Reactome: A Curated Pathway Database

DBC-1 is phosphorylated by ATM/ART (R-HSA-3371567)

Species Homo sapiens


The stress-induced DBC1-SIRT1 interaction required the ATM/ATR-dependent phosphorylation of DBC1 at Thr454 (Yuan J et al. 2012; Zannini L et al. 2012).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
ATM/ATR kinase protein serine/threonine kinase activity (0004674)
Literature References
pubMedId Title Journal Year
22735644 DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage J Mol Cell Biol 2012
22465953 Regulation of SIRT1 activity by genotoxic stress Genes Dev. 2012