccharomyces cerevisiae)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Schizosaccharomyces pombe)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Saccharomyces cerevisiae)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Saccharomyces cerevisiae)
PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)
PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Saccharomyces cerevisiae)
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Schizosaccharomyces pombe)
PC is hydrolyzed to PA and choline by PLD1/2 (Schizosaccharomyces pombe)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)
PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Schizosaccharomyces pombe)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)
PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Caenorhabditis elegans)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Caenorhabditis elegans)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Drosophila melanogaster)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Drosophila melanogaster)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Drosophila melanogaster)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Drosophila melanogaster)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Drosophila melanogaster)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Drosophila melanogaster)
PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)
PCho is dephosphorylated to Cho by PHOSPHO1 (Drosophila melanogaster)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Drosophila melanogaster)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Xenopus tropicalis)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Danio rerio)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)
PA is dephosphorylated to DAG by LPIN (Danio rerio)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Danio rerio)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Rattus norvegicus)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Gallus gallus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Gallus gallus)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Gallus gallus)
PA is dephosphorylated to DAG by LPIN (Gallus gallus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Gallus gallus)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Gallus gallus)
PC is hydrolyzed to PA and choline by PLD1/2 (Gallus gallus)
PCho is dephosphorylated to Cho by PHOSPHO1 (Gallus gallus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)
PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Gallus gallus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Gallus gallus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Sus scrofa)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Rattus norvegicus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Mus musculus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Xenopus tropicalis)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Xenopus tropicalis)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Xenopus tropicalis)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)
PA is dephosphorylated to DAG by LPIN (Xenopus tropicalis)
PC is hydrolyzed to PA and choline by PLD1/2 (Xenopus tropicalis)
PCho is dephosphorylated to Cho by PHOSPHO1 (Danio rerio)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Sus scrofa)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Sus scrofa)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Sus scrofa)
PA is dephosphorylated to DAG by LPIN (Sus scrofa)
PCho is dephosphorylated to Cho by PHOSPHO1 (Sus scrofa)
PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Mus musculus)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)
PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Saccharomyces cerevisiae)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Drosophila melanogaster)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Gallus gallus)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Xenopus tropicalis)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Danio rerio)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Sus scrofa)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Rattus norvegicus)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Canis familiaris)
PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)
PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)
PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)
PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Homo sapiens)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)
PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)
PC is hydrolyzed to PA and choline by PLD1/2 (Rattus norvegicus)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Rattus norvegicus)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Rattus norvegicus)
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)
2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)
GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)
PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)
PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Plasmodium falciparum)
TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)
TAG is hydrolyzed to DAG by PNPLA2/3 (Drosophila melanogaster)
TAG is hydrolyzed to DAG by PNPLA2/3 (Gallus gallus)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Gallus gallus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Xenopus tropicalis)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Xenopus tropicalis)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)
TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)
TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)
TAG is hydrolyzed to DAG by PNPLA2/3 (Bos taurus)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Bos taurus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)
TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)
TAG is hydrolyzed to DAG by PNPLA2/3 (Homo sapiens)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)
TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)
DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Mus musculus)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Mus musculus)
PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)
PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)
PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)
PA is dephosphorylated to DAG by LPIN (Homo sapiens)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Homo sapiens)
PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)
PC is hydrolyzed to PA and choline by PLD1/2 (Homo sapiens)
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Homo sapiens)
PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Canis familiaris)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Canis familiaris)
PTEN dephosphorylates PIP3 (Canis familiaris)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Canis familiaris)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)
