Liganded Gi-activating GPCR acts as a GEF for Gi (R-HSA-380073) [Homo sapiens]


The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.

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Additional Information
Compartment cytoplasmic side of plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) guanyl-nucleotide exchange factor activity (0005085)  
Literature References
pubMedId Title Journal Year
2834384 Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs J Biol Chem 1988
8015379 Human taste cells express the G protein alpha-gustducin and neuron-specific enolase Brain Res Mol Brain Res 1994
2534964 Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina Neuron 1989
2748346 Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye Nucleic Acids Res 1989
Inferred Entries
Orthologous events