Reactome: A Curated Pathway Database

XBP1(S) activates chaperone genes

Stable Identifier
R-HSA-381038
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER.

Literature References
Participants
events
Participant Of
Orthologous Events