Reactome: A Curated Pathway Database

CD28 co-stimulation (R-HSA-389356)

Species Homo sapiens

Summation

In naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation of an antiapoptotic program. CD28 engages with one or both members of the B7 receptor family, B7.1 and B7.2. Upon ligand binding the tyrosines and proline-rich motifs present in the cytoplasmic tail of CD28 are phosphorylated by Lck or Fyn. Upon phosphorylation CD28 recruits and induces phosphorylation and activation of a more restricted set of intracellular signaling components that, together with those mobilized by the TCR, contribute to convert membrane-based biochemical and biophysical changes into gene activation events. Proteins like PI3K, Vav-1, Tec and Itk kinases, AKT, and the Dok-1 adaptor have been identified as elements of the CD28 signaling pathway by biochemical or genetic approaches or both.

Locations in the PathwayBrowser
Additional Information
GO Biological Process T cell costimulation (0031295)
Cross References
Database Identifier
BioModels Database BIOMD0000000175, BIOMD0000000468, BIOMD0000000424, BIOMD0000000255