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NPFF(69-76) [extracellular region]
Stable Identifier
R-HSA-389415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neuropeptide FF, RecName: Full=FMRFamide-related peptides; Contains: RecName: Full=Neuropeptide SF; Short=NPSF; Contains: RecName: Full=Neuropeptide FF; Short=NPFF; Contains: RecName: Full=Neuropeptide AF; Short=NPAF; Flags: Precursor;
GN Name=NPFF;
OS Homo sapiens, NPFF_HUMAN, NPFF
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
Two NPFF receptors can bind neuropeptide FF (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
NPFF(69-76) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15130 NPFF
Gene Names
NPFF
Chain
signal peptide:1-20, propeptide:21-65, peptide:66-76, peptide:69-76, propeptide:79-92, peptide:93-110
Reference Genes
BioGPS Gene:8620 NPFF
COSMIC (genes):NPFF NPFF
CTD Gene:8620 NPFF
dbSNP Gene:8620 NPFF
ENSEMBL:ENSG00000139574 NPFF
ENSEMBL_homo_sapiens_GENE:ENSG00000139574.9 NPFF
HGNC:7901 NPFF
KEGG Gene (Homo sapiens):8620 NPFF
Monarch:8620 NPFF
NCBI Gene:8620 NPFF
OMIM:604643 NPFF
UCSC:O15130 NPFF
Reference Transcript
RefSeq:NM_003717.3 NPFF
RefSeq:NM_001320296.1 NPFF
Other Identifiers
11733586_a_at
16765357
206402_PM_s_at
206402_s_at
3456252
3456253
3456254
3456256
37130_g_at
7963689
8620
A_23_P204079
A_24_P347185
GE54063
GO:0001664
GO:0005102
GO:0005184
GO:0005576
GO:0005615
GO:0007218
GO:0007268
GO:0023052
GO:0030425
GO:0043204
GO:0043679
GO:0048018
GO:0050877
GO:0060079
GO:0098772
GO:0098794
HMNXSV003008589
ILMN_1682503
PH_hs_0005800
TC12001551.hg
g4503768_3p_a_at
Participates
as an input of
Two NPFF receptors can bind neuropeptide FF (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
NPFFR1,NPFFR2:NPFF(69-76) [plasma membrane] (Homo sapiens)
Inferred To
NPFF [extracellular region]
(Bos taurus)
NPFF [extracellular region]
(Danio rerio)
NPFF(69-76) [extracellular region]
(Sus scrofa)
Npff [extracellular region]
(Mus musculus)
Npff [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_003708.1
,
NP_001307225.1
OpenTargets
ENSG00000139574
HPA
ENSG00000139574-NPFF
GeneCards
O15130
Ensembl
ENST00000267017
,
ENSG00000139574
,
ENSP00000267017
PRO
O15130
Pharos - Targets
O15130
HMDB Protein
HMDBP13488
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