ECM proteoglycans (R-HSA-3000178) [Homo sapiens]


Proteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans (GAGs), linear polysaccharides consisting of a repeating disaccharide, generally of an acetylated amino sugar alternating
with a uronic acid. Most proteoglycans are located in the extracellular
space. Proteoglycans are highly diverse, both in terms of the core proteins and the subtypes of GAG chains, namely chondroitin sulfate (CS), keratan sulfate (KS), dermatan sulfate (DS) and heparan sulfate (HS). Hyaluronan is a non-sulfated GAG whose molecular weight runs into millions of Dalton; in articular cartilage, a single hyaluronan molecule can hold upto 100 aggrecan molecules and these aggregates are stabilized by a link protein.

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
20301236 Proteoglycans and Sulfated Glycosaminoglycans 2009
21307119 Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor J. Endocrinol. 2011
Cell Biology of Extracellular Matrix 1991
Cell Biology of Extracellular Matrix 1991
Inferred Entries
Orthologous events