Reactome: A Curated Pathway Database

Liganded Gi-activating GPCR acts as a GEF for Gi (R-HSA-380073)

Species Homo sapiens


The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein.

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Additional Information
Compartment cytoplasmic side of plasma membrane