Reactome: A Curated Pathway Database

Formation of tubulin folding intermediates by CCT/TriC (R-HSA-389960) [Homo sapiens]


TriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Five additional protein cofactors (cofactor A-E) are required for the generation of properly folded alpha- and beta-tubulin and for the formation of alpha/beta-tubulin heterodimers (Gao et al., 1993) (Tian et al., 1997, Cowan and Lewis 2001).

Additional Information
Compartment cytosol
GO Biological Process protein folding (0006457)