Reactome: A Curated Pathway Database

Phosphorylation of COP1 at Ser-387 by ATM (R-HSA-349444) [Homo sapiens]


ATM phosphorylates COP1 on Ser387 in response to DNA damage (Dornan et al., 2006).

Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
p-S1981,Ac-K3016-ATM protein serine/threonine kinase activity (0004674)  
Literature References
pubMedId Title Journal Year
16931761 ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage Science 2006