LKB1 forms a trimeric complex with STRAD and MO25

Stable Identifier
R-HSA-380942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).
Literature References
PubMed ID Title Journal Year
12805220 Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

Clevers, HC, Medema, R, Smit, L, Alessi, DR, Baas, AF, Morrice, NA, Sapkota, GP, Boudeau, J

EMBO J 2003
14517248 MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Prescott, AR, Clevers, HC, Schutkowski, M, Kieloch, A, Alessi, DR, Deak, M, Baas, AF, Morrice, NA, Boudeau, J

EMBO J 2003
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