Reactome: A Curated Pathway Database

Recruitment Of HIV Virion Budding Machinery (R-HSA-3159232)

Species Homo sapiens


The human ESCRT pathway comprises more than 30 different proteins, and this complexity is expanded further by associated regulatory and ubiquitylation machinery. Functional studies have identified a minimal core set of human ESCRT proteins, machinery that is essential for HIV-1 budding. ESCRT-1 recruitment follows an unusal path. The PTAP motif in p6 mimics the ESCRT-1 recruitment motif, bypassing the need for ESCRT-0. The TSG101/ ESCRT-I and ALIX both function by recruiting downstream ESCRT-III and VPS4 complexes, which in turn mediate membrane fission and ESCRT factor recycling.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 [HIV infection]
Literature References
pubMedId Title Journal Year
15473846 Retrovirus budding Annu Rev Cell Dev Biol 2004
22762019 HIV-1 Assembly, Budding, and Maturation Cold Spring Harb Perspect Med 2012
23305486 Wrapping up the bad news: HIV assembly and release Retrovirology 2013