Reactome: A Curated Pathway Database

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

Stable Identifier
R-HSA-389758
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PD-1 delivers inhibitory signals and downregulates antigen receptor signaling through direct dephosphorylation of signaling intermediates. The phosphatases SHP-1 and SHP-2 dephosphorylate CD3 zeta and inhibit the phosphorylation of ZAP-70 and PKC theta.

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] protein tyrosine phosphatase activity (0004725)
Orthologous Events