Scavenging by Class A Receptors (R-HSA-3000480) [Homo sapiens]


Class A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009, Bowdish and Gordon 2009). The coiled coil domains interact to form trimers. The collagenous domain (Rohrer et al. 1990, Acton et al. 1993) and/or the SR cysteine-rich domain (Brannstrom et al. 2002) bind ligands and determine the specificity of the receptor.

Locations in the PathwayBrowser
Additional Information
Compartment endocytic vesicle membrane , extracellular region , plasma membrane
GO Biological Process receptor-mediated endocytosis (0006898)
Literature References
pubMedId Title Journal Year
19388903 Scavenger receptors: role in innate immunity and microbial pathogenesis Cell. Microbiol. 2009
19120472 Conserved domains of the class A scavenger receptors: evolution and function Immunol. Rev. 2009
2300208 Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II Nature 1990
8429029 The collagenous domains of macrophage scavenger receptors and complement component C1q mediate their similar, but not identical, binding specificities for polyanionic ligands J. Biol. Chem. 1993
11820786 Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO Biochem. Biophys. Res. Commun. 2002
Inferred Entries
Orthologous events