Dephosphorylation of AKT by PP2A

Stable Identifier
R-HSA-390329
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

When CTLA4 is engaged by B7 molecules, PP2A disassociates from CTLA4 in a phosphorylation dependent manner. Released PP2A acts downstream of early TCR and CD28 signaling, by inhibition of the PKB/Akt pathway.

Literature References
PubMed ID Title Journal Year
19405949 Structure-Function analysis of the CTLA-4 interaction with PP2A BMC Immunol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidate phosphatase activity of PP2A [cytosol]
Physical Entity
Activity
Orthologous Events