Reactome: A Curated Pathway Database

Liganded Gs-activating GPCR acts as a GEF for Gs (R-HSA-379044) [Homo sapiens]


The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.

Additional Information
Compartment cytosol , plasma membrane