SCARF1 (SREC-I) and SCARF2 (SREC-II) are transmembrane proteins that contain multiple extracellular EGF-like domains (Ishii et al. 2002, reviewed in Areschoug and Gordon 2009). SCARF2 may be involved in cell adhesion rather than ligand binding.
|Compartment||endocytic vesicle membrane , extracellular region , plasma membrane|
|GO Biological Process||receptor-mediated endocytosis (0006898)|
|19388903||Scavenger receptors: role in innate immunity and microbial pathogenesis||Cell. Microbiol.||2009|
|12154095||SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain||J. Biol. Chem.||2002|