Reactome: A Curated Pathway Database

SMAD4 D351del

Stable Identifier
R-HSA-3310974
Type
Protein
Species
Homo sapiens
Compartment
Synonyms
SMAD4 Asp351del
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
External Reference Information
External Reference
Gene Names
SMAD4, DPC4, MADH4
Chain
chain:1-552
Reference Genes
Reference Transcript
Other Identifiers
 0000540341  11725360_a_at  11725361_s_at  11725362_x_at  11725363_s_at
 11744679_a_at  11750827_a_at  11753117_a_at  16852354  1DD1
 1G88  1MR1  1U7F  1U7V  1YGS
 202526_at  202527_s_at  235725_at  36953_at  3788304
 3788305  3788306  3788307  3788308  3788315
 3788316  3788318  3788320  3788324  3788327
 3788328  3788330  3788335  3788337  3788344
 3788346  3788347  3788348  3788349  3788350
 3788351  3788353  3788355  3788357  3788358
 3788359  4089  46885_at  509_at  510_g_at
 57902_at  58962_at  74813_at  8021228  A0A024R274
 A_14_P134632  A_19_P00323665  A_19_P00804817  A_19_P00812250  A_23_P27346
 AAA91041  AAC03051  AAH02379  AF045438  AF045439
 AF045440  AF045441  AF045442  AF045443  AF045444
 AF045445  AF045446  AF045447  AK290770  ALQ33626
 BAF83459  BC002379  CAB002312  CCDS11950  CH471096
 EAW62985  EAW62986  EAW62987  ENSG00000141646  ENSP00000341551
 ENSP00000381452  ENST00000342988  ENST00000398417  EntrezGene:4089  g4885456_3p_a_at
 GE887174  HGNC:6770  HPA019154  Hs.50438.0.A1_3p_at  Hs.75862
 Hs.75862.0.S2_3p_at  ILMN_1741477  IPR001132  IPR003619  IPR008984
 IPR013019  IPR013790  IPR017855  KU178168  LRG_318
 LRG_318t1  MIM:600993  NM_005359  NP_005350  PF03165
 PF03166  PH_hs_0004380  SM00523  SM00524  SMAD4
 SMAD4-001  SMAD4-201  U44378  U44378_at  uc010xdp.3
 uc060pfa.1  UPI0000053431
Participant Of
Other forms of this molecule
Modified Residues
Name Coordinate Modification PsiMod
Deletion of residues 351 to 351
Disease
Diseases
Name Identifier Synonyms
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]
malignant neoplasm of large intestine 5672 [malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS]
Cross References
RefSeq
UCSC human
COSMIC
GeneCards
DOCK Blaster
PRO
Protein Data Bank
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.964 P84022 SMAD3_HUMAN 21
0.957 Q15796 SMAD2_HUMAN 21
0.909 Q15797 SMAD1_HUMAN 9
0.878 P12755 SKI_HUMAN 12
0.748 Q9UPN9 TRI33_HUMAN 6
0.743 O43524 FOXO3_HUMAN 9
0.721 P63279 UBC9_HUMAN 4
0.719 Q9UBE8 NLK_HUMAN 6
0.696 P61968 LMO4_HUMAN 5
0.695 Q9NPI6 DCP1A_HUMAN 4
0.609 P17676 CEBPB_HUMAN 2
0.602 Q92988 DLX4_HUMAN 5
0.602 P70398 USP9X_MOUSE 4
0.556 Q8WWW0 RASF5_HUMAN 3
0.553 Q6VMQ6 MCAF1_HUMAN 2
0.553 O75925 PIAS1_HUMAN 2
0.547 O15198 SMAD9_HUMAN 2
0.547 Q13485 SMAD4_HUMAN 3
0.547 P12757 SKIL_HUMAN 3
0.527 SMAD7 ENSG00000101665 3
0.524 Q9UI36 DACH1_HUMAN 3
0.524 P98177 FOXO4_HUMAN 2
0.508 P23769 GATA2_HUMAN 2
0.499 P70056 FOXH1_XENLA 2
0.499 EBI-11165649 P21_CIP1_OLIGO_SBR_DISTAL_PROMOTER_REGION 2
0.488 O15198-2 SMAD9 2
0.488 Q96F07 CYFP2_HUMAN 2
0.488 P43268-3 ETV4 2
0.488 Q8NI38 IKBD_HUMAN 2
0.488 Q15915 ZIC1 2
0.488 Q08117-2 Q081172 2