Reactome: A Curated Pathway Database
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Dopamine clearance from the synaptic cleft

Stable Identifier
R-HSA-379401
Type
Pathway
Species
Homo sapiens
Synonyms
Clearance of dopamine
Locations in the PathwayBrowser
Summation

The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.

Participants
Participant Of
Orthologous Events
Cross References