Reactome: A Curated Pathway Database

Dephosphorylation of inactive SRC by PTPB1 (R-HSA-377643) [Homo sapiens]


The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. The phosphorylated tail of SRC tail interacts with the SH2 domain thereby repressing kinase activity; removal of phosphorylation activates SRC kinase activity.

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
PTPN1 protein tyrosine phosphatase activity (0004725)  
Literature References
pubMedId Title Journal Year
16115959 PTP-1B is an essential positive regulator of platelet integrin signaling J Cell Biol 2005
16005629 Integrins and Src: dynamic duo of adhesion signaling Trends Cell Biol 2005