Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

Stable Identifier
R-HSA-3134973
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) can bind exogenous double-stranded RNA and double-stranded DNA (Wilson SA et al. 1998; Yang P et al. 2010). LRRFIP1 was shown to mediate Listeria monocytogenes- and vesicular stomatitis virus (VSV)-induced IFN-beta production in mouse primary macrophages by regulating beta-catenin activity. Beta-catenin possibly functions as a transcriptional cofactor of IRF3 to initiate Ifnb1 transcription (Yang P et al. 2010).

Literature References
Participants
Participant Of
Orthologous Events