Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).

• LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)
• LKB1 forms a trimeric complex with STRAD and MO25 (Bos taurus)
• LKB1 forms a trimeric complex with STRAD and MO25 (Xenopus tropicalis)
• LKB1 forms a trimeric complex with STRAD and MO25 (Taeniopygia guttata)
• LKB1 forms a trimeric complex with STRAD and MO25 (Drosophila melanogaster)
• LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)
• LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)
• LKB1 forms a trimeric complex with STRAD and MO25 (Rattus norvegicus)
• LKB1 forms a trimeric complex with STRAD and MO25 (Danio rerio)
• LKB1 forms a trimeric complex with STRAD and MO25 (Saccharomyces cerevisiae)
• LKB1 forms a trimeric complex with STRAD and MO25 (Caenorhabditis elegans)