Reactome: A Curated Pathway Database
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Dephosphorylation of inactive SRC by PTPB1

Stable Identifier
R-HSA-377643
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. The phosphorylated tail of SRC tail interacts with the SH2 domain thereby repressing kinase activity; removal of phosphorylation activates SRC kinase activity.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of PTPN1 [cytosol] PTPN1 [cytosol] protein tyrosine phosphatase activity (0004725)
Orthologous Events