PTEN dephosphorylates PIP3 (Mus musculus)
PTEN dephosphorylates PIP3 (Rattus norvegicus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Rattus norvegicus)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Homo sapiens)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Mus musculus)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Mus musculus)
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)
PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)
PLC-gamma1 hydrolyses PIP2 (Schizosaccharomyces pombe)
PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Sus scrofa)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Mus musculus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Bos taurus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Sus scrofa)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Schizosaccharomyces pombe)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Mus musculus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Xenopus tropicalis)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)
Dephosphorylation of phospho-Cdh1 (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
PTEN dephosphorylates PIP3 (Homo sapiens)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Homo sapiens)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Gallus gallus)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Schizosaccharomyces pombe)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Saccharomyces cerevisiae)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Plasmodium falciparum)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
Active Plcg1 hydrolyses PIP2 (Rattus norvegicus)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)
Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)
as an output of
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)
dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O (Gallus gallus)
N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)
5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O (Gallus gallus)
hydroxymethylbilane => uroporphyrinogen I + H2O (Gallus gallus)
2 delta-aminolevulinate => porphobilinogen + 2 H2O (Gallus gallus)
hydroxymethylbilane => uroporphyrinogen III + H2O (Gallus gallus)
2-phosphoglycerate <=> phosphoenolpyruvate + H2O (Gallus gallus)
CYP26A1,B1,C1 4-hydroxylate atRA (Gallus gallus)
CYP26A1,B1,C1 4-hydroxylate atRA (Xenopus tropicalis)
CYP26A1,B1,C1 4-hydroxylate atRA (Danio rerio)
CYP26A1,B1,C1 4-hydroxylate atRA (Sus scrofa)
CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)
CYP26A1,B1,C1 4-hydroxylate atRA (Canis familiaris)
CYP26A1,B1,C1 4-hydroxylate atRA (Rattus norvegicus)
CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)
CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)
Pks5 transforms LFCA adenylate ester to mycocerosyl (Mycobacterium tuberculosis)
Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)
acetylglucosamine is transferred from UDP-GlcNAc onto inositol-1-phosphate (Mycobacterium tuberculosis)
sulfite is reduced to sulfide (Mycobacterium tuberculosis)
Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)
Methionine is oxidised to methionine sulfoxide (Homo sapiens)
PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)
δ12-PGJ3 spontaneously dehydrates to 15d-PGJ3 (Homo sapiens)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Plasmodium falciparum)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Gallus gallus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Sus scrofa)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Canis familiaris)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Rattus norvegicus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)
GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Homo sapiens)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Caenorhabditis elegans)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Drosophila melanogaster)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Gallus gallus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Danio rerio)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)
CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Homo sapiens)
CYP4 ω-oxidises 14(R)-HDHA to MaR-L2 (Homo sapiens)
CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Drosophila melanogaster)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Gallus gallus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Xenopus tropicalis)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)
CYPs hydroxylate DHA to 14(R)-HDHA (Dictyostelium discoideum)
CYPs hydroxylate DHA to 14(R)-HDHA (Caenorhabditis elegans)
CYPs hydroxylate DHA to 14(R)-HDHA (Drosophila melanogaster)
CYPs hydroxylate DHA to 14(R)-HDHA (Gallus gallus)
CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)
CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)
CYPs hydroxylate DHA to 14(R)-HDHA (Sus scrofa)
CYPs hydroxylate DHA to 14(R)-HDHA (Bos taurus)
CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)
CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)
CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Gallus gallus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Bos taurus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)
CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Gallus gallus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Canis familiaris)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Rattus norvegicus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Mus musculus)
GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Homo sapiens)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Plasmodium falciparum)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Gallus gallus)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Sus scrofa)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Bos taurus)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Canis familiaris)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Rattus norvegicus)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Gallus gallus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Gallus gallus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Canis familiaris)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Drosophila melanogaster)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Gallus gallus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Sus scrofa)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Mus musculus)
Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Dictyostelium discoideum)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Drosophila melanogaster)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Gallus gallus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Bos taurus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)
Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Sus scrofa)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Bos taurus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Mus musculus)
