Enzymatic degradation of dopamine by COMT

Stable Identifier
R-HSA-379397
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Dopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catecholamine o-methyl transferase and the subsequent reaction is catalyzed by monoamine oxidase A.
Literature References
PubMed ID Title Journal Year
17185601 Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure

Shabalina, SA, Maixner, W, Nackley, AG, Korchynskyi, O, Satterfield, K, Diatchenko, L, Tchivileva, IE, Makarov, SS

Science 2006
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