Reactome: A Curated Pathway Database

SMAD4 K428R

Stable Identifier
R-HSA-3311001
Type
Protein
Species
Homo sapiens
Compartment
Synonyms
SMAD4 Lys428Arg
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
SMAD4, DPC4, MADH4
Chain
chain:1-552
Reference Genes
Reference Transcript
Other Identifiers
 0000540341  11725360_a_at  11725361_s_at  11725362_x_at  11725363_s_at
 11744679_a_at  11750827_a_at  11753117_a_at  16852354  1DD1
 1G88  1MR1  1U7F  1U7V  1YGS
 202526_at  202527_s_at  235725_at  36953_at  3788304
 3788305  3788306  3788307  3788308  3788315
 3788316  3788318  3788320  3788324  3788327
 3788328  3788330  3788335  3788337  3788344
 3788346  3788347  3788348  3788349  3788350
 3788351  3788353  3788355  3788357  3788358
 3788359  4089  46885_at  509_at  510_g_at
 57902_at  58962_at  74813_at  8021228  A0A024R274
 A_14_P134632  A_19_P00323665  A_19_P00804817  A_19_P00812250  A_23_P27346
 AAA91041  AAC03051  AAH02379  AF045438  AF045439
 AF045440  AF045441  AF045442  AF045443  AF045444
 AF045445  AF045446  AF045447  AK290770  ALQ33626
 BAF83459  BC002379  CAB002312  CCDS11950  CH471096
 EAW62985  EAW62986  EAW62987  ENSG00000141646  ENSP00000341551
 ENSP00000381452  ENST00000342988  ENST00000398417  EntrezGene:4089  g4885456_3p_a_at
 GE887174  HGNC:6770  HPA019154  Hs.50438.0.A1_3p_at  Hs.75862
 Hs.75862.0.S2_3p_at  ILMN_1741477  IPR001132  IPR003619  IPR008984
 IPR013019  IPR013790  IPR017855  KU178168  LRG_318
 LRG_318t1  MIM:600993  NM_005359  NP_005350  PF03165
 PF03166  PH_hs_0004380  SM00523  SM00524  SMAD4
 SMAD4-001  SMAD4-201  U44378  U44378_at  uc010xdp.3
 uc060pfa.1  UPI0000053431
Participant Of
Other forms of this molecule
Modified Residues
Name Coordinate Modification PsiMod
L-lysine residue 428 replaced with L-arginine 428
L-arginine residue [MOD:00011] A protein modification that effectively converts a source amino acid residue to an L-arginine.
L-lysine residue [MOD:00021] A protein modification that effectively converts a source amino acid residue to L-lysine.
Disease
Diseases
Name Identifier Synonyms
bile duct carcinoma 4897
cancer 162 [malignant tumor, malignant neoplasm, primary cancer]
Cross References
RefSeq
UCSC human
COSMIC
GeneCards
DOCK Blaster
PRO
Protein Data Bank
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.964 P84022 SMAD3_HUMAN 21
0.957 Q15796 SMAD2_HUMAN 21
0.909 Q15797 SMAD1_HUMAN 9
0.878 P12755 SKI_HUMAN 12
0.748 Q9UPN9 TRI33_HUMAN 6
0.743 O43524 FOXO3_HUMAN 9
0.721 P63279 UBC9_HUMAN 4
0.719 Q9UBE8 NLK_HUMAN 6
0.696 P61968 LMO4_HUMAN 5
0.695 Q9NPI6 DCP1A_HUMAN 4
0.609 P17676 CEBPB_HUMAN 2
0.602 Q92988 DLX4_HUMAN 5
0.602 P70398 USP9X_MOUSE 4
0.556 Q8WWW0 RASF5_HUMAN 3
0.553 Q6VMQ6 MCAF1_HUMAN 2
0.553 O75925 PIAS1_HUMAN 2
0.547 O15198 SMAD9_HUMAN 2
0.547 Q13485 SMAD4_HUMAN 3
0.547 P12757 SKIL_HUMAN 3
0.527 SMAD7 ENSG00000101665 3
0.524 Q9UI36 DACH1_HUMAN 3
0.524 P98177 FOXO4_HUMAN 2
0.508 P23769 GATA2_HUMAN 2
0.499 P70056 FOXH1_XENLA 2
0.499 EBI-11165649 P21_CIP1_OLIGO_SBR_DISTAL_PROMOTER_REGION 2
0.488 O15198-2 SMAD9 2
0.488 Q96F07 CYFP2_HUMAN 2
0.488 P43268-3 ETV4 2
0.488 Q8NI38 IKBD_HUMAN 2
0.488 Q15915 ZIC1 2
0.488 Q08117-2 Q081172 2