Reactome | LKB1 forms a trimeric complex with STRAD and MO25

LKB1 forms a trimeric complex with STRAD and MO25

Stable Identifier

R-HSA-380942

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Summation

Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).

Literature References

PubMed ID	Title	Journal	Year
14517248	MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm	EMBO J	2003
12805220	Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD	EMBO J	2003

Participants

Input

Output

LKB1:STRAD:MO25 [cytosol] (Homo sapiens)

Participant Of

hasEvent

Energy dependent regulation of mTOR by LKB1-AMPK

Orthologous Events

LKB1 forms a trimeric complex with STRAD and MO25 (Bos taurus)

LKB1 forms a trimeric complex with STRAD and MO25 (Caenorhabditis elegans)

LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)

LKB1 forms a trimeric complex with STRAD and MO25 (Danio rerio)

LKB1 forms a trimeric complex with STRAD and MO25 (Drosophila melanogaster)

LKB1 forms a trimeric complex with STRAD and MO25 (Gallus gallus)

LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)

LKB1 forms a trimeric complex with STRAD and MO25 (Rattus norvegicus)

LKB1 forms a trimeric complex with STRAD and MO25 (Saccharomyces cerevisiae)

LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)

LKB1 forms a trimeric complex with STRAD and MO25 (Taeniopygia guttata)

LKB1 forms a trimeric complex with STRAD and MO25 (Xenopus tropicalis)

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