20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)
20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)
5S-HpETE is reduced to 5S-HETE by GPX1 (Oryctolagus cuniculus)
5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Gallus gallus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)
MIOX oxidises Ins to GlcA (Dictyostelium discoideum)
MIOX oxidises Ins to GlcA (Caenorhabditis elegans)
MIOX oxidises Ins to GlcA (Drosophila melanogaster)
MIOX oxidises Ins to GlcA (Gallus gallus)
MIOX oxidises Ins to GlcA (Danio rerio)
MIOX oxidises Ins to GlcA (Sus scrofa)
MIOX oxidises Ins to GlcA (Bos taurus)
MIOX oxidises Ins to GlcA (Canis familiaris)
MIOX oxidises Ins to GlcA (Rattus norvegicus)
MIOX oxidises Ins to GlcA (Mus musculus)
MIOX oxidises Ins to GlcA (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Plasmodium falciparum)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Drosophila melanogaster)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Gallus gallus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)
Cipro is oxidized to oxo-Cipro (Homo sapiens)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Xenopus tropicalis)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Danio rerio)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Sus scrofa)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Bos taurus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Canis familiaris)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Gallus gallus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Danio rerio)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Bos taurus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Canis familiaris)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Xenopus tropicalis)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Canis familiaris)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Rattus norvegicus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Mus musculus)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)
PGE2 is dehydrated to PGA2 (Homo sapiens)
GSTs transfer GSH to NAPQI to form APAP-SG (Plasmodium falciparum)
GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)
GSTs transfer GSH to NAPQI to form APAP-SG (Caenorhabditis elegans)
GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)
GSTs transfer GSH to NAPQI to form APAP-SG (Gallus gallus)
GSTs transfer GSH to NAPQI to form APAP-SG (Xenopus tropicalis)
GSTs transfer GSH to NAPQI to form APAP-SG (Danio rerio)
GSTs transfer GSH to NAPQI to form APAP-SG (Sus scrofa)
GSTs transfer GSH to NAPQI to form APAP-SG (Bos taurus)
GSTs transfer GSH to NAPQI to form APAP-SG (Canis familiaris)
GSTs transfer GSH to NAPQI to form APAP-SG (Rattus norvegicus)
GSTs transfer GSH to NAPQI to form APAP-SG (Mus musculus)
GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)
CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)
CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)
CYP2E1 monooxygenates APAP to NAPQI (Drosophila melanogaster)
CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)
CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)
CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)
CYP2E1 monooxygenates APAP to NAPQI (Sus scrofa)
CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)
CYP2E1 monooxygenates APAP to NAPQI (Canis familiaris)
CYP2E1 monooxygenates APAP to NAPQI (Rattus norvegicus)
CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)
CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)
CYP3A4 oxidizes PREDN,PREDL (Gallus gallus)
CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)
CYP3A4 oxidizes PREDN,PREDL (Danio rerio)
CYP3A4 oxidizes PREDN,PREDL (Sus scrofa)
CYP3A4 oxidizes PREDN,PREDL (Bos taurus)
CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)
CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)
CYP3A4 oxidizes PREDN,PREDL (Mus musculus)
CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)
NRPE condenses with atRAL to form A2PE (Homo sapiens)
OPN1MW binds 11cRAL (Caenorhabditis elegans)
OPN1MW binds 11cRAL (Gallus gallus)
OPN1MW binds 11cRAL (Xenopus tropicalis)
OPN1MW binds 11cRAL (Danio rerio)
OPN1MW binds 11cRAL (Sus scrofa)
OPN1MW binds 11cRAL (Bos taurus)
OPN1MW binds 11cRAL (Canis familiaris)
OPN1MW binds 11cRAL (Rattus norvegicus)
OPN1MW binds 11cRAL (Mus musculus)
OPN1MW binds 11cRAL (Homo sapiens)
OPN1SW binds 11cRAL (Caenorhabditis elegans)
OPN1SW binds 11cRAL (Xenopus tropicalis)
OPN1SW binds 11cRAL (Danio rerio)
OPN1SW binds 11cRAL (Sus scrofa)
OPN1SW binds 11cRAL (Bos taurus)
OPN1SW binds 11cRAL (Canis familiaris)
OPN1SW binds 11cRAL (Rattus norvegicus)
OPN1SW binds 11cRAL (Mus musculus)
OPN1SW binds 11cRAL (Homo sapiens)
OPN1LW binds 11cRAL (Caenorhabditis elegans)
OPN1LW binds 11cRAL (Gallus gallus)
OPN1LW binds 11cRAL (Xenopus tropicalis)
OPN1LW binds 11cRAL (Danio rerio)
OPN1LW binds 11cRAL (Sus scrofa)
OPN1LW binds 11cRAL (Bos taurus)
OPN1LW binds 11cRAL (Canis familiaris)
OPN1LW binds 11cRAL (Rattus norvegicus)
OPN1LW binds 11cRAL (Mus musculus)
OPN1LW binds 11cRAL (Homo sapiens)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Saccharomyces cerevisiae)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Dictyostelium discoideum)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Gallus gallus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Danio rerio)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Sus scrofa)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)
Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Gallus gallus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Gallus gallus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)
Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)
CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)
CYP2A13 oxidises AFM1 to AFM1E (Caenorhabditis elegans)
CYP2A13 oxidises AFM1 to AFM1E (Drosophila melanogaster)
CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)
CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)
CYP2A13 oxidises AFM1 to AFM1E (Sus scrofa)
CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)
CYP2A13 oxidises AFM1 to AFM1E (Canis familiaris)
CYP2A13 oxidises AFM1 to AFM1E (Rattus norvegicus)
CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)
CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)
CYP1A2 hydroxylates AFB1 to AFM1 (Gallus gallus)
CYP1A2 hydroxylates AFB1 to AFM1 (Danio rerio)
CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)
CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)
CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)
CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)
CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Gallus gallus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Danio rerio)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Sus scrofa)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Mus musculus)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Gallus gallus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Bos taurus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Mus musculus)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)
