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Nuclear Envelope Breakdown

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelope from chromatin. NEBD allows mitotic spindle microtubules to access condensed chromosomes at kinetochores and enables nuclear division and segregation of genetic material to two daughter cells. For a recent review, please refer to Guttinger et al. 2009.

Literature References
PubMed ID Title Journal Year
19234477 Orchestrating nuclear envelope disassembly and reassembly during mitosis Nat. Rev. Mol. Cell Biol. 2009
Participant Of
Event Information
Orthologous Events