Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER.
|Compartment||nucleoplasm , cytosol , endoplasmic reticulum lumen , endoplasmic reticulum membrane|
|16539657||XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells||J Neurochem||2006|
|16461360||pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response||J Cell Biol||2006|
|14559994||XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response||Mol Cell Biol||2003|
|17612490||XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks||Mol Cell||2007|
|18664523||Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds||J Biochem||2008|