CYP26C1 4-hydroxylates 9cRA (Gallus gallus)
CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)
CYP26C1 4-hydroxylates 9cRA (Danio rerio)
CYP26C1 4-hydroxylates 9cRA (Sus scrofa)
CYP26C1 4-hydroxylates 9cRA (Bos taurus)
CYP26C1 4-hydroxylates 9cRA (Canis familiaris)
CYP26C1 4-hydroxylates 9cRA (Rattus norvegicus)
CYP26C1 4-hydroxylates 9cRA (Mus musculus)
CYP26C1 4-hydroxylates 9cRA (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Mus musculus)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)
27-hydroxycholesterol is 7alpha-hydroxylated (Gallus gallus)
27-hydroxycholesterol is 7alpha-hydroxylated (Xenopus tropicalis)
27-hydroxycholesterol is 7alpha-hydroxylated (Sus scrofa)
27-hydroxycholesterol is 7alpha-hydroxylated (Bos taurus)
27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)
27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)
27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)
CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)
CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)
CYP4V2 omega-hydroxylates DHA to HDoHE (Danio rerio)
CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)
CYP4V2 omega-hydroxylates DHA to HDoHE (Bos taurus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)
CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)
CYP4V2 omega-hydroxylates DHA to HDoHE (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Gallus gallus)
CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)
CYP7A1 7-hydroxylates CHOL (Sus scrofa)
CYP7A1 7-hydroxylates CHOL (Bos taurus)
CYP7A1 7-hydroxylates CHOL (Canis familiaris)
CYP7A1 7-hydroxylates CHOL (Rattus norvegicus)
CYP7A1 7-hydroxylates CHOL (Mus musculus)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
CYP39A1 7-hydroxylates 24OH-CHOL (Gallus gallus)
CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)
CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)
CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)
CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)
CYP39A1 7-hydroxylates 24OH-CHOL (Rattus norvegicus)
CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)
CYP46A1 24-hydroxylates CHOL (Gallus gallus)
CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)
CYP46A1 24-hydroxylates CHOL (Danio rerio)
CYP46A1 24-hydroxylates CHOL (Sus scrofa)
CYP46A1 24-hydroxylates CHOL (Bos taurus)
CYP46A1 24-hydroxylates CHOL (Canis familiaris)
CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)
CYP46A1 24-hydroxylates CHOL (Mus musculus)
CYP46A1 24-hydroxylates CHOL (Homo sapiens)
CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
CYP1B1 4-hydroxylates EST17b (Gallus gallus)
CYP1B1 4-hydroxylates EST17b (Danio rerio)
CYP1B1 4-hydroxylates EST17b (Sus scrofa)
CYP1B1 4-hydroxylates EST17b (Bos taurus)
CYP1B1 4-hydroxylates EST17b (Canis familiaris)
CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)
CYP1B1 4-hydroxylates EST17b (Mus musculus)
CYP1B1 4-hydroxylates EST17b (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Gallus gallus)
CYP7B1 7-hydroxylates 25OH-CHOL (Xenopus tropicalis)
CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)
CYP7B1 7-hydroxylates 25OH-CHOL (Bos taurus)
CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)
CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)
CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)
CYP4F22 20-hydroxylates TrXA3 (Danio rerio)
CYP4F22 20-hydroxylates TrXA3 (Sus scrofa)
CYP4F22 20-hydroxylates TrXA3 (Bos taurus)
CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)
CYP4F22 20-hydroxylates TrXA3 (Mus musculus)
CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)
CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)
CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)
CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)
CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)
CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)
CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)
MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)
MARC1,MARC2 reduce N-hydroxylated compounds (Caenorhabditis elegans)
MARC1,MARC2 reduce N-hydroxylated compounds (Drosophila melanogaster)
MARC1,MARC2 reduce N-hydroxylated compounds (Gallus gallus)
MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)
MARC1,MARC2 reduce N-hydroxylated compounds (Danio rerio)
MARC1,MARC2 reduce N-hydroxylated compounds (Sus scrofa)
MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)
MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)
MARC1,MARC2 reduce N-hydroxylated compounds (Rattus norvegicus)
MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)
MARC1,MARC2 reduce N-hydroxylated compounds (Homo sapiens)
CYP21A2 21-hydroxylates PROG (Dictyostelium discoideum)
CYP21A2 21-hydroxylates PROG (Gallus gallus)
CYP21A2 21-hydroxylates PROG (Sus scrofa)
CYP21A2 21-hydroxylates PROG (Bos taurus)
CYP21A2 21-hydroxylates PROG (Canis familiaris)
CYP21A2 21-hydroxylates PROG (Rattus norvegicus)
CYP21A2 21-hydroxylates PROG (Mus musculus)
CYP21A2 21-hydroxylates PROG (Homo sapiens)
CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)
CYP19A1 hydroxylates ANDST to E1 (Drosophila melanogaster)
CYP19A1 hydroxylates ANDST to E1 (Gallus gallus)
CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)
CYP19A1 hydroxylates ANDST to E1 (Danio rerio)
CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)
CYP19A1 hydroxylates ANDST to E1 (Bos taurus)
CYP19A1 hydroxylates ANDST to E1 (Canis familiaris)
CYP19A1 hydroxylates ANDST to E1 (Rattus norvegicus)
CYP19A1 hydroxylates ANDST to E1 (Mus musculus)
CYP19A1 hydroxylates ANDST to E1 (Homo sapiens)
CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)
CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)
CYP19A1 hydroxylates TEST to EST17b (Gallus gallus)
CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)
CYP19A1 hydroxylates TEST to EST17b (Danio rerio)
CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)
CYP19A1 hydroxylates TEST to EST17b (Bos taurus)
CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)
CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)
CYP19A1 hydroxylates TEST to EST17b (Mus musculus)
CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)
CYP21A2 oxidises 17HPROG (Dictyostelium discoideum)
CYP21A2 oxidises 17HPROG (Gallus gallus)
CYP21A2 oxidises 17HPROG (Sus scrofa)
CYP21A2 oxidises 17HPROG (Bos taurus)
CYP21A2 oxidises 17HPROG (Canis familiaris)
CYP21A2 oxidises 17HPROG (Rattus norvegicus)
CYP21A2 oxidises 17HPROG (Mus musculus)
