Reactome: A Curated Pathway Database

Interaction of NCAM1:GFRalpha-1 with GDNF

Stable Identifier
R-HSA-375144
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NCAM was identified as an alternative signaling receptor for GDNF family ligands (GFLs). The GFLs is a small group of soluble neurotrophic growth factors involved in neuronal survival, neurite growth and differentiation. Four members are known in the family including GDNF, Neurturin (NTN), Persephin (PSP), and Artemin (ART). NCAM, in collaboration with GFR? receptors, function as a signaling receptor for these GFLs. Signaling downstream of GDNF binding to the NCAM-GFRalpha1 complex activates Fyn-FAK-MAPK signaling pathway and mediates long-range intercellular communication.

Participants
Participant Of
Inferred From