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LKB1 forms a trimeric complex with STRAD and MO25 (R-HSA-380942) [Homo sapiens]

Reaction
Summation

Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).

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Additional Information
Compartment cytosol
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Output entries
Literature References
pubMedId Title Journal Year
12805220 Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD EMBO J 2003
14517248 MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm EMBO J 2003
Inferred Entries
Orthologous events
 
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