Reactome: A Curated Pathway Database

Metabolism of polyamines (R-HSA-351202)

Species Homo sapiens

Summation

Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , peroxisomal matrix
GO Biological Process polyamine metabolic process (0006595)
Literature References
pubMedId Title Journal Year
12686127 Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide Biochim Biophys Acta 2003
15784477 Polyamines: metabolism and implications in human diseases Clin Nutr 2005
11564948 Polyamine metabolism revisited Eur J Gastroenterol Hepatol 2001