The human ESCRT pathway comprises more than 30 different proteins, and this complexity is expanded further by associated regulatory and ubiquitylation machinery. Functional studies have identified a minimal core set of human ESCRT proteins, machinery that is essential for HIV-1 budding. ESCRT-1 recruitment follows an unusal path. The PTAP motif in p6 mimics the ESCRT-1 recruitment motif, bypassing the need for ESCRT-0. The TSG101/ ESCRT-I and ALIX both function by recruiting downstream ESCRT-III and VPS4 complexes, which in turn mediate membrane fission and ESCRT factor recycling.
|Human immunodeficiency virus infectious disease||526||[HIV infection]|
|15473846||Retrovirus budding||Annu Rev Cell Dev Biol||2004|
|22762019||HIV-1 Assembly, Budding, and Maturation||Cold Spring Harb Perspect Med||2012|
|23305486||Wrapping up the bad news: HIV assembly and release||Retrovirology||2013|