The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.
|Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive)||guanyl-nucleotide exchange factor activity (0005085)|
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