Reactome: A Curated Pathway Database

Recruitment Of HIV Virion Budding Machinery (R-HSA-3159232) [Homo sapiens]


The human ESCRT pathway comprises more than 30 different proteins, and this complexity is expanded further by associated regulatory and ubiquitylation machinery. Functional studies have identified a minimal core set of human ESCRT proteins, machinery that is essential for HIV-1 budding. ESCRT-1 recruitment follows an unusal path. The PTAP motif in p6 mimics the ESCRT-1 recruitment motif, bypassing the need for ESCRT-0. The TSG101/ ESCRT-I and ALIX both function by recruiting downstream ESCRT-III and VPS4 complexes, which in turn mediate membrane fission and ESCRT factor recycling.

Additional Information
Compartment plasma membrane
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
15473846 Retrovirus budding Annu Rev Cell Dev Biol 2004
22762019 HIV-1 Assembly, Budding, and Maturation Cold Spring Harb Perspect Med 2012
23305486 Wrapping up the bad news: HIV assembly and release Retrovirology 2013