Reactome: A Curated Pathway Database

Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270) [Homo sapiens]


The mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centrosomes recruiting additional gamma TuRC complexes and acquiring mitosis-associated centrosomal proteins including NuMA, Plk1 and CDK11p58 (reviewed in Schatten 2008; Raynaud-Messina and Merdes 2007).

Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
17178454 Gamma-tubulin complexes and microtubule organization Curr Opin Cell Biol 2007
18437411 The mammalian centrosome and its functional significance Histochem Cell Biol 2008