Reactome: A Curated Pathway Database

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (R-HSA-389758)

Species Homo sapiens


PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol