Reactome: A Curated Pathway Database

Cytosolic tRNA aminoacylation

Stable Identifier
R-HSA-379716
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthetases, those specific for arginine, aspartate, glutamate and proline, glutamine, isoleucine, leucine, lysine, and methionine, associate to form a complex with three accessory proteins. Each of the component synthetases is active in vitro as a purified protein; complex formation is thought to channel aminoacylated tRNAs more efficiently to the site of protein synthesis in mRNA:ribosome complexes (Quevillon et al. 1999; Wolfe et al. 2003, 2005).

Literature References
Participants
events
Participant Of
Orthologous Events