Reactome: A Curated Pathway Database

ABC-family proteins mediated transport (R-HSA-382556) [Homo sapiens]


The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but are also involved in intracellular compartmental transport. Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. Human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease (Dean et al. 2001, Borst and Elferink 2002, Rees et al. 2009).

Additional Information
GO Biological Process transmembrane transport (0055085)
Literature References
pubMedId Title Journal Year
12045106 Mammalian ABC transporters in health and disease Annu Rev Biochem 2002
11435397 The human ATP-binding cassette (ABC) transporter superfamily Genome Res 2001
19234479 ABC transporters: the power to change Nat Rev Mol Cell Biol 2009