Reactome: A Curated Pathway Database

Post-chaperonin tubulin folding pathway (R-HSA-389977)

Species Homo sapiens


Alpha and beta tubulin folding intermediates are formed through ATP-dependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of interactions with five proteins: (cofactors A-E) following release from TriC/CCT (reviewed in Cowan and Lewis et al., 2001). These interactions are described in the reactions below. Ultimately, alpha tubulin, when associated with cofactor E, interacts with cofactor D-bound beta-tubulin. The entry of cofactor C into this complex results in the discharge of native heterodimer triggered by GTP hydrolysis in beta tubulin (Tian et al., 1997).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
GO Biological Process post-chaperonin tubulin folding pathway (0007023)
Literature References
pubMedId Title Journal Year
17709011 The alpha- and beta-tubulin folding pathways Trends Cell Biol 1997