Reactome: A Curated Pathway Database
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Dephosphorylation of AKT by PP2A

Stable Identifier
R-HSA-390329
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

When CTLA4 is engaged by B7 molecules, PP2A disassociates from CTLA4 in a phosphorylation dependent manner. Released PP2A acts downstream of early TCR and CD28 signaling, by inhibition of the PKB/Akt pathway.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
phosphatidate phosphatase activity of PP2A [cytosol] PP2A [cytosol] phosphatidate phosphatase activity (0008195)
Orthologous Events