G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.
|Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive)||guanyl-nucleotide exchange factor activity (0005085)|
|3086311||The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins||J Biol Chem||1986|
|16754659||Stable association between G alpha(q) and phospholipase C beta 1 in living cells||J Biol Chem||2006|
|10191087||Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC)||Genomics||1999|
|1905813||G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells||Proc Natl Acad Sci U S A||1991|
|8664309||Human G(alpha q): cDNA and tissue distribution||Biochim Biophys Acta||1996|