Reactome: A Curated Pathway Database

Nuclear Envelope Breakdown (R-HSA-2980766)

Species Homo sapiens


The nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelope from chromatin. NEBD allows mitotic spindle microtubules to access condensed chromosomes at kinetochores and enables nuclear division and segregation of genetic material to two daughter cells. For a recent review, please refer to Guttinger et al. 2009.

Locations in the PathwayBrowser
Additional Information
GO Biological Process mitotic nuclear envelope disassembly (0007077)
Literature References
pubMedId Title Journal Year
19234477 Orchestrating nuclear envelope disassembly and reassembly during mitosis Nat. Rev. Mol. Cell Biol. 2009