Reactome: A Curated Pathway Database
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DBC1 is phosphorylated by ATM/ART

Stable Identifier
R-HSA-3371567
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The stress-induced DBC1-SIRT1 interaction required the ATM/ATR-dependent phosphorylation of DBC1 at Thr454 (Yuan J et al. 2012; Zannini L et al. 2012).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of ATM/ATR kinase [nucleoplasm] ATM/ATR kinase [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events