The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.
|Compartment||cytoplasmic side of plasma membrane|
|Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive)||guanyl-nucleotide exchange factor activity (0005085)|
|2834384||Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs||J Biol Chem||1988|
|8015379||Human taste cells express the G protein alpha-gustducin and neuron-specific enolase||Brain Res Mol Brain Res||1994|
|2534964||Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina||Neuron||1989|
|2748346||Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye||Nucleic Acids Res||1989|