XBP1(S) activates chaperone genes (R-HSA-381038) [Homo sapiens]


Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm , cytosol , endoplasmic reticulum lumen , endoplasmic reticulum membrane
Literature References
pubMedId Title Journal Year
16539657 XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells J Neurochem 2006
16461360 pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response J Cell Biol 2006
14559994 XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response Mol Cell Biol 2003
17612490 XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks Mol Cell 2007
18664523 Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds J Biochem 2008
Inferred Entries
Orthologous events