Reactome: A Curated Pathway Database

Semaphorin interactions (R-HSA-373755)

Species Homo sapiens


Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins.

Locations in the PathwayBrowser
Literature References
pubMedId Title Journal Year
12471249 Molecular mechanisms of axon guidance Science 2002
12593985 Semaphorin junction: making tracks toward neural connectivity Curr Opin Neurobiol 2003
18374575 Semaphorin signaling: progress made and promises ahead Trends Biochem Sci 2008
16939971 Semaphorins in axon regeneration: developmental guidance molecules gone wrong? Philos Trans R Soc Lond B Biol Sci 2006
18269210 Role of semaphorins during axon growth and guidance Adv Exp Med Biol 2007