Reactome: A Curated Pathway Database

Dephosphorylation of AKT by PP2A (R-HSA-390329) [Homo sapiens]


When CTLA4 is engaged by B7 molecules, PP2A disassociates from CTLA4 in a phosphorylation dependent manner. Released PP2A acts downstream of early TCR and CD28 signaling, by inhibition of the PKB/Akt pathway.

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
PP2A phosphatidate phosphatase activity (0008195)  
Literature References
pubMedId Title Journal Year
19405949 Structure-Function analysis of the CTLA-4 interaction with PP2A BMC Immunol 2009