Reactome: A Curated Pathway Database

Netrin-1 signaling

Stable Identifier
R-HSA-373752
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
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Orthologous Events