Reactome: A Curated Pathway Database

Dopamine clearance from the synaptic cleft (R-HSA-379401)

Species Homo sapiens


The human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degraded by either COMT or monoamine oxidase.

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000575, BIOMD0000000268