Reactome: A Curated Pathway Database

Formation of tubulin folding intermediates by CCT/TriC

Stable Identifier
R-HSA-389960
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

TriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Five additional protein cofactors (cofactor A-E) are required for the generation of properly folded alpha- and beta-tubulin and for the formation of alpha/beta-tubulin heterodimers (Gao et al., 1993) (Tian et al., 1997, Cowan and Lewis 2001).

Literature References
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