Reactome: A Curated Pathway Database

SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Stable Identifier
R-HSA-3065678
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SUMO is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun et al. 2010, Gareau and Lima 2010). UBC9 is the only known E2 enzyme for SUMO and on certain substrates such as RanGAP1 may act without the requirement of an E3 ligase.

Literature References
Participants
Participant Of
Orthologous Events