Reactome: A Curated Pathway Database

Chemokine receptors bind chemokines (R-HSA-380108) [Homo sapiens]


Chemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of intracellular calcium which leads to chemotaxis. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind.

Literature References
pubMedId Title Journal Year
10807766 Chemokine receptors and their role in inflammation and infectious diseases Blood 2000
15578986 Chemokine-chemokine receptor network in immune cell trafficking Curr Drug Targets Immune Endocr Metabol Disord 2004
11544102 Chemokine receptors Cytokine Growth Factor Rev 2001