Reactome: A Curated Pathway Database

MRN complex bound to DNA ends recruits ATM (R-HSA-3785781)

Species Homo sapiens


Activation of ATM kinase in response to DNA damage in the form of DNA double strand breaks (DSBs) requires association of ATM dimers with the MRN complex bound to DNA ends. MRN subunit RAD50 is essential for ATM dimer binding (Lee and Paull 2005, Wu et al. 2007). ATM dimer exists in a preformed complex with KAT5 (Tip60) histone acetyltransferase (Sun et al. 2005).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
15790808 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex Science 2005
17694070 MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control Nat. Struct. Mol. Biol. 2007