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CXCL12(22-93) [extracellular region]
Stable Identifier
R-HSA-2980693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CXCL12, Stromal cell-derived factor 1, SDF1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
SLIT2:ROBO1 binds CXCR4 (Homo sapiens)
CXCL12:CXCR4:ROBO1:SLIT2 [plasma membrane] (Homo sapiens)
CXCR4:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
CXCR4:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Nuclear signaling by ERBB4 (Homo sapiens)
CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)
CXCL12(22-93) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48061 CXCL12
Gene Names
CXCL12, SDF1, SDF1A, SDF1B
Chain
signal peptide:1-21, chain:22-93, chain:24-93, chain:24-88
Reference Genes
BioGPS Gene:6387 CXCL12
COSMIC (genes):CXCL12 CXCL12
CTD Gene:6387 CXCL12
dbSNP Gene:6387 CXCL12
ENSEMBL:ENSG00000107562 CXCL12
ENSEMBL_homo_sapiens_GENE:ENSG00000107562.18 CXCL12
HGNC:10672 CXCL12
KEGG Gene (Homo sapiens):6387 CXCL12
Monarch:6387 CXCL12
NCBI Gene:6387 CXCL12
OMIM:600835 CXCL12
UCSC:P48061 CXCL12
Reference Transcript
RefSeq:NM_000609.6 CXCL12
RefSeq:NM_001033886.2 CXCL12
RefSeq:NM_001178134.1 CXCL12
RefSeq:NM_001277990.1 CXCL12
RefSeq:NM_199168.3 CXCL12
Other Identifiers
11718743_a_at
11718744_a_at
11720818_a_at
11720819_s_at
11753257_a_at
16713530
203666_PM_at
203666_at
209687_PM_at
209687_at
32666_at
3286605
3286606
3286607
3286608
3286609
3286614
3286615
3286616
3286617
3286618
3286619
3286620
3286621
3286622
3286623
33834_at
6387
7933194
87847_at
A_23_P202448
A_24_P412156
A_33_P3372840
A_33_P3712341
GE61544
GE706270
GO:0001666
GO:0001764
GO:0001938
GO:0002376
GO:0003013
GO:0005102
GO:0005125
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006874
GO:0006935
GO:0006952
GO:0006955
GO:0007010
GO:0007155
GO:0007165
GO:0007186
GO:0007411
GO:0008009
GO:0008015
GO:0008064
GO:0008083
GO:0008284
GO:0008344
GO:0009605
GO:0009612
GO:0009615
GO:0009897
GO:0012501
GO:0022029
GO:0023052
GO:0030154
GO:0030312
GO:0030335
GO:0031012
GO:0031100
GO:0033603
GO:0033622
GO:0038146
GO:0038160
GO:0042379
GO:0043226
GO:0043434
GO:0045236
GO:0045666
GO:0045785
GO:0048018
GO:0048842
GO:0048856
GO:0048870
GO:0050877
GO:0050930
GO:0050965
GO:0050966
GO:0051924
GO:0055065
GO:0060326
GO:0062023
GO:0065003
GO:0070062
GO:0070098
GO:0090026
GO:0090280
GO:0098772
GO:1902230
GO:1903237
GO:1904018
GO:1990478
GO:1990869
GO:2000406
GO:2000669
HMNXSV003001021
HMNXSV003020052
HMNXSV003035345
ILMN_1689111
ILMN_1791447
ILMN_1803825
L36033_at
PH_hs_0025467
TC10002589.hg
U19495_s_at
g10834987_3p_at
g1754834_3p_at
p26608
Participates
as a component of
CXCR4:CXCL12 [plasma membrane] (Homo sapiens)
CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
as an output of
CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)
as an input of
Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
Inferred To
CXCL12(22-93) [extracellular region]
(Gallus gallus)
CXCL12(22-93) [extracellular region]
(Mus musculus)
SDF-1 [extracellular region]
(Danio rerio)
Cxcl12 [extracellular region]
(Rattus norvegicus)
CXCL12 [extracellular region]
(Bos taurus)
CXCL12 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001171605.1
,
NP_000600.1
,
NP_954637.1
,
NP_001264919.1
,
NP_001029058.1
OpenTargets
ENSG00000107562
HPA
ENSG00000107562-CXCL12
GeneCards
P48061
Ensembl
ENSP00000363551
,
ENST00000343575
,
ENSP00000379139
,
ENSG00000107562
,
ENST00000395794
,
ENST00000374429
,
ENSP00000339913
,
ENST00000395793
,
ENST00000374426
,
ENSP00000379140
,
ENSP00000363548
ZINC target
P48061
PRO
P48061
Pharos - Targets
P48061
Orphanet
25958
PDB
3GV3
,
2J7Z
,
2KEC
,
2K01
,
7SK8
,
2KED
,
4LMQ
,
7SK7
,
6SHR
,
7SK6
,
1VMC
,
7SK5
,
2K05
,
1A15
,
2N55
,
1QG7
,
7SK4
,
2K03
,
2KOL
,
7SK3
,
2SDF
,
2KEE
,
1SDF
,
4UAI
,
2K04
,
3HP3
,
2NWG
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRJ3 CCL28
1
CCL28 [extracellular region]
(R-HSA-373300)
0.558
2
UniProt:O00585 CCL21
1
CCL21 [extracellular region]
(R-HSA-373116)
0.558
2
UniProt:P19875 CXCL2
1
CXCL2(35-107) [extracellular region]
(R-HSA-373777)
0.558
2
UniProt:Q6UXB2 CXL17
0.558
2
UniProt:P10720 PF4V1
1
PF4V1(31-104) [extracellular region]
(R-HSA-203106)
0.558
4
UniProt:P80162 CXCL6
1
CXCL6(38-114) [extracellular region]
(R-HSA-373784)
0.558
2
UniProt:Q07325 CXCL9
1
CXCL9 [extracellular region]
(R-HSA-373856)
0.558
2
UniProt:P02776 PF4
4
PF4(32-101) [platelet alpha granule lumen]
(R-HSA-114652)
PF4(48-101) [platelet alpha granule lumen]
(R-HSA-114628)
PF4(32-101) [extracellular region]
(R-HSA-61823)
PF4(48-101) [extracellular region]
(R-HSA-114629)
0.558
4
UniProt:P47992 XCL1
1
XCL1 [extracellular region]
(R-HSA-373360)
0.558
2
UniProt:O95715 CXL14
0.558
2
UniProt:P51671 CCL11
1
CCL11 [extracellular region]
(R-HSA-443966)
0.558
2
UniProt:O14625 CXCL11
1
CXCL11 [extracellular region]
(R-HSA-373852)
0.558
3
UniProt:Q9Y258 CCL26
0.558
2
UniProt:Q9UBD3 XCL2
1
XCL2 [extracellular region]
(R-HSA-373349)
0.558
2
UniProt:P02778 CXCL10
1
CXCL10(22-98) [extracellular region]
(R-HSA-373853)
0.558
2
UniProt:O15444 CCL25
1
CCL25 [extracellular region]
(R-HSA-373096)
0.558
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
5
UniProt:P78556 CCL20
1
CCL20(27-96) [extracellular region]
(R-HSA-373097)
0.558
2
UniProt:Q99616 CCL13
1
CCL13 [extracellular region]
(R-HSA-8862740)
0.558
2
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