Reactome: A Curated Pathway Database
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GPCR downstream signaling

Stable Identifier
R-HSA-388396
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

G protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it has become clear that this greatly oversimplifies the complexities of GPCR signaling (see Gurevich & Gurevich, 2008). The beta:gamma G-protein dimer is also involved in downstream signaling (Smrcka, 2008), and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events (Kristiansen 2004), using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK.

Literature References
PubMed ID Title Journal Year
12040175 G protein pathways Science 2002
Participants
Participant Of
Orthologous Events