Reactome: A Curated Pathway Database

Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Stable Identifier
R-HSA-379048
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
guanyl-nucleotide exchange factor activity of Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events