SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Stable Identifier
R-HSA-3065678
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Summation

SUMO is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). UBC9 is the only known E2 enzyme for SUMO and on certain substrates such as RanGAP1 may act without the requirement of an E3 ligase.

Literature References
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
protein sumoylation (0016925)
Orthologous Events
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Arabidopsis thaliana)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Bos taurus)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Caenorhabditis elegans)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Canis familiaris)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Danio rerio)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Dictyostelium discoideum)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Gallus gallus)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Mus musculus)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Oryza sativa)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Plasmodium falciparum)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Rattus norvegicus)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Saccharomyces cerevisiae)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Schizosaccharomyces pombe)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Sus scrofa)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Taeniopygia guttata)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Xenopus tropicalis)