Reactome: A Curated Pathway Database

Loss of Nlp from mitotic centrosomes (R-HSA-380259) [Homo sapiens]


During interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated at the onset of mitosis and phosphorylates Nlp triggering its displacement from the centrosome (Casenghi et al.,2003). Removal of Nlp appears to contribute to the establishment of a mitotic scaffold with enhanced microtubule nucleation activity.

Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
12852856 Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation Dev Cell 2003