CYP21A2 oxidises 17HPROG (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Gallus gallus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Bos taurus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Canis familiaris)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Gallus gallus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Bos taurus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Canis familiaris)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Rattus norvegicus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
CYP17A1 cleaves 17aHPROG to ANDST (Gallus gallus)
CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)
CYP17A1 cleaves 17aHPROG to ANDST (Danio rerio)
CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)
CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)
CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)
CYP17A1 cleaves 17aHPROG to ANDST (Rattus norvegicus)
CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Gallus gallus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Xenopus tropicalis)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Bos taurus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Canis familiaris)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Rattus norvegicus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Mus musculus)
CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)
CYP17A1 cleaves 17aHPROG to ANDST (Homo sapiens)
CYP17A1 cleaves 17aHPREG to DHA (Gallus gallus)
CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)
CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)
CYP17A1 cleaves 17aHPREG to DHA (Sus scrofa)
CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)
CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)
CYP17A1 cleaves 17aHPREG to DHA (Rattus norvegicus)
CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)
CYP17A1 17-hydroxylates PREG (Gallus gallus)
CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)
CYP17A1 17-hydroxylates PREG (Danio rerio)
CYP17A1 17-hydroxylates PREG (Sus scrofa)
CYP17A1 17-hydroxylates PREG (Bos taurus)
CYP17A1 17-hydroxylates PREG (Canis familiaris)
CYP17A1 17-hydroxylates PREG (Rattus norvegicus)
CYP17A1 17-hydroxylates PREG (Mus musculus)
CYP17A1 17-hydroxylates PREG (Homo sapiens)
CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Drosophila melanogaster)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Gallus gallus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Bos taurus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Mus musculus)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)
GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)
GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)
GSTO1 dimer reduces methylarsonate to methylarsonite (Gallus gallus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Xenopus tropicalis)
GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)
GSTO1 dimer reduces methylarsonate to methylarsonite (Sus scrofa)
GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)
GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Mus musculus)
GSTO1 dimer reduces methylarsonate to methylarsonite (Homo sapiens)
11cRAL binds to opsin to form 11c-retinyl:RHO (Caenorhabditis elegans)
11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)
11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)
11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Canis familiaris)
11cRAL binds to opsin to form 11c-retinyl:RHO (Rattus norvegicus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Mus musculus)
11cRAL binds to opsin to form 11c-retinyl:RHO (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Plasmodium falciparum)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Bos taurus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Rattus norvegicus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Mus musculus)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)
p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)
p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)
p-S256-Aquaporin-2 passively transports water into cell (Drosophila melanogaster)
p-S256-Aquaporin-2 passively transports water into cell (Gallus gallus)
p-S256-Aquaporin-2 passively transports water into cell (Xenopus tropicalis)
p-S256-Aquaporin-2 passively transports water into cell (Danio rerio)
p-S256-Aquaporin-2 passively transports water into cell (Sus scrofa)
p-S256-Aquaporin-2 passively transports water into cell (Bos taurus)
p-S256-Aquaporin-2 passively transports water into cell (Canis familiaris)
p-S256-Aquaporin-2 passively transports water into cell (Rattus norvegicus)
p-S256-Aquaporin-2 passively transports water into cell (Mus musculus)
Aquaporin-1 passively transports water into cell (Plasmodium falciparum)
Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)
Aquaporin-1 passively transports water into cell (Drosophila melanogaster)
Aquaporin-1 passively transports water into cell (Gallus gallus)
Aquaporin-1 passively transports water into cell (Xenopus tropicalis)
Aquaporin-1 passively transports water into cell (Danio rerio)
Aquaporin-1 passively transports water into cell (Sus scrofa)
Aquaporin-1 passively transports water into cell (Bos taurus)
Aquaporin-1 passively transports water into cell (Canis familiaris)
Aquaporin-1 passively transports water into cell (Rattus norvegicus)
Aquaporin-1 passively transports water into cell (Mus musculus)
Aquaporin-1 passively transports water into cell (Homo sapiens)
p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)
Aquaporins passively transport water into cells (Plasmodium falciparum)
Aquaporins passively transport water into cells (Saccharomyces cerevisiae)
Aquaporins passively transport water into cells (Schizosaccharomyces pombe)
Aquaporins passively transport water into cells (Dictyostelium discoideum)
Aquaporins passively transport water into cells (Caenorhabditis elegans)
Aquaporins passively transport water into cells (Drosophila melanogaster)
Aquaporins passively transport water into cells (Gallus gallus)
Aquaporins passively transport water into cells (Xenopus tropicalis)
Aquaporins passively transport water into cells (Danio rerio)
Aquaporins passively transport water into cells (Sus scrofa)
Aquaporins passively transport water into cells (Bos taurus)
Aquaporins passively transport water into cells (Canis familiaris)
Aquaporins passively transport water into cells (Rattus norvegicus)
Aquaporins passively transport water into cells (Mus musculus)
Aquaporins passively transport water into cells (Homo sapiens)
UROS transforms HMB to URO3 (Saccharomyces cerevisiae)
UROS transforms HMB to URO3 (Schizosaccharomyces pombe)
UROS transforms HMB to URO3 (Dictyostelium discoideum)
UROS transforms HMB to URO3 (Drosophila melanogaster)
UROS transforms HMB to URO3 (Gallus gallus)
UROS transforms HMB to URO3 (Xenopus tropicalis)
UROS transforms HMB to URO3 (Danio rerio)
UROS transforms HMB to URO3 (Sus scrofa)
UROS transforms HMB to URO3 (Bos taurus)
UROS transforms HMB to URO3 (Canis familiaris)
UROS transforms HMB to URO3 (Rattus norvegicus)
UROS transforms HMB to URO3 (Mus musculus)
UROS transforms HMB to URO3 (Homo sapiens)
ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)
ALAD condenses 2 dALAs to form PBG (Saccharomyces cerevisiae)
ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)
ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)
ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)
ALAD condenses 2 dALAs to form PBG (Gallus gallus)
ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)
ALAD condenses 2 dALAs to form PBG (Danio rerio)
ALAD condenses 2 dALAs to form PBG (Sus scrofa)
ALAD condenses 2 dALAs to form PBG (Bos taurus)
ALAD condenses 2 dALAs to form PBG (Canis familiaris)
ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)
ALAD condenses 2 dALAs to form PBG (Mus musculus)
ALAD condenses 2 dALAs to form PBG (Homo sapiens)
HMBL spontaneously transforms to URO1 (Homo sapiens)
Nitrogen dioxide is reduced to NO by F420 (Homo sapiens)
Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)
MscR reduces nitrosomycothiol to ammonia (Homo sapiens)
Peroxynitrite is reduced by AhpE (Homo sapiens)
Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)
BfrB stores iron (Homo sapiens)
BfrA stores iron (Homo sapiens)
AhpC reduces peroxidated lipids (Homo sapiens)
AhpC reduces H2O2 (Homo sapiens)
KatG reduces H2O2 (Homo sapiens)
Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)
Hydroxyl-initiated lipid peroxidation (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Saccharomyces cerevisiae)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Saccharomyces cerevisiae)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Canis familiaris)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Plasmodium falciparum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Saccharomyces cerevisiae)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Schizosaccharomyces pombe)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Caenorhabditis elegans)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Xenopus tropicalis)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Canis familiaris)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Rattus norvegicus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Homo sapiens)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Plasmodium falciparum)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Gallus gallus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Sus scrofa)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Canis familiaris)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Rattus norvegicus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)
GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Plasmodium falciparum)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Gallus gallus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Sus scrofa)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Bos taurus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Canis familiaris)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Mus musculus)
GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)
FA2H hydroxylates 1,2-saturated fatty acids (Saccharomyces cerevisiae)
FA2H hydroxylates 1,2-saturated fatty acids (Schizosaccharomyces pombe)
FA2H hydroxylates 1,2-saturated fatty acids (Dictyostelium discoideum)
FA2H hydroxylates 1,2-saturated fatty acids (Caenorhabditis elegans)
FA2H hydroxylates 1,2-saturated fatty acids (Drosophila melanogaster)
FA2H hydroxylates 1,2-saturated fatty acids (Gallus gallus)
FA2H hydroxylates 1,2-saturated fatty acids (Xenopus tropicalis)
FA2H hydroxylates 1,2-saturated fatty acids (Sus scrofa)
FA2H hydroxylates 1,2-saturated fatty acids (Bos taurus)
FA2H hydroxylates 1,2-saturated fatty acids (Canis familiaris)
FA2H hydroxylates 1,2-saturated fatty acids (Rattus norvegicus)
FA2H hydroxylates 1,2-saturated fatty acids (Mus musculus)
FA2H hydroxylates 1,2-saturated fatty acids (Homo sapiens)
DEGS1 dehydrogenates dihydroceramide (Schizosaccharomyces pombe)
DEGS1 dehydrogenates dihydroceramide (Dictyostelium discoideum)
DEGS1 dehydrogenates dihydroceramide (Caenorhabditis elegans)
DEGS1 dehydrogenates dihydroceramide (Drosophila melanogaster)
DEGS1 dehydrogenates dihydroceramide (Gallus gallus)
DEGS1 dehydrogenates dihydroceramide (Xenopus tropicalis)
DEGS1 dehydrogenates dihydroceramide (Danio rerio)
DEGS1 dehydrogenates dihydroceramide (Sus scrofa)
DEGS1 dehydrogenates dihydroceramide (Bos taurus)
DEGS1 dehydrogenates dihydroceramide (Canis familiaris)
DEGS1 dehydrogenates dihydroceramide (Rattus norvegicus)
DEGS1 dehydrogenates dihydroceramide (Mus musculus)
DEGS1 dehydrogenates dihydroceramide (Homo sapiens)
DEGS2 oxygenates dihydroceramide (Schizosaccharomyces pombe)
DEGS2 oxygenates dihydroceramide (Dictyostelium discoideum)
DEGS2 oxygenates dihydroceramide (Caenorhabditis elegans)
DEGS2 oxygenates dihydroceramide (Drosophila melanogaster)
DEGS2 oxygenates dihydroceramide (Gallus gallus)
DEGS2 oxygenates dihydroceramide (Xenopus tropicalis)
DEGS2 oxygenates dihydroceramide (Sus scrofa)
DEGS2 oxygenates dihydroceramide (Bos taurus)
DEGS2 oxygenates dihydroceramide (Canis familiaris)
DEGS2 oxygenates dihydroceramide (Rattus norvegicus)
DEGS2 oxygenates dihydroceramide (Mus musculus)
DEGS2 oxygenates dihydroceramide (Homo sapiens)
GMDS dehydrates GDP-Man to GDP-DHDMan (Plasmodium falciparum)
GMDS dehydrates GDP-Man to GDP-DHDMan (Dictyostelium discoideum)
GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)
GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)
GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)
GMDS dehydrates GDP-Man to GDP-DHDMan (Sus scrofa)
GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Canis familiaris)
GMDS dehydrates GDP-Man to GDP-DHDMan (Rattus norvegicus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)
GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)
Dehydration of methylthio-ribulose-P (Saccharomyces cerevisiae)
Dehydration of methylthio-ribulose-P (Homo sapiens)
FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)
FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)
FMO1:FAD oxidizes HTAU to TAU (Xenopus tropicalis)
FMO1:FAD oxidizes HTAU to TAU (Danio rerio)
FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)
FMO1:FAD oxidizes HTAU to TAU (Bos taurus)
FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)
FMO1:FAD oxidizes HTAU to TAU (Rattus norvegicus)
FMO1:FAD oxidizes HTAU to TAU (Mus musculus)
FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Drosophila melanogaster)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Gallus gallus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Saccharomyces cerevisiae)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Gallus gallus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Sus scrofa)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Rattus norvegicus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Mus musculus)
SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)
SeHCys and Ser are dehydrated into SeCysta by Cbs (Rattus norvegicus)
SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)
SeO3(2-) is reduced to H2Se by TXNRD1 (Bos taurus)
SeO3(2-) is reduced to H2Se by TXNRD1 (Homo sapiens)
MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)
MeSeOH is reduced to MeSeH by TXNRD1 (Caenorhabditis elegans)
MeSeOH is reduced to MeSeH by TXNRD1 (Gallus gallus)
MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)
MeSeOH is reduced to MeSeH by TXNRD1 (Rattus norvegicus)
MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)
MeSeOH is reduced to MeSeH by TXNRD1 (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Plasmodium falciparum)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Gallus gallus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Rattus norvegicus)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Rattus norvegicus)
PAPSe is reduced to SeO3(2-) by MET16 (Saccharomyces cerevisiae)
PAPSe is reduced to SeO3(2-) by PAPSe reductase (Homo sapiens)
SeO3(2-) combines with GSH to form GSSeSG and GSSG (Homo sapiens)
MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)
ACS transforms to QUIN non-enzymatically (Homo sapiens)
4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Homo sapiens)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Bos taurus)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Rattus norvegicus)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Mus musculus)
GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Plasmodium falciparum)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Dictyostelium discoideum)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Xenopus tropicalis)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
PRDX5 reduces peroxynitrite to nitrite using TXN (Plasmodium falciparum)
PRDX5 reduces peroxynitrite to nitrite using TXN (Saccharomyces cerevisiae)
PRDX5 reduces peroxynitrite to nitrite using TXN (Schizosaccharomyces pombe)
PRDX5 reduces peroxynitrite to nitrite using TXN (Dictyostelium discoideum)
PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)
PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)
PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)
PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)
PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)
PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)
PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)
PRDX5 reduces peroxynitrite to nitrite using TXN (Homo sapiens)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Gallus gallus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)
FAICAR => IMP + H2O (Saccharomyces cerevisiae)
FAICAR => IMP + H2O (Schizosaccharomyces pombe)
FAICAR => IMP + H2O (Dictyostelium discoideum)
FAICAR => IMP + H2O (Caenorhabditis elegans)
FAICAR => IMP + H2O (Drosophila melanogaster)
FAICAR => IMP + H2O (Gallus gallus)
FAICAR => IMP + H2O (Danio rerio)
FAICAR => IMP + H2O (Sus scrofa)
FAICAR => IMP + H2O (Bos taurus)
FAICAR => IMP + H2O (Canis familiaris)
FAICAR => IMP + H2O (Mus musculus)
FAICAR => IMP + H2O (Homo sapiens)
FAICAR => IMP + H2O (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Danio rerio)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)
CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Homo sapiens)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Caenorhabditis elegans)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Gallus gallus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)
CYP2R1 25-hydroxylates VD3 to 25(OH)D (Homo sapiens)
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Gallus gallus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Sus scrofa)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Mus musculus)
SC5D desaturates LTHSOL to 7-dehydroCHOL (Homo sapiens)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Gallus gallus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Sus scrofa)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Bos taurus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Canis familiaris)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)
Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Gallus gallus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Danio rerio)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)
CYP51A1 demethylates LNSOL (Saccharomyces cerevisiae)
CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)
CYP51A1 demethylates LNSOL (Dictyostelium discoideum)
CYP51A1 demethylates LNSOL (Gallus gallus)
CYP51A1 demethylates LNSOL (Danio rerio)
CYP51A1 demethylates LNSOL (Sus scrofa)
CYP51A1 demethylates LNSOL (Bos taurus)
CYP51A1 demethylates LNSOL (Canis familiaris)
CYP51A1 demethylates LNSOL (Rattus norvegicus)
CYP51A1 demethylates LNSOL (Mus musculus)
CYP51A1 demethylates LNSOL (Homo sapiens)
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)
Squalene is oxidized to its epoxide (Saccharomyces cerevisiae)
Squalene is oxidized to its epoxide (Schizosaccharomyces pombe)
Squalene is oxidized to its epoxide (Dictyostelium discoideum)
Squalene is oxidized to its epoxide (Gallus gallus)
Squalene is oxidized to its epoxide (Xenopus tropicalis)
Squalene is oxidized to its epoxide (Danio rerio)
Squalene is oxidized to its epoxide (Sus scrofa)
Squalene is oxidized to its epoxide (Bos taurus)
Squalene is oxidized to its epoxide (Canis familiaris)
Squalene is oxidized to its epoxide (Rattus norvegicus)
Squalene is oxidized to its epoxide (Mus musculus)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Plasmodium falciparum)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Saccharomyces cerevisiae)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Schizosaccharomyces pombe)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Dictyostelium discoideum)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Drosophila melanogaster)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Gallus gallus)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Danio rerio)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Rattus norvegicus)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Mus musculus)
ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)
Squalene is oxidized to its epoxide (Homo sapiens)
SCD5 desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
SCD5 desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
SCD5 desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
SCD5 desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
SCD5 desaturates ST-CoA to OLE-CoA (Gallus gallus)
SCD5 desaturates ST-CoA to OLE-CoA (Sus scrofa)
SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)
SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)
SCD5 desaturates ST-CoA to OLE-CoA (Homo sapiens)
SCD desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)
SCD desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)
SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)
SCD desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)
SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)
