Reactome: A Curated Pathway Database

SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Stable Identifier
R-HSA-3065678
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Summation

SUMO is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). UBC9 is the only known E2 enzyme for SUMO and on certain substrates such as RanGAP1 may act without the requirement of an E3 ligase.

Literature References
PubMed ID Title Journal Year
20462400 Mechanisms, regulation and consequences of protein SUMOylation Biochem. J. 2010
20674646 Post-translational modification by SUMO Toxicology 2010
19923268 SUMOylation and deSUMOylation at a glance J. Cell. Sci. 2009
21102611 The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition Nat. Rev. Mol. Cell Biol. 2010
Participants
events
Participant Of
hasEvent
Orthologous Events
 
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