Reactome: A Curated Pathway Database

Liganded Gi-activating GPCR acts as a GEF for Gi

Stable Identifier
R-HSA-380073
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
guanyl-nucleotide exchange factor activity of Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events