Reactome: A Curated Pathway Database
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Nuclear Envelope Breakdown

Stable Identifier
R-HSA-2980766
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelope from chromatin. NEBD allows mitotic spindle microtubules to access condensed chromosomes at kinetochores and enables nuclear division and segregation of genetic material to two daughter cells. For a recent review, please refer to Guttinger et al. 2009.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
hasEvent
Orthologous Events