Reactome: A Curated Pathway Database

Enzymatic degradation of dopamine by COMT (R-HSA-379397) [Homo sapiens]


Dopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catecholamine o-methyl transferase and the subsequent reaction is catalyzed by monoamine oxidase A.

Cross References
Database Identifier
BioModels Database BIOMD0000000575, BIOMD0000000268