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Tachykinin receptors bind tachykinins
Stable Identifier
R-HSA-380095
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Tachykinin receptors bind tachykinins (Homo sapiens)
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Tachykinin peptides are one of the largest family of neuropeptides, so named due to their ability to rapidly induce contraction of gut tissue. Tachykinins excite neurons, elicit behavioural responses, are potent vasodilators and contract many smooth muscles. The tachykinin family is characterized by a common C-terminal sequence, Phe-X-Gly-Leu-Met-NH2 (where X can be either an aromatic or an aliphatic amino acid) and are ten to twelve residues long.
These peptides elicit their effects via the tachykinin receptors, of which there are three types in humans (NK1,2 and 3). There are two human tachykinin peptide genes in humans, TAC1 and TAC3. TAC1 encodes substance P and substance K while TAC3 encodes neurokinin B.
Antagonists of these receptors are promising candidates for classes of antidepressants, anxiolytics and antipsychotics.
Literature References
PubMed ID
Title
Journal
Year
16918325
Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors
Satake, H
,
Kawada, T
Curr Drug Targets
2006
15224188
Hemokinins and endokinins
Page, NM
Cell Mol Life Sci
2004
Participants
Events
Tachykinin receptor 1 (NK1) binds to substance P
(Homo sapiens)
Tachykinin receptor 2 (NK2) binds to nuerokinin A
(Homo sapiens)
Tachykinin receptor 3 (NK3) binds to neurokinin B
(Homo sapiens)
Participates
as an event of
Peptide ligand-binding receptors (Homo sapiens)
Orthologous Events
Tachykinin receptors bind tachykinins (Bos taurus)
Tachykinin receptors bind tachykinins (Canis familiaris)
Tachykinin receptors bind tachykinins (Danio rerio)
Tachykinin receptors bind tachykinins (Gallus gallus)
Tachykinin receptors bind tachykinins (Mus musculus)
Tachykinin receptors bind tachykinins (Rattus norvegicus)
Tachykinin receptors bind tachykinins (Sus scrofa)
Tachykinin receptors bind tachykinins (Xenopus tropicalis)
Authored
Jassal, B (2008-11-24)
Reviewed
D'Eustachio, P (2009-03-02)
Created
Jassal, B (2008-11-07)
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