SCD desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)
SCD desaturates ST-CoA to OLE-CoA (Gallus gallus)
SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)
SCD desaturates ST-CoA to OLE-CoA (Danio rerio)
SCD desaturates ST-CoA to OLE-CoA (Sus scrofa)
SCD desaturates ST-CoA to OLE-CoA (Bos taurus)
SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)
SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)
SCD desaturates ST-CoA to OLE-CoA (Mus musculus)
SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Plasmodium falciparum)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Saccharomyces cerevisiae)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Dictyostelium discoideum)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Gallus gallus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Rattus norvegicus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Mus musculus)
PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Homo sapiens)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Gallus gallus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)
ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)
ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)
ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)
ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)
ACSL3,4 ligate CoA to AA to form AA-CoA (Gallus gallus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Xenopus tropicalis)
ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)
ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)
ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)
ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)
ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Dictyostelium discoideum)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Caenorhabditis elegans)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Drosophila melanogaster)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Gallus gallus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Xenopus tropicalis)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Danio rerio)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Sus scrofa)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Bos taurus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Canis familiaris)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Rattus norvegicus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Mus musculus)
acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O (Homo sapiens)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Dictyostelium discoideum)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Gallus gallus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Bos taurus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)
PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Homo sapiens)
Cytosolic H2O2 decarboxylates PYR to acetate (Homo sapiens)
PXLP-K56-SRR dimer deaminates L-Ser (Saccharomyces cerevisiae)
PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)
PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)
PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)
PXLP-K56-SRR dimer deaminates L-Ser (Gallus gallus)
PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)
PXLP-K56-SRR dimer deaminates L-Ser (Sus scrofa)
PXLP-K56-SRR dimer deaminates L-Ser (Bos taurus)
PXLP-K56-SRR dimer deaminates L-Ser (Canis familiaris)
PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)
PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)
PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)
PXLP-K56-SRR dimer deaminates D-Ser (Saccharomyces cerevisiae)
PXLP-K56-SRR dimer deaminates D-Ser (Schizosaccharomyces pombe)
PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)
PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)
PXLP-K56-SRR dimer deaminates D-Ser (Gallus gallus)
PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)
PXLP-K56-SRR dimer deaminates D-Ser (Sus scrofa)
PXLP-K56-SRR dimer deaminates D-Ser (Bos taurus)
PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)
PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)
PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)
PXLP-K56-SRR dimer deaminates D-Ser (Mus musculus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
PRDX1 overoxidizes (Saccharomyces cerevisiae)
PRDX1 overoxidizes (Schizosaccharomyces pombe)
PRDX1 overoxidizes (Dictyostelium discoideum)
PRDX1 overoxidizes (Caenorhabditis elegans)
PRDX1 overoxidizes (Drosophila melanogaster)
PRDX1 overoxidizes (Gallus gallus)
PRDX1 overoxidizes (Xenopus tropicalis)
PRDX1 overoxidizes (Danio rerio)
PRDX1 overoxidizes (Sus scrofa)
PRDX1 overoxidizes (Bos taurus)
PRDX1 overoxidizes (Canis familiaris)
PRDX1 overoxidizes (Rattus norvegicus)
PRDX1 overoxidizes (Mus musculus)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Plasmodium falciparum)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Saccharomyces cerevisiae)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Caenorhabditis elegans)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Danio rerio)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)
PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)
PRDX1 overoxidizes (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)
HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)
HMOX1 dimer, HMOX2 cleave heme (Danio rerio)
HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)
HMOX1 dimer, HMOX2 cleave heme (Bos taurus)
HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)
HMOX1 dimer, HMOX2 cleave heme (Rattus norvegicus)
HMOX1 dimer, HMOX2 cleave heme (Mus musculus)
HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)
HMOX1 dimer, HMOX2 cleave heme (Drosophila melanogaster)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Plasmodium falciparum)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Schizosaccharomyces pombe)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Dictyostelium discoideum)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Gallus gallus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Danio rerio)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Sus scrofa)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Rattus norvegicus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)
2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)
Other forms of this molecule
H2O [cytoplasm]
H2O [lipid droplet]
H2O [early endosome]
H2O [multivesicular body lumen]
H2O [phagocytic vesicle lumen]
H2O [endocytic vesicle lumen]
H2O [Golgi lumen]
H2O [endoplasmic reticulum quality control compartment]
H2O [melanosome lumen]
H2O [secretory granule lumen]
H2O [lysosomal lumen]
H2O [endoplasmic reticulum lumen]
H2O [peroxisomal matrix]
H2O [mitochondrial intermembrane space]
H2O [mitochondrial matrix]
H2O [extracellular region]
H2O [nucleoplasm]
Cross References
COMPOUND
C00001
PubChem Substance
8145132
HMDB Metabolite
HMDB0002111
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