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What is Reactome ?
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L-Phe [cytosol]
Stable Identifier
R-ALL-29502
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
(S)-alpha-amino-beta-phenylpropionic acid, L-phenylalanine zwitterion, L-phenylalanine
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)
L-Phe [cytosol]
Tryptophan catabolism (Bos taurus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Bos taurus)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)
L-Phe [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Na+/Cl- dependent neurotransmitter transporters (Bos taurus)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Amino acid transport across the plasma membrane (Bos taurus)
SLC16A10-mediated uptake of aromatic amino acids (Bos taurus)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Bos taurus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Bos taurus)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Caenorhabditis elegans)
L-Phe [cytosol]
Tryptophan catabolism (Caenorhabditis elegans)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Caenorhabditis elegans)
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)
L-Phe [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Canis familiaris)
L-Phe [cytosol]
Tryptophan catabolism (Canis familiaris)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Canis familiaris)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)
L-Phe [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Na+/Cl- dependent neurotransmitter transporters (Canis familiaris)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Amino acid transport across the plasma membrane (Canis familiaris)
SLC16A10-mediated uptake of aromatic amino acids (Canis familiaris)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Canis familiaris)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)
L-Phe [cytosol]
Tryptophan catabolism (Danio rerio)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Danio rerio)
L-Phe [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Na+/Cl- dependent neurotransmitter transporters (Danio rerio)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Amino acid transport across the plasma membrane (Danio rerio)
SLC16A10-mediated uptake of aromatic amino acids (Danio rerio)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)
neutral amino acids [cytosol]
L-Phe [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)
L-Phe [cytosol]
Tryptophan catabolism (Dictyostelium discoideum)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Dictyostelium discoideum)
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)
L-Phe [cytosol]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Dictyostelium discoideum)
Amino acid transport across the plasma membrane (Dictyostelium discoideum)
SLC16A10-mediated uptake of aromatic amino acids (Dictyostelium discoideum)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)
L-Phe [cytosol]
Tryptophan catabolism (Drosophila melanogaster)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Drosophila melanogaster)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)
L-Phe [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Na+/Cl- dependent neurotransmitter transporters (Drosophila melanogaster)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Amino acid transport across the plasma membrane (Drosophila melanogaster)
SLC16A10-mediated uptake of aromatic amino acids (Drosophila melanogaster)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Drosophila melanogaster)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Drosophila melanogaster)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Gallus gallus)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Gallus gallus)
L-Phe [cytosol]
Tryptophan catabolism (Gallus gallus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Gallus gallus)
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Gallus gallus)
L-Phe [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Na+/Cl- dependent neurotransmitter transporters (Gallus gallus)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Amino acid transport across the plasma membrane (Gallus gallus)
SLC16A10-mediated uptake of aromatic amino acids (Gallus gallus)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Gallus gallus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Gallus gallus)
neutral amino acids [cytosol]
L-Phe [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Phenylketonuria (Homo sapiens)
Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)
L-Phe [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)
L-Phe [cytosol]
Tryptophan catabolism (Homo sapiens)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)
L-Phe [cytosol]
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)
L-Phe [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Amino acid transport across the plasma membrane (Homo sapiens)
SLC16A10-mediated uptake of aromatic amino acids (Homo sapiens)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Homo sapiens)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Homo sapiens)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Homo sapiens)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Homo sapiens)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Phenylalanine and tyrosine metabolism (Mus musculus)
Phenylalanine metabolism (Mus musculus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)
L-Phe [cytosol]
Tryptophan catabolism (Mus musculus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Mus musculus)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)
L-Phe [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Na+/Cl- dependent neurotransmitter transporters (Mus musculus)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Amino acid transport across the plasma membrane (Mus musculus)
SLC16A10-mediated uptake of aromatic amino acids (Mus musculus)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Mus musculus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Mus musculus)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of bile salts and organic acids, metal ions and amine compounds (Plasmodium falciparum)
Na+/Cl- dependent neurotransmitter transporters (Plasmodium falciparum)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Plasmodium falciparum)
Amino acid transport across the plasma membrane (Plasmodium falciparum)
SLC16A10-mediated uptake of aromatic amino acids (Plasmodium falciparum)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)
neutral amino acids [cytosol]
L-Phe [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Phenylalanine metabolism (Rattus norvegicus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Rattus norvegicus)
L-Phe [cytosol]
Tryptophan catabolism (Rattus norvegicus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Rattus norvegicus)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)
GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)
L-Phe [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Na+/Cl- dependent neurotransmitter transporters (Rattus norvegicus)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Amino acid transport across the plasma membrane (Rattus norvegicus)
SLC16A10-mediated uptake of aromatic amino acids (Rattus norvegicus)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Rattus norvegicus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Rattus norvegicus)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Phenylalanine and tyrosine metabolism (Saccharomyces cerevisiae)
Phenylalanine metabolism (Saccharomyces cerevisiae)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)
L-Phe [cytosol]
Tryptophan catabolism (Saccharomyces cerevisiae)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Saccharomyces cerevisiae)
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of cofactors (Saccharomyces cerevisiae)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Saccharomyces cerevisiae)
GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)
L-Phe [cytosol]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of inorganic cations/anions and amino acids/oligopeptides (Saccharomyces cerevisiae)
Amino acid transport across the plasma membrane (Saccharomyces cerevisiae)
SLC16A10-mediated uptake of aromatic amino acids (Saccharomyces cerevisiae)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Phenylalanine and tyrosine metabolism (Schizosaccharomyces pombe)
Phenylalanine metabolism (Schizosaccharomyces pombe)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Schizosaccharomyces pombe)
L-Phe [cytosol]
Tryptophan catabolism (Schizosaccharomyces pombe)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Schizosaccharomyces pombe)
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Schizosaccharomyces pombe)
GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)
L-Phe [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Phenylalanine and tyrosine metabolism (Sus scrofa)
Phenylalanine metabolism (Sus scrofa)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)
L-Phe [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)
L-Phe [cytosol]
Tryptophan catabolism (Sus scrofa)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Sus scrofa)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of cofactors (Sus scrofa)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Sus scrofa)
GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)
L-Phe [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Na+/Cl- dependent neurotransmitter transporters (Sus scrofa)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Amino acid transport across the plasma membrane (Sus scrofa)
SLC16A10-mediated uptake of aromatic amino acids (Sus scrofa)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Sus scrofa)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Sus scrofa)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Sus scrofa)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Phenylalanine metabolism (Xenopus tropicalis)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)
L-Phe [cytosol]
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Xenopus tropicalis)
L-Phe [cytosol]
Tryptophan catabolism (Xenopus tropicalis)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Xenopus tropicalis)
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of cofactors (Xenopus tropicalis)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Xenopus tropicalis)
GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)
L-Phe [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Na+/Cl- dependent neurotransmitter transporters (Xenopus tropicalis)
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)
neutral amino acids [cytosol]
L-Phe [cytosol]
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Amino acid transport across the plasma membrane (Xenopus tropicalis)
SLC16A10-mediated uptake of aromatic amino acids (Xenopus tropicalis)
ligands of SLC16A10 [cytosol]
L-Phe [cytosol]
SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Xenopus tropicalis)
ligands of SLC43A1 and SLC43A2 [cytosol]
L-Phe [cytosol]
SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)
neutral amino acids [cytosol]
L-Phe [cytosol]
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)
ligands of SLC7A5 [cytosol]
L-Phe [cytosol]
SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)
ligands of SLC7A8 [cytosol]
L-Phe [cytosol]
External Reference Information
External Reference
L-phenylalanine zwitterion [ChEBI:58095]
Participates
as an input of
phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)
Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Schizosaccharomyces pombe)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Caenorhabditis elegans)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Gallus gallus)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Xenopus tropicalis)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Rattus norvegicus)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)
phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Canis familiaris)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
as an output of
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Gallus gallus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Danio rerio)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Rattus norvegicus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Mus musculus)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Homo sapiens)
ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)
as a member of
ligands of SLC7A8 [cytosol]
neutral amino acids [cytosol]
ligands of SLC7A5 [cytosol]
ligands of SLC43A1 and SLC43A2 [cytosol]
ligands of SLC16A10 [cytosol]
This entity regulates
Negatively
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Saccharomyces cerevisiae)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Schizosaccharomyces pombe)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Dictyostelium discoideum)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Caenorhabditis elegans)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Drosophila melanogaster)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Gallus gallus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Xenopus tropicalis)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Danio rerio)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Sus scrofa)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Bos taurus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Canis familiaris)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Rattus norvegicus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Mus musculus)
PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu
(Homo sapiens)
Positively
GCH1 reduces GTP to dihydroneopterin triphosphate
(Saccharomyces cerevisiae)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Schizosaccharomyces pombe)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Dictyostelium discoideum)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Caenorhabditis elegans)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Drosophila melanogaster)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Gallus gallus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Xenopus tropicalis)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Sus scrofa)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Bos taurus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Canis familiaris)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Rattus norvegicus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Mus musculus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Homo sapiens)
Other forms of this molecule
L-Phe [mitochondrial matrix]
L-Phe [extracellular region]
Cross References
COMPOUND
C00079
ZINC
000000105196
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![L-Phe [cytosol] icon](/icon/R-ICO-013985.svg){kind